Halophenols

Organic compounds derived from phenols that contain a halogen atom (bromine, chlorine, fluorine, iodine).

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2,221 – 2,235 of 8,378 results

2,221

Medchemexpress LLC (+)-JQ1 PA | 2115701-93-2 | 98.2% | 437.95 | 1 ML

(+)-JQ1 PA is a derivative of the Bromodomain and extra-terminal (BET) inhibitor JQ1, with an IC50 of 10.4 nM. It is a click chemistry reagent containing an Alkyne group, which allows it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Derivative of the BET inhibitor JQ1.
IC50 of 10.4 nM for BET.
Click chemistry reagent with an alkyne group.
Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc).

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2,222

Medchemexpress LLC IITZ-01 | 1807988-47-1 | 98.18% | 482.51 | 1 ML

IITZ-01 is a potent lysosomotropic autophagy inhibitor with single-agent antitumor activity, with an IC50 of 2.62 μM for PI3Kγ. For research use only.

Potent lysosomotropic autophagy inhibitor.
Single-agent antitumor activity.
IC50 of 2.62 μM for PI3Kγ.
Enhances autophagosomes formation in triple-negative breast cancer (TNBC) cell lines (MDA-MB-231 and MDA-MB-453) by increasing LC3-II levels time- and dose-dependently.
Demonstrates potent autophagy inhibitory activity in other breast, lung, and colon cancer cells.
Inhibits average breast tumor growth in triple-negative breast tumor models in mice.

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2,223

Medchemexpress LLC MEDCHEMEXPRESS LLC

5000429081 TRYPSIN-CHYMOTRYPSIN 25G

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2,224

BIOHIPPO

5000858948 HUMAN AS2886401-00 BIOSIMILAR

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2,225

Apexbio Technology LLC HyperScript™ III First-Strand cDNA Synthesis Kit 100rxn

HyperScript III First-Strand cDNA Synthesis Kit is an enzymatic reagent kit designed for generating first-strand complementary DNA (cDNA) from total RNA or poly(A) RNA templates It utilizes HyperScript III Reverse Transcriptase an engineered derivative of M-MLV reverse transcriptase with reduced RNase H activity and enhanced thermostability and fidelity HyperScript III First-Strand cDNA Synthesis Kit enables efficient synthesis of cDNA with extended length superior efficiency on GC-rich templates and compatibility with various primer types including random primers Oligo(dT) V/N and gene-specific primers Based on these features HyperScript III First-Strand cDNA Synthesis Kit is applicable for downstream applications such as PCR qPCR and gene expression analyses

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2,226

Medchemexpress LLC Ethanol, 2,2'-[[6-[[(4-methoxyphenyl)methyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis | 199986-75-9 | C20H28N6O3 | 25 MG

CVT-313 (Cdk2 Inhibitor III) is a potent, selective, reversible, and ATP-competitive inhibitor of CDK2 with an IC50 of 0.5 μM. It effectively inhibits CDC5L phosphorylation and shows profound effects on cell proliferation at concentrations of 5-20 μM. It exhibits high selectivity, requiring much higher concentrations to inhibit other kinases like CDK1 and CDK4.

Potent, selective, reversible, and ATP-competitive inhibitor of CDK2
Inhibits CDC5L phosphorylation
Profound effects on cell proliferation at 5-20 μM
Exhibits high selectivity against other kinases
Inhibition is competitive with respect to ATP (Ki=95 nM)
For research use only

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2,227

Medchemexpress LLC DNA, d(P-thio)(T-C-C-T-G-G-C-G-c7G-G-G-A-A-G-T), sodium salt | 1964506-29-3 | 1 MG

ODN 20844 sodium is a guanine-modified inhibitory oligonucleotide (INH-ODN) that is more potent than its parent INH-ODN 2088. It impairs TLR7- and TLR9-induced responses by murine immune cells and effectively blocks TLR9-mediated IFN-α release while inhibiting IL-6 secretion in human peripheral blood mononuclear cells.

Molecular weight of 4872.9 (free acid)
Off-white to light yellow solid
Purity of 92.74% by LCMS
Recommended storage at -20°C, sealed and away from moisture
In solvent, stable for 6 months at -80°C or 1 month at -20°C

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2,228

Apexbio Technology LLC ODN 1826 sodium 1mg

ODN 1826 sodium is a synthetic oligodeoxynucleotide agonist targeting Toll-like receptor 9 (TLR9) It is designed to activate TLR9-mediated immune responses thereby modulating both innate and adaptive immunity ODN 1826 sodium exerts its biological activity primarily through direct interaction with TLR9 which is expressed in intracellular compartments of immune cells such as dendritic cells macrophages and B lymphocytes Upon binding it triggers downstream signaling cascades leading to the secretion of cytokines including type I interferons and interleukin-12 (IL-12) promoting the polarization of T-helper type 1 (Th1) immune responses Based on these pharmacological properties ODN 1826 sodium holds research potential in studies of immune activation mechanisms tumor immunology infectious disease modeling and vaccine adjuvant development

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2,229

Apexbio Technology LLC HyperScript™ IV First-Strand cDNA Synthesis SuperMix 50rxn

HyperScript IV First-Strand cDNA Synthesis SuperMix is a reagent kit incorporating an engineered reverse transcriptase derived from M-MLV Reverse Transcriptase It is designed to efficiently catalyze first-strand cDNA synthesis from RNA templates thereby enabling reverse transcription required for downstream molecular analyses HyperScript IV First-Strand cDNA Synthesis SuperMix exhibits high activity enhanced inhibitor resistance extended elongation capability improved reaction kinetics and reduced RNase H activity supporting efficient full-length cDNA synthesis Synthesized cDNA is compatible with downstream applications such as PCR amplification and quantitative PCR (qPCR)

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2,230

Medchemexpress LLC ODN 2007 sodium | 455348-63-7 | [DNA, d(P-thio)(T-C-G-T-C-G-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T), sodium salt] | 1 MG

ODN 2007 sodium is a class B CpG oligodeoxynucleotide (ODN) and a Toll-like receptor (TLR) ligand. It functions as an immunomodulator and vaccine adjuvant, enhancing immune responses in mammals, fish, and humans. The sequence is 5'-TCGTCGTTGTCGTTTTGTCGTT-3'.

Purity of 99.69%
Appears as a solid
Color is white to off-white
Enhances immune responses
Functions as an immunomodulator
Acts as a vaccine adjuvant
TLR ligand
Induces chicken macrophage interferon IFN-γ and IFN-β expression in vitro
Increases phosphorylation of ERK2 and AKT, and stimulates NO production in vitro
Enhances immune response in zebrafish against Vibrio traumaticus infection in vivo
Reduces cumulative mortality rate in treated zebrafish group in vivo
Decreases expression levels of intestinal immune-related genes in vivo

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2,231

Medchemexpress LLC Pf-06815345 (hydrochloride) | 2334434-49-8 | 98.15% | 634.49 | 25 MG

PF-06815345 hydrochloride is an orally active and potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) with an IC50 value of 13.4 μM. It significantly decreases the PCSK9 level in vivo in mouse.

Orally active.
Potent inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9).
Has an IC50 value of 13.4 μM for PCSK9 inhibition.
Significantly decreases PCSK9 levels in vivo in mice.
Lowers plasma PCSK9 to 72% at 500 mg/kg 4 hours after treatment in a humanized PCSK9 mouse model.

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2,232

Apexbio Technology LLC Doxapram HCl 7081-53-0 10mM (in 1mL DMSO)

Doxapram hydrochloride (CAS 7081-53-0) is a respiratory stimulant that exerts its biological effects primarily through inhibition of two-pore domain potassium (K2P) channels specifically the TASK-1 and TASK-3 subtypes as well as their heterodimers Electrophysiological studies demonstrate that Doxapram HCl suppresses the activity of these channels with varying potency depending on concentration and channel subtype This selective TASK channel blockade makes Doxapram HCl a useful research tool for investigating the physiological and pathophysiological roles of TASK channels in respiratory regulation central nervous system function and oxygen-sensing mechanisms

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2,233

eMolecules 7521-41-7 | 2-Aminonicotinaldehyde | ChemScene | MFCD01830382 | 122.127 | C6H6N2O | 98.000 | Nc1ncccc1C=O | 100g | 572223476

2-Aminonicotinaldehyde | ChemScene | 7521-41-7 | MFCD01830382 | 122.127 | C6H6N2O | 98.000 | Nc1ncccc1C=O | 100g | 572223476

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2,234

Apexbio Technology LLC Amitriptyline HCl 549-18-8 10mM (in 1mL DMSO)

Amitriptyline HCl (CAS 549-18-8) is a tricyclic compound that modulates multiple neurotransmitter systems It acts as an inhibitor at serotonin and norepinephrine receptors demonstrating potent activity with IC50 values of 3 45 nM and 13 3 nM respectively Amitriptyline also exhibits notable affinity for 5-HT4 (IC50 7 31 nM) 5-HT2 (IC50 235 nM) and sigma-1 receptors (IC50 287 nM) indicating a broad spectrum of receptor interactions This pharmacological profile supports its application in neuropharmacological research including studies of synaptic transmission antidepressant mechanisms and receptor signaling pathways

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2,235

Medchemexpress LLC Norverapamil (hydrochloride) | 67812-42-4 | MFCD00078605 | 99.8% | 477.04 g·mol⁻¹ | C26H37ClN2O4 | 1 MG

Norverapamil hydrochloride is the monohydrochloride salt of an N-demethylated metabolite of verapamil. It acts as an L-type calcium channel blocker and an inhibitor of P-glycoprotein (P-gp), and is used in pharmacological and transporter research.

Acts as an L-type calcium channel blocker.
Inhibits P-glycoprotein (P-gp) function.
Suitable for in vitro pharmacology and transporter studies.
Supplied as a solid or as a DMSO solution for experimental use.
High reported purity (99.8%).
Molecular weight 477.04 g·mol⁻¹; formula C26H37ClN2O4.

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Halophenols

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Medchemexpress LLC (+)-JQ1 PA | 2115701-93-2 | 98.2% | 437.95 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC IITZ-01 | 1807988-47-1 | 98.18% | 482.51 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MEDCHEMEXPRESS LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

BIOHIPPO Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC HyperScript™ III First-Strand cDNA Synthesis Kit 100rxn Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethanol, 2,2'-[[6-[[(4-methoxyphenyl)methyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]imino]bis | 199986-75-9 | C20H28N6O3 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC DNA, d(P-thio)(T-C-C-T-G-G-C-G-c7G-G-G-A-A-G-T), sodium salt | 1964506-29-3 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC ODN 1826 sodium 1mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC HyperScript™ IV First-Strand cDNA Synthesis SuperMix 50rxn Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC ODN 2007 sodium | 455348-63-7 | [DNA, d(P-thio)(T-C-G-T-C-G-T-T-G-T-C-G-T-T-T-T-G-T-C-G-T-T), sodium salt] | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Pf-06815345 (hydrochloride) | 2334434-49-8 | 98.15% | 634.49 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Doxapram HCl 7081-53-0 10mM (in 1mL DMSO) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC Amitriptyline HCl 549-18-8 10mM (in 1mL DMSO) Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Norverapamil (hydrochloride) | 67812-42-4 | MFCD00078605 | 99.8% | 477.04 g·mol⁻¹ | C26H37ClN2O4 | 1 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More