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Filtered Search Results
Medchemexpress LLC Ternidazole Hydroch 5Mg | HY-136436-5MG
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Ternidazole Hydroch 5Mg
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Medchemexpress LLC IACS-010759 hydrochloride | 1807523-99-4 | 99.6% | 599.02 | 1 ML
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This orally active, potent mitochondrial complex I inhibitor of oxidative phosphorylation (OXPHOS) reduces cell viability and induces apoptosis in primary acute myeloid leukemia (AML) models. It is similarly active in mouse, rat, and cynomolgus monkey cell lines, demonstrating potential for relapsed/refractory AML and solid tumor research.
- Inhibits mitochondrial complex I of oxidative phosphorylation.
- Inhibits proliferation and induces apoptosis in models reliant on OXPHOS.
- Active across various mammalian cell lines.
- Has potential for addressing relapsed/refractory AML and solid tumors.
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STA PHARMACEUTICAL US LLC Fmoc-(S)-2-amino-6,6,6-Triflurohexanoic acid | 100 g | CAS 2230472-61-2 | InChIKey RVXLFAQYYCBCAT-SFHVURJKSA-N
Fmoc-(S)-2-amino-6,6,6-Triflurohexanoic acid is a Amino Acid reagent (Subcategory: Unusual AA) sold by WuXi TIDES. Offered in 100 g. Store at 4 °C. SDS available for reference.
Specifications
- CAS: 2230472-61-2
- MDL: No data
- InChIKey: RVXLFAQYYCBCAT-SFHVURJKSA-N
- Molecular Weight: 407.389
- Molecular Formula: C21H20F3NO4
- Purity: ≥95%
- Container Type: 500 mL HDPE
- Pack Size: 100 g
- Net Weight: 100 g
- Gross Weight: 160.5 g
- Commodity Code: 29242970
- Country Of Origin: China
- IUPAC: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-6,6,6-trifluorohexanoic acid
- SMILES: O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)N[C@H](C(O)=O)CCCC(F)(F)F
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Medchemexpress LLC (1S,2S)-2-PCCA hydrochloride | 1609563-70-3 | 99.7% | 528.56 | C30H39Cl2N3O | 10 MG
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(1S,2S)-2-PCCA hydrochloride is the less-active diastereomer of 2-PCCA, a small-molecule GPR88 agonist. It inhibits GPR88-mediated cAMP production in HEK293 cells (EC50 = 116 nM) and is supplied as a solid hydrochloride salt for research applications, with defined purity and storage recommendations.
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Medchemexpress LLC 3-chlorobenzaldehyde | 587-04-2 | MFCD00003350 | 500g
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3-Chlorobenzaldehyde (m-Chlorobenzenecarboxaldehyde) is a kind of biological materials or organic compounds that are widely used in life science research[1]
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Medchemexpress LLC Pyrazolo[1,5-a]pyrido[4,3-d]pyrimidin-9(1H)-one derivative, hydrochloride | 1775330-54-5 | 99.9% | 571.78 g·mol⁻¹ | C22H19BrClF3N6O2 | 10 MG
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PAT1inh-B01 hydrochloride is a research-grade small-molecule inhibitor selective for SLC26A6 (PAT1), supplied as the hydrochloride salt and intended for in vitro studies of PAT1-mediated anion exchange.
- Selective inhibitor of SLC26A6 with a reported IC50 of 350 nM.
- Supplied as a hydrochloride salt suitable for aqueous handling and formulation.
- High purity (~99.9%) for reliable experimental performance.
- Well-characterized physicochemical profile (MW 571.78 g·mol⁻¹; formula C22H19BrClF3N6O2).
- Soluble in DMSO at approximately 10 mg/mL with ultrasonic warming.
- Available in small research pack sizes for assay development and screening.
- Store solid at 4°C; follow solvent storage recommendations for long-term stability.
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Medchemexpress LLC Amisulpride (hydrochloride) | 81342-13-4 | MFCD09836932 | 99.8% | C17H28ClN3O4S | 50 MG
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Amisulpride hydrochloride is a dopamine D2/D3 receptor antagonist with Kis of 2.8 and 3.2 nM for human dopamine D2 and D3, respectively. It is intended for research use only.
- Dopamine D2/D3 receptor antagonist
- Ki values of 2.8 nM for human dopamine D2 and 3.2 nM for human dopamine D3
- Intended for research use only
- Stable under recommended storage conditions
- Appearance is a colorless to light yellow oil
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Medchemexpress LLC HDAC10-IN-2 (hydrochloride) | 95.0% | C19H23ClN2O2 | 25 MG
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HDAC10-IN-2 hydrochloride is a potent and highly selective HDAC10 inhibitor with an IC50 of 20 nM. This compound modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells and is for research use only.
- Potent and highly selective HDAC10 inhibitor
- IC50 of 20 nM (drHDAC10)
- Modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells
- Relevant to epigenetics and autophagy pathways
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Ambeed 5 7Dihydroxy2 3hydroxy4methoxy
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one, 520-34-3, 96%
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Medchemexpress LLC Mavorixafor hydrochloride | 880549-30-4 | MFCD11977316 | 99.1% | 385.93 g·mol⁻1 | C21H28ClN5 | 10 MG
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Mavorixafor hydrochloride is a potent, selective CXCR4 antagonist supplied as the hydrochloride salt for research use. It is provided as a viscous liquid with high purity and is intended for in vitro and preclinical studies of CXCR4 signaling and related disease models.
- High purity: 99.1%.
- Molecular weight: 385.93 g·mol⁻1.
- Cas number: 880549-30-4.
- Physical form: viscous liquid, light yellow to brown.
- Storage: store at -20 °C, sealed, protect from moisture and light.
- Application: research into CXCR4 biology and WHIM syndrome models.
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Medchemexpress LLC HY-078020 | 2756222-90-7 | 98.9% | 515.09 | 5 MG
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HY-078020 (compound III-4) is a selective, orally active antagonist for the histamine H1 receptor with an IC50 of 24.12 nM. It exhibits an anti-inflammatory effect in allergic diseases.
- Selective, orally active histamine H1 receptor antagonist.
- Exhibits an anti-inflammatory effect in allergic diseases.
- Potent inhibitory activity towards H1R (IC50 of 24.12 nM).
- Weak inhibition against M3R and hERG.
- Moderate permeability and good liver microsome stability.
- Long half-life in human, beagles, and mice.
- Inhibits cytochrome P450 (CYP) isozyme CYP3A4.
- Inhibits histamine-induced skin vasodilation and capillary permeability in mice.
- Exhibits weak anticholinergic activity in mice.
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Medchemexpress LLC ML-00253764 hydrochloride | 1706524-94-8 | 99.29% | 413.71 | 10 MM * 1 ML
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ML-00253764 hydrochloride is a brain penetrant nonpeptidic melanocortin receptor 4 (MC4R) antagonist with a Ki and IC50 of 0.16 μM and 0.103 μM, respectively. It can cross the blood-brain barrier.
- Acts as a melanocortin receptor 4 (MC4R) antagonist.
- Crosses the blood-brain barrier.
- Decreases cAMP production in MC4R-expressing HEK293 cell membranes.
- Demonstrates in vivo protection against tumor-induced body weight loss in mouse models.
- Off-white to light yellow solid appearance.
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Medchemexpress LLC Drotaverine (hydrochloride) | 985-12-6 | 99.65% | 433.97 | 25 MG
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Drotaverine hydrochloride is a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor and an L-type voltage-dependent calcium channel (L-VDCC) blocker, which blocks the degradation of 3',5'-cyclic adenosine monophosphate. It exhibits in vivo antispasmodic efficacy without anticholinergic effects.
- Type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor
- L-type voltage-dependent calcium channel (L-VDCC) blocker
- Blocks the degradation of 3',5'-cyclic adenosine monophosphate
- Exhibits in vivo antispasmodic efficacy without anticholinergic effects
- Relaxant for pre-contracted airways
- Suppresses bronchial contractions in guinea pigs
- Shows higher selectivity for KCl-induced contractions
- Improves cognitive impairment and regulates levels of neurotransmitters in the brain in animal models
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Medchemexpress LLC Opiranserin hydrochloride | 1440796-75-7 | 99.6% | 430.97 | 25 MG
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Opiranserin hydrochloride is a non-opioid and non-NSAID analgesic candidate. It acts as a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A). It also exhibits antagonistic activity on rP2X3. This compound is being developed as an injectable agent for the treatment of postoperative pain. In preclinical studies, it effectively reduced mechanical allodynia and pain-related behaviors, with efficacy comparable to morphine. It also reduced mechanical allodynia in a rat spinal nerve ligation model.
- Acts as a dual antagonist of glycine transporter type 2 (GlyT2)
- Antagonizes serotonin receptor 2A (5HT2A)
- Exhibits antagonistic activity on rP2X3
- Developed as an injectable agent for postoperative pain
- Effectively reduced mechanical allodynia and pain-related behaviors in preclinical studies
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Medchemexpress LLC Mardepodect hydrochloride | 2070014-78-5 | 99.9% | C25H21ClN4O | 25 MG
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Mardepodect hydrochloride is a potent, orally active, and selective PDE10A inhibitor with an IC50 of 0.37 nM, demonstrating over 1000-fold selectivity compared to other PDEs. It is capable of crossing the blood-brain barrier.
- Potent, orally active, and selective PDE10A inhibitor
- IC50 of 0.37 nM
- Exhibits >1000-fold selectivity over other PDEs
- Can cross the blood-brain barrier
- Active in the conditioned avoidance response (CAR) assay with an ED50 of 1 mg/kg
- Induces a dose-dependent increase in striatal cGMP in mice
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