Thiazoles
Medchemexpress LLC Hth-02-006 | 99.4% | 588.44 | C25H29IN6O3 | 10 MG
HTH-02-006 is a small-molecule NUAK2 inhibitor (IC50 = 126 nM) used in cellular and animal models to study YAP-driven liver and prostate cancer. It reduces NUAK2-mediated signaling and has demonstrated growth inhibition in YAP-high cancer cells and anti-tumor efficacy in mouse models.
- Target: NUAK2
- IC50 126 nM (NUAK2)
- Purity 99.4%
- Molecular formula C25H29IN6O3
- Molecular weight 588.44
- Form off-white to light yellow solid
- Solubility DMSO 100 mg/mL (in vitro)
- Storage powder -20°C (long term), 4°C (short term); in solvent -80°C (6 months), -20°C (1 month)
- Pack size 10 mg
- Suitable for cellular and in vivo cancer research models
Medchemexpress LLC YL-939 | 3023925-68-7 | C25H26N6O | 25 MG
YL-939 | 3023925-68-7 | C25H26N6O | 25 MG
Medchemexpress LLC YL-939 | 3023925-68-7 | C25H26N6O | 100 MG
YL-939 is a potent ferroptosis inhibitor. It inhibits ferroptosis by targeting the PHB2/ferritin/iron axis.
- Efficiently protects cells from ferroptosis with varying IC50 values across different cell lines.
- Reduces the level of reactive oxygen species in cytosolic and membrane lipids.
- Improves ferritin protein expression and blocks autophagosomes/lysosomes, inhibiting ferritinophagy.
- Ameliorates liver damage in an acetaminophen-induced acute liver injury model.
- Inhibits cell death and inflammatory infiltration in liver tissues.
Medchemexpress LLC 3-Chloro-N-(4-hydroxy-2-oxo-2H-chromen-3-yl)benzamide | 94205-22-8 | C16H10ClNO4 | 25 MG
Anticancer agent 93 is a 4-Hydroxycoumarin derivative. It can inhibit invasion and migration of lung cancer cells by modulating the expression of epithelial-mesenchymal transition (EMT) effectors.
- 4-Hydroxycoumarin derivative
- Inhibits invasion and migration of lung cancer cells
- Modulates expression of epithelial-mesenchymal transition (EMT) effectors
- Purity of 98.01%
- White to off-white solid appearance
- Inhibits A549 cell invasion by approximately 50% at concentrations of 5-15 μM for 24 hours
- Significantly inhibits A549 cell migration at 15 μM for 24-72 hours
- Inhibits lung cancer cell motility by downregulating EMT markers at 5-15 μM for 4 hours
- Decreases expression of N-cadherin and E-cadherin in A549 cells
Medchemexpress LLC Yl-939 | 3023925-68-7 | C25H26N6O | 1 ML
YL-939 is a potent ferroptosis inhibitor that targets the PHB2/ferritin/iron axis. It efficiently protects cells from ferroptosis with IC50 values ranging from 0.14 μM to 0.25 μM for various cell lines. It also reduces the level of reactive oxygen species (ROS) in cytosolic and membrane lipids.
- Ameliorates liver damage in an acetaminophen-induced acute liver injury mouse model.
- Inhibits cell death and inflammatory infiltration in liver tissues.
- Improves ferritin protein expression in a concentration-dependent manner.
- Blocks autophagosomes/lysosomes, inhibiting ferritinophagy.
Medchemexpress LLC YL-939 | 3023925-68-7 | C25H26N6O | 5 MG
YL-939 is a potent ferroptosis inhibitor. YL-939 inhibits ferroptosis by targeting the PHB2/ferritin/iron axis.
- Potent ferroptosis inhibitor
- Inhibits ferroptosis by targeting the PHB2/ferritin/iron axis
Medchemexpress LLC 3-Chloro-N-(4-hydroxy-2-oxo-2H-chromen-3-yl)benzamide | 94205-22-8 | C16H10ClNO4 | 100 MG
Anticancer agent 93 is a 4-Hydroxycoumarin derivative that demonstrates efficacy against lung cancer cells. It inhibits invasion and migration by modulating epithelial-mesenchymal transition (EMT) effectors, making it a potential candidate for cancer research.
- Inhibits A549 cell invasion by approximately 50%
- Significantly inhibits A549 cell migration
- Decreases lung cancer cell motility by downregulating EMT markers
- Reduces expression of N-cadherin and E-cadherin in A549 cells
Medchemexpress LLC C14H11NO2S | 36341-25-0 | 99.3% | 257.31 | 50 MG
YL-109 is an antitumor agent that can induce carboxyl terminus of Hsp70-interacting protein (CHIP) expression through aryl hydrocarbon receptor (AhR) signaling. It has the ability to inhibit breast cancer cell growth and invasiveness.
- Inhibits cell proliferation, motility, and invasiveness in breast cancer cells.
- Increases both CHIP mRNA and protein levels in MDA-MB-231 cells.
- Inhibits tumor growth and cancer metastasis of breast cancer cells in vivo.
Medchemexpress LLC Trans-4-(6,8-dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol hydrochloride | 15942-08-2 | MFCD26967902 | 426.57 g/mol | C14H19Br2ClN2O | 5 MG
trans-4-(6,8-dibromo-1,2-dihydroquinazolin-3(4H)-yl)cyclohexanol hydrochloride is a dibromo-substituted dihydroquinazoline cyclohexanol salt documented as an impurity of ambroxol hydrochloride. It is intended for use as an analytical standard or impurity reference in pharmaceutical research; consult the certificate of analysis for purity and storage details.
- Provided as an impurity reference for analytical testing.
- Molecular formula C14H19Br2ClN2O; molecular weight 426.57 g/mol.
- CAS number 15942-08-2 for unambiguous identification.
- Certificate of analysis contains purity and recommended storage.
- Suitable for impurity profiling and method development.
Medchemexpress LLC Amoscanate | 26328-53-0 | 99.5% | 10 MG
Amoscanate (CGP4540) is a phenyl isothiocyanate where a 4-nitroanilinyl group replaces hydrogen at the para-position. It acts as an anti-schistosomal agent and uncoupler of oxidative phosphorylation, known to potently injure rodent ependyma. This compound is intended for research use only.
- Effective against schistosomiasis
- Classified as an isothiocyanate compound
- Acts by uncoupling oxidative phosphorylation
- Has a purity of 99.5%
NC(=O)OCC1c2ccccc2-c2ccccc12 | 0.25g | 397212083](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000165010.jpg-250.jpg)
eMolecules 478183-62-9 | FMOC-(S)-3-CYCLOBUTYLALANINE | AstaTech | MFCD03840400 | 365.429 | C22H23NO4 | 95.000 | OC(=O)[C@H](CC1CCC1)NC(=O)OCC1c2ccccc2-c2ccccc12 | 0.25g | 397212083
FMOC-(S)-3-CYCLOBUTYLALANINE | AstaTech | 478183-62-9 | MFCD03840400 | 365.429 | C22H23NO4 | 95.000 | OC(=O)[C@H](CC1CCC1)NC(=O)OCC1c2ccccc2-c2ccccc12 | 0.25g | 397212083
eMolecules 88950-64-5 | Boc-Acpc-OH | Ambeed | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 1g | 552676112
Boc-Acpc-OH | Ambeed | 88950-64-5 | MFCD00083257 | 201.222 | C9H15NO4 | 97.000 | CC(C)(C)OC(=O)NC1(CC1)C(O)=O | 1g | 552676112
Medchemexpress LLC 1,3-oxazolidine-2-thione | 5840-81-3 | MFCD00125763 | 99.4% | 103.14 g/mol | C3H5NOS | 5 MG
1,3-Oxazolidine-2-thione is a small heterocyclic thiocarbonyl compound supplied for laboratory research. It is provided as a solid research reagent with documented physical and storage properties and reported biological effects in animal studies (effects on thyroid size and hepatic trimethylamine oxidase activity). The material is characterized by a defined purity, molecular formula, and high solubility in DMSO.
- Small heterocyclic thiocarbonyl solid.
- Purity 99.44%.
- Molecular weight 103.14 g/mol; formula C3H5NOS.
- High DMSO solubility: 250 mg/mL (ultrasonic assistance recommended).
- Powder storage: -20°C up to 3 years, 4°C up to 2 years.
- Reported biological activity affecting thyroid size and hepatic trimethylamine oxidase in animal studies.
- Available in multiple small pack sizes for research use.
Medchemexpress LLC 2-isobutyl-3-methoxypyrazine-d3 | 588732-63-2 | >98.0% | 169.24 g/mol | C9H11D3N2O | 10 MG
2-Isobutyl-3-methoxypyrazine-d3 is the deuterium-labeled analogue of 2-isobutyl-3-methoxypyrazine, an aroma constituent in grapes, wines, green pepper, and asparagus. The labeled material (d3) is provided as a reference standard for analytical and research use, including isotope-dilution assays, method development, and trace-level quantitation.