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Filtered Search Results
Apexbio Technology LLC Perphenazine 58-39-9 1g
Perphenazine (CAS 58-39-9) is a phenothiazine derivative that primarily acts as an antagonist at dopamine D receptors with dissociation constant (Ki) of 1 4 nM and also displays significant binding to histamine H (Ki 8 nM) A-adrenergic (Ki 10 nM) A- B- C-adrenergic and muscarinic M (Ki 1848 nM) receptors Its antagonism at D receptors underlies its ability to modulate dopaminergic neurotransmission while interaction with additional receptor subtypes may account for its effects on the central nervous system and antiemetic properties Perphenazine is widely utilized in research investigating mechanisms of antipsychotic activity dopaminergic regulation and drug-induced cell death pathways
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Medchemexpress LLC HY-111444 5mg Medchemexpress, Auxinole CAS:86445-22-9 Purity:>98%
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Medchemexpress, HY-111444 5mg Auxinole CAS:86445-22-9 Auxinole is a potent auxin antagonist of TIR1/AFB receptors, binding TIR1 to block the formation of the TIR1-IAA-Aux/IAA complex and so inhibits auxin-responsive gene expression. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Axitinib-d3 | 1126623-89-9 | 98.1% | 389.49 g/mol | C22H15D3N4OS | 5 MG
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Axitinib-d3 is a deuterium-labeled analog of axitinib supplied as an analytical standard for research and quantitative assays. It is intended as an internal standard or reference material for LC-MS and other analytical methods.
- Deuterium-labeled internal standard for quantitative assays.
- High chemical purity: 98.1%.
- Chemical formula C22H15D3N4OS; molecular weight 389.49 g/mol.
- CAS number 1126623-89-9 for unambiguous identification.
- Suitable for LC-MS, stability studies, and method development.
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Medchemexpress LLC HY-100811A 10mg Medchemexpress, 7-Chlorokynurenic acid sodium salt CAS:1263094-00-3 Purity:>98%
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Medchemexpress, HY-100811A 10mg 7-Chlorokynurenic acid sodium salt CAS:1263094-00-3 7-Chlorokynurenic acid sodium salt is a potent and selective antagonist of the glycine B coagonist site of the N-methyl-D-aspartate (NMDA) receptor ( IC 50 =0.56 μM). 7-Chlorokynurenic acid sodium salt is also a potent inhibitor of the reuptake of glutamate into synaptic vesicles with a K i of 0.59 μM. 7-Chlorokynurenic acid sodium salt has potent antinociceptive actions after neuraxial delivery [1] [2] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Sting agonist-7 | 2767442-46-4 | 97.2% | C17H12N4O4 | 10MG
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STING agonist-7 is a non-nucleotide agonist of the stimulator of interferon genes (STING) pathway used in research to probe STING-mediated immunology and inflammation. It binds selectively to mouse STING but not human STING and has limited cell membrane permeability. The compound is supplied at high purity and is DMSO-soluble for experimental applications.
- Non-nucleotide STING agonist suitable for pathway studies.
- Selective binding to mouse STING with minimal activity on human STING.
- Poor cell membrane permeability, relevant for assay design.
- High purity (~97.2%) for reproducible results.
- Soluble in DMSO (62.5 mg/mL); ultrasonic aid recommended.
- Storage: 4°C protected from light; in solvent store at -80°C (6 months) or -20°C (1 month).
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Medchemexpress LLC HDAC-IN-4 | 1252003-13-6 | 50 MG
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HDAC-IN-4 is a selective inhibitor targeting both HDAC6 and HDAC10, exhibiting pIC50 values of 7.2 and 6.8 in BRET assays, respectively. This compound has demonstrated antitumoral activity.
- Selective HDAC6 and HDAC10 inhibitor
- Exhibits antitumoral activity
- Used in BRET assays
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Medchemexpress LLC Medroxyprogesterone acetate-d3 | 98.1% | 389.54 g/mol | C24H31D3O4 | 10 MG
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Medroxyprogesterone acetate-d3 is the deuterated analog of medroxyprogesterone acetate, provided as an analytical internal standard for quantitative LC-MS and related mass spectrometry applications. It offers an isotopic match to the target analyte to improve accuracy and correct for matrix effects during sample preparation and analysis.
- Deuterated internal standard for LC-MS quantitation.
- Purity: 98.13% (typical, verified by HPLC).
- Molecular weight 389.54 g/mol.
- Chemical formula C24H31D3O4.
- Supplied in milligram quantities suitable for analytical use.
- Suitable for standard curve preparation and recovery experiments.
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Medchemexpress LLC HY-19535A 5mg Medchemexpress, Nemiralisib CAS:1254036-71-9 Purity:>98%
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Medchemexpress, HY-19535A 5mg Nemiralisib CAS:1254036-71-9 Nemiralisib (GSK2269557 free base) is a potent and highly selective PI3Kδ inhibitor with a pKi of 9.9. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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American Radiolabeled Chemicals Inc LINOLEOYL ETH 1-3H 250UC
Linoleoyl ethanolamide-1-3H 250uCi in ethanol, 1 mCi/ml, S.A. 40-60 Ci/mmol, M.W. 323.0, Shipped in Dry Ice, Exclusive
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AG Scientific Inc Tetracycline HCl 25 G
Tetracycline hydrochloride is a hydrochloride salt form of the antibiotic tetracycline. This polyketide antibiotic binds to both the 30S and 50S ribosomal subunits, thus inhibiting proper protein synthesis. Although it is capable of binding to both subunits, the binding at the 30S subunit is more pronounced than that at the 50S.Clinically, tetracycline is used as a broad spectrum antibiotic for a variety of Gram-positive and Gram-negative bacterial infections. Conditions which may indicate for tetracycline administration include upper respiratory infection, typhus fever and rikkettsialpox. It can also be administered to treat severe cases of acne.Tetracycline has played a prominent research role in studies of the efficacy of local antibiotic application in cases of dental trauma. Owing to the fluorescent properties of tetracycline and its ability to bind to bone tissue, this antibiotic is also regularly used in bone histomorphometry studies.
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eMolecules 1122579-42-3 | 2-(((9H-Purin-6-yl)amino)methyl)-6-methylphenol | 250mg
Ambeed | (3-Chloro-4-(hydroxymethyl)phenyl)boronic acid | 100mg | 721602243 | A451882 | 1190875-60-5 | MFCD18384123 | 186.400 | C7H8BClO3
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Medchemexpress LLC HY-100225 5mg Medchemexpress, ME0328 CAS:1445251-22-8 Purity:>98%
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Medchemexpress, HY-100225 5mg ME0328 CAS:1445251-22-8 ME0328 is a potent and selective ARTD3 / PARP3 inhibitor with an IC 50 of 0.89±0.28 μM. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Medchemexpress LLC Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- | 1391737-01-1 | 99.8% | 382.50 | 50 MG
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VU0463271 is a selective KCC2 antagonist, with an IC50 of 61 nM. It targets and inhibits the neuronal-specific potassium-chloride cotransporter 2 (KCC2) with over 100-fold selectivity against NKCC1. The compound shows no activity in a broader panel of GPCRs, ion channels, and transporters.
- Selective KCC2 antagonist.
- Exhibits an IC50 of 61 nM for KCC2.
- Displays high selectivity (>100-fold over NKCC1) and no activity across a wide range of other GPCRs, ion channels, and transporters.
- Shows antagonist activity at KCC2 in human HEK293 cells.
- Significantly increases firing rates in Drosophila CNS preparations.
- Rapidly cleared in vitro.
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eMolecules 1071625-31-4 | N-Acetyl-D-mannosamine monohydrate | Oakwood Chemical | MFCD00149493 | 239.224 | C8H17NO7 | 98.000 | O.CC(=O)N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O | 1g | 537705647
N-Acetyl-D-mannosamine monohydrate | Oakwood Chemical | 1071625-31-4 | MFCD00149493 | 239.224 | C8H17NO7 | 98.000 | O.CC(=O)N[C@@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O | 1g | 537705647
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Medchemexpress LLC HY-13734 5mg Medchemexpress, PX-12 CAS:141400-58-0 Purity:>98%
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Medchemexpress, HY-13734 5mg PX-12 CAS:141400-58-0 PX-12(IV-2) is an irreversible inhibitor of Thioredoxin-1 (Trx-1); inhibits the growth of MCF-7 and HT-29 cells with IC50 values of 1.9 and 2.9 μM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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