General Cell Lines and Cell Cultures
Discovery Life Sciences Kidney Cancer Active Tx PBMC
PBMCs Peripheral Blood Mononuclear Cells are immune cells isolated from whole blood and viably cryopreserved providing a foundational material for immunology studies cell therapy research and functional immune assays
Discovery Life Sciences Gentest TransportoCellsTM
Gentest TransportoCellsTM HEK Human MRP3 Vesicles 0 5 mL
Discovery Life Sciences Multiple Myeloma Actv Tx PBMC
PBMCs Peripheral Blood Mononuclear Cells are immune cells isolated from whole blood and viably cryopreserved providing a foundational material for immunology studies cell therapy research and functional immune assays
Biochain Institute Inc Paraffin Tissue Section - Parkinson's Disease: Brain: Frontal Lobe, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Biochain Institute Inc Frozen Tissue Section - Emphysema: Lung, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's Frozen Tissue Slides are ideal for rapidly identifying cellular localization of RNA or protein. A single human adult normal tissue with 5-10 um thickness is mounted on a positively charged glass slide. The slides are fixed and dehydrated with acetone for consistent results with in situ hybridization and immunohistochemistry. More organs may be available upon request.
Eurofins Discoverx Ready-to-Assay Y4 Neuropeptide Y Receptor Frozen Cells, 2 Vials of Cells. (HTS204RTA)
The Ready-to-Assay Y4 Neuropeptide Y Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. peptide YY) based activation of NPY4R GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses NPY4R alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of NPY4R, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
ATCC Plasmodium falciparum; FCR-3/FMG
Plasmodium falciparum strain FCR-3/FMG was isolated from a clinical specimen from Fajara, Gambia. This strain is cultivated in human erythrocytes and can be used in infectious disease research and vector-borne disease research.
ATCC Escherichia coli; Bacteriophage T3
Escherichia coli bacteriophage T3 is a virus propagated in Escherichia coli strain B (ATCC 11303).
Biochain Institute Inc Paraffin Tissue Section - Pulmonary embolism: Lung, 5 slides/PK
BioChain's tissue products are based on the sample repository network established following the IRB-approved ethical standard and procedures. BioChain's formalin fixed paraffin embedded (FFPE) tissue section line encompasses a large selection of tissue sections which are suitable for immunohistochemistry and in situ hybridization assays. The tissue sections are approximately 5 um thick. Each slide contains tissue from single human diseased sample. Documentation of tissues' clinical histories may be available upon request. For those customers who want to perform FFPE DNA and RNA isolation, BioChain can provide tissue section slices in tubes instead of mounting them on glass slides.
Eurofins Discoverx ChemiScreen P2Y1 Purinergic Receptor Stable Cell Line, 2 vials. (HTS049C)
The ChemiScreen P2Y1 Purinergic Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. ADP, ATP) based activation of P2RY1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses P2RY1 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of P2RY1, the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, visit www.discoverx.com/targets/gpcr-target-biology.
ATCC Pseudomonas sp.
Pseudomonas sp. strain 3P is a bacterium that was isolated in South Carolina from a wastewater lagoon. This strain is cited to degrade detergents and surface active agents (US Patent 4,274,954, US Patent 4,317,885, US Patent 4,483,923).
Abeomics Nrf2 Reporter Mcf7 Cell Line
The Nrf2 Leeporter Luciferase Reporter cell line is a stably transfected MCF7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the antioxidant response element (ARE). ARE is known to regulate expression and induction of various detoxifying enzyme genes in response to antioxidants and xenobiotics, and is primarily regulated by the Keap1-Nrf2 pathway in which induction and nuclear translocation of Nrf2 mediated by antioxidants and xenobiotics results in the binding of Nrf2 to ARE leading to the expression of defensive genes. Cell line application: (1) Monitor the Nrf2 induction activity, and (2) Screen for activators or inhibitors of the Nrf2 signaling pathway. .
Eurofins Discoverx Ready-to-Assay NK1 Tachykinin Receptor Frozen Cells, 2 Vials of Cells. (HTS080RTA)
The Ready-to-Assay NK1 Tachykinin Receptor Frozen Cells are a simple, thaw-and-assay cell format for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This assay assesses ligand (e.g. tachykinins) based activation of TACR1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses TACR1 alongside endogenous high levels of a promiscuous G-protein, coupling the receptor to the calcium signaling pathway. Upon activation of TACR1, the resulting calcium activity can be fluorescently assayed. Ready-to-assay kits consist of two vials of the stably modified clonal cell line in a convenient thaw-and-use format. For detailed product information, User manual and datasheet, visit www.discoverx.com/products-applications/frozen-cells.
Eurofins Discoverx InCELL Hunter A549 EP300 Bromodomain Cell Line, 2 vials. (96-0073C15)
The InCELL Hunter A549 EP300 Bromodomain Cell Line is a stable, engineered cell line for use in studying small molecule drug candidates that engage with regulators of epigenetics pathways. This cell line enables assessment of compound-engagement-based stabilization of EP300 via detection of EP300 levels. This product uses EFC technology. The cell line included overexpresses EP300 target protein fused to ProLabel. In the absence of compound that binds and stabilizes the target, this protein is degraded and no EFC signal is produced. When compound engages and stabilizes the target, EA contained in the detection reagent produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. For detailed product information, User Manual and datasheet, visit www.discoverx.com/epigenetics.
Genscript Corporation CHO-K1/cyno TIGIT Stable Cell
TIGIT (T cell immunoreceptor with Ig and ITIM domains) was recently characterized as an inhibitory receptor which is expressed mainly on NK Treg CD8 T and CD4 T cells TIGIT harbors an immunoglobulin tail tyrosine (ITT)-like phosphorylation motif and an ITIM (immunoreceptor tyrosine-based inhibition motif) in its cytoplasmic tail The poliovirus receptor (PVR or CD155) was identified as the physical ligand of TIGIT with high affinity and PVRL2 (Nectin2 or CD112) also binds to TIGIT with a weaker binding capacity TIGIT/PVR engagement suppresses T cell activation through IL-10 secretion mediated by dendritic cells Furthermore TIGIT also exerts an intrinsic inhibitory function to T cell activation