General Cell Lines and Cell Cultures
Genscript Corporation CHO-K1/NPS1b/G15 Stable Cell
Recombinant CHO-K1 cells stably overexpress human neuropeptide S receptor 1 (NPSR1) isoform B on the surface and contain high levels of G protein G s and G q to couple with the receptor in downstream signaling pathways
Genscript Corporation CHO-K1/CD40 Stable Cell Line
Cluster of differentiation 40 CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects
Genscript Corporation CHO-K1/LTB4/G15 Stable Cell L
The dihydroxy-leukotriene leukotriene B4 (LTB4) is a member of the G protein-coupled receptor (GPCR) family in a subfamily of GPCRs that includes receptors for chemokines and other chemotactic factors Recently a second lower affinity receptor for LTB4 (BLT2) has also been cloned with broader ligand specificity for various eicosanoids LTB4 stimulates neutrophil chemotaxis and secretion but may also affect immunomodulation contraction of certain smooth muscles via an indirect mechanism and activation of the nuclear transcription factor PPAR (peroxisome proliferation activated receptor alpha) Chemotaxis the principal effects of LTB4 and related dihydroxy-acids on leukocytes occurs via activation of BLT1 receptors
Genscript Corporation CHO-K1/CD38 Stable Cell Line
Recombinant CHO-K1 cells stably overexpress human CD38 on the surface The surface expression of CD38 is validated by FACS analysis
Genscript Corporation CHO-K1/D2s/G15 Stable Cell Li
The short form of D2 (D2S) and the long form (D2L) are two isoforms that contribute differentially to dopamine signaling in both prefrontal cortex and striatum The D2 dopamine receptor short form (D2s) has been shown to stimulate phospholipase D (PLD) activity independent of the activation of phospholipase C (PLC) activity in GH4 derived cells stably transfected with the D2s receptor Agonist activation of D2s has been shown to mediate the inhibition of growth in the same cell line
Genscript Corporation CHO-K1/M5 Stable Cell Line
Muscarinic acetylcholine receptors belong to a superfamily of seven-TM-domain receptors that interact with G-proteins to initiate intracellular responses Five muscarinic receptor subtypes have been identified named M1 through M5 Receptors of the M5 receptor subtype couple through the G sub q/11 /sub class of G-proteins and activate the phospholipase C pathway Activation of this pathway in turn leads to increases in free intracellular calcium levels as inositol triphosphate mediates release of calcium from the endoplasmic reticulum RT-PCR reveals that M5 mRNA is quite uniformly expressed in brain However there is little data regarding the expression and function of the M5 receptor in peripheral tissues Currently it is clear that the M5 receptor due to the high likelihood that its distribution is restricted to the CNS probably plays a discrete role in dopaminergic transmission Although the identification of M5 expression in salivary glands and iris-ciliary muscle sugge
Genscript Corporation HEK293/5-HT2C Stable Cell Line
5-Hydroxytryptamine (5-HT also commonly known as serotonin) is synthesized in enterochromaffin cells in the intestine and in serotonergic nerve terminals In the periphery 5-HT mediates gastrointestinal motility platelet aggregation and contraction of blood vessels Many functions of the central nervous system are influenced by 5-HT including sleep motor activity sensory perception arousal and appetite A family of 12 GPCRs and one ion channel mediate the biological effects of 5-HT (Hoyer et al 1994) 5HT2C is expressed in the brain and spinal cord especially the choroid plexus 5HT2C receptor agonists may have important clinical value in the treatment of mental and eating disorders such as depression panic anxiety OCD bulimia and obesity GenScript s cloned human 5-HT2C expressing cell line is generated in the CHO-K1 host
ABclonal Technology PE anti-Human ICOS/CD278
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family It forms homodimers and plays an important role in cell-cell signaling immune responses and regulation of cell proliferation
Charles River Labs Cell Solutions C57BL/6 Macrophages, 5 to 10 Million cells, Cryopreserved
C57BL/6 Macrophages, 5 to 10 Million cells, Cryopreserved
Charles River Labs Cell Solutions Peripheral Blood CD3+ Pan T Cells (Negative Selection), 50 Million cells, Cryopreserved
CD3+ T cells are isolated from leukopaks by either positive or negative selection (NS) using immunomagnetic cell separation procedures.
ACROBiosystems HEK293/Human OX40 / TNFRSF4 / CD134 Stable Cell Line
Tumor necrosis factor receptor superfamily member 4 (TNFRSF4) is also known as ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor, CD antigen CD134, OX40. OX40 / TNFRSF4 contains four TNFR-Cys repeats. TNFRSF4 is receptor for TNFSF4 / OX40L / GP34 and can interacts with TRAF2, TRAF3 and TRAF5.
ACROBiosystems HEK293/Human OX40 Ligand / TNFSF4 Stable Cell Line
Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.
ACROBiosystems HEK293/Human FOLR1 Stable Cell Line
Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.