Human Sera
Cayman Chemical TeIcoplnIn Complex 100mg
A mixture of closely related metabolites produced by A. teichomyceticus that are effective against Gram-positive bacteria; prevents bacterial cell-wall synthesis by binding and sequestering a cell-wall precursor with a D-alanine-containing peptide
Cayman Chemical IsoproTRenolhydroCLOrID 100mg
A β1- and β2-AR agonist (Kis = 224 and 458 nM, respectively); selective for β1- and β2-ARs over β3-ARs (Ki = 1,570 nM); inhibits contractions in isolated field-stimulated rat vas deferens (EC50 = 45.6 nM); decreases blood pressure and increases water intake in nephrectomized rats at 0.33 mg/kg; reduces blood pressure and increases heart rate in renal hypertensive rabbits; inhibits histamine-induced bronchospasms in anesthetized dogs
Cayman Chemical O6-BenzylgunIn 50mg
A guanine analog with antineoplastic activity; irreversibly inactivates AGT, with 40% reduction in alkyltransferase activity achieved at 0.06 µM with recombinant human AGT; effective in vivo as well as in vitro
Cayman Chemical RamosetronhydrochlorIde 50mg
A potent and selective antagonist of the serotonin (5-HT) receptor subtype 5-HT3 (Ki = 0.06 nM); has little or no effect at other 5-HT receptor subtypes or at adrenergic or histamine receptors
Cayman Chemical PF-04981517 50mg
A potent, selective, and time-dependent inhibitor of CYP3A4 (IC50 = 30 nM)
Cayman Chemical MTEPhydrochlorIde 50mg
A negative allosteric modulator of the mGlu5a receptor subtype (Ki = 42 nM; IC50 = 110 nM); produces antidepressant, and anxiolytic effects
Cayman Chemical R S-AMPAhydrate 50mg
The defining agonist for the AMPA subgroup of ionotropic glutamate receptors, which mediate excitatory neurotransmission; contains an equal mixture of the active (S)-enantiomer and the inactive (R)-enantiomer
Cayman Chemical WIskostatIn 50mg
A cell-permeable, selective inhibitor of N-WASP (IC50 = ~10 μM); directly associates with the GTPase-binding domain of N-WASP, preventing its activation by Cdc42 and PIP2; interferes with membrane transport, endocytosis, and neurological development
Cayman Chemical ClotrImazole 100mg
An imidazole antifungal; tightly binds sterol 14-α demethylase isoform B from A. fumigatus (KD = 103 nM) and disturbs the fungal cell membrane; inhibits the calcium-dependent potassium channels Kv1.3 and IK-1 (IC50 = 6.0 and 0.07 µM, respectively) in mammalian cells
Cayman Chemical Metanephrine 50mg
An inactive metabolite of epinephrine; urinary and plasma levels are increased in patients with pheochromocytoma
Cayman Chemical FIdaxomycIn 100mg
A natural macrocyclic antibiotic that inhibits RNA polymerase with selectivity for Gram-positive bacteria over Gram-negative bacteria (IC50s = 0.4 and 6 μM, respectively); has potent antibacterial activity against most Gram-positive bacteria and effectively targets the Gram-positive C. difficile (MIC = 12 ng/ml)
Cayman Chemical AbacavIrsulfate 50mg
A nucleoside analog and HIV-1 reverse transcriptase inhibitor (Ki = 2.1 µM for the wild-type enzyme); inhibits replication of a variety of HIV-1 and HIV-2 strains, including strains resistant to zidovudine or didanosine in HeLa cells stably expressing CD4 (IC50s = 5.8-21 µM); inhibits replication of eight HIV-1 clinical isolates in phytohemagglutinin-stimulated isolated human peripheral blood lymphocytes (mean IC50 = 0.26 µM); inhibits HBV DNA synthesis in HepG2 cells (IC50 = 7 µM) and is also active against human cytomegalovirus (CMV) strain AD169 and the Petaluma strain of FIV in plaque reduction assays (IC50s = 32 and 0.4 µM, respectively)
Cayman Chemical -CromakalIm 50mg
An activator of the ATP-sensitive K+ channels that displays anti-ischemic (EC25 = 8.9 μM) and cardioprotective (IC50 = 0.03 μM) effects in rat hearts
Cayman Chemical ImIpenmhydrate 100mg
An intravenous β-lactam antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria (MICs range from 0.5-2 UG/ml for E. cloacae and P. aeruginosa), including several multi-drug resistant bacterial species
Cayman Chemical MedetomIdInhydrochlorIde 50mg
An α2-AR agonist (Ki = 1.08 nM); selective for α2-ARs over α1-ARs (Ki = 1,750 nM); induces sedation in dogs