Human Sera
Cayman Chemical 6-O-SulfocyclodextrInsod 100mg
A SMN2 splicing modifier enhances SMN2 splicing (EC1 5x 40 nM) and increases SMN protein levels (EC1 5x 163 nM) in cellular assays increases brain and quadricep muscle SMN protein levels in the adult C/C-allele mouse model of SMA and the SMND7 neonate mouse model of severe SMA at 3 mg/kg increases vGLUT1 proprioceptive inputs on motor neurons the number of L3-L5 motor neurons the percentage of fully innervated NMJs and the size of the extensor digitorum longus muscles in adult SMND7 mice
Cayman Chemical TAS 103hydrochlorIde 50mg
A CXCR4 antagonist (IC50 13 nM in a radioligand binding assay) selective for CXCR4 over CCR1 CCR2b CCR4 CCR5 CXCR1 and CXCR2 (IC50s 10 UM for all) reduces CXCL12-induced chemotaxis of CCRF-CEM T cells (IC50 19 nM) inhibits fusion of CHO-K1 cells expressing gp120 to P4 MAGI cells IC50 1 5 nM decreases HIV-1 NL4 3 viral replication in MT-4 cells and isolated human PBMCs (IC50s 2 and 9 nM respectively)
Cayman Chemical LIgustrazInhydrochlorIde 50mg
An anticancer agent inhibits growth in a panel of 12 cancer cell lines (IC50s 1 8-6 M) an effect that is enhanced in SCC VII cells under hypoxic conditions increases intracellular ROS levels in HT-29 and SCC VII cells induces apoptosis in SCC VII HL-60 and Daudi cells at 5 5 and 4 M respectively reduces tumor growth and enhances radiation-induced tumor growth reduction in an SCC VII murine squamous cell carcinoma model at 5 mg/kg per day for five days pre-incubation of red blood cells and hemolysate at 3 mM increases nitrite-induced NO release under hypoxic conditions decreases parasitemia and increases survival in a mouse model of P berghei ANKA infection at 10 mg/kg
Cayman Chemical PrenylamIn 100mg
A triacylglycerol dietary administration at 15 of a calcium-deficient diet transiently increases heart triglyceride levels which return to baseline after 28 days
Cayman Chemical 8Cyclopentyl1 3dImethylxn 50mg
A terpene trilactone with diverse biological activities inhibits PAF-induced platelet in rabbit and human platelet-rich plasma (IC50s 27 and 43 5 g/ml respectively) inhibits AB42-induced cell death in primary rat hippocampal neurons and AB42-induced impairment of LTP in the mouse CA1 region at 1 M
Cayman Chemical ThonzonIumbromIde 50mg
A very long-chain fatty alcohol with diverse biological activities active against the bacteria K pneumoniae S flexneri S typhi and E faecalis (MICs 4 8 2 and 32 Ug/ml respectively) as well as the pathogenic fungi T ajelloi and T rubrum (MICs 4 and 32 Ug/ml respectively) reduces LPS-induced expression of TNF-a iNOS IL-1B and IL-6 in RAW 264 7 cells at 30 and 100 Ug/ml increases body weight decreases diarrhea and hematochezia and improves histopathological and morphological changes in the colon in a mouse model of DSS-induced ulcerative ecolitis at 100 mg/kg per day reduces carbon tetrachloride-induced increases in serum transaminase hepatic myeloperoxidase and hepatic xanthine oxidase activity as well as lipid peroxidation in a rat model of acute liver injury progression at 10 50 or 100 mg/kg reverses decreases in hepatic superoxide dismutase and catalase activity as well as GSH levels in a rat model of acute liver injury progression at 10 50 or 100 mg/kg
Cayman Chemical AlarelInacetate 100mg
A coumarin with diverse biological activities inhibits proliferation of HeLa and HepG2 cells in vitro (IC50s 23 59 and 15 57 M respectively) increases histamine release from mast cells decreases DNP-HSA-induced secretion of TNF-a IL-4 and IL-1B from RBL-2H3 cells nematocidal against M incognita (IC50 68 mg/L) inhibits predatory mouse and rat killing behavior in dogs and cats at 3-100 and 5-20 mg/kg respectively reduces amphetamine-induced hypermobility in mice and hamsters reduces brain edema neutrophil infiltration blood-brain barrier disruption production of IL-1B TNF-a IL-8 and NO and intercellular levels of ICAM-1 and E-selectin in a rat model of focal cerebral ischemia at 5 and 10 mg/kg
Cayman Chemical 6Chloro3IndolylDGlucur 100mg
An inhibitor of Plk1 (IC50 2 nM) selective for Plk1 over Plk2 and Plk3 (IC50s 10000 nM for both) inhibits proliferation of A2780 cells (IC50 42 nM) halts the cell cycle at the G2/M phase in A2780 cells at 20-200 nmol/L and induces apoptosis reduces tumor growth in an HCT116 mouse xenograft model at 60 mg/kg once per day induces tumor regression in an HT-29 mouse xenograft model at 45 mg/kg in combination with CPT11
Cayman Chemical DesvenlafaxInsuccInAT hyd 50mg
An orally bioavailable antiprotozoal agent inhibits the growth of the parasites T cruzi T vaginalis G lamblia and E histolytica (IC50s 8 1 18 62 22 58 and 4 27 M respectively) inhibits clonogenic growth of human C33A cervical and KNS42 glioblastoma cancer cells under hypoxic but not normoxic conditions at 100 M decreases T cruzi blood parasitemia to below detectable levels in a mouse model of chronic stable Chagas disease at 100 mg/kg per day
Cayman Chemical MosaprIdecItrate 100mg
A Nur77 receptor agonist selectively activates Nur77 over PPARY in reporter assays at 20 M inhibits growth of and induces apoptosis in L3 6pL pancreatic cancer cells at 10 15 and 20 M stabilizes nuclear localization of Nur77 and Nurr1 and reduces secretion of pro-inflammatory cytokines in primary mouse astrocytes oral administration prevents loss of dopaminergic neurons in the substantia nigra pars compacta and striatal dopamine terminals in a mouse model of MPTP-induced Parkinsons disease at 50 mg/kg
Cayman Chemical LCysteInsulfInIc ACDhydr 100mg
A phthalimide with diverse biological activities an EGFR inhibitor that selectively inhibits the EGFR intracellular kinase domain over v-Abl c-Src PKCa PKCB1 PKCB2 and PKCY (IC50s 0 3 50 16 6 30 4 8 and 30 M respectively) and a panel of 11 other kinases inhibits EGFR autophosphorylation in A431 human epidermoid carcinoma cell membrane preparations and intact cells (IC50s 1 and 50 0 58 M)
Cayman Chemical Fenvalerate 50mg
A triacylglycerol has been found in ostrich and emu oils as well as cow milk fat
Cayman Chemical Pulsatla korna Ajmaln 50mg
A synthetic polypeptide and CCK2 receptor agonist binds selectively to CCK2 in guinea pig brain over CCK1 receptors in rat pancreas (IC50s 11 and 1100 nM respectively) increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s 23 and 3 9 nM respectively) increases histidine decarboxylase activity in mucous and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 2 9 nM) induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 30 pM) increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s 1 29 and 57 3 nmol/kg2 per hour respectively)