Goat Secondary Antibodies
Cayman Chemical Paromomycin (sulfate), Purity: ≥98%, CAS: 1263-89-4, 25 g
An aminoglycoside antibiotic; effective against Gram-negative and Gram-positive bacteria (MICs = 0.08-3.9 µg/ml); antiprotozoal; decreases the parasite burden of mice infected with L. tropica when administered at a dose of 50 mg/kg and 15 mg/kg, through intramuscular or intralesional routes, respectively; binds to the tRNA decoding A site of the 16S ribosomal RNA in bacteria; inhibits protein synthesis
Cayman Chemical Flunarizine (hydrochloride), Purity: ≥98%, CAS: 30484-77-6, 1 g
A calcium antagonist that acts as a potent dilator of peripheral vessels; reduces calcium fluxes in vascular smooth muscle by blocking both voltage-dependent calcium channels and receptor-operated channels
Cayman Chemical Sorafenib (tosylate), Purity: ≥98%, CAS: 475207-59-1, 25 g
A multi-kinase inhibitor; inhibits Raf-1 and B-RAF (IC50s = 6 and 22 µM, respectively); inhibits VEGFR2, VEGFR3, PDGFRβ, FLT3, and c-Kit (IC50s = 90, 15, 20, 57, and 58 nM, respectively); selective for these kinases over 12 other kinases (IC50s = >10 µM for all); inhibits proliferation of PLC/PRF/5 and HepG2 cells (IC50s = 6.3 and 4.5 µM, respectively); inhibits tumor growth in a PLC/PRF/5 mouse xenograft model at 30 mg/kg; induces ferroptotic cell death in HT-1080 fibrosarcoma cells at 10 µM but not in a variety of other cancer cell lines; inhibits HCV replication in Huh7.5 cells (IC50 = 7.2 µM)
Cayman Chemical 2,3-Butanedione-2-monoxime, Purity: ≥95%, CAS: 57-71-6, 10 g
A non-selective, reversible myosin ATPase inhibitor with phosphatase-like properties; inhibits L-type Ca2+ channels
Cayman Chemical Tridecanoic Acid, Purity: ≥95%, CAS: 638-53-9, 25 g
A 13-carbon saturated fatty acid found in dairy products and also as a product of anaerobic biodegradation of n-hexadecane; acts as a substrate of phospholipase A2
Cayman Chemical Terazosin (hydrochloride), Purity: ≥98%, CAS: 63074-08-8, 250 mg
A potent and selective α1-AR antagonist; selective for α1-AR (Kis = 3.28, 0.68, and 1.09 for α1A-, α1B- and α1D-ARs, respectively) over α2-AR subtypes (Kis = 1,510, 7.71, and 78.2 nM for A2a-, A2b-, and A2c-ARs, respectively); decreases blood pressure in spontaneously hypertensive rats when administered at 0.1-30 mg/kg
Cayman Chemical Prostaglandin D2-MOX Express ELISA Kit, 96 solid
Cayman’s PGD2-MOX Express ELISA is a competitive assay that permits the rapid measurement of PGD2 from biological samples, requiring only 1 hour incubation and development times for each step. The methodology for the assay is the same as that employed in the PGD2-MOX ELISA (Item No. 512011). The ELISA offers the convenience of a fast assay while still achieving a sensitivity of ~16 pg/ml and an assay range of 7.8-1,000 pg/ml.
Cayman Chemical ProstaglndIn D2MOX ExprS 480
A fluorescent mitochondrial probe has been used to image actively respiring mitochondria in vitro ex/em 474/605 nm respectively
Cayman Chemical UTP (sodium salt), Purity: ≥95%, CAS: 19817-92-6, 5 g
A nucleotide and dual P2Y2 and P2Y4 receptor agonist (EC50s = 55 and 80 nM, respectively, for stimulation of phospholipase C in 1321N1 cells expressing human receptors); selective for P2Y2 and P2Y4 receptors over P2Y6 receptors (EC50 = >10,000 nM); stimulates proliferation of PANC-1 cells (EC50 = 13.1 μM), an effect that can be prevented by siRNA against the P2Y2 receptor; induces vasoconstriction in perfused isolated canine epicardial coronary artery; formed from UMP and can be converted to CTP; reacts with glucose-1-phosphate to form UDP-glucose
Cayman Chemical THUNDERPhosphocMetY1234 480Wel
Sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-Met (Y1234/Y1235) and Total Met in cell lysates
Cayman Chemical THUNDRPhosphoBTKY223 T 4800Wel
Sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-BTK (Y223) in cell lysates
Cayman Chemical THUNDRPhosphoSTAT3Y705 9600Wel
A sandwich TR-FRET immunoassay for semi-quantitative detection of Phospho-STAT3 (Y705) in cell lysates
Cayman Chemical VItelogenInzebrafIsh Mon 500uL
A selective brain-penetrable LRRK2 inhibitor (Kis 2 and 18.7 nM in biochemical and cell-based assays respectively) inhibits LRRK2 Ser1292 autophosphorylation in BAC transgenic mice expressing human LRRK2 protein with the G2019S Parkinsons disease mutation (IC50 20 nM in vivo)
Cayman Chemical 1-Pyrenesulfonic Acid (sodium salt), Purity: ≥90%, CAS: 59323-54-5, 500 mg
A fluorescent probe; abs/em = 346/376 nm, respectively; fluorescence can be quenched by ferric ions and the nitroaromatic compounds and explosive components 2,4-DNT and TNT in aqueous solutions; fluorescence quenching has been used in study of reverse micelles, including intermicellar migration of reactants and in the estimation of the number of micelles per cluster; has also been used as a surfactant and dopant in the synthesis of polypyrrole micro- and nanowires
Cayman Chemical 5-Methyluridine, Purity: ≥98%, CAS: 1463-10-1, 5 g
A pyrimidine nucleoside; enhances the antitumor activity of 5-fluorouracil in a mouse Erlich solid carcinoma model and a P388 murine leukemia model; has been used to characterize the activity of a variety of enzymes