Custom Enzymes and Inhibitors
Enzo Life Sciences TAPI-2 (1 mg)
Inhibitor of TNF-α processing. Inhibitor of TACE, other ADAMs, ACE secretase and other metalloproteinases. Blocks release of TNFα, TGF-α, DCC, APP, L-selectin, ACE, IL6R, NOTCH, and erbB2/HER2. Has been used in culture (typical concentration 5-100µM). Alternative Name: IC3. N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide. Formula: C19H37N5O5. MW: 415.28. Purity: ≥99% (HPLC). Sequence (IC-3). N-(R)-(2-(Hydroxyaminocarbonyl)methyl)-4-methylpentanoyl-L-t-butyl-glycine-L-alanine 2-aminoethyl amide. Appearance: Lyophilized solid. Solubility: Soluble in water (at least 20mM) or 100% ethanol (at least 5mg/ml). Long Term Storage: -20°C
Sigma Aldrich Fine Chemicals Biosciences IDRA 21 >=98% | 22503-72-6 | MFCD00270874 | 5MG
IDRA 21 >=98% | Purity: >=98% | Mol Wt: 232.69 | 22503-72-6 | MFCD00270874 | 5MG
Selleck Chemical LLC Dovitinib (TKI-258) 50mg 405169-16-6 CHIR-258
Dovitinib (TKI258, CHIR258) is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Phase 4. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC AT9283 5mg 896466-04-9
AT9283 is a potent JAK2/3 inhibitor with IC50 of 1.2 nM/1.1 nM in cell-free assays; also potent to Aurora A/B, Abl1(T315I). Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
TARGETMOL CHEMICALS INC JNK-IN-7 5mg
JNK-IN-7 is a selective JNK1/2/3 inhibitor (IC50: 1.54/1.99/0.75 nM). It can also inhibit phosphorylation of c-Jun, which is a substrate of JNK kinase.
Bioworld Pectinase, 1 g
Pectinase Also known as Poly-(1,4-a-D-galacturonide)glycanohydrolase. Used in plant protoplast preparation to digest cell wall prior to organelle isolation.
Selleck Chemical LLC Aprepitant 5mg 170729-80-3 MK-0869, L-754030
Aprepitant (MK-0869, L-754030) is a potent and selective neurokinin-1 receptor antagonist with IC50 of 0.1 nM. Aprepitant reduces levels of pro-inflammatory cytokines including G-CSF, IL-6, IL-8 and TNF?. Aprepitant inhibits HIV infection of human macrophages. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Topotecan HCl 50mg 119413-54-6 NSC609699, Nogitecan HCl, SKFS 104864A
Topotecan HCl (NSC609699, Nogitecan, SKFS 104864A) is a topoisomerase I inhibitor for MCF-7 Luc cells and DU-145 Luc cells with IC50 of 13 nM and 2 nM in cell-free assays, respectively. Topotecan HCl induces autophagy and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Celecoxib 100mg 169590-42-5 SC 58635
Celecoxib (SC 58635) is a selective COX-2 inhibitor with IC50 of 40 nM in Sf9 cells. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Roscovitine (Seliciclib) 200mg 186692-46-6 CYC202
Roscovitine (Seliciclib, CYC202) is a potent and selective CDK inhibitor for Cdc2, CDK2 and CDK5 with IC50 of 0.65 ?M, 0.7 ?M and 0.16 ?M in cell-free assays. It shows little effect on CDK4/6. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Varespladib (LY315920) 50mg 172732-68-2
Varespladib (LY315920) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC CUDC-101 10mg 1012054-59-9
CUDC-101 is a potent multi-targeted inhibitor against HDAC, EGFR and HER2 with IC50 of 4.4 nM, 2.4 nM, and 15.7 nM, and inhibits class I/II HDACs, but not class III, Sir-type HDACs. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.