Custom Peptides
Cayman Chemical 3DeazaadenosInhydrochLRI 10mg
An inhibitor of S-adenosylhomocysteine hydrolase (Ki = 3.9 μM); has anti-inflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling; has antiviral and antibacterial activities
Cayman Chemical N 2Fluorophenthyl5 2me 10mg
An inhibitor of HIF-1 signaling (IC50 = 0.32 μM in a cell-based HRE reporter assay under hypoxic conditions); inhibits hypoxia-induced increases in HIF-1α levels in MDA-MB-231, SKOV3, and HeLa cells in a concentration-dependent manner; inhibits hypoxia-induced VEGF expression and capillary-like tube formation in HUVECs; inhibits migration and invasion of MDA-MB-231 cells in wound healing and transwell assays under hypoxic conditions; reduces lung metastasis in an MDA-MB-231 mouse xenograft model at 15 and 30 mg/kg every other day
Cayman Chemical 5-HenIcosylresorcInol 10mg
An alkylresorcinol; reduces hydrogen peroxide-induced DNA damage in HT-29 cells at 100 µmol/L; inhibits migration and invasion, reduces the number of LC3 puncta, a marker of autophagy, and decreases survival in HepG2 cells at 160 UG/ml when used in combination with 5-nonadecanoylresorcinol
Cayman Chemical 71 1HTetrazolylACTAmIdo 10mg
A potential impurity in commercial preparations of cefazolin
Cayman Chemical Daursoln 10mg
An alkaloid with diverse biological activities; enhances camptothecin-induced cytotoxicity in HeLa cells at 10 µM; inhibits camptothecin-induced autophagy in HeLa, A549, and HCT116 cells (IC50s = 74.75, 50.54, and 80.81 μM, respectively); inhibits ADP-induced aggregation of platelets in isolated rabbit whole blood (IC50 = 100 µM); prolongs APD and reduces EADs in papillary muscle preparations isolated from hypertrophied rabbit hearts at 15 µM
Cayman Chemical Uncaa yncopyla sutn 10mg
An indole with diverse biological activities; selectively inhibits BChE (IC50s = 1.97 and 4.97 µM for the human and horse enzymes, respectively) over AChE, for which it has no activity; an inhibitor of 5-HT3A and 5-HT3AB (IC50s = 65.35 and 28.44 µM, respectively); reduces glutamate-induced increases in cell death in HT22 cells at 50 and 100 µM; induces apoptosis in A549 and H1299 NSCLC cells at 40, 60, and 80 µM; reduces tumor growth and intratumoral levels of phosphorylated GSK3β in an A549 mouse xenograft model at 10 mg/kg; also reduces infarct size and cardiac cell apoptosis and prevents cardiac dysfunction in a rat model of ischemia-reperfusion injury at 20 mg/kg
Cayman Chemical AlolIthocholIc AcId 10mg
A secondary allomonohydroxy bile acid; activates BK/KCa channels (EC50 = 44.21 µM in Xenopus oocytes expressing rat channels); fecal levels are increased in patients with colorectal cancer; has been found in the urine of infants with biliary atresia
Cayman Chemical MItochonIc AcId 5 10mg
An inhibitor of mitochondrial dysfunction; increases intracellular ATP levels in Hep3B cells at a 3 µM; rescues LPS-induced apoptosis and decreases in the mitochondrial membrane potential in BV-2 microglial cells at 5 µM; protects against BSO-induced decreases in cell viability in fibroblasts isolated from patients with various mitochondrial diseases (EC50s = 2.3-5.1 µM) in an electron transport chain-independent manner; reduces plasma levels of creatinine and decreases acute renal tubular necrosis in a mouse model of bilateral retroperitoneal renal ischemia-reperfusion injury at 50 mg/kg
Cayman Chemical SafInamIde AcId 10mg
A potential impurity found in commercial preparations of safinamide; a degradation product formed under conditions of thermal and oxidative stress
Cayman Chemical OrselInIc AcId 10mg
A fungal metabolite and benzoic acid derivative with antioxidant and neuroprotective activities; scavenges DPPH radicals (IC50 = 5 mM); prevents PAF-induced PARP cleavage in PC12-AC cells and PAF-induced cytotoxicity in Pafr-/-mouse cerebellar granule cells at 1 μg/ml
Genelink Random Hexamers, 100 μg, 6 bases, 5'-d(NNNNNN)-3', Equimolar 25% A, C, G, T, ~54 nmol/molecule, HPLC purified
Random Hexamers (100 μg) from GENELINK are a versatile mixture of oligonucleotides, six bases in length, designed for a range of molecular biology applications. These primers are crucial for processes like DNA probe labeling, first-strand cDNA synthesis, and the detection of genetic variations. The random nature of the sequence allows for extensive coverage of target DNA or RNA templates, making them ideal for numerous genomic studies.
- Facilitates DNA probe labeling, cDNA synthesis, and RAPD analysis.
- Enables production of high specific activity labeled DNA probes for sensitive detection.
- Provides random initiation sites across varied RNA templates.
- Supports identification of genetic variations for genetic mapping.
Cayman Chemical 2 cyclohexylmethylPLMbagI 10mg
A derivative of plumbagin; selectively cytotoxic to PANC-1 cells in nutrient-deprived medium over PANC-1 cells in DMEM (PC50s = 0.11 and 47.2 µM, respectively); induces apoptosis in PANC-1 cells at 1 µM; selectively reduces Akt and mTOR phosphorylation in PANC-1 cells under nutrient-deprived, but not nutrient-rich, conditions; tumor volume and weight in a MiaPaCa-2 mouse xenograft model at 50 and 250 UG/animal five times per week
Cayman Chemical AMPR22trIfluoroACTAte sal 10mg
An antimicrobial peptide; active against S. aureus, MRSA, P. aeruginosa, and carbapenem-resistant P. aeruginosa (MBCs = 2, 2, 2, and 4 UG/ml, respectively); induces bacterial outer membrane permeability and ATP leakage to the extracellular space in S. aureus and P. aeruginosa; increases survival in a mouse model of sepsis induced by S. aureus at 10 mg/kg
Cayman Chemical 4F 4PPoxalate 10mg
A 5-HT2A receptor antagonist (Ki = 5.3 nM); selective for 5-HT2A receptors over 5-HT1C receptors (Ki = 620 nM); inhibits 5-HT-induced current in Xenopus oocytes expressing human 5-HT2A receptors (IC50 = 5.15 µM); spinal superfusion reduces the area of electrically stimulated spinal field potentials in a rat model of SNL-induced neuropathic pain at 100 µM