Custom Peptides
Cayman Chemical 4acetoxy DEThydrochLRIde 10mg
An analytical reference standard categorized as a tryptamine; induces the HTR in mice; intended for research and forensic applications
Cayman Chemical SalvInorIn B 10mg
An analytical reference standard categorized as a diterpene; a presumptive metabolite of salvinorin A; has been found in S. divinorum, a plant with hallucinogenic properties; intended for research and forensic applications
Cayman Chemical MSG606trIfluoROCTAte salt 10mg
A peptide MC1R antagonist (IC50 = 17 nM); selectively binds to MC1R over MC3R and MC5R (IC50s = 3,900 and 1,000 nM, respectively), as well as MC4R at 10 µM; increases the latency to tail withdrawal in the tail-flick test in female, but not male, mice in a model of opioid-induced hyperalgesia at 7.5 UG/animal, i.c.v.; reduces protein levels of merlin in the cortex, reduces the number of surviving neurons in the cortex and hippocampal CA2 region, and increases the number of apoptotic cells in the cortex in rats 24 hours after injury in a model of controlled cortical impact-induced TBI at 1 nmol/animal, i.c.v.
Cayman Chemical Dynole 34-2 10mg
A dynamin inhibitor (IC50s = 6.9 and 14.2 µM for dynamin 1 and dynamin 2 GTPase activity, respectively); induces multinucleation, inhibits cytokinesis, and induces apoptosis in HeLa cells at 10 µM; inhibits proliferation of several cancer cell lines (GI50s = 5.8-15 µM)
Cayman Chemical NundecnoylLHomoserIn lac 10mg
A bacterial quorum-sensing signaling molecule; induces GFP production in E. coli expressing the V. fischeri LuxR-PluxI quorum-sensing operon from 100-1,000 nM; inhibits concanavalin A-induced proliferation of isolated mouse splenocytes (IC50 = 90 µM)
Cayman Chemical nglada oxbugna ngltn 10mg
A flavonoid glycoside; scavenges ABTS radicals in a cell-free assay (IC50 = 18.13 UG/ml); induces apoptosis in MCF-7 and MDA-MB-231 human breast cancer cells at 2 UG/ml; inhibits LPS-induced production of IL-1β, IL-6, and NO in isolated rat chondrocytes, as well as reduces cartilage erosion and the loss of proteoglycan in the inflamed joints in a rat model of surgically induced osteoarthritis
Cayman Chemical LeucetIn L41 10mg
An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 (IC50s = 0.04, 0.035, 0.015, and 4.5 µM, respectively); an inhibitor of GSK3α/β and Pim1 (IC50s = 0.41and 4.1 µM, respectively); inhibits TNF-α-induced SRp75 and SRp55 phosphorylation in human microvascular endothelial cells at 0.1-10 µM; modulates alternative pre-RNA splicing of a synthetic CLK1 minigene; prevents amyloid-β 25-35-induced lipid peroxidation and ROS accumulation in the hippocampus in a mouse model of Alzheimer’s disease-like toxicity; prevents amyloid-β 25-35-induced memory deficits in the same model at 0.4, 1.2, and 4 UG
Cayman Chemical CalIndolhydrochlorIde 10mg
A phenylalkylamine calcimimetic that facilitates the activation of CaSR, a GPCR that triggers PI-intracellular Ca2+ signaling; stimulates PI hydrolysis and proliferation through human CaSR (pEC50 values are 6.9 and 7.4, respectively) in the presence of calcium
Cayman Chemical R 715trIfluoroacetAT salt 10mg
A bradykinin B1 receptor antagonist; inhibits bradykinin-induced contractions in isolated human umbilical cords, which express bradykinin B1 receptors (pA2 = 8.49); decreases the latency to tail withdrawal in the tail-flick test in an STZ-induced mouse model of diabetic neuropathy at 200, 400, and 600 UG/kg; reduces the incidence of hind limb weakness and paralysis, improves symmetrical gait, as well as decreases spinal inflammatory foci numbers, neuron demyelination, and lesion monocyte invasion, in a MOG35-55 peptide-induced mouse model of EAE at 1 mg/kg per day; reduces mean arterial blood pressure and increases heart rate in spontaneously hypertensive rats at 0.01 nmol/animal, i.c.v
Cayman Chemical 3- 4-PyrIdylIndole 10mg
A ROCK1 inhibitor (IC50 = 25 µM) that promotes cell spreading, inhibits membrane blebbing, and induces dissolution of actin stress fibers in a wound healing assay; also inhibits ROCK2 and PRK2 with similar potency, while inhibiting MSK-1 and PKA with relatively weaker potency
Cayman Chemical LenacapavIr 10mg
An inhibitor of HIV capsid protein-protein interactions; inhibits viral replication in HIV-1-infected primary human CD4+ T cells and macrophages (mean IC50s = 32 and 56 pM, respectively), two HIV-2 clinical isolates (mean IC50 = 885 pM), and 23 HIV-1 clinical isolates (mean IC50 = 50 pM); prevents stHIV-A19 infection in pigtail macaques at 25 mg/kg, s.c.
Cayman Chemical GSK484hydrochlorIde 10mg
A reversible inhibitor of PAD4 (IC50 = 50 nM) that binds to the low-calcium form of the enzyme; blocks the citrullination of PAD4 target proteins in human neutrophils and inhibits the formation of NETs in both mouse and human neutrophils
Cayman Chemical 4-MTAhydrochlorIde 10mg
A selective serotonergic agent which increases serotonin release, blocks its re-uptake (IC50 = 102 nM), and inhibits MAO A; intended for research and forensic applications
Cayman Chemical 3 4-EDMAhydrochlorIde 10mg
An analog of 3,4-MDMA that stimulates the release of serotonin and dopamine from rat brain synaptosomes at 1 µM
Cayman Chemical 1 3DIpalmItol2Starol Gl 10mg
A triacylglycerol; levels decrease in rats with reduced food intake-induced energy depletion