Custom Peptides
Cayman Chemical FursultIamIn 10mg
A synthetic derivative of vitamin B1; reduces LPS-induced increases in IL-6, IL-8, and CCL2 at 100 and 20 µM, respectively; reduces the area and severity of laser-induced lesions in a mouse model of CNV at 50 mg/kg; prevents physical-fatigue loading decreases in skeletal muscle ATP levels induced by forced swimming with a weight load in rats at 50 mg/kg; enhances the protective effects of glucosamine and chondroitin sulfate on cartilage lesion formation in a rabbit model of osteoarthritis at 100 mg/kg
Cayman Chemical N3oxotetradec7 ZenoylL 10mg
A bacterial quorum sensing compound that possesses antimicrobial activity, the ability to inhibit biofilm formation, and exhibits immune suppressive activity
Cayman Chemical cyclo RGDyCtrIfluoroACTAt 10mg
A cyclic pentapeptide; has been used to generate doxorubicin-containing liposomes and fluorescent silicon nanoparticles to target tumors and ocular neovasculature, respectively
Cayman Chemical GSK205hydrobromIde 10mg
A TRPV4 and TRPA1 inhibitor (IC50s = 4.19 and 5.56, respectively, for the rat channels); inhibits GSK1016790A-induced calcium influx in whole-cell patch-clamp assays using Neuro2a cells expressing TRPV4 at 5 µM; prevents compression-induced increases in NF-κB transcriptional activity and secreted levels of IL-6 and VEGFA, as well as inhibits compression-induced fractures, abnormal cell morphology, and fissures in the intervertebral space, in primary mouse lumbar spines at 10 µM
Cayman Chemical CTX1211trIfluoroACTAte sa 10mg
A peptide agonist of melanocortin receptors; increases cAMP levels in cells expressing MC1R, MC3R, or MC4R (EC50s = 6.2, 3.9, and 2.7, nM, respectively); sensitizes male and female mice to liraglutide-induced reductions in food intake and body weight at 1 mg/kg
Cayman Chemical BIOnT PremIM Fragmnt lbra 10mg
Customers are supplied with the following data package for EAch fragment purchases: • Aqueous buffer 1H NMR raw data file • Structures and physiochemical properties in an sd file • SPR Clean Screen results The parameters used in the design of the library are: • Heavy atoms ≤ 16 • clogP ≤ 3 • Hydrogen bond donors ≤ 3 • Hydrogen bond acceptors ≤ 3 • tPSA ≤ 60 • Rotatable bonds ≤ 3
Cayman Chemical ACTH11-24humnmouser 10mg
A peptide fragment of ACTH and an MC2R antagonist (IC50 = ~1 nM in HeLa cells expressing the mouse receptor); induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively; inhibits ACTH-induced stretching, yawning, and penile erections in rats at 1.69 UG/animal, i.c.v.
Cayman Chemical 2propyl4PentenoIc AcId 10mg
A metabolite of valproic acid; undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats; neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos
Cayman Chemical -Glu-AlatrIfluoroACTAte500mg
A dipeptide; has been found in P. roqueforti; has been found in ripened Gouda, goat, and Milner cheeses; a positive allosteric modulator of CaSR (EC50 = 4.8 µM in CaSR-expressing HEK293 cells); induces glutathionuria in mice at 4 mmol/kg; plasma levels are increased in malnourished neonatal mice; increased serum levels are positively associated with an increased risk of chronic kidney disease
Cayman Chemical CalcInurIn SubstrATtrIflu 10mg
A synthetic peptide substrate; can be used as a substrate to quantify calcineurin activity
Cayman Chemical 3 4-DmAhydrochlorIde 10mg
An MDMA analog that appears to act as a serotonin-norepinephrine-dopamine releasing agent binding to and inhibiting uptake at noradrenalin and serotonin transporters (Kis = 22.8 and 7.7 μM and IC50s = 253.4 and 108 μM, respectively); significantly less potent than MDMA; intended for forensic and research applications
Cayman Chemical ML-095hydrochlorIde 10mg
An inhibitor of PLAP (IC50 = 3.7 μM) that demonstrates high selectivity against the related alkaline phosphatases, TNAP and IAP (IC50s > 100 μM)
Cayman Chemical 4-fluoro PV9hydrochlorIde 10mg
Differs from PV9 by having a fluorine atom at the four, or para, position of the phenyl group
Cayman Chemical BetazolehydrochlorIde 10mg
A histamine H2 receptor agonist; induces acid secretion in isolated human gastric glands (EC50 = 120 µM); increases pepsin and acid levels in gastric juice in dogs at 3-10 mg/kg