Custom Peptides
Cayman Chemical DIclofensInhydrochlorIde 10mg
A potent inhibitor of monoamine reuptake, blocking the uptake of dopamine, noradrenaline, and serotonin by rat brain synaptosomes with IC50 values of 0.74, 2.3, and 3.7 nM, respectively; intended for research and forensic applications
Cayman Chemical CynIdIn 3-OD-Galactopyrn 10mg
An anthocyanin flavonoid with antioxidant properties; scavenges radicals in DPPH, TEAC, ORAC, and hydrogen peroxide assays; decreases the release of LDH and the activation of caspase-3 in lymphocytes with t-butyl hydroperoxide-induced oxidative damage
Cayman Chemical VU6036720hydrochlorIde 10mg
An inhibitor of heteromeric Kir4.1/5.1 channels (IC50 = 0.24 µM); selective for Kir4.1/5.1 channels over a variety of homomeric Kir channels, including Kir4.1 (IC50 = >10 µM), as well as heteromeric Kir3.1/3.2, Kir3.1/3.4, Kir6.2/SUR1, and Kir6.1/SUR2b channels at 30 µM but does inhibit the voltage-gated potassium channel Kv1.1 (IC50 = 6.4 µM); does not inhibit diuresis in mice at 30 and 100 mg/kg due to low oral bioavailability and high hepatic clearance
Cayman Chemical PyrIntegrIn 10mg
A 2,4-disubstituted pyrimidine that, at 2 µM, enhances the survival of hESC more than 30-fold after trypsin-mediated dissociation; increases integrin-dependent attachment of hESC to extracellular matrices
Cayman Chemical noruscogenIn 10mg
A natural sapogenin that acts as a bioavailable, potent, and high-affinity agonist of the nuclear receptor RORα (EC50 = 110 nM); up-regulates the expression of several RORα-inducible genes in the livers of mice, when given at 3 mg/kg/d orally for seven days
Cayman Chemical NortrIptylInhydrochlorIde 10mg
A tricyclic antidepressant that blocks norepinephrine and serotonin transporters (KDs = 4.4 and 18 nM, respectively) more potently than the dopamine transporter (KD = 1.1 µM)
Cayman Chemical Nacetyl3 4MethylendIoxyme 10mg
An acetylated analog of methylone, the MDMA-type designer drug that has been detected in products marketed as bath salts, plant food, and tablets; intended for forensic and research purposes
Cayman Chemical MethylpIperIdIno pyrazole 10mg
A highly selective ERα receptor antagonist (Ki = 5.6 nM; IC50 = 80 nM)
Cayman Chemical PalustrIc AcId 10mg
A diterpenoid with diverse biological activities; increases secreted hydrogen peroxide levels in isolated mouse macrophages at 2 mg/ml; toxic to water fleas and rainbow trout (LC50s = 0.1 and 0.5 mg/L, respectively); phloem levels are increased in mechanically injured, as well as mechanically injured and L. abietinum-infected, red pine and white spruce trees; has been found as an environmental contaminant in pulp and paper mill effluent
Cayman Chemical C22 CeramIded18 122 0 10mg
A bioactive sphingolipid; forms small channels in liposomes, suggesting that acyl chain length is important in mitochondrial-mediated apoptosis; decreases the mitochondrial-to-cytosolic stress response in C. elegans following hsp-6 RNAi
Cayman Chemical 20 S-ProtopnaxatrIol 10mg
An active ginsenoside metabolite; cytotoxic to HL-60 cancer cells (IC50 = 16 µM); inhibits the proliferation of HUVECs (EC50 = 6.64 UG/ml); blocks LPS-induced increases in the protein levels of COX-2 and iNOS and decreases LPS-induced NF-κB activity in RAW 264.7 cells from 1-20 µM
Cayman Chemical 3EthylmethcathInonhydroch 10mg
A potential stimulant/entactogen designer drug of the amphetamine, phenethylamine, and cathinone chemical classes; intended for forensic purposes
Cayman Chemical PItavastatIncalcIum salt 10mg
An HMG-CoA reductase inhibitor (Ki = 1.7 nM for the rat liver microsomal enzyme); inhibits sterol biosynthesis in rat liver and ileum (ED50s = 0.13 and 0.2 mg/kg, respectively); reduces plasma levels of triglycerides and total cholesterol in dogs; increases survival in Dahl salt-sensitive rats fed a high-salt diet at 0.3 mg/kg
Cayman Chemical 15keto17phenl trInor Pros 10mg
A keto derivative of an F-series prostaglandin and a metabolite of 17-phenyl trinor PGF2α ethyl amide