Custom Peptides
Cayman Chemical trcetrapb 10mg
A CETP inhibitor (IC50s = 47 and 51 nM for cholesteryl and triglyceride transfer, respectively); selective for CETP over PLTP, LCAT, and hepatic and lipoprotein lipases at 10 µM; inhibits CETP activity and increases HDL cholesterol levels in serum from transgenic mice expressing human CETP and ApoA1 at 30 mg/kg; increases mean arterial blood pressure in Zucker fa/fa diabetic rats at 60 and 200 mg/kg
Cayman Chemical aHydroxyglutarIc AcIdodIu 10mg
An α-hydroxy acid; levels are increased in 2-hydroxyglutaric aciduria; can be metabolized from isocitrate by mutated forms of IDH1 and IDH2; competitively inhibits α-ketoglutarate-dependent dioxygenases, including histone lysine demethylases and DNA hydroxylases
Cayman Chemical FUB-JWH 018 10mg
A synthetic cannabinoid whose physiological and toxicological properties have not been tested; intended for forensic and research applications
Cayman Chemical 5fluoro PB22 8hdroxIsoqu 10mg
Differs from 5-fluoro PB-22 by having the quinoline group replaced with an isoquinoline group attached at its eight position; intended for forensic and research purposes
Cayman Chemical HalofntrInhydrochlorIde 10mg
An antimalarial agent; active against chloroquine-sensitive and chloroquine-resistant strains of P. falciparum (IC50s = 1.5-2.5 and 1.3-3.9 UG/L, respectively); reduces parasitemia in a mouse model of P. berghei infection (CD50 = 15 mg/kg); reduces parasitemia in an Aotus monkey model of P. falciparum infection (CD50 = 58.3 mg/kg)
Cayman Chemical ACtoACtylCoenzyme AsodIu 10mg
A precursor to HMG-CoA in the isoprenoid pathway; reversibly converted to acetyl-CoA by acetoacetyl-CoA thiolase
Cayman Chemical PropentofylIn 10mg
A xanthine derivative and neuroprotective agent; increases NGF production in primary mouse astroglia maximally at 1.11 mM; reduces Aβ42-induced cell death in primary rat hippocampal neurons at 20 UG/ml; reduces infarct volume in a rat model of ischemic brain damage induced by permanent MCAO when administered following MCAO as an i.v. infusion at 0.01, 0.05, and 0.1 mg/kg per minute; inhibits cAMP phosphodiesterases, is an antagonist of adenosine A1 and A2 receptors, and binds to adenosine transporters
Cayman Chemical AurothIoglucosehydrate 10mg
A TrxR inhibitor (IC50 = 0.065 µM for the human placental enzyme); selective for TrxR over glutathione reductase and GPX (IC50s = >100 and 80 µM, respectively); inhibits IL-1β-induced production of IL-6 and IL-8 in isolated human rheumatoid synovial fibroblasts at 100 µM; reduces HIV-1 replication induced by TNF-α in OM10.1 cells latently infected with HIV-1 at 10 and 25 µM; improves survival in a mouse model of ARDS induced by LPS and hyperoxia at 25 mg/kg; induces obesity and increases food intake and blood glucose levels in genetically diabetic KK mice
Cayman Chemical NBQXsodIum salt 10mg
A water-soluble receptor antagonist which targets both AMPA- and kainate-sensitive glutamate receptors (IC50 = 0.15 and 4.8 µM, respectively); does not block the NMDA-sensitive glutamate receptor (IC50 = ≥ 90 µM)
Cayman Chemical YM90KhydroCLOrID hydrate 10mg
An AMPA receptor antagonist (Ki = 0.084 μM in a radioligand binding assay using rat brain membranes); selective for AMPA over kainate, NMDA-sensitive glutamate, and strychnine-insensitive glycine receptors (Kis = 2.2, >100, and 37 μM, respectively); intrastriatal administration inhibits AMPA-induced decreases in ChAT activity in rat striatum ex vivo; inhibits audiogenic seizures in susceptible DBA/2 mice with a minimum effective dose of 3 mg/kg, i.p.; intravenous infusion reduces infarct size in a rat model of focal cerebral ischemia induced by thrombotic MCAO in rats at 20 mg/kg per hour for 4 hours
Cayman Chemical DMAhydrochlorIde 10mg
A radi; oprotective agent; decreases radiation-induced lethality without affecting radiation-induced tumor regression in an Ehrlich murine spontaneous adenocarcinoma model at 300 mg/kg; prevents radiation-induced damage of intestinal, hepatic, and splenic tissues, increases in splenic MDA production, and decreases in splenic SOD activity in a B16/F10 murine melanoma model at 50 mg/kg
Cayman Chemical SURVODUTIDE 10MG
A dual peptide agonist of GLP-1R and GCGR; increases cAMP accumulation in CHO-K1 cells expressing GLP-1R or GCGR in reporter assays (EC50s = 0.33 and 0.52 nM, respectively); potentiates glucose-induced insulin secretion in isolated mouse, rat, and perifused human pancreatic islets; reduces body weight and food intake in diet-induced obese mice at 3 and 30 nmol/kg per day; reduces the levels of hepatic triglycerides and cholesterol, as well as plasma levels of glucagon, cholesterol, triglycerides, ALT, AST, insulin, and leptin in diet-induced obese mice; increases energy expenditure in diet-induced obese mice at 10 nmol/kg per day
Cayman Chemical DoxorubIcInhydrochlorIde 10mg
An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA
Cayman Chemical aPyroldInobutIothIophenon 10mg
An analog of α-PBP that has a thiofuran group in place of the phenyl group