Custom Peptides
Cayman Chemical AzImIlIdehydrochlorIde 10mg
A class III antiarrhythmic agent; blocks IKr and IKs currents in isolated guinea pig ventricular myocytes (IC50s = 0.3 and 3 μM, respectively); prolongs APD in isolated calf Purkinje fibers and ventricular trabeculae from 0.1-10 μM; increases the ERP in isolated perfused guinea pig hearts and ferret papillary muscles; increases ERP and the absolute refractory period and decreases heart rate in dogs from 0.3-30 mg/kg; reduces mean arrhythmia score in a rat model of coronary artery ligation and reperfusion-induced severe ventricular arrhythmia; prevents sustained and non-sustained ventricular tachyarrhythmias in dogs from 10-30 mg/kg
Cayman Chemical 4NItrophenylNacetylaDga 10mg
A chromogenic substrate for N-acetyl-D-galactosaminidase that generates a yellow solution upon cleavage
Cayman Chemical BretylIumtosylate 10mg
A class III antiarrhythmic agent; has antiadrenergic activity in isolated tissue preparations; an inhibitor of the Na+/K+-ATPase (IC50 = 4.5 mM); prevents ventricular fibrillation in anesthetized dogs in a model of sudden coronary death at 10 mg/kg; inhibits NCTs, as well as increases action potential delay and the absolute refractory period in isolated mouse vas deferens sympathetic nerve terminals
Cayman Chemical SophocarpIn 10mg
An alkaloid with diverse biological activities; cytotoxic to various cancer cell lines (IC50s = 1.64-12.86 mM); nematocidal against B. xylophilus in vitro; reduces infarct size, cardiac muscle fiber swelling and hypertrophy, and neutrophil infiltration in a rat model of myocardial ischemia and reperfusion injury at 30 mg/kg; decreases liver weight, fibrosis, and levels of IL-6, TNF-α, and TGF-β1 in a rat model of NASH; reduces carrageenan-induced hind paw edema in rats and decreases acetic acid-induced writhing in mice at 15 and 30 mg/kg
Cayman Chemical SencIo cInrarIa MareIn 10mg
A glucoside chalcone; scavenges DPPH radicals (IC50 = 48.35 μM); inhibits EGFR (IC50 = 19.94 μM); reduces fasting blood glucose and fasting serum insulin, triglycerides, LDL cholesterol, total cholesterol, IL-6, and CCL2 levels and renal IL-6 and CCL2 levels, as well as decreases fibrosis, in diabetic db/db mice at 50 mg/kg
Cayman Chemical 1S 3R-RSL3 10mg
A ferroptosis inducer; inhibits GPX4 in a context-dependent manner; inhibits GPX4 in the presence of cell cytosol or recombinant human 14-3-3ε but does not inhibit recombinant human selenocysteine-containing GPX4 or purified rat testis GPX4, at 100 µM; inhibits peroxidase activity in GPX4-overexpressing COH-BR1 breast cancer cell lysates at 50 nM; inhibits TrxR1 (IC50 = 7.9 µM in a cell-free assay); selectively cytotoxic to H-RasV12-expressing BJeLR cells over wild-type Ras-expressing BJeH cells (EC50s = 0.01 and 2 µM, respectively); induces lipid peroxidation in Pfa1 fibroblasts at 100 nM; prevents tumor formation and inhibits tumor growth in BJeLR mouse xenograft models at 100 mg/kg
Cayman Chemical TaurocholIc AcId 3sulfatS 10mg
A metabolite of taurocholic acid; plasma levels are elevated in wild-type and Sort1 knockout mice at 6 hours post-BDL and are further elevated in Sort1 knockout mice at 24 hours post-BDL
Cayman Chemical RabeprazolesodIum salt 10mg
A proton pump inhibitor; inhibits the gastric H+/K+ ATPase (IC50 = 72 nM); activated more rapidly and over a greater pH range than other proton pump inhibitors; inhibits gastric acid secretion in pylorus-ligated rats and a rat model of gastric fistula at 30 mg/kg; inhibits the growth of several strains of H. pylori in vitro (MIC50s = 1.57-3.13 μg/mL)
Cayman Chemical ON-01910sodIum salt 10mg
A potent, non-ATP-competitive inhibitor of Plk1 (IC50 = 9 nM); induces apoptosis in a wide array of tumor cell lines (GI50 = 50-200 nM); active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents
Cayman Chemical ABCHMINACA metabolIte M5A 10mg
A potential metabolite produced during metabolism of AB-CHMINACA in the liver; intended for forensic and research applications
Cayman Chemical Deslnosde 10mg
A cardiac glycoside; induces ventricular tachycardia in anesthetized dogs at 0.18 mg/kg
Cayman Chemical Maackan 10mg
the histamine H1 receptor in serum-starved HeLa cells at 10, 20, or 30 µM; inhibits PMA-induced increases in the levels of mRNA encoding Il-4 in RBL-2H3 cells at 50 or 150 µM; decreases LPS-induced increases in NO production in RAW 264.7 macrophages (IC50 = 27 µM); increases survival in a mouse model of CLP-induced sepsis at 2.5 or 5 mg/kg; reduces the number of sneezes and the extent of nasal redness, swelling, and watery rhinorrhea in a rat model of TDI-induced allergies at 20 mg/kg per day
Cayman Chemical 4 4-DIcynobenzhydrol 10mg
An analytical reference standard that is a metabolite of letrozole; has been used as a marker of letrozole use in athletes; intended for research and forensic applications
Cayman Chemical 25INBOMe 4methoxy Isomerh 10mg
Differs from 25I-NBOMe by having a methoxy group at the four, rather than two, position on the benzene ring; intended for research and forensic applications