Custom Peptides
Cayman Chemical AcVDVADAFCtrIfluoroACTAt 10mg
A fluorogenic substrate for caspase-2; AFC is released upon enzymatic cleavage by caspase-2 and its fluorescence can be used to quantify caspase-2 activity; ex/em = 400/505 nm, respectively
Cayman Chemical PentratIntrIfluoroacetate 10mg
A cell-penetrating peptide; has been used in the surface functionalization of liposomes for drug delivery across the BBB
Cayman Chemical FebrIfugInhydrochlorIde 10mg
A quinazolinone with antimalarial activity; reduces parasitemia and decreases mortality in mice infected with the P. berghei strain NK65 at 1 mg/kg per day
Cayman Chemical SynthetIc TapInarof 10mg
A stilbene with diverse biological activities; active against C. tropicales, C. neoformans, A. fumigatus, A. flavus, and B. cinerea (MICs = 25, 12, 12, 25, 12 UG/ml, respectively); induces nuclear translocation of AhR in HaCaT keratinocytes (EC50 = 0.16 nM); induces expression of the AhR target gene CYP1A1 in HaCaT keratinocytes at 1µM; reduces activated immune cell-induced mRNA expression of the gene encoding IL-17a in isolated human keratinocytes at 10 µM
Cayman Chemical TrotabresIb 10mg
A BRD4 inhibitor (IC50 = =0.5 µM); inhibits the proliferation of Raji and HL-60 cells (IC50 = =0.5 µM for both)
Cayman Chemical FlavokawaIn 1I 10mg
A flavokawain derivative with anticancer and antiviral activities; inhibits the proliferation of gefitinib-resistant H1975 NSCLC cells by 36%, as well as decreases protein levels of EGFR, c-Met, HER2, Akt, and Cdk4 and increases protein levels of Hsp70, markers of Hsp90 inhibition, at 30 µM; intramuscular administration reduces viral titers in PRRSV-infected pigs
Cayman Chemical PalustrIc AcId 10mg
A diterpenoid with diverse biological activities; increases secreted hydrogen peroxide levels in isolated mouse macrophages at 2 mg/ml; toxic to water fleas and rainbow trout (LC50s = 0.1 and 0.5 mg/L, respectively); phloem levels are increased in mechanically injured, as well as mechanically injured and L. abietinum-infected, red pine and white spruce trees; has been found as an environmental contaminant in pulp and paper mill effluent
Cayman Chemical XL413hydrochlorIde 10mg
A potent inhibitor of Cdc7 (IC50 = 3.4 nM); >60, >10, and >300-fold selective for Cdc7 over CK2, PIM1, and a panel of over 100 protein kinases, respectively; inhibits the growth of MDA-MB-231T and COLO 205 cells (IC50s = 118 and 140 nM, respectively); inhibits Cdc7-specific phosphorylation of MCM2 and induces cell cycle accumulation in the S and G2 phases in MDA-MB-231T and COLO 205 cells; inhibits MCM2 phosphorylation (ED50 = <3 mg/kg) and reduces tumor growth in a COLO 205 mouse xenograft model at 10, 30, and 100 mg/kg
Cayman Chemical 6 7 4-TrIhydroxyIsoflavon 10mg
An active metabolite of daidzein; suppresses anchorage-dependent and -independent growth of HCT116 and DLD-1 colon cancer cells, as well as induces cell cycle arrest at the S and G2/M phases in HCT116 cells from 12.5-100 µM; inhibits MDI-induced adipogenesis in 3T3-L1 preadipocytes at 40 and 80 µM; reverses scopolamine-induced memory impairments and increases hippocampal BDNF and CREB levels in mice at 5 mg/kg; prevents LPS-induced bone loss in mice
Cayman Chemical Adnopoa tapyla Lupnon 10mg
A triterpenoid; inhibits HIV-1 reverse transcriptase (IC50 = 2.1 μM); active against the W2 and D6 strains of P. falciparum (IC50s = 208.1 and 394.7 ng/ml, respectively); induces melanogenesis in (EC50 = 0.35 µM), and inhibits the growth of, B16 2F2 cells in vitro (IC50 = 25.4 µM); topical application reduces TPA-induced EAr edema in mice at 1 mg/ear; inhibits acetic acid-induced writhing in mice at 100 mg/kg
Cayman Chemical 1 1EthylIdenbIs Ltrypto 10mg
A potential impurity found in commercial preparations of L-tryptophan; increases the proliferation of EoL-3 eosinophilic leukemia cells, release of eosinophil cationic protein from isolated human peripheral blood eosinophils, and IL-5 production in isolated human T cells; induces fascia thickening and increases mast cell infiltration, inflammation, and fibrosis in superficial adipose and panniculus carnosus tissues in a mouse model of eosinophilia-myalgia syndrome at 40 UG/kg
Cayman Chemical Astoloca mnsuns Astolon 10mg
A sesquiterpene with anticancer activity; cytotoxic to H460, ES-2, and DU145 cells (IC50s = 51.3, 61.5, and 58 UG/ml, respectively)
Cayman Chemical BRC4wtrIfluoroacetAT salt 10mg
An inhibitor of the BRCA2-RAD51 protein-protein interaction; shortens DNA replication tract lengths and reduces homologous repair frequency of camptothecin-induced DNA damage in vitro, as well as potentiates olaparib-induced cell death in HeLa and U2OS cells but not in non-cancerous hTERT RPE-1, MRC-5, or MCF-10A cells when coupled to (Arg)9
Cayman Chemical CInamoylglycIn 10mg
A metabolite of trans-cinnamic acid; urinary levels are decreased in a mouse model of piperacillin- and tazobactam-induced gut microbiota colonization resistance; serum levels are increased in patients with CKD
Cayman Chemical ArnIcolIde D 10mg
A sesquiterpene lactone with anticancer activity; inhibits the proliferation of MDA-MB-231, MDA-MB-468, and MCF-7 human breast cancer cells (IC50s = 5.211, 3.405, and 9.083 µM, respectively, after 48 hours); inhibits migration of MDA-MB-231 cells at 2.5, 5, and 10 µM; reduces tumor volume in an MDA-MB-231 orthotopic mouse xenograft model at 25 and 50 mg/kg