Custom Peptides
Cayman Chemical Cl-ncrostatIn-1 10mg
A RIPK1 inhibitor; inhibits RIPK1 activity at 0.3, 3, and 30 µM; inhibits TNF-α-induced necroptosis in FADD-deficient Jurkat cells (EC50 = 180 nM); reduces infarct size when administered i.c.v. pre- and post-occlusion, or post-occlusion only, as 2 µl of a 4 mM solution in a mouse model of MCAO
Cayman Chemical FlavokawaIn B 10mg
A natural chalcone that induces apoptosis in prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours); increases Bim expression and inhibits growth of DU145 xenografts in mice; hepatotoxic
Cayman Chemical AdenylosuccInIc ACDamonIu 10mg
A purine nucleotide and an intermediate in the purine nucleotide cycle; converted into AMP and fumarate by ADSL in the cytosol; inhibits calcium-induced activation of non-selective cation channels in isolated rat brown adipocytes in a patch-clamp assay at 10 µM; induces contractions in isolated guinea pig uterus strips at 100 µM; increases glucose-induced insulin exocytosis in INS-1 832/13 insulinoma cells at 10 µM; decreases muscle damage and pseudohypertrophy in a dystrophin-deficient mdx mouse model of DMD
Cayman Chemical 7ahydroxy DehydroepIndROS 10mg
An active metabolite of dehydroepiandrosterone; formed from dehydroepiandrosterone via 7-hydroxylation by CYPs; increases antigen-induced production of anti-tetanus toxoid and anti-pertussis antigen IgGs in co-cultures of human tonsil-derived B and T cells at 1 µM; increases serum concentrations of anti-lysozyme IgG in mice at 6.25 mg/kg
Cayman Chemical BInImetInIb 10mg
A MEK1 and MEK2 inhibitor (IC50s = 1.8 and 0.92 nM, respectively); selective for MEK1/2 over RAF/MEK/ERK pathway kinases at 10 µM; reduces cell growth in HT-29, COLO 205, and LoVo cells (IC50s = 0.48, 0.52, and 2.2 nM, respectively); reduces tumor volume in a COLO 205 mouse xenograft model at 0.3 mg/kg
Cayman Chemical pIodoClonIdInhydrochLRI 10mg
A partial agonist of the α2-adrenergic receptor, minimally inhibiting adenylate cyclase through this Gi protein-coupled receptor although it binds avidly (Ki = 1.0 nM); potentiates platelet aggregation by ADP (EC50 = 1.5 µM) and inhibits epinephrine-induced aggregation (IC50 = 5.1 µM)
Cayman Chemical 11-keto Fluprostenol 10mg
11-keto Fluprostenol is an analog of PGD2 with structural modifications intended to give it a prolonged half-life and greater potency. Fluprostenol is a well-studied, potent analog of PGF2α and acts primarily through the FP receptor.{1182} Oxidation at C-11 of fluprostenol yields 11-keto fluprostenol. 11-keto Fluprostenol exhibits moderate binding to the CRTH2/DP2 receptor compared to PGD2 and essentially no activity at the DP1 receptor.{10723}
Cayman Chemical 2Phenyl2 1pIperIdInylpro 10mg
A mechanism-based inactivator of human CYP2B6 (Ki = 5.6 µM; IC50 = 5.1 µM) with potent selectivity for CYP2B6 over other CYP450 isoforms
Cayman Chemical CapsIconIate 10mg
A coniferyl ester that acts as a partial agonist of TRPV1 (EC50 = 3.2 µM), eliciting only 20% of the maximum response induced by capsaicin
Cayman Chemical DorIpenmhydrate 10mg
A broad-spectrum antibiotic; is active against Gram-negative and Gram-positive bacteria, including S. aureus, S. pneumoniae, E. coli, and K. pneumoniae (MICs = 0.03-0.06, 0.016-0.06, P. aeruginosa respiratory tract infection at 100 mg/kg per day
Cayman Chemical P3298hemIfumarate 10mg
A competitive transition-state substrate analog inhibitor of DPP IV (Ki = 126 nM); used to improve glucose tolerance, insulin sensitivity, and β-cell glucose responsiveness in diabetic rat models at 20 mg/kg/day
Cayman Chemical MIvacurIumchlorIde 10mg
An antagonist of nAChRs and muscarinic M2 and M3 receptors (ED50s = 0.08, 0.3, and 0.1 mg/kg for ex vivo human skeletal muscle nAChRs, guinea pig cardiac M2 receptors, and guinea pig bronchial M3 receptors, respectively); inhibits acetylcholine-induced activation of neuronal nAChRs (IC50s = 69.04, 3.71, 1.52, and 2.90 for human α3β2-, α3β4-, α4β2-, and α7-containing nAChRs expressed in Xenopus oocytes); inhibits adult human muscular α1β1εδ-containing nAChRs (IC50 = 3.69 nM in Xenopus oocytes expressing the human recombinant receptor); inhibits bradycardia and bronchoconstriction induced by vagal stimulation or acetylcholine in guinea pigs; induces neuromuscular blockade in sheep (ED95 = 80 μg/kg)
Cayman Chemical MIrodenafIlhydrochlorIde 10mg
A PDE5 inhibitor; increases penile ICP in rat models of STZ-induced diabetes and cavernosal nerve injury at 1 and 10 mg/kg, respectively; decreases bladder wall submucosal fibrosis and degeneration in a rat model of chronic bladder ischemia at 4 mg/kg per day; decreases bladder overactivity in a female rat model of partial bladder outlet obstruction
Cayman Chemical GInsenosIde Rc 10mg
A saponin; prevents UVB-induced increases in ROS levels in HaCaT keratinocytes by 34.3, 54.4, and 65.4% when used at concentrations of 5, 12, and 30 µM, respectively; reduces increases in LPS-induced expression of Tnf, Il1b, and Ifnb1 in RAW 264.7 cells at 40 UG/ml; reduces gastric ulcer and joint lesion indices in mouse models of HCl/ethanol-induced gastritis and collagen-induced arthritis, respectively, as well as reduced increased serum levels of AST induced by LPS/D-galactosamine in a mouse model of hepatitis, at 20 mg/kg; increases GABA-induced inward current in Xenopus oocytes expressing recombinant human α1β1ɣ2S subunit-containing GABAA receptors (EC50 = 53.2 µM)
Cayman Chemical 1Naphthyl 3 5DNItrobenzAT 10mg
A dual 5-LO and mPGES-1 inhibitor (IC50s = 1 and 3.6 µM, respectively)