Custom Peptides
Cayman Chemical GInkgotoxIn 10mg
A pyridoxine antimetabolite; inhibits pyridoxal kinase (Ki = 3 µM); induces seizure-like behavior in zebrafish larvae at 200-1,000 µM
Cayman Chemical nglca pubscns Subrosn 10mg
A prenylated coumarin with diverse biological activities; inhibits arachidonic acid-, collagen-, PAF-, ADP-, or U-46619-induced aggregation of washed isolated rabbit platelets (IC50s = 60, 132, 200, 234, and 200 µM, respectively); reduces arachidonic acid-induced TXB2 formation in the same model; inhibits PHA-induced NF-κB nuclear translocation in, as well as proliferation of, human PBMCs at 100 µM
Cayman Chemical BromosporIn 10mg
A non-selective bromodomain inhibitor that at 1 µM has been shown to accelerate FRAP recovery of BRD4 and CREBBP bromodomains in HeLa cells
Cayman Chemical GemIglIptIntartrate 10mg
A DPP-4 inhibitor (IC50 = 0.01 µM); selective for DPP-4 over DPP-8, DPP-9, and FAP- α (IC50s = 277.28, 233.72, 418.43 µM, respectively); inhibits DPP-4 activity in isolated human plasma (IC50 = 11.5 nM); scavenges methylglyoxal in vitro and inhibits AGE formation between BSA and methylglyoxal and cross-linking of AGE-BSA with rat tail tendon collagen (IC50s = 1.15, 11.69, and 1.39 mM, respectively); reduces the levels of circulating AGE and red blood cell IgG content in db/db diabetic mice at 100 mg/kg; decreases blood glucose and HbA1c levels and reduces pancreatic β-cell damage in a mouse model of STZ- and high-fat diet-induced diabetes; induces cytotoxicity in SW1736 and TPC-1 cells
Cayman Chemical 6 8DIfluoro7hydroxy4meth 10mg
A fluorophore; has been conjugated to streptavidin or secondary antibodies for flow cytometry and used to label bacteria for multi-color FISH; has been coupled to peptides to improve electrospray ionization and MS sensitivity in MALDI-TOF MS; displays absorption/emission maxima of 358/455 nm, respectively
Cayman Chemical 15 R-ProstaglndIn F2a 10mg
15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α. It has only 25% of the potency of PGF2α in hamster antifertility studies, which may be due to reduced affinity for FP receptors. Compared to PGF2α, 15(R)-PGF2α has a binding affinity of 6.7% to ovine luteal cell receptors. Similarly, the binding affinity to rat vascular smooth muscle cells is negligible as compared to PGF2α.
Cayman Chemical 3-EpIdeoxycholIc AcId 10mg
A secondary bile acid produced by gut microbiota; increases the growth of Caco-2 cells at 10 and 20 µM; increases Foxp3+CD4+ Treg levels in a co-culture of naïve T cells and dendritic cells
Cayman Chemical SynthetIc SpongosIn 10mg
A nucleoside with diverse biological activities; antagonist of adenosine A1, A2A, and A3 receptors (Kis = 155, 970, and 156 nM, respectively, in CHO cells expressing the human receptors); inhibits collagen-induced platelet aggregation in isolated human whole blood and platelet-rich plasma at 100 µM; decreases contractile force and frequency in spontaneously contracting isolated guinea pig atrial muscles (EC50s = 32.7 and 127.7 µM, respectively)
Cayman Chemical methyl1 cyclohexylmethyl1 10mg
An analog of BB-22 that lacks the quinoline group; intended for forensic and research applications
Cayman Chemical ArachIdoyl glycIn 10mg
Consists of arachidic acid with glycine attached at its carboxy terminus
Sino Biological Anti-IRAK4 Antibody, Rabbit Polyclonal 100 µL
Produced in rabbits immunized with purified, recombinant Human IRAK4 (rh IRAK4; Catalog#10735-H07B; Q9NWZ3-1; Met1-Ser460). IRAK4 specific IgG was purified by Human IRAK4 affinity chromatography.
Cayman Chemical C6 NBD CeramIded18 16 0 10mg
C6 NBD ceramide is a biologically active fluorescent analog of short chain, membrane-permeable ceramides.{2754} It is as effective as C6 ceramide in the inhibition of viral glycoprotein transport through the Golgi.{2754} C6 NBD ceramide has been used as a fluorescent substrate for the activity of UDP-glucose:ceramide glucosyltransferase{2814} and to demonstrate the translocation of glucocerebroside and sphingomyelin from the Golgi to the plasma membrane.{3460}
Cayman Chemical 3hydroxy3methylglutarylCo 10mg
An intermediate in several metabolic pathways; conversion to mevalonate by HMG-CoA reductase is the rate-limiting first step in the cholesterol biosynthetic pathway; can be cleaved into acetyl-CoA and the ketone body acetoacetate in mitochondria by HMG-CoA lyase; an intermediate in the degradation of leucine
Cayman Chemical DroxInostat 10mg
An inhibitor of HDAC3, HDAC6, and HDAC8 (IC50s = 16.9, 2.47, and 1.46 μM, respectively); selective for HDAC3, 6, and 8 over HDAC1, 2, 7, 9, and 10 (IC50s = >20 μM); inhibits proliferation and colony formation of SMMC-7721 and HepG2 hepatocellular carcinoma cell lines via activation of mitochondrial apoptosis and reduction of c-FLIP