Custom Peptides
Cayman Chemical RemodelInhydrobromIde 10mg
A 2-thiazolylhydrazone derivative that, at 10 µM, improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria; inhibits NAT10
Cayman Chemical 5fluoro PB22 7hdroxquIno 10mg
Differs from 5-fluoro PB-22 by having the ester linkage inserted at the seven, rather than at the eight, position of the quinoline moiety; intended for forensic and research purposes.
Cayman Chemical CardIogenol ChydrochLRIde 10mg
Induces the differentiation of MHC-positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 µM
Cayman Chemical N3oxopentnoylLHomoserIn 10mg
A bacterial quorum-sensing signaling molecule; inhibits binding of N-3-oxo-hexanoyl homoserine lactone to E. coli containing the transcription factor LuxR; acts as an autoinducer to activate the V. fischeri luminescence system in E. coli at 20-200 nM
Cayman Chemical PenIcIlIc AcId 10mg
A mycotoxin produced from Penicillium species that inhibits bacterial quorum sensing communication in P. aeruginosa; inhibits Fas-mediated apoptosis (100-200 μM) by targeting caspase-8 activity in Burkitt’s lymphoma Raji cells
Cayman Chemical BatbulInsodIum salt 10mg
An inhibitor of tubulin polymerization; covalently binds to Cys239 of the β1, β2, and β4 tubulin isotypes and inhibits polymerization of bovine brain tubulin (IC50 = 2 µM) in cell-free assays; induces cytoskeletal collapse and cell cycle arrest at the G2/M phase in MCF-7 cells at 30, 100, and 300 nM; cytotoxic against a panel of drug-sensitive and -resistant cancer cell lines (IC50s = 11-165 nM); reduces tumor volume in CCRF CEM and CEM/VBL100 mouse xenograft models
Cayman Chemical AlopurInol RIbosIde 10mg
A ribonucleoside; inhibits Leishmania promastigote growth and prevents amastigote maturation into promastigotes; prevents mortality in mouse models of T. cruzi infection at 239, 511, and 929 mg/kg per day
Cayman Chemical Exatecnmesylate 10mg
A DNA topoisomerase I inhibitor (IC50 = 0.975 UG/ml); inhibits cell growth in a panel of 32 breast, colon, stomach, and lung cancer cell lines (GI50s = 0.125-10.4 ng/ml); reduces tumor growth in an SC-6-JCK gastric adenocarcinoma mouse xenograft model from 3.325-50 mg/kg; reduces tumor weight in HCT116, PC-6, and PC12 mouse xenograft models at 75 mg/kg; has been used in the synthesis of cytotoxic payload moieties of ADCs
Cayman Chemical 10 11dIhydro10 11dIhydrxy 10mg
A metabolite of carbamazepine and oxcarbazepine; has been found in wastewater effluent
Cayman Chemical 3-demethyl ColchIcIn 10mg
An active metabolite of colchicine; suppresses antibody production induced by sheep red blood cells in co-culture with isolated mouse spleen cells from 0.1-10 UG/ml; inhibits carrageenan-induced paw edema in rats at 100 UG/animal
Cayman Chemical Sitostenone 10mg
A phytosterol with diverse biological activities; inhibits NO production in RAW 264.7 macrophages (IC50 = 15.9 µM); active against the T. evansi (IC50 = 150 nM); reduces mean blood pressure in normotensive rats at 2 mg/kg; decreases blood glucose levels in dogs at 1.3 and 3 mg/kg
Cayman Chemical BlarcamesIn 10mg
A σ1 receptor agonist; inhibits reductions in mitochondrial oxygen consumption and lipid peroxidation induced by Aβ (25-35) in isolated mouse hippocampus at 1 mg/kg; improves deficits in novel object recognition induced by Aβ (25-35) in mice, as well as reduces tau phosphorylation and Aβ (1-42) levels in the hippocampus in the same model at 1 mg/kg; increases the latency to fall in the rotarod test, reduces gait impairments, and reduces increases in the mean acoustic startle response in an Mecp2-/- mouse model of Rett syndrome at 30 mg/kg per day