Custom Peptides
Cayman Chemical FFN102trIfluoroACTAte sal 10mg
A pH-dependent fluorescent probe to label dopaminergic cells; excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values; emission spectrum of 453 nm, with a higher intensity at pH 7.4; inhibits DAT (13.6% at a concentration of 10 µM) and the 5-HT receptor subtype 5-HT2c (Ki = ~3 µM); does not bind to 37 central nervous system receptors, including dopamine and serotonin receptors, up to a concentration of 10 µM
Cayman Chemical A11trIfluoroacetate salt 10mg
A cell-penetrating peptide; decreases annexin A1 binding to EphA2 and increases EphA2 ubiquitination in HK1 NPC cells; inhibits HK1 and 5-8F NPC cell proliferation, migration, and invasion; reduces tumor volume in 5-8F and HK1 NPC mouse xenograft models
Cayman Chemical DehydrocorydalInchlorIde 10mg
An alkaloid with diverse biological activities; inhibits 5-HT reuptake by OCT2 and dopamine reuptake by OCT3 (IC50s = 0.137 and 0.354 µM, respectively, for human recombinant transporters), as well as reduces dopamine, 5-HT, and norepinephrine reuptake in mouse brain synaptosomes; decreases immobility time in the forced swim test in a mouse model of depression induced by chronic unpredictable mild stress at 1.5 and 3 mg/kg; reduces acetic acid-induced writhing in mice and increases the mechanical paw withdrawal threshold in a mouse model of bone cancer pain at 10 mg/kg
Cayman Chemical ElagolIxsodIum salt 10mg
An antagonist of GnRHR (Ki = 0.9 nM in a radioligand binding assay); selective for GnRHR over CYP3A4 (IC50 = 56 μM) as well as a panel of 100 receptors, ion channels, enzymes, and transporters (IC50s = >10 μM); inhibits GnRH-induced inositol phosphate production in RBL-1 cells expressing human GnRHR (IC50 = 1.5 nM); suppresses production of luteinizing hormone in castrated male cynomolgus macaques at 30 mg/kg
Cayman Chemical AKOS B018304 10mg
A derivative of 1,3-thiazolidin-4-one; inhibits the binding of ΔFosB to an oligonucleotide containing the Cdk5-AP-1 consensus site in a cell-free assay (IC50 = 10.1 µM); induces ΔFosB- and ΔFosB/JunD-mediated gene transcription in a reporter assay using Neuro2a cells at 12.5 µM
Cayman Chemical tnofovIr DIsoproxIlfumart 10mg
A prodrug of the HIV reverse transcriptase and hepatitis B virus polymerase inhibitor, tenofovir; >100-fold greater anti-HIV activity than that of poorly bioavailable tenofovir in a T cell line and primary blood lymphocytes
Cayman Chemical Black Tea TheaflavIn 10mg
A polyphenolic flavonoid with antioxidant and anticancer activities; scavenges singlet oxygen and hydrogen peroxide as well as superoxide and hydroxide radicals in vitro (IC50s = 0.73, 0.49, 14.5, and 38.0 µM, respectively); inhibits the growth of OVCAR-3 and A2780/CP70 human ovarian cancer cell lines, but not the ovarian epithelial cell line IOSE 364 (IC50s = 11.9, 38.5, and >40 µM, respectively)
Cayman Chemical ArnbIa sInsIs AlknIn 10mg
A naphthoquinone with diverse biological activities; enantiomer of shikonin; selectively inhibits tumor-specific PKM2 (IC50 = 0.3 μM) over PKM1 and PKL; inhibits proliferation of HCT116 and SW480 colorectal cancer cells (IC50s = 2.38 and 4.53 μM, respectively); halts the cell cycle at the G1 phase and induces apoptosis in HCT116 cells at 3 μM; increases levels of Hsp70 in untreated and UVB-irradiated HaCaT cells as well as inhibits UVB-induced DNA fragmentation and caspase-3 activity in HaCaT cells at 1 μM; active against methicillin-sensitive and -resistant S. aureus (MICs = 6.25 μg/ml) as well as vancomycin-sensitive and -resistant E. faecalis (MICs = 50 and 25 μg/ml, respectively); scavenges DPPH radicals in a cell-free assay (EC50 = 22 ppm)
Cayman Chemical Lycors radta Ungeremn 10mg
A betaine-type alkaloid with diverse biological activities; an inhibitor of AChE (IC50 = 0.35 µM); a topoisomerase-IIβ poison; inhibits the relaxation of supercoiled DNA by human topoisomerase I and -IIα and E. coli topoisomerase I and -IV (IC50s = 6.1, 25.8, 15, and 7.3 µM, respectively); inhibits the growth of a variety of cancer cells (IC50s = 0.7-2.5 µM); cytotoxic to a variety of drug-sensitive and -resistant cancer cells (IC50s = 4.89-6.45 and 3.67-75.24 µM, respectively); induces ferroptosis, necroptosis, apoptosis, and autophagy in CCRF-CEM leukemia cells; reduces tumor growth in a GXF251L mouse xenograft model at 60 mg/kg twice per week
Cayman Chemical ChlorpyrIfos-methyl 10mg
An organophosphate insecticide; induces mortality of adult stored-grain pests when applied to grain at 10 mg/kg; reduces the number of live progeny produced by L. bostrychophila, L. decolor, L. entomophila, and L. paeta when applied to grain at 2.5 mg/kg; reduces outgrowth of axon-like processes in mouse N2a neuroblastoma cells at 3 μM; decreases H19 gene methylation in sperm as well as decreases anogenital distance and increases thymus and epididymis weights and serum testosterone levels in male offspring when administered to pregnant female rats from 4-100 mg/kg
Cayman Chemical BrexpIprazole 10mg
A serotonin and dopamine receptor modulator; partial agonist of human 5-HT1A, D2L, and D3 receptors (EC50s = 0.49, 4.0, and 2.8 nM, respectively); antagonist of 5-HT2A, 5-HT2B, as well as α1B- and α2C-adrenergic receptors (IC50s = 6.5, 14, 0.66, and 63 nM, respectively); dose-dependently reduces conditioned avoidance response (CAR) time, inhibits apomorphine- and amphetamine-induced locomoter hyperactivity, and reverses cognitive defects in rats; antagonizes apomorphine-induced eye blinking in cynomolgus monkeys
Cayman Chemical R-ZINC3573 10mg
An MRGPRX2 agonist; induces β-arrestin recruitment in a reporter assay using MRGPRX2-expressing HTLA cells and calcium mobilization in LAD 2 mast cells (EC50s = 0.74 and 1 µM, respectively); selective for MRGPRX2 over 21 other GPCRs; induces degranulation of LAD 2 mast cells
Cayman Chemical ANTIBODYR-AS-1 10mg
A positive allosteric modulator of EAAT2 (EC50 = 11 nM in a glutamate uptake assay); selective for EAAT2 over EAAT1, EAAT3, and a panel of 30 other ion channels, transporters, receptors, and enzymes; increases spontaneous locomotor activity in mice at 60 and 90 mg/kg; has anticonvulsant activity in mouse models of seizures induced by MES, PTZ, or electrical stimuli of 32 or 44 mA (ED50s = 66.3, 36.3, 15.6, and 41.6 mg/kg, respectively)
Cayman Chemical N3oxohexadecnoylLHomose 10mg
An unusual, substituted, long-chain N-acyl-homoserine lactone (AHL) produced by some bacteria
Cayman Chemical NoctadecnoylLHomoserIn l 10mg
One of four lipophilic, long acyl side-chain bearing AHLs produced by the LuxI AHL synthase homolog SinI involved in quorum sensing signaling in strains of S. meliloti, a nitrogen-fixing bacterial symbiont of the legume M. sativa