Custom Peptides
Cayman Chemical Endosulfn II 10mg
An organochlorine insecticide; active against a variety of insects including bollworms and tobacco budworms (LD50s = 4.14 and 4.95 mg/g, respectively); binds to GABA receptors (IC50 = 60 nM in rat brain membranes); toxic to rats (LD50 = 240 mg/kg)
Cayman Chemical CCT241533hydrochlorIde 10mg
A selective Chk2 inhibitor (IC50 = 3 nM); potentiates the cytotoxicity of the PARP inhibitors, rucaparib and olaparib
Cayman Chemical Catechn 10mg
A diastereoisomer of catechin having a trans 2S,3R configuration at the chiral center; a potent antioxidant that inhibits the free radical-induced oxidation of isolated LDL by AAPH
Cayman Chemical S1HtrIfluoroacetate salt 10mg
A synthetic peptide antagonist of the human growth hormone receptor; decreases STAT5 phosphorylation induced by human growth hormone in SK-MEL-28 and MALME-3M cell lines, as well as by prolactin in IM-9 B cells, at 100 and 200 nM
Cayman Chemical 6 2 4-TrImethoxyflavon 10mg
A flavonoid; inhibits benzo[a]pyrene-induced AhR-dependent transcription in a reporter assay at 2 and 10 µM; decreases LPS-induced production of TNF-α in THP-1 cells (IC50 = 47.7 UG/ml); inhibits cell migration and invasion of HN-30 HNSCC cells at 10 µM
Cayman Chemical Black Tea TheaflavIn 10mg
A polyphenolic flavonoid with antioxidant and anticancer activities; scavenges singlet oxygen and hydrogen peroxide as well as superoxide and hydroxide radicals in vitro (IC50s = 0.73, 0.49, 14.5, and 38.0 µM, respectively); inhibits the growth of OVCAR-3 and A2780/CP70 human ovarian cancer cell lines, but not the ovarian epithelial cell line IOSE 364 (IC50s = 11.9, 38.5, and >40 µM, respectively)
Cayman Chemical AcnthosIde B 10mg
A lignan with diverse biological activities; scavenges DPPH and ABTS radicals in cell-free assays (IC50s = 9.9 and 12.7 µM, respectively); inhibits LPS-induced NO production in RAW 264.7 cells at 20 µM; reverses scopolamine-induced memory impairment, reduces hippocampal MDA levels, and increases hippocampal SOD, catalase, and GPX levels in a mouse model of scopolamine-induced amnesia at 20 mg/kg
Cayman Chemical Coydals duls max. Coydn 10mg
An aporphine alkaloid with diverse biological activities; inhibits the proliferation murine L1210 lymphocytic leukemia, B16/F10 melanoma, and P388 leukemia cells from 10-100 UG/ml; binds to μ-opioid receptors (Ki = 2.82 µM) and induces [35S]GTPγS binding in CHO cells expressing human μ-opioid receptors (EC50 = 0.51 µM); active against L. donovani promastigotes (IC50 = 26.7 µM)
Cayman Chemical 4MethylumbelIferyl DN N 10mg
A fluorogenic substrate for chitinases and chitobiosidases; cleaved by chitinases and chitobiosidases to release the fluorescent moiety 4-ΜU; ex/em = 320 and 360 at low (1.97-6.72) and high pH (7.12-10.3), respectively/445-455 nm, increasing as pH decreases
Cayman Chemical PaederosIdIc AcId 10mg
An iridoid glycoside; inhibits the proliferation of NCI H1650, HCC827, and A549 cells (IC50s = 40.68, 42.58, and 36.48 UG/ml, respectively); protects against PTZ- or maximal electroshock-induced seizures in mice from 10-40 mg/kg; increases duration of pentobarbital-induced sleep and decreases the latency to sleep onset in mice
Cayman Chemical BTS-54-505hydrochlorIde 10mg
An active metabolite of sibutramine; inhibits norepinephrine, 5-HT, and dopamine uptake in rat cortical synaptosomes (IC50s = 0.066, 5.1, and 0.61 µM, respectively); prevents reserpine-induced ptosis in rats (ED50 = 3.7 mg/kg); decreases immobility in the Porsolt learned helplessness test in mice at 10 mg/kg; increases colonic temperature and decreases food intake in rats at 10 mg/kg
Cayman Chemical SC144hydrochlorIde 10mg
A gp130 inhibitor; inhibits phosphorylation of STAT1, STAT3, and Akt induced by LIF and IL-6, but not IFN-γ, in OVCAR-8 ovarian cancer cells at 20 µM; induces cycle arrest at the G0/G1 phase in MDA-MB-435 breast and HT-29 colorectal cancer cells and inhibits proliferation of 14 cancer cell lines (IC50s = 0.4-4 µM); reduces tumor growth in OVCAR-8 and MDA-MB-435 mouse xenograft models
Cayman Chemical DHODH-IN 11 10mg
A derivative of leflunomide; does not inhibit DHODH (IC50 = >100 µM)