Custom Peptides
Cayman Chemical ngenol-3-ngelate 10mg
A hydrophobic diterpene ester that rapidly induces cell death in proliferating keratinocytes through plasma membrane and mitochondrial disruption; causes inflammation due, at least in part, to activation of PKC, leading to antibody-dependent cellular cytotoxicity
Cayman Chemical 5mthyltetrahydrofolc ACD 10mg
A biologically active form of folic acid that functions, in conjunction with vitamin B12, as a methyl-group donor involved in the conversion of homocysteine to methionine
Cayman Chemical DexmedetomIdInhydrochLRId 10mg
The (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity; its activation of α2-adrenoceptors produces analgesic, sedative, and anxiolytic effects
Cayman Chemical Desacetyl BIsacodyl 10mg
An active metabolite of two stimulant laxatives, bisacodyl and sodium picosulfate
Cayman Chemical CGP 55845hydrochlorIde 10mg
A GABAB receptor antagonist (Ki = 4.5 nM); increases electrical stimulation-induced GABA release in the absence and presence of (–)-baclofen, as well as glutamate release in the presence of (–)-baclofen, in rat cerebral cortex slices (EC50s = 8.3, 25, and 14 nM, respectively); inhibits (–)-baclofen-induced postsynaptic hyperpolarization of evoked IPSPs and fEPSPs in rat CA1 hippocampal slices at 1 µM; increases swimming time, but does not decrease immobility time, in the forced swim test in rats at 3 or 10 mg/kg; reverses age-induced impairments in olfactory discrimination learning in rats at 0.01 and 0.1 mg/kg; increases seizure intensity in a mouse model of PTZ kindling-induced epilepsy
Cayman Chemical RezIvertInIb 10mg
An inhibitor of mutant EGFR; selectively inhibits the proliferation of mutant-EGFR-containing PC-9, HCC827, and H1975 cells (GI50s = 13.3, 6.8, and 22 nM, respectively) over wild-type EGFR-containing A431 cells (GI50 = >1,000 nM); increases survival in an H1975 brain orthotopic rat model
Cayman Chemical TFMB-R-2-HG 10mg
A cell-permeable form of (R)-2-HG; has been used to assess the role of (R)-2-HG in leukemogenesis
Cayman Chemical DIhydrosnguInarIn 10mg
A metabolite of sanguinarine with diverse biological activities; inhibits proliferation of PANC-1, SW 1990, and HPDE6c7 cancer cells at 10, 20, and 30 µM; reduces the levels of phosphorylated ERK and C-RAF, halts the cell cycle at the G0/G1 and G2/M phases, and induces apoptosis in PANC-1 cells
Cayman Chemical Semagacestat 10mg
A potent inhibitor of γ-secretase that blocks the production of Aβ38, Aβ40, and Aβ42 with IC50 values of 12.0, 12.1, and 10.9 nM, respectively; also blocks Notch signaling (IC50 = 14.1 nM); modulates γ-secretase activity in vivo, altering Aβ levels in brain, cerebrospinal fluids, and plasma in a dose-dependent fashion
Cayman Chemical 7hydroxy DPAThydrobromIde 10mg
A dopamine D3 receptor agonist; selectively binds to the dopamine D3 over the D2, D1, and D4 receptors (Kis = 0.78, 61, 650, and 5,300 nM, respectively, in radioligand binding assays); increases calcium mobilization in HEK293 cells expressing the D3 receptor (EC50 = 13.5 nM in a FLIPR assay); decreases the release of striatal dopamine and DOPAC in rats at 0.25 mg/kg, i.p.; reduces the loss of ipsilateral SNC dopaminergic neurons in a rat model of 6-OHDA-induced Parkinson's disease at 2 UG/µl for eight weeks, i.c.v.; decreases amphetamine-induced ipsilateral rotations and increases the number of steps reached with the contralateral paw in the staircase test in the same model
Cayman Chemical AtomoxetInhydrochlorIde 10mg
A selective norepinephrine reuptake inhibitor (Kis = 5, 77, and 1,451 nM for norepinephrine, serotonin, and dopamine transporters, respectively); selective over other transporters, and a number of neurotransmitter receptors, ion channels, second messengers, and brain/gut peptides; increases extracellular norepinephrine and dopamine by 3-fold in the PFC; reduces premature responding by rats in the 5CSRTT when administered at doses of 0.1, 0.5, and 1 mg/kg; has neuroprotective effects in a gerbil model of transient cerebral ischemia
Cayman Chemical IACS-010759 10mg
An orally bioavailable inhibitor of mitochondrial complex I; inhibits the ubiquinone reduction activity of isolated murine mitochondrial complex I at 60 nM; reduces basal and spare respiratory capacities and increases glycolytic flux in primary CLL cells at 100 nM; induces apoptosis in CLL cells grown under low glucose conditions or when administered in combination with 2-deoxy-D-glucose; induces tumor regression in a glycolysis-deficient NB1 mouse xenograft model when administered at doses of 5 and 10 mg/kg