Bioactive Small Molecules
Cayman Chemical ANTIBODY NulscrIpt 10mg
An analog of scriptaid that lacks scriptaid’s HDAC inhibitory effects; used as a negative control in experiments involving scriptaid
C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 | 50mg | 573896656](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502203129.JPG-250.jpg)
eMolecules 1005342-46-0 | LCL161 | Broadpharm | MFCD23160049 | 500.630 | C26H33FN4O3S | 0.000 | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 | 50mg | 573896656
LCL161 | Broadpharm | 1005342-46-0 | MFCD23160049 | 500.630 | C26H33FN4O3S | 0.000 | CN[C@@H](C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1ccc(F)cc1 | 50mg | 573896656
Cayman Chemical ANTIBODY ABD-F 10mg
A thiol-reactive fluorogenic reagent; has been used to detect and quantify thiol-containing amino acids, protein and tissue thiols, and disulfide linkages; ex/em = 389/513 nm, respectively
Cayman Chemical 4-hydroxy DETfumarate 5mg
An analytical reference standard categorized as a tryptamine; induces the HTR in mice, indicating hallucinogenic potential; intended for research and forensic applications
Cayman Chemical ANTIBODY CAY10677 1mg
A cysmethynil analog that inhibits Icmt with an IC50 value of 0.86 μM; demonstrates nearly 10-fold more potent antiproliferative activity than cysmethynil on human breast cancer MDA-MB-231 cells (IC50s = 2.63 vs. 27.4 μM, respectively) and human prostate cancer PC3 cells (IC50s = 2.55 vs. 25.2 μM, respectively)
Medchemexpress LLC IL-23 Rat HEK293 100ug
IL-23 alpha protein has cytokine activity and binds to the interleukin 23 receptor It regulates cytokine production lymphocyte activation and peptidyl tyrosine phosphorylation IL-23 Protein Rat (HEK293 His) is a recombinant protein dimer complex containing rat-derived IL-23 alpha IL-12 beta Heterodimer protein expressed by HEK293 with C-10 His labeled tag
Medchemexpress LLC AZD5582 dihydrochloride | 1883545-51-4 | 99.8% | 1088.21 | 100 MG
AZD5582 dihydrochloride is an antagonist of the inhibitor of apoptosis proteins (IAPs). It binds to the BIR3 domains of cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively, and induces apoptosis. This compound has demonstrated a range of biological activities both in vitro and in vivo.
- Inhibits cell viability in H1975 NSCLC cells when cooperating with IFNγ or viral dsRNA.
- Downregulates cIAP-1, activates RIPK1, and triggers activation of extrinsic and intrinsic apoptosis pathways in H1975 NSCLC cells.
- Induces apoptosis and active caspase-3/8 activities when co-treated with IFNγ in HCC827 NSCLC cells.
- Causes degradation of cIAP1 and caspase 3 cleavage in tumor cells of MDA-MB-231 xenograft models.
- Achieves substantial tumor regressions in MDA-MB-231 xenograft models with two weekly doses.
Cayman Chemical trns-ClovamIde 5mg
A naturally occurring caffeoyl conjugate with antioxidant and antiradical properties; demonstrates neuroprotective effects (EC50s = 0.9-3.7 µM) in several in vitro models of neuronal death
Medchemexpress LLC LY-411575 (isomer 1) | 209984-58-7 | 99.5% | C26H23F2N3O4 | 5 MG
LY-411575 isomer 1 is an isomer of LY411575, which is a potent γ-secretase inhibitor. It has a molecular weight of 479.48 and appears as a solid, white to off-white in color.
- Potent γ-secretase inhibitor
- Appears as a solid
- White to off-white in color
- Store powder at -20°C for 3 years or 4°C for 2 years
- Store in solvent at -80°C for 2 years or -20°C for 1 year
- For research use only
Cayman Chemical ANTIBODY 15 S-HETE 25ug
An active metabolite of arachidonic acid; inhibits proliferation of HT-29 colorectal and PC3 prostate cancer cells (IC50s = 40 and 30 µM, respectively); increases KLF10 and decreases Bcl-2 protein levels in HT-29 cells at 40 µM; increases HMG-CoA reductase levels in HDMVECs at 0.1 µM; increases Rac1 protein levels and induces farnesylation of Rac1 in HDMVECs at 0.1 µM
Cayman Chemical ANTIBODY JT010 10mg
A TRPA1 agonist (EC50 = 0.65 nM in a calcium influx assay); selective for TRPA1 over TRPV1, TRPV3, and TRPV4, TRPC5, TRPM2, and TRPM8 channels at 1 µM
Cayman Chemical MCC950sodIum salt 5mg
An inhibitor of NLRP3 inflammasome activation; inhibits ATP-induced IL-1β release in LPS-primed mouse BMDMs (IC50 = 7.5 nM), as well as cytosolic LPS-induced IL-1β release in Pam3CSK4-primed mouse BMDMs at 0.1 and 1 µM; selective for NLRP3 over NLRC4 and AIM2 inflammasomes and does not inhibit LPS-induced NLRP3 priming in mouse BMDMs at 10 µM; reduces ox-LDL-induced increases in caspase-1 activity and inhibits pyroptosis in THP-1 macrophages at 1 µM; reduces myocardial fibrosis in mice following myocardial infarction induced by left coronary artery ligation at 10 mg/kg; improves forelimb grip strength and reduces spinal edema in a mouse model of spinal crush injury at 10 mg/kg
![Medchemexpress LLC N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide | 942206-85-1 | 99.9% | 655.61 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000400477-logo.png-250.jpg){kind=logo}
Medchemexpress LLC N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide | 942206-85-1 | 99.9% | 655.61 | 1 ML
GSK1016790A is a potent and selective transient receptor potential vanilloid 4 (TRPV4) channel agonist. It can elicit Ca2+ influx and elevate intracellular Ca2+ in HEK cells.
- GSK1016790A (0.1-1000 nM) elicits Ca2+ influx in mouse and human TRPV4-expressing human embryonic kidney (HEK) cells (EC50 values of 18 and 2.1 nM, respectively) and it evokes a dose-dependent activation of whole-cell currents at concentrations above 1 nM.
- GSK1016790A (100 nM) treatment elicits a rapid elevation of intracellular Ca2+ in a subset of neurons.
- GSK1016790A (0.001-0.1 mg/kg; i.p.) produces a dose-dependent inhibitory effect on whole gut transit time in mice.
- GSK1016790A (0.1-1000 nM; pretreatment 10 min) significantly inhibits the electrical field stimulation (EFS)-induced twitch contractions in isolated mouse colon strips in a concentration-dependent manner.
Apexbio Technology LLC AMG 510(Synonyms: Sotorasib, Lumakras, AMG510, KRAS G12C inhibitor, AMG-510), 10mg, CAS: 2296729-00-3.
AMG 510 (CAS 2296729-00-3) is an orally bioavailable selective covalent inhibitor targeting KRAS G12C Its mechanism involves binding KRAS G12C mutant protein and stabilizing it in an inactive GDP-bound conformation By preventing nucleotide exchange AMG 510 suppresses downstream signaling pathways linked to cellular proliferation and survival resulting in tumor regression in preclinical KRAS G12C-driven cancer models It serves as an important tool for biomedical research focused on RAS-driven oncogenic signaling and targeted cancer therapeutics development
Cayman Chemical ANTIBODY nonacIn 1mg
A mitochondrial complex I inhibitor from A. muricata (IC50 = 54.8 nM); induces ATP depletion, tau pathologies, and dopaminergic cell death in rats (EC50s = 134, 44.1, and 60.8 nM, respectively); reduces cell survival (ED50 = 0.31 µM in MCF-7 cells); decreases MCF-7 xenograft tumor size in nude mice at a dose of 50 mg/kg per day