Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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4,966 – 4,980 of 60,541 results

4,966

Medchemexpress LLC Dalidnetug 10mg | 10mg

Dalidnetug is a humanized monoclonal antibody targeting human amyloid-beta precursor protein (APP) Dalidnetug specifically binds to APP to reduce the production of amyloid-beta (A ) thus exerting the activity of clearing amyloid-beta Dalidnetug is promising for research of Alzheimer s disease[1]

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4,967

TARGETMOL CHEMICALS INC WNT PATHWAY INHIBITOR 3 5MG

Also available in 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimental osteoarthritis. purity: 99%

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4,968

Medchemexpress LLC Meropenem-vaborbactam | 2031124-72-6 | 97.9% | 680.60 | 25 MG

Meropenem-vaborbactam is a Carbapenem antibiotic and boronic acid-based beta-lactamase inhibitor. This fixed-dose combination product shows potent in vitro activity against Enterobacteriaceae, including Klebsiella pneumoniae carbapenemase producers. It also demonstrates activity against Pseudomonas aeruginosa isolates.

Potently inhibits Enterobacteriaceae isolates.
Exhibits activity against Pseudomonas aeruginosa isolates.
Demonstrates potent in vitro activity against 991 KPC-producing Enterobacterales strains.
Achieves bacteriostasis at an fAUC:MIC ratio of 9 in a murine model.
Achieves a 1-log10 bacterial kill at an fAUC:MIC ratio of 38 in a murine model.

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4,969

Cayman Chemical PQ-10, Purity: ≥98%, CAS: 927691-21-2, 1 mg

A potent and selective inhibitor of phosphodiesterase type 10 (PDE10; Ki = 4 nM); has >38-fold selectivity for PDE10 over a panel of 60 CNS-associated receptors, enzymes, and ion channels in vitro; increases striatal cGMP and CREB phosphorylation in vivo; reduces scopolamine- and MK-801-induced memory deficits in rats; inhibits tumor cell growth with IC50 values of 0.29 and 0.22 mM for HCT116 and SW480 colon cancer cells, respectively

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4,970

Selleck Chemical LLC Apoptosis Compound Library L3300-2X100UL/WELL

A unique collection of 1223 small molecules used for apoptosis research targeting Bcl-2 Caspase p53 TNF-alpha Mdm2 survivin etc

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4,971

Cayman Chemical UM-164, Purity: ≥98%, CAS: 903564-48-7, 10 mg

An inhibitor of Src and p38 MAPK kinases (Kds = 2.7, 2.2, and 5.5 nM for c-Src, p38α, and p38β, respectively); also inhibits Fyn, Yes, Lyn, Abl, Arg, Ack, Csk, EphB2, EphB4, and Zak at 500 nM; inhibits cell growth in a panel of TNBC cell lines (IC50s = 6.1-260 nM) and in a patient-derived TNBC cell line (IC50 = 320 nM); induces cell cycle arrest at the G1/S phase MDA-MB-231 and SUM149 cells at 1 μM; inhibits cell motility and invasion in MDA-MB-231 and SUM149 cells at ≥ 50 nM; reduces tumor growth in SUM149 and MDA-MB-231 mouse xenograft models at ≥10 mg/kg

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4,972

Cayman Chemical EN6, Purity: ≥95%, CAS: 1808714-73-9, 10 mg

An activator of autophagy; inhibits mTORC1 signaling by covalently binding to the lysosomal v-ATPase; selective for inhibition of mTORC1 over mTORC2 signaling; increases lysosome acidification and increases cellular clearance of TDP-43 protein aggregates in a v-ATPase-dependent manner in U2OS osteosarcoma cells; inhibits mTORC1 signaling and enhances autophagy in mouse skeletal muscle and heart at 50 mg/kg

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4,973

Cayman Chemical BSJ-4-116, Purity: ≥95%, CAS: 2519823-34-6, 5 mg

A PROTAC that drives Cdk12 degradation; induces time- and concentration-dependent degradation of Cdk12 in Jurkat cells; decreases expressions of various genes associated with DNA double-strand break repair in Jurkat cells at 50 nM; inhibits the growth of MOLT-4 leukemia cells in a cereblon-dependent manner

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4,974

Cayman Chemical SCH 527123, Purity: ≥95%, CAS: 473727-83-2, 5 mg

An allosteric antagonist of CXCR1 and CXCR2 (IC50s = 43 and 0.97 nM, respectively); inhibits CXCL8-induced chemotaxis of Ba/F3 cells expressing human recombinant CXCR2 and CXCL1-induced chemotaxis of isolated human PMNs at 3 nM; inhibits LPS-induced neutrophil infiltration into the lung (ED50 = 1.8 mg/kg) and increases mucin levels in BALF in a rat model of airway inflammation; inhibits proliferation of wild-type (IC50s = 28.95 and 18.78 µM, respectively) and IL-8 overexpressing HCT116 and Caco-2 cells (IC50s = 39.45 and 25.45 µM, respectively); reduces tumor growth in an HCT116 mouse xenograft model at 50 mg/kg per day

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4,975

Medchemexpress LLC Indole-3-lactic acid | 1821-52-9 | MFCD00005642 | 100.0% | 205.21 g·mol⁻1 | C11H11NO3 | 5 MG

Indole-3-lactic acid is an endogenous tryptophan metabolite supplied as an analytical reference standard for research and analytical applications. The compound is an off-white to light-yellow solid (CAS 1821-52-9) with a molecular formula of C11H11NO3 and molecular weight 205.21 g·mol⁻1; it is intended for method development, calibration, and metabolite identification.

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4,976

Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 100 MG

NVP-BSK805 dihydrochloride is an ATP-competitive JAK2 inhibitor with IC50s of 0.48 nM for JAK2 JH1, 31.63 nM for JAK1 JH1, 18.68 nM for JAK3 JH1, and 10.76 nM for TYK2 JH1. It inhibits both wild-type and V617F mutant JAK2 activity. This compound suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocks STAT5 phosphorylation. In vivo, it blocks STAT5 phosphorylation, splenomegaly, and leukemic cell spreading, and suppresses rhEpo-mediated polycythemia.

ATP-competitive JAK2 inhibitor
Inhibits wild-type and V617F mutant JAK2 activity
Suppresses growth of acute myeloid leukemia cell lines
Blocks STAT5 phosphorylation
Enhances P-gp inhibitory activity
Sensitizes drug-resistant cancer cells
Blocks splenomegaly and leukemic cell spreading
Suppresses rhEpo-mediated polycythemia

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4,977

Medchemexpress LLC 1,3,2-benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | 117089-08-4 | 95.0% | 100MG

1,3,2-benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | 117089-08-4 | 95.0% | 100MG

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4,978

Cayman Chemical BAY 12-17389, Purity: ≥95%, CAS: 1554458-53-5, 25 mg

An Mps1 inhibitor (IC50 = 0.63 nM); selective for Mps1 over a panel of kinases at 10 nM; promotes mitosis progression in metaphase-arrested HeLa cells (IC50 = 11 nM); enhances paclitaxel-induced inhibition of tumor growth in a SUM149 TNBC mouse xenograft model

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4,979

Cayman Chemical Aloperine, Purity: ≥95%, CAS: 56293-29-9, 1 g

An alkaloid with diverse biological activities; inhibits HIV-1 replication and envelope-mediated cell-cell fusion (EC50s = 1.75 and 1.2 μM, respectively); inhibits the growth of HL-60, U937, and K562 leukemia cell lines (IC50s = 40, 270, and 360 μM, respectively); reduces NOX2, NOX4, superoxide dismutase, and glutathione peroxidase expression in lungs in a rat model of pulmonary hypertension; reduces ear swelling, ear erythema, and production of inflammatory cytokines TNF-α, IL-1β, and IL-6 in a mouse model of allergic contact dermatitis

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4,980

Cayman Chemical AMG 837, Purity: ≥98%, CAS: 865231-46-5, 1 mg

An FFAR1 (GPR40) partial agonist; induces calcium mobilization in CHO cells expressing FFAR1/GPR40 but not FFAR2/GPR43, FFAR3/GPR41, or FFAR4/GPR120 (EC50s = 0.0135, >10, >10, and >10 µM, respectively); induces insulin secretion in MIN6 pancreatic β-cells and isolated mouse islets (EC50s = 0.0048 and 0.142 µM, respectively); decreases plasma glucose levels and increases plasma levels of insulin in Zucker fa/fa rats at 0.3, 1, and 3 mg/kg; decreases plasma glucose and increases plasma insulin levels in a mouse model of diabetes induced by a high-fat diet and streptozotocin

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Bioactive Small Molecules

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Medchemexpress LLC Dalidnetug 10mg | 10mg Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Meropenem-vaborbactam | 2031124-72-6 | 97.9% | 680.60 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Indole-3-lactic acid | 1821-52-9 | MFCD00005642 | 100.0% | 205.21 g·mol⁻1 | C11H11NO3 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1,3,2-benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | 117089-08-4 | 95.0% | 100MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dalidnetug 10mg | 10mg

Medchemexpress LLC Meropenem-vaborbactam | 2031124-72-6 | 97.9% | 680.60 | 25 MG

Medchemexpress LLC Indole-3-lactic acid | 1821-52-9 | MFCD00005642 | 100.0% | 205.21 g·mol⁻1 | C11H11NO3 | 5 MG

Medchemexpress LLC NVP-BSK805 dihydrochloride | 1942919-79-0 | 99.0% | 563.47 | 100 MG

Medchemexpress LLC 1,3,2-benzoxazaphosphole, 2,3-dihydro-2-phenyl-, 2-sulfide | 117089-08-4 | 95.0% | 100MG