Bioactive Small Molecules
Cayman Chemical NVP-TNKS656 5mg
A TNKS2 inhibitor (IC50 = 6 nM); inhibits Wnt ligand-induced signaling in an HEK293 cell reporter assay (IC50 = 3.5 nM); reduces Axin 2 mRNA expression in MMTV-Wnt1 tumor bearing mice
Cayman Chemical ANTIBODY ATB-343 50mg
A hybrid molecule of an H2S donor and the NSAID indomethacin that does not cause gastric damage or promote leukocyte adherence to vascular endothelium
Selleck Chemical LLC Etanercept P1240-5MG
Etanercept a dimeric fusion protein functions as an inhibitor of TNF by binding to TNF It competitively blocks the attachment of both TNF- and TNF- to their cell surface receptors thereby neutralizing TNF s biological activity Etanercept has proven effectiveness in treating rheumatoid arthritis juvenile idiopathic arthritis and plaque psoriasis
Cayman Chemical 3 4MethylendIoxyabutylamI 5mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
Cayman Chemical ANTIBODY AG-1024 1mg
A selective inhibitor of IGF-1R that inhibits insulin-stimulated cellular proliferation and IGF-1R autophosphorylation with IC50 values of 0.4 and 7 μM, respectively; inhibits proliferation of human breast cancer MCF-7 cells (10 nM) and human prostate cancer DU145 cells (IC50 = 2.5 μM)
Apexbio Technology LLC YM 022 145084-28-2 10mg
YM022 (CAS 145084-28-2) is a potent orally active small molecule antagonist of the gastrin/cholecystokinin-B (CCK-B) receptor exhibiting high selectivity over the CCK-A receptor In binding assays YM022 demonstrates Ki values of 68 pM for CCK-B receptors and 63 nM for CCK-A receptors indicating preferential affinity Preclinical studies indicate that YM022 suppresses gastrin-stimulated gastric acid secretion and inhibits activation of histidine decarboxylase Due to its defined receptor selectivity and modulatory effects on gastrointestinal physiology YM022 is widely employed in research investigating gastrointestinal disorders and related regulatory pathways
Medchemexpress LLC Tepotinib | 1100598-32-0 | 99.9% | 492.57 | 50 MG
Tepotinib is an orally active, highly selective, reversible, and ATP-competitive inhibitor of c-Met with an IC50 of 3 nM. It demonstrates over 200-fold selectivity for c-Met compared to IRAK4, TrkA, Axl, IRAK1, and Mer. This compound inhibits c-Met phosphorylation and induces autophagy, exhibiting antitumor effects.
- Orally active
- Highly selective c-Met inhibitor
- Reversible and ATP-competitive mechanism
- Inhibits c-Met phosphorylation
- Induces autophagy
- Demonstrates antitumor effects
![Medchemexpress LLC N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine | 1623002-61-8 | 98.2% | 553.55 | C25H26F3N3O6S | 1MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237013.png-250.jpg)
Medchemexpress LLC N-[(5-{[(4-methylphenyl)sulfonyl]amino}-3-(trifluoroacetyl)-1H-indol-1-yl)acetyl]-l-leucine | 1623002-61-8 | 98.2% | 553.55 | C25H26F3N3O6S | 1MG
NTRC-824 is a selective, non-peptide neurotensin receptor type 2 (NTS2) antagonist provided as a solid research compound. It is characterized by a molecular formula of C25H26F3N3O6S, a molecular weight of 553.55, and high purity, and is intended for in vitro pharmacology, receptor characterization, and screening applications.
- Selective NTS2 antagonist (IC50 38 nM).
- High purity ≥98.2% (HPLC).
- Molecular weight 553.55 and formula C25H26F3N3O6S.
- Off-white to light yellow solid appearance.
- Recommended storage: powder at -20°C; in solvent at -80°C for long-term.
- Supplied in a 1 mg quantity suitable for assay development and screening.
Cayman Chemical ANTIBODY ThIamet G 10mg
A potent and selective inhibitor of O-GlcNAcase (Ki = 21 nM); increases cellular O-GlcNAc-modified protein levels (EC50 = 30 nM) and blocks phosphorylation of tau protein both in cultured PC-12 cells and in rats (200 mg/kg/day); is orally bioavailable and effectively cross the blood brain barrier
Medchemexpress LLC Cofrogliptin | 1844874-26-5 | 99.29% | 466.43 | 100 MG
Cofrogliptin (HSK7653), a tetrahydropyran derivative, is a potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor with long-acting antidiabetic efficacy. It has great potential for type 2 diabetes mellitus (T2DM).
- Potent oral dipeptidyl aminopeptidase 4 (DPP-4) inhibitor
- Long-acting antidiabetic efficacy
- Potential for treating type 2 diabetes mellitus (T2DM)
- DPP-4 inhibitory activity with an IC₅₀ value of 4.18 nM
- Exhibits extremely long half-lives
- Low rate of drug concentration reduction after oral administration
Medchemexpress LLC JAK1-IN-4 25mg | 2091134-35-7 | 521.59 | C26H32FN9O2 | 25 MG
JAK1-IN-4 is a potent, selective small-molecule inhibitor of Janus kinase 1 used in preclinical research to probe JAK/STAT signaling.
- Potent JAK1 inhibition, biochemical IC50 85 nM.
- High selectivity versus JAK2 and JAK3 (IC50 12.8 μM and >30 μM).
- Cellular activity inhibits STAT3 phosphorylation in NCI-H1975 cells (IC50 227 nM).
- High chemical purity, 99.26%.
- Soluble in DMSO at 100 mg/mL (requires sonication).
- Molecular formula C26H32FN9O2; molecular weight 521.59 g/mol.
Cayman Chemical ANTIBODY CM-272 1mg
An inhibitor of G9a, GLP, and DNA methyltransferases (IC50s = 8, 2, 382, 85, and 1,200 nM for G9a, GLP, DNMT1, DNMT3A, and DNMT3B, respectively); inhibits the growth of, and induces apoptosis in, hematological cancer cell lines (GI50s = 218-455 nM); induces the expression of IFN-stimulated genes and immunologic cell death markers in hematological cancer cell lines; reduces tumor growth in MV4-11 and EGI-1 mouse xenograft models at 2.5 mg/kg; increases survival in CEMO-1 and RT112 mouse xenograft models at 2.5 and 5 mg/kg, respectively
Medchemexpress LLC SLF 10mM 1mL | 195513-96-3 | 524.65 | C30H40N2O6 | 1 ML
SLF is a synthetic ligand of FK506-binding proteins (FKBP) used as a ligand in targeted protein degradation and FKBP-targeted studies. It binds FKBP51 (affinity 3.1 μM) and inhibits FKBP12 (IC50 2.6 μM). Supplied as a concentrated solution for biochemical and in vivo use.
- Synthetic ligand for FKBP proteins.
- Useful for design and synthesis of PROTACs.
- Affinity for FKBP51: 3.1 μM; IC50 for FKBP12: 2.6 μM.
- Molecular formula C30H40N2O6; molecular weight 524.65.
- Supplied as a 10 mM solution in DMSO (1 mL).
- High DMSO solubility (100 mg/mL) and demonstrated in vivo formulation solubility.
Medchemexpress LLC HY-14776 5mg , Quarfloxin CAS:865311-47-3 Purity:>98%
HY-14776 5mg Quarfloxin CAS: 865311-47-3 Quarfloxin (CX-3543), a fluoroquinolone derivative with antineoplastic activity, targets and inhibits RNA pol I activity, with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Vitamin D Binding Protein Antibody (YA009) | 10 UL
Vitamin D Binding Protein Antibody (YA009) is a rabbit-derived, non-conjugated IgG monoclonal antibody that targets Vitamin D Binding Protein. This product is intended for laboratory chemicals and the manufacture of substances, and is suitable for research use only.
- Rabbit-derived IgG monoclonal antibody
- Targets Vitamin D Binding Protein
- Suitable for laboratory chemical applications
- Recommended for research use only