Bioactive Small Molecules
Medchemexpress LLC Monooctyl succinate | 50MG
Monooctyl succinate is a monoester which can be used as a surfactants and a potential fragrance releaser[1]
Cayman Chemical ANTIBODY TP-0463518 10mg
A pan HIF-PH inhibitor; inhibits human HIF-PH1 (Ki = 5.3 nM), as well as human HIF-PH2 and HIF-PH3 (IC50s = 18 and 63 nM, respectively); increases serum levels of EPO in mice at 5 mg/kg; increases serum EPO levels in a 5/6 nephrectomy-induced rat model of chronic kidney disease at 10 mg/kg
Cayman Chemical ANTIBODY MW-150 1mg
An inhibitor of p38α MAPK (Ki = 101 nM); 6-, 10-, and 14-fold selective for p38α MAPK over NLK, p38β MAPK, and p38δ MAPK, respectively; selective for p38α MAPK over p38α MAPKT106M; inhibits p38α MAPK phosphorylation of MK2 in LPS-activated glia; improves spatial reference memory in the radial arm water maze in aged APP/PS1 mice
Cayman Chemical STng AgonIst 12b 1mg
A STING agonist; binds to STING (Kd = 26.4 µM); induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively); induces expression of inflammatory cytokines in THP-1 cells at 40 µM
Cayman Chemical CarbazomycIn C 5mg
A bacterial metabolite with diverse biological activities; active against S. aureus, B. anthracis, B. subtilis, and M. flavus (MICs = 50, 25, 100, and 50 UG/ml, respectively), the fungi T. asteroides and T. mentagrophytes (MICs = 25 and 100 UG/ml, respectively), and P. falciparum (IC50 = 2.1 UG/ml); active against a panel of five plant pathogenic fungi (MICs = 12.5-100 UG/ml); cytotoxic to MCF-7, KB, and NCI H187 cells (IC50s = 9.8, 21.4, and 8.2 UG/ml, respectively); inhibits 5-LO activity in RBL-1 cell extracts (IC50 = 1.9 µM)
Cayman Chemical ANTIBODY LSN2814617 1mg
A positive allosteric modulator of mGluR5 receptors; potentiates glutamate-induced calcium mobilization in MCB3901 cells expressing human mGluR5 (EC50 = 52 nM); increases rat hippocampal mGluR5 receptor occupancy (ED50 = 13 mg/kg); increases wakefulness and decreases NREM and REM sleep in rats at 0.3, 1, and 3 mg/kg
Selleck Chemical LLC LIT-927 S8813-5MG
LIT-927 is a novel neutraligand of CXCL12 with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma
![Medchemexpress LLC 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride | 502656-68-0 | 98.0% | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000230380.png-250.jpg)
Medchemexpress LLC 6-[4-(1H-imidazol-1-yl)phenoxy]-N,N-dimethyl-1-hexanamine, dihydrochloride | 502656-68-0 | 98.0% | 10 MG
CAY10462 dihydrochloride is the dihydrochloride salt of CAY10434 and a potent, selective inhibitor of CYP4A (20-HETE synthase) used for research applications. Supplied as an off-white to light-yellow crystalline solid with high purity and reported solubility in DMSO.
- Potent inhibitor of CYP4A/20-HETE synthase.
- High purity (≈98%).
- Off-white to light-yellow crystalline solid appearance.
- Soluble in DMSO (reported 35.71 mg/mL with sonication/warming).
- Storage: -20°C for solid; in solvent -80°C for up to 6 months, -20°C for up to 1 month.
- Intended for research use only.
Selleck Chemical LLC URMC-099
URMC-099 is an orally bioavailable brain penetrant mixed lineage kinase (MLK) inhibitor with IC50 of 19 nM 42 nM 14 nM and 150 nM for MLK1 MLK2 MLK3 and DLK respectively and also inhibits LRRK2 activity with IC50 of 11 nM URMC-099 also inhibits ABL1 with IC50 of 6 8 nM URMC-099 induces autophagy
Cayman Chemical ANTIBODY V-9302 1mg
An inhibitor of ASCT2; inhibits glutamine uptake (IC50s = 9 and 9.6 µM for the rat and human transporters, respectively); reduces cell viability of a variety of cancer cell lines, including HCT116, HT-29, COLO 205, and RKO cells (EC50s = 8.9, 9.4, 14.5, and 8.3 µM, respectively); reduces glutamine uptake into tumor tissue and prevents tumor growth in HCT116 and HT-29 mouse xenograft models expressing K-RasG13D and BRAFV600E mutations, respectively, at 75 mg/kg per day for 21 days
Cayman Chemical ANTIBODY BMS 466442 1mg
An Asc-1 inhibitor; selectively inhibits Asc-1 in HEK293 cells expressing Asc-1 (IC50 = 36.8 nM) over 40 other transporters (IC50s = >10 µM); inhibits serine, cysteine, glycine, and alanine import and cAMP-induced increases in the OCR and decreases UCP1 levels in primary human white and brown adipose cells at 100 nM; decreases the number of malformed neurons and reduces contextual fear memory deficits in a mouse model of surgery-induced brain damage when intracerebroventricularly infused
Medchemexpress LLC RI-1 | 415713-60-9 | C14H11Cl3N2O3 | 50 MG
RI-1 is a potent RAD51 inhibitor that acts by covalently binding to cysteine 319 on the RAD51 protein, thereby inactivating it and disrupting homologous recombination in human cells. This action allows RI-1 to sensitize cancer cells to cross-linking chemotherapy and has been shown to reduce triple-negative breast cancer tumor growth in vivo.
- Inhibits RAD51 by covalently binding to cysteine 319.
- Disrupts homologous recombination in human cells.
- Sensitizes human cancer cells to cross-linking chemotherapy.
- Reduces triple-negative breast cancer tumor growth in mice.
- Specifically inhibits homologous recombination (HR) in U2OS cells and stimulates single-strand annealing (SSA) in HEK293 cells.
Cayman Chemical K-7174hydrochlorIde 5mg
A 20S proteasome inhibitor; inhibits the 20S proteasome β1, β2, and β5 catalytic subunits at 5 µM; reduces TNF-α- or IL-1β-induced adherence of U937 monocytes to HUVECs at 10 µM; inhibits tumor growth in U266 and RPMI-8226 multiple myeloma mouse xenograft models at 75 mg/kg; an inhibitor of the GATA consensus sequence