Bioactive Small Molecules
Medchemexpress LLC HY-N2065 5mg , Withaferin A CAS:5119-48-2 Purity:>98%
HY-N2065 5mg Withaferin A CAS: 5119-48-2 Withaferin A is a steroidal lactone isolated from Withania somnifera, inhibits NF-kB activation and targets vimentin, with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC All-trans-4-oxoretinoic acid | 38030-57-8 | MFCD00870472 | 98.0% | 314.42 g·mol⁻¹ | C20H26O3 | 1 ML
All-trans-4-oxoretinoic acid is an active metabolite of vitamin A that binds nuclear retinoic acid receptors (RARs) to induce gene transcription. It is provided as a 10 mM solution in DMSO for use in biochemical and cell-based research; handle and store under recommended cold conditions.
- Active metabolite that modulates RAR-mediated gene transcription.
- Supplied as a 10 mM solution in DMSO for convenient dosing.
- High purity for research applications (≈98.0%).
- Chemical formula C20H26O3 and molecular weight 314.42 g·mol⁻¹.
- Store in solvent at -80°C for optimal long-term stability.
Cayman Chemical Glaucine, Purity: ≥95%, CAS: 475-81-0, 10 mg
An analytical reference standard categorized as an antitussive; has hallucinogenic properties; intended for research and forensic applications
Medchemexpress LLC VE-Cadherin Mouse 10ug
VE-cadherin is a calcium-dependent glycoprotein critical for mediating cell adhesion and coordinating morphogenetic events during development Lack of VE-cadherin in mice leads to uterine death due to increased endothelial cell apoptosis leading to vascular insufficiency VE-Cadherin Protein Mouse (HEK293 His) is the recombinant mouse-derived VE-Cadherin protein expressed by HEK293 with C-10 His labeled tag
![Medchemexpress LLC 3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-propan-2-yloxybenzonitrile | 1820934-93-7 | 98.6% | 387.43 g/mol | C22H21N5O2 | 5 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 3-[2-(2-methylpyridin-4-yl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5-carbonyl]-4-propan-2-yloxybenzonitrile | 1820934-93-7 | 98.6% | 387.43 g/mol | C22H21N5O2 | 5 MG
GlyT1 Inhibitor 1 is a potent, selective inhibitor of the glycine transporter 1 (GlyT1) that inhibits rat GlyT1 with an IC50 of 38 nM. It is supplied as a research reagent with reported antipsychotic activity, defined chemical identity, and high purity.
- Selective GlyT1 inhibition (IC50 = 38 nM for rGlyT1).
- Reported antipsychotic activity in preclinical studies.
- High purity (98.6%) suitable for research applications.
- Molecular formula C22H21N5O2; molecular weight 387.43 g/mol.
- Available in multiple pack sizes and provided as DMSO solution or solid.
- Intended for research use only, not for human or veterinary use.
Cayman Chemical BAY-2402234, Purity: ≥98%, CAS: 2225819-06-5, 25 mg
A DHODH inhibitor (IC50 = 1.2 nM); induces CD11b upregulation in MOLM-13 and HEL AML cells (EC50s = 3.16 and 0.96 nM, respectively); inhibits the proliferation of nine leukemia cell lines (IC50s = 0.08-8.2 nM); induces cell cycle arrest at the G2/M phase and apoptosis in TF-1 cells; reduces tumor volume in an MV4-11 mouse xenograft model at 1.25, 2.5, and 5 mg/kg; increases survival in PDX mouse models of AML
![Medchemexpress LLC 4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine | 1046447-90-8 | MFCD28502028 | 99.7% | 221.16404563 g·mol⁻¹ | C11H19N5 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000212078.png-250.jpg)
Medchemexpress LLC 4-[(3R)-3-aminopyrrolidin-1-yl]-6-propan-2-ylpyrimidin-2-amine | 1046447-90-8 | MFCD28502028 | 99.7% | 221.16404563 g·mol⁻¹ | C11H19N5 | 1 ML
JNJ-39758979 is a selective histamine H4 receptor antagonist supplied for research use. It is available as a ready-to-use 10 mM solution in DMSO (1 mL) and as solid material in multiple milligram quantities. The compound is used in receptor pharmacology and in vitro assays to evaluate H4-mediated activity.
- Selective histamine H4 receptor antagonist suitable for pharmacology studies.
- Provided as a 10 mM solution in DMSO (1 mL) and as solid in multiple mg sizes.
- High purity, 99.7%.
- CAS number 1046447-90-8 and molecular formula C11H19N5.
- Exact molecular weight 221.164 g·mol⁻¹.
Medchemexpress LLC Wnk-in-1 (compound 7) | 2125724-72-1 | 98.9% | 2MG
Wnk-in-1 (compound 7) | 2125724-72-1 | 98.9% | 2MG
Medchemexpress LLC 5-bromo-2-chloroanisole | 16817-43-9 | 98.3% | 221.48 | 50 G
5-Bromo-2-chloroanisole is a biochemical reagent. It can be used as a biological material or organic compound for life science related research.
- Suitable for life science related research
- For research use only
Medchemexpress LLC BMS-265246 | 582315-72-8 | C18H17F2N3O2 | 50 MG
BMS-265246 is a potent and selective cyclin-dependent kinase (CDK1 and CDK2) inhibitor, with IC50 values of 6 nM and 9 nM, respectively. It inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). This product is applicable for ovarian cancer and COVID-19 research, and is intended for research use only.
- Potent and selective CDK1 inhibitor (IC50: 6 nM)
- Potent and selective CDK2 inhibitor (IC50: 9 nM)
- Inhibits CHI3L1 stimulation of ACE2 and SPP
- Applicable for ovarian cancer research
- Applicable for COVID-19 research
- Shows cytotoxic activity in A2780 ovarian cancer cell line (IC50: 0.76 μM)
- Increases iTreg cell differentiation
- Prevents E2 induction of EGF3, AREG, and CXCL12 in MCF7 cells
- Can cooperate with Tamoxifen to induce apoptosis in MCF7 cells
Medchemexpress LLC Tam-in-2 (pyrrolotriazine compound 0904) | 2135642-56-5 | 99.9% | 583.59 g/mol | C31H27F2N7O3 | 100MG
TAM-IN-2 is a pyrrolotriazine-derived small-molecule inhibitor of TAM family receptor tyrosine kinases (described in patent US 20170275290 A1, compound 0904). Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies of TAM signaling and pathway modulation.
- CAS number 2135642-56-5
- Molecular weight 583.59 g/mol
- Chemical formula C31H27F2N7O3
- Purity 99.9%
- Physical form solid; color white to light yellow
- Solubility DMSO 5 mg/mL (may require sonication)
- Storage: powder -20°C (stable 3 years); in solvent -80°C (2 years)
- Available as a 100 mg laboratory package
- Safety data sheet available in multiple languages
Cayman Chemical Betaine, Purity: ≥95%, CAS: 107-43-7, 500 g
A quaternary ammonium compound with diverse biological activities; has roles in osmoregulation and serves as a methyl donor in the conversion of homocysteine to methionine; reduces serum ALT and AST activity, increases serum HDL levels, decreases serum LDL levels, and reduces hepatic steatosis and inflammation in a mouse model of NAFLD induced by a methionine- and choline-deficient diet at 1.5% w/v in drinking water; reduces plasma levels of tHcy, AdoMet, AdoHcy, and cystathionine and attenuates hypercoagulation in a mouse model of homocystinuria
Medchemexpress LLC Lalistat 1 5mg | 501104-16-1 | 298.37 g·mol⁻1 | C12H18N4O3S | 5 MG
Lalistat 1 is a potent, selective, competitive inhibitor of lysosomal acid lipase (LAL) used as a research reagent for biochemical assays and studies of lysosomal storage disorders such as Niemann-Pick type C.
- Potent LAL inhibitor (IC50 = 68 nM).
- Selective for lysosomal acid lipase over pancreatic lipase.
- Suitable for biochemical assays and disease-model research.
- Available as solid masses and as a DMSO solution for stock preparation.
- Characterized molecular formula C12H18N4O3S and molecular weight 298.37 g·mol⁻1.
Medchemexpress LLC Osilodrostat (phosphate) | 1315449-72-9 | 98.8% | 325.23 | 100 MG
Osilodrostat (phosphate) | 1315449-72-9 | 98.8% | 325.23 | 100 MG
Medchemexpress LLC Topoisomerase I inhibitor 8 | 210346-40-0 | 99.9% | 420.43 | 5 MG
Topoisomerase I inhibitor 8 is a potent topoisomerase I inhibitor and a hexacyclic analogue of camptothecin. It demonstrates cytotoxic effects against tumor cells.
- Potent topoisomerase I inhibitor
- Hexacyclic analogue of camptothecin
- Displays cytotoxic effects against tumor cells
- Inhibits murine leukemia cells (P388) with an IC50 of 0.22 ng/mL
- Inhibits human lung cancer cells (QG-56) with an IC50 of 0.17 ng/mL
- Shows stronger effectiveness than SN-38 in changing DNA from supercoiled to relaxed form
- Appears as a light yellow to brown solid
- Soluble in DMSO at 50 mg/mL