Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ANTIBODY AGI-5198 10mg
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Selective inhibitor of IDH1 R132H and R132C mutants in vitro (IC50s = 0.07 and 0.16 µM, respectively) but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 μM); anti-tumor efficacy in vitro and in vivo; induces demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation
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Cayman Chemical SalvIa japonIca SalvIgeIn 5mg
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A polyphenol flavonoid with diverse biological activities; inhibits hydrogen peroxide-induced apoptosis and reduces the generation of ROS in SH-SY5Y cells at 25 µM; decreases cleaved caspase-3 levels and the Bax/Bcl-2 ratio in SH-SY5Y cells at 25 and 50 µM; reduces the viability of MCF-7 human breast cancer cells; enhances the DTH response to sheep red blood cells in mice at 3.65-9.68 UG/mouse per day; increases lysate antigen-induced production of IFN-γ in isolated mouse splenocytes; reduces tumor growth in a SMMT model at 9.68 UG/mouse per day
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Cayman Chemical ANTIBODY PYR41 5mg
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An irreversible inhibitor of ubiquitin-activating enzyme (E1; IC50 = 50 = 6.4 µM); selective for E1 over E2 but does inhibit autoubiquitination of the HECT domain E3 Nedd4 at 50 µM; inhibits proteasome-dependent and -independent ubiquitination and protein degradation at 50 µM; preferentially induces apoptosis of E1A-transformed RPE cells expressing wild-type p53 over non-transformed RPE cells at 1-20 µM; also increases net cellular sumoylation and irreversibly cross-links proteins such as JAK2 and Bcr-Abl
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Cayman Chemical ANTIBODY Safngol 25mg
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A dual inhibitor of PKC and SPHK; inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM); inhibits SPHK (Ki = ~5 µM); restores sensitivity to cisplatin in resistant AGScis5 cells and N87 gastric cancer cells from 0.2-6 µM
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Cayman Chemical ANTIBODY SalermIde 50mg
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An inhibitor of SIRT1 and SIRT2, causing tumor-specific apopoptic cell death; causes 90% apoptosis within 72 hours (IC50 ~20 μM) by reactivating proapototic genes that are repressed by SIRT1 in MOLT4 leukemia cells
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Cayman Chemical ANTIBODY NIvalenol 1mg
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A trichothecene mycotoxin; lethal to mice (LD50 = 6.9 mg/kg); induces thymic, splenic, and Peyer's patch cell apoptosis in mice at 5, 10, and 15 mg/kg
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Cayman Chemical ANTIBODY Psoralen 50mg
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A photoactive probe that has been used to investigate nucleic acid structure and function; induces DNA interstrand crosslinks, resulting in apoptosis
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![Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 10 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000399306.png-250.jpg)
Medchemexpress LLC [D-Leu-4]-OB3 | 289056-32-2 | 98.9% | 734.82 | 10 MG
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[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. It also stimulates the expression of pro-apoptotic genes.
- Inhibits expressions of pro-inflammatory genes
- Inhibits expressions of proliferative genes
- Inhibits expressions of metastatic genes
- Inhibits PD-L1 expression
- Stimulates expression of pro-apoptotic genes
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Medchemexpress LLC 3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine tartrate | 134002-26-9 | 99.9% | 430.45 | 5 G
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3-(S)-(1-Carbamoyl-1,1-diphenylmethyl)pyrrolidine tartrate is a valuable drug intermediate utilized in the synthesis of various active compounds. It serves as a foundational building block for pharmaceutical research and development, enabling the creation of new chemical entities.
- Serves as a drug intermediate.
- Applicable for the synthesis of various active compounds.
- Supports pharmaceutical research and development.
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Cayman Chemical CeramIde PhosphoethnolamIn 5mg
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A mixture of ceramide phosphoethanolamines; produced and used by invertebrates such as Drosophila, which lacks sphingomyelin and produced only in very small amounts in mammals; has a role in glial ensheathment of axons in Drosophila; depletion in vitro in mammalian cells leads to ER accumulation of ceramides and apoptosis but ceramide levels are not altered in transgenic mice lacking its biosynthetic enzymes
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Cayman Chemical 25I-NBOHhydrochlorIde 5mg
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A derivative of 2C-I that acts as a potent agonist for the human serotonin 5-HT2A receptor (Ki = 0.061 nM); intended for research and forensic applications
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Cayman Chemical ANTIBODY SR 17018 25mg
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An analytical reference standard categorized as an opioid; increases latency to withdraw in the hot plate and warm water tail-flick assay without inducing respiratory depression in mice; induces place preference in a conditioned place preference test; induces antinociceptive tolerance after repeated administration in mice; intended for research and forensic applications
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Cayman Chemical ANTIBODY UPF-1069 1mg
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A PARP inhibitor that demonstrates a modest preference for PARP2 over PARP1 (IC50s = 0.3 and 8 µM, respectively)
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Cayman Chemical ANTIBODY KC01 500ug
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A covalent inhibitor of ABHD16A (IC50s = 90 and 520 nM for human and mouse, respectively); depletes lyso-PS from various human cancer cell lines, a lymphoblast cell line, and mouse brain membrane lysates and decreases LPS-induced cytokine production in macrophages
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Abcam BD 1063 dihydrochloride, sigma-1 antagonist, 10MG
MW 346.1 Da, Purity >99%. Potent selective σ1 receptor antagonist (Ki values are 9 and 449 nM at σ1 and σ2 receptors, respectively). Shown to prevent hyperlocomotion, active in vivo.
The product is subject to the following: Abcam Restricted Use Statement
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