Bioactive Small Molecules
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Filtered Search Results
Apexbio Technology LLC Telatinib (BAY 57-9352) 332012-40-5 5mg
Telatinib (BAY 57-9352 CAS 332012-40-5) is a selective small molecule inhibitor targeting VEGFR2 (IC50 6 nM) VEGFR3 (IC50 4 nM) c-Kit (IC50 1 nM) and PDGFR (IC50 15 nM) By blocking the kinase activity of these receptors key mediators of angiogenesis and vascular remodeling Telatinib disrupts signaling pathways implicated in tumor growth and progression In various tumor cell lines including MDA-MB-231 Colo-205 DLD-1 and H460 Telatinib suppresses VEGFR2 autophosphorylation and inhibits PDGF- -driven responses It is widely investigated in preclinical and clinical studies for cancer therapy including trials in advanced solid tumors and research on overcoming multidrug resistance via ABCG2 inhibition
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Cayman Chemical UNC926, Purity: ≥98%, CAS: 1184136-10-4, 10 mg
An antagonist of L3MBTL1, L3MBTL3, and L3MBTL4; inhibits methyl-lysine histone peptide substrate binding of L3MBTL1, L3MBTL3, and L3MBTL4 (IC50s =3.9, 3.2, and 15.6 μM, respectively) selectively over MBTD1, SFMBT1, and CBX7 (IC50s = >30 μM)
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Cayman Chemical 1β-Acetoxypolygodial, Purity: ≥95%, CAS: 1818425-44-3, 5 mg
A sesquiterpenoid; active against T. cruzi amastigotes and trypomastigotes (GI50s = 57.8 and 72 µM, respectively) but not T. cruzi epimastigotes (GI50 = >100 µM)
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Medchemexpress LLC FXR antagonist 2 hydrochloride | 100.0% | 457.82 | 5 MG
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FXR antagonist 2 (compound A-26) hydrochloride is a diarylamide derivative that functions as a moderate FXR antagonist. It is primarily used in the study of hyperlipidemia and type 2 diabetes.
- Diarylamide derivative
- Moderate FXR antagonist
- Applicable in hyperlipidemia studies
- Applicable in type 2 diabetes studies
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Medchemexpress LLC MEK4 inhibitor-1 | 2570386-36-4 | 98.9% | 291.30 | 50 MG
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MEK4 inhibitor-1 is a novel MEK4 inhibitor developed for its activity against pancreatic adenocarcinoma.
- Novel MEK4 inhibitor
- Active against pancreatic adenocarcinoma
- IC50 value of 61 nM
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Medchemexpress LLC Benzoic acid, 3,4,5-trihydroxy-, hydrate (1:1) | 5995-86-8 | 188.13 | 25 MG
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Gallic acid hydrate (3,4,5-Trihydroxybenzoic acid hydrate) is a natural polyhydroxyphenolic compound and a free radical scavenger. It inhibits cyclooxygenase-2 (COX-2) and exhibits a range of biological activities including antimicrobial, antioxidant, anti-inflammatory, and anticancer properties. This product is intended for research use only.
- Natural polyhydroxyphenolic compound
- Acts as a free radical scavenger
- Inhibits cyclooxygenase-2 (COX-2)
- Exhibits antimicrobial activity
- Provides antioxidant properties
- Demonstrates anti-inflammatory effects
- Possesses anticancer activities
- Improves glucose tolerance in vivo
- Reduces serum triglyceride concentration in vivo
- Intended for research use only
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Selleck Chemical LLC Savolitinib(AZD6094) 2mg 1313725-88-0 HMPL-504
Savolitinib (volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Medchemexpress LLC BIO-2007817 | 99.35% | 552.67 | 25 MG
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BIO-2007817 is a Parkin positive allosteric modulator (PAM) that enhances the activity of wildtype Parkin. It stimulates Parkin (an E3 ligase) autoubiquitination and induces the appearance of monoubiquitinated forms of Miro1 with an EC50 of 0.17 μM.
- Parkin positive allosteric modulator (PAM)
- Enhances activity of wildtype Parkin
- Stimulates Parkin (an E3 ligase) autoubiquitination
- Induces monoubiquitinated forms of Miro1 (EC50: 0.17 μM)
- For research use only
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Medchemexpress LLC 4-Br-Bnlm | 1654775-71-9 | 99.5% | 50 MG
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4-Br-Bnlm is a small-molecule inhibitor of glucose-regulated protein 94 (Grp94) supplied for research use. It has been used to promote clearance of toxic myocilin forms and to reduce myocilin-associated cellular toxicity. For research use only; not for human use.
- Selective Grp94 inhibitor
- Promotes clearance of toxic myocilin forms
- High reported chemical purity
- Multiple pack sizes for experimental flexibility
- Stable when stored under recommended conditions
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Cayman Chemical 1-Stearoyl-2-Eicosapentaenoyl-sn-glycero-3-PE, Purity: ≥95%, CAS: 96935-44-3, 5 mg
A phospholipid; has been found in fish oils
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Cayman Chemical Carebastine, Purity: ≥98%, CAS: 90729-42-3, 5 mg
An active metabolite of ebastine and a histamine H1 receptor antagonist; inhibits histamine-induced contraction of isolated guinea pig trachea (IC50 = 120 nM); inhibits histamine release from isolated rat peritoneal mast cells and human basophils at 30-100 µM; decreases production of CCL5 and CCL2 in primary human nasal epithelial cells isolated from patients with nasal allergies
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Medchemexpress LLC (2R)-2-(methoxymethyl)oxirane | 64491-70-9 | MFCD00273372 | 100g
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Rivaroxaban impurity 6 is an impurity of Rivaroxaban (HY-50903)
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Cayman Chemical GNE-477, Purity: ≥98%, CAS: 1032754-81-6, 50 mg
A dual PI3K (IC50 = 4 nM for PI3Kα) and mTOR inhibitor (apparent Ki = 21 nM); inhibits proliferation of MCF-7.1 cells (EC50 = 143 nM); reduces tumor growth in a PC3-NCI tumor xenograft model at 1-20 mg/kg per day
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Cayman Chemical VX-984, Purity: ≥95%, CAS: 1476074-39-1, 1 mg
An inhibitor of DNA-PK; inhibits radiation-induced increases in phosphorylated DNA-PK levels in U251 and NSC11 cells at 250 or 500 nM; induces mutagenic NHEJ and homologous recombination DNA repair pathways in a reporter assay using U2OS cells at 1 µM; potentiates radiation-induced cytotoxicity and DNA damage in U251 and NSC11 cells when used at concentrations of 250 or 500 nM; increases survival in combination with radiation in a U251 orthotopic mouse xenograft model at 50 mg/kg twice per day
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Apexbio Technology LLC Idazoxan hydrochloride 79944-56-2 25mg
Idazoxan hydrochloride (CAS 79944-56-2) is a selective antagonist of 2-adrenergic and imidazoline receptors that modulates central nervous system signaling by inhibiting endogenous ligand activity at these sites In experimental studies the compound competitively blocks the hypotensive effects of imidazoline agents and has demonstrated efficacy in alleviating motor deficits in Parkinson s disease models Idazoxan hydrochloride is utilized extensively in investigations of neuropharmacological mechanisms and the pathophysiology of neurological disorders
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