Bioactive Small Molecules
Selleck Chemical LLC Tetramethylcurcumin E2644-5MG
Tetramethylcurcumin (FLLL31) a small-molecule signal transducer and activator of transcription 3 (STAT3) inhibitor derived from curcumin binds selectively to Janus kinase 2 and the STAT3 Src homology-2 domain which serve crucial roles in STAT3 dimerization and signal transduction
Selleck Chemical LLC Mozavaptan E4957-100MG
Mozavaptan hydrochloride(OPC 31260 HCl) a benzazepine derivative is a potent selective competitive and orally active antagonist of vasopressin V2 receptor with an IC50 value of 14 nM Mozavaptan hydrochloride shows 85-fold selectivity for V2 receptor over V1 receptor Mozavaptan hydrochloride has the potential for hyponatremia syndrome of inappropriate antidiuretic hormone (SIADH) and congestive heart failure treatment
Medchemexpress LLC Curcumin analogue | 1258513-40-4 | 99.2% | C18H17N3O | 10MG
UBS109 is a curcumin analogue used in bone research that promotes osteoblast differentiation and mineralization by activating Smad signaling and inhibiting NF-κB. It is supplied as a high-purity research chemical suitable for in vitro studies in bone tissue engineering and osteoporosis models.
- Promotes osteoblast differentiation and mineralization
- Activates Smad signaling and inhibits NF-κB
- Suitable for bone tissue engineering and osteoporosis research
- High purity (99.2%) for research applications
- Available in small research pack sizes (10 mg)
Cayman Chemical ANTIBODY CGI1746 5mg
A potent, selective inhibitor of BTK (IC50 = 1.9 nM); prevents BCR-mediated B lymphocyte proliferation; reduces cytokine levels within joints and ameliorates symptoms in a mouse model of autoantibody-induced arthritis
Cayman Chemical IcatIbntacetate 5mg
A synthetic peptide antagonist of the bradykinin B2 receptor (IC50 = 1.07 nM; Ki = 0.798 nM); inhibits bradykinin-induced contractions in isolated guinea pig ileum and pulmonary arteries as well as in rat uterus (IC50s = 11, 5.4, and 4.9 nM, respectively); inhibits bradykinin-induced bronchoconstriction in a guinea pig model (ID50s = 13.4 and 31.8 pmol/kg, i.v., for pulmonary resistance and dynamic lung compliance, respectively); reduces vascular permeability in a mouse model of hereditary angioedema (30 UG, i.v.)
Medchemexpress LLC BMS-192364 25mg | 202822-21-7 | 25 MG
BMS-192364 is a small-molecule regulator of G protein signaling (RGS) agonist for research use. It enhances GAP activity on Gq proteins, reduces urinary bladder contraction, and inhibits calcium flux. The compound is supplied as a white to off-white solid with high purity and recommended low-temperature storage.
- High purity: 99.01% as reported by supplier.
- Molecular weight: 355.70 g/mol.
- Solid form; white to off-white powder suitable for biochemical and cellular assays.
- Recommended storage: powder at -20°C for long-term stability; in solvent at -80°C for extended storage.
- Available in a 25 mg pack size for small-scale research applications.
Medchemexpress LLC (S)-TNG260 | 2935964-93-3 | C20H18FN3O2S | 1 ML
(S)-TNG260 is an isomer of TNG260, which functions as a CoREST selective deacetylase (CoreDAC) inhibitor. It demonstrates significant selectivity, inhibiting HDAC1 with 10-fold preference over HDAC3. This compound is known to induce HDAC1 inhibition, effectively reversing anti-PD1 resistance associated with STK11 deletion. Additionally, it reduces intratumoral neutrophil infiltration and exhibits immune-mediated cell killing.
- CoREST selective deacetylase (CoreDAC) inhibitor
- Inhibits HDAC1 with 10-fold selectivity over HDAC3
- Reverses anti-PD1 resistance driven by STK11 deletion
- Reduces intratumoral infiltration of neutrophils
- Exhibits immune-mediated cell killing
- Purity of 98.84%
- Molecular weight is 383.44
- Appears as an off-white to light yellow solid
Medchemexpress LLC HBED 10mg | 35998-29-9 | 10 MG
HBED is a synthetic iron chelator used in research to bind and sequester iron; it is commonly used to study transfusional iron overload and iron-mediated pathways such as ferroptosis. The compound is supplied as a white to off-white solid, with molecular formula C20H24N2O6 and molecular weight 388.41 g/mol.
- Potent iron chelator for in vitro and ex vivo studies.
- Useful for modeling transfusional iron overload and related pathways.
- White to off-white powder form suitable for dissolution in common solvents.
- Stable as a powder at -20°C for extended storage.
- Available in small milligram quantities for laboratory research.
Medchemexpress LLC Tamnorzatinib 10mM 1mL | 1646839-59-9 | 1 ML
Tamnorzatinib is a potent, selective inhibitor of the Axl and Mer receptor tyrosine kinases, supplied as a 10 mM solution in DMSO for research applications. It is used in biochemical and cellular assays to study Axl/Mer signaling and related oncology pathways.
- Potent Axl and Mer kinase inhibition with low-nanomolar activity.
- Supplied as a 10 mM solution in DMSO for convenience in assays.
- High purity, suitable for research applications.
- Chemical formula C32H26N4O6 and molecular weight 562.57 g/mol.
- CAS number 1646839-59-9 for unambiguous identification.
- Provided as a 1 mL aliquot; store per recommended conditions to preserve stability.
Medchemexpress LLC L-ANAP hydrochloride | 00-00-0 | 99.9% | 308.76 | C15H17ClN2O3 | 5 MG
L-ANAP hydrochloride is a genetically encodable, polarity-sensitive fluorescent unnatural amino acid used as a site-specific probe to monitor local environment polarity and conformational changes in proteins. It is provided as the hydrochloride salt for research use and is soluble in DMSO with very low water solubility.
- Genetically encodable fluorescent probe for site-specific labeling.
- Polarity-sensitive fluorescence reports local environmental changes.
- High purity suitable for biochemical and biophysical assays.
- DMSO-soluble formulation for straightforward sample preparation.
- Supplied as a hydrochloride salt for improved stability and handling.
Cayman Chemical trns-VaccenIc AcId-d13 5mg
An internal standard for the quantification of trans-vaccenic acid by GC- or LC-MS
Medchemexpress LLC Plk4-in-1 | 1247001-12-2 | 99.8% | 431.23 | 5 MG
Plk4-in-1 is a Plk4 inhibitor with an IC50 of ≤ 0.1 μM. It is for research use only.
- Plk4 inhibitor
- IC50 of ≤ 0.1 μM (Plk4)
- High purity (99.84%)
Cayman Chemical ANTIBODY CDPPB 1mg
A positive allosteric modulator of mGluR5; potentiates glutamate-induced increases in intracellular calcium in CHO cells expressing mGluR5 (EC50s = 10 and 20 nM for the human and rat receptor, respectively); inhibits amphetamine-induced PPI disruptions in rats at 30 mg/kg, s.c.