Bioactive Small Molecules
AdipoGen ID-8 (25 mg)
Chemical. CAS: 147591-46-6. Formula: C16H14N2O4. MW: 298.3. Synthetic. Cell culture supplement that can sustain self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. At 10µM it stimulates proliferation in serum-free media at a steady rate for more than 30 days. Reversibly maintains the long-term culture of ESCs by sustaining Nanog gene expression through Sox2-Oct3/4 activation and enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs (DYRK2 and DYRK4).
Cayman Chemical Doxorubicinol (hydrochloride), Purity: ≥90% (mixture of isomers), 5 mg
A doxorubicin metabolite; formed by NADPH-dependent reduction of the side chain carbonyl group of doxorubicin in human, rabbit, and canine cardiac tissue; inhibits sodium-potassium-dependent ATPase activity (IC50 = 5.40 μg/ml) and ATP-dependent calcium uptake (IC50= 4.5 μg/ml) in canine cardiac muscle; increases resting stress in contracting rabbit cardiac muscle
Medchemexpress LLC JYQ-173 | 99.8% | 466.49 | 5 MG
JYQ-173 is a chemical probe and a selective inhibitor for human Parkinson disease protein 7 (PARK7), with an IC50 of 19 nM. It exhibits good cell permeability and acts as a ligand for target protein PARK7, which can be utilized for the synthesis of PROTAC Degrader JYQ-194.
- Selective inhibitor for human Parkinson disease protein 7 (PARK7)
- Exhibits good cell permeability
- Can be used as a ligand for the synthesis of PROTAC Degrader
Cayman Chemical Sonepiprazole, Purity: ≥98%, CAS: 170858-33-0, 5 mg
A selective D4 receptor antagonist (Kis = 10 nM); selective over D1, D2, and D3 receptors, serotonin 1A and 2 receptors, as well as α1- and α2-adrenergic receptors (Kis > 2,000 nM)
AdipoGen Clevudine (5 mg)
Chemical. CAS: 163252-36-6. Formula: C10H13FN2O5. MW: 260.2. Clevudine is a synthetic pyrimidine nucleoside analog antiviral agent with activity against hepatitis B virus (HBV) and Epstein-Barr virus (EBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The triphosphate metabolite competes with thymidine for incorporation into viral DNA, thereby causing DNA chain termination and inhibiting the function of HBV DNA polymerase and reverse transcriptase, consequently blocking the viral replication. It also blocks the DNA supply of the virus into the nucleus, reducing the amount of cccDNA by 20-100 times.Potentially useful for the treatment of the SARS-CoV-2 (COVID-19) infection, acting as a potent inhibitor of the RdRp protein.
Cayman Chemical ThioLox, Purity: ≥98%, CAS: 1202193-89-2, 5 mg
A 15-LO-1 inhibitor (Ki = 3.3 µM); a P. falciparum aspartate carbamoyltransferase inhibitor (IC50 = 3.32 µM); reduces LPS-induced expression of the mRNAs encoding TNF-α, iNos, Il-1β, Il-6, Il-8, and Il-12b in mouse lung slices at 50 µM; inhibits glutamate-induced increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, in mouse HT22 cells at 10 µM
Medchemexpress LLC PKC-iota inhibitor 1 | 2328094-11-5 | MFCD32062834 | 99.6% | 374.44 g/mol | C21H22N6O | 10MM 1ML
PKC-iota inhibitor 1 is a small-molecule research reagent that inhibits protein kinase C iota (PKC-ι) with an IC50 of 0.34 μM. It is supplied as a ready-to-use 10 mM solution in DMSO or as solid powder in multiple sizes, and is intended for biochemical and cellular research; safety data sheet and product datasheet are provided.
Medchemexpress LLC Zedoresertib (Debio 0123) | 2243882-74-6 | 99.5% | 511.45 | C26H28Cl2N6O | 5 MG
Zedoresertib (Debio 0123) is a potent, selective WEE1 kinase inhibitor used in preclinical research on cell-cycle regulation and DNA damage response. Supplied as a solid or as a DMSO solution, the compound is characterized by high purity and defined physicochemical properties to support reproducible laboratory experiments.
- Potent WEE1 kinase inhibitor (IC50 0.8 nM).
- High recommended purity of 99.46%.
- Available as a solid and as a 10 mM solution in DMSO.
- Molecular weight 511.45 and formula C26H28Cl2N6O.
- Intended for cell-cycle and DNA damage response studies.
- Includes product datasheet and SDS for handling and safety information.
Medchemexpress LLC Monocarboxylic acid transporter 1 antibody (YA3244) | 50 UL
Monocarboxylic Acid Transporter 1 Antibody (YA3244) is a rabbit-derived, non-conjugated IgG monoclonal antibody, targeting Monocarboxylic Acid Transporter 1. It catalyzes the movement of monocarboxylates like lactate and pyruvate across the plasma membrane. This product is intended for research use only and should be handled by experienced, qualified scientists.
- Rabbit-derived IgG monoclonal antibody
- Targets monocarboxylic acid transporter 1
- Supplied in 50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
- Stable under recommended storage conditions
- Suitable for laboratory centrifugation and storage
Medchemexpress LLC Thiol-PEG6-alcohol (HS-PEG6-OH) | 194425-46-2 | ≥97.0% | 100 MG
Thiol-PEG6-alcohol is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs feature two distinct ligands connected by a linker, one targeting an E3 ubiquitin ligase and the other binding to the target protein. This mechanism allows PROTACs to leverage the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker.
- Used in the synthesis of PROTACs.
- PROTACs utilize the ubiquitin-proteasome system.
- Designed for selective degradation of target proteins.
Medchemexpress LLC FAK inhibitor 2 | 2354405-14-2 | 98.3% | 50 MG
FAK inhibitor 2 is a potent focal adhesion kinase (FAK) inhibitor with an IC50 of 0.07 nM, demonstrating antitumor and anti-angiogenesis activities. This product is intended for research use only.
- Potent FAK inhibitor (IC50 of 0.07 nM).
- Exhibits antitumor and anti-angiogenesis activities.
- High purity of 98.26%.
- Soluble in DMSO at 100 mg/mL.
- Available in various quantities.
- Comprehensive documentation included.
- Cited in multiple research publications.
- Specific storage conditions for optimal stability.
- Relevant for research in Cancer, Metabolic Disease, and more.
Medchemexpress LLC Edoxaban (tosylate monohydrate) | 1229194-11-9 | MFCD28400751 | >98.0% | 738.27 | C31H40ClN7O8S2 | 100 MG
Edoxaban tosylate monohydrate is the tosylate monohydrate salt of edoxaban, a potent and selective direct Factor Xa (FXa) inhibitor used in anticoagulation research. Supplied as a solid reagent for laboratory and pharmacological studies; not for human or veterinary use.
- Solid form suitable for laboratory handling.
- Molecular formula C31H40ClN7O8S2, molecular weight 738.27 g/mol.
- Typical storage: 4°C, sealed and away from moisture; in solvent: -80°C (6 months), -20°C (1 month).
- Intended for research and reference testing involving Factor Xa inhibition.
- Safety data and handling precautions available in supplier SDS.
Cayman Chemical Cintirorgon, Purity: ≥98%, CAS: 2055536-64-4, 5 mg
A RORɣ agonist (EC50s = <0.5 µM in a reporter assay and TR-FRET assay)
Medchemexpress LLC YOK-2204 | 2409959-99-3 | 98.6% | 449.58 | 25 MG
YOK-2204 is a ligand of the p62-ZZ domain. It can activate p62-dependent selective macroautophagy and can be utilized for AUTOTAC design.
- Ligand of p62-ZZ domain.
- Activates p62-dependent selective macroautophagy.
- Can be used for AUTOTAC design.
Cayman Chemical SZL P1-41, Purity: ≥98%, CAS: 222716-34-9, 5 mg
An inhibitor of Skp2; inhibits the interaction between Skp2 and Skp1 to block Skp2 E3 ubiquitin ligase activity at 5 μM; inhibits Skp2 over Fbw7 and β-TrCP E3 ubiquitin ligase activity in HEK293T cells; reduces survival of LNCaP and PC3 prostate cancer cells via inhibition of aerobic glycolysis and induction of apoptosis; reduces tumor volume in A549 lung cancer and PC3 prostate cancer mouse xenograft models at 40 and 80 mg/kg