Bioactive Small Molecules
Enzo Life Sciences BMPO (high purity) (10mg)
Nitrone spin trap for the specific in vivo or in vitro detection of short-lived superoxide, hydroxyl and thiyl radicals. Forms distinguishable adducts which can be measured by EPR spectroscopy. Unlike with DMPO, the superoxide adduct does not decay into a hydroxyl adduct and it has a much longer half-life (t1/2=23min). Low paramagnetic impurities. No further purification required. Alternative name: 5-tert-Butoxycarbonyl-5-methyl-1-pyrroline-N-oxide. Purity: ≥99% (HPLC). Appearance: White to pinkish crystalline solid. Solubility: Soluble in water. Long Term Storage: -20°C.
Apexbio Technology LLC BMS-754807(Synonyms: BMS754807, IGF-1R/InsR inhibitor BMS-754807, IGF-1R Inhibitor BMS-754807, BMS 754807), 100mg, CAS: 1001350-96-4.
BMS-754807 (CAS 1001350-96-4) is a small molecule inhibitor targeting insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) Acting as an ATP-competitive antagonist it directly interferes with the catalytic kinase domains of IGF-1R/IR thereby disrupting their enzymatic activities In vitro studies demonstrated potent antiproliferative activity against various cancer cell lines including mesenchymal hematopoietic and epithelial tumors (IC50 ranging from 5 to 365 nmol/L) Furthermore evidence from apoptosis assays in human rhabdomyosarcoma cells indicates BMS-754807 can induce apoptosis characterized by increased caspase cleavage and poly(ADP-ribose) polymerase (PARP) fragmentation This compound is primarily applied in oncology research aimed at elucidating IGF-1R/IR signaling pathways
Cayman Chemical PIrIprostpotasIum salt 5mg
Piriprost is a structural analog of PGI2 with low IP receptor-mediated activity. Piriprost inhibits 5-LO with an IC50 value around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.{994} Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 value of 0.11 µM.{4708}
STA PHARMACEUTICAL US LLC 1-DMTr-2-(S)-propanediyl amidite | 1 g | CAS 161029-25-0 | InChIKey XCLJWHBPKOARSH-VNFCCXQASA-N
1-DMTr-2-(S)-propanediyl amidite is a Amidite reagent (Subcategory: Spacer Modifiers) sold by WuXi TIDES. Offered in 1 g. Store at -20 °C. Ships on dry ice. SDS available for reference.
Specifications
- CAS: 161029-25-0
- MDL: No data
- InChIKey: XCLJWHBPKOARSH-VNFCCXQASA-N
- Molecular Weight: 578.689761998
- Molecular Formula: C33H43N2O5P
- Purity: ≥95%
- Container Type: 30 mL Glass (20-400)
- Pack Size: 1 g
- Net Weight: 1 g
- Gross Weight: 47.3 g
- Commodity Code: 29299090
- Country Of Origin: China
- IUPAC: (S)-1-(bis(4-methoxyphenyl)(phenyl)methoxy)propan-2-yl (2-cyanoethyl) diisopropylphosphoramidite
- SMILES: C[C@@H](COC(C1=CC=C(OC)C=C1)(C2=CC=CC=C2)C3=CC=C(OC)C=C3)OP(N(C(C)C)C(C)C)OCCC#N
Medchemexpress LLC Deschloroclozapine dihydrochloride | 99.9% | 365.30 | 100 MG
Deschloroclozapine dihydrochloride, a metabolite of Clozapine, is a highly potent muscarinic DREADDs agonist. It binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging.
- Highly potent muscarinic DREADDs agonist.
- Binds to DREADD receptor subtypes hM3Dq and hM4Di.
- Developed as a promising PET tracer for DREADD imaging.
Cayman Chemical ANTIBODY Avacopn 10mg
A C5a1 receptor antagonist (IC50 = 0.1 nM); selective for C5a1 over the C5a2 receptor and CMKLR2 (IC50s = >10,000 nM for both), as well as the C3a receptor, CMKLR1, and FPR1 (IC50s = >10,000 nM for all), and over panels of 18 chemokine receptors (IC50s = ≥6,700 nM for all), 54 other receptors at 10 µM, and five CYP isoforms (IC50s = >10,000 nM for all); reduces the migration of isolated cynomolgus monkey neutrophils at 50 nM; reduces C5a-induced increases in CD11b levels on neutrophils in isolated whole blood from human C5AR1 knock-in mice at 10 and 100 nM or at 0.075 and 0.15 mg/kg
Cayman Chemical ANTIBODY EfavIrenz 5mg
An NNRTI (Kis = 2.93 and 3.85-56.5 nM for wild-type and mutant HIV-1 RTs, respectively); inhibits wild-type and mutant HIV-1 viral replication in MT-4 human T lymphoid cells (IC95s = 1.5-1,500 nM); prevents RNA plus-strand initiation (IC50 = 17 nM); reduces HIV-1 cDNA in spleen of HIV-1-challenged HIV-susceptible transgenic rats
Cayman Chemical ANTIBODY OTX015 10mg
An orally bioavailable, small molecule inhibitor of BRD2, BRD3, and BRD4 (EC50s = 10-19 nM) that displays antiproliferative effects at a sub-micromolar range in vitro in a wide range of solid tumor types and leukemias
Cayman Chemical ANTIBODY PTIO 100mg
An oxidizing reagent that reacts with nitric oxide to form nitric dioxide and corresponding imino nitroxides
Cayman Chemical ANTIBODY 4E1RCat 10mg
An inhibitor of the eIF4F translation initiation complex that inhibits cap-dependent translation with an IC50 value of ~4 μM; reverses tumor chemoresistance in a mouse model of lymphoma by sensitizing cells to the proapoptotic action of DNA damage
Cayman Chemical Akt InhIbItr XI 10mg
A cell-permeable, copper-containing 3-formylchromone derivative that inhibits Akt in an array of cancer cells (IC50s = 10-34 µM); also causes NF-κB inactivation in an orthotopic pancreatic tumor model using COLO 357 cells
Biotang Inc Olaparib, > 99%, 250MG, CAS#763113-22-0, M.W.434.46, AZD-2281;KU-59436. RS315-250MG
Olaparib, > 99%, 250MG, CAS#763113-22-0, M.W.434.46, AZD-2281;KU-59436. RS315-250MG. Lead time of this kit is 1-2 weeks. Shipped by FedEx air. Storage: 2 - 8 C. Shelf Time: 6 months. Kit Experimental Time:< 2 hs. TSZELISA brand.
Apexbio Technology LLC A-443654 552325-16-3 5mg
A-443654 (CAS 552325-16-3) is a potent selective small molecule inhibitor targeting all three Akt isoforms by binding the ATP pocket and reversibly inhibiting kinase activity (Ki 160 pM) It shows strong selectivity for Akt over other kinases and suppresses downstream substrate phosphorylation including GSK3 FOXO3 TSC2 mTOR 4EBP-1 and S6 In cellular assays A-443654 inhibits Akt activity and induces apoptosis or cell cycle arrest across cancer models with reported EC50 values of 100 nM (MiaPaCa-2) and 0 63 M (CLL cells) In in vivo xenograft models it significantly reduces tumor growth either as monotherapy or in combination with rapamycin A-443654 is widely applied in studies of PI3K/Akt signaling cancer progression and therapeutic response
Cayman Chemical Esmolol AcIdhydrochlorIde 5mg
An active metabolite of esmolol; inhibits isoproterenol-induced increases in the beating rate of isolated guinea pig right atria (pA2 = 3.73); prevents isoproterenol-induced tachycardia and hypotension in anesthetized dogs; a potential impurity in commercial preparations of esmolol
Cayman Chemical ANTIBODY CC-401 1mg
A potent, selective inhibitor of all three JNK isoforms (Ki values range from 25 to 50 nM); bioavailable when delivered by gavage, blocking JNK signaling and renal fibrosis in a rat obstructed kidney model; decreases hepatic necrosis and apoptosis after orthotopic liver transplantation in rats