Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical ANTIBODY R-59-022 5mg
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An inhibitor of DGK (IC50 = 2.8 µM), increasing DAG-dependent PKC activity; blocks vascular contraction induced by U-46619 (Item No. 16450); induces apoptosis in glioblastoma cells without being toxic to non-cancerous cells; inhibits A. thaliana DGK2 (IC50 = 50 µM) and suppresses root growth but does not affect DGK7 at 50 µM
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Cayman Chemical ANTIBODY U-0126 10mg
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A non ATP-competitive MEK inhibitor (IC50 = 72 and 58 nM for MEK1 and MEK2, respectively); an activator of AMPK (EC50 = 15 µM); increases the ratios of ADP:ATP and AMP:ATP
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Cayman Chemical ANTIBODY PHOP 500UG
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A potent FAAH inhibitor, exhibiting Ki values of 0.094 and 0.2 nM for the human and rat enzymes, respectively
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Cayman Chemical ANTIBODY Wy 14643 5mg
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An agonist of PPARα; selectively transactivates PPARα over PPARγ in a reporter assay using CV-1 mouse fibroblasts at 100 µM; decreases distal colon protein levels of IFN-γ, TNF-α, IL-1β, and IL-6 in a mouse model of DSS-induced experimental colitis at 2 mg/kg; reduces hepatic triglycerides, leukocyte recruitment, and fibrosis in a mouse model of methionine- and choline-deficient diet-induced steatohepatitis at 0.1% w/w in the diet
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Medchemexpress LLC Agatolimod | 525625-52-9 | 98.8% | 7699.00 | 1 MG
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Agatolimod is a potent TLR9 agonist and immunomodulator, active against human TLR9 with an EC50 of 180 nM. It functions by activating and upregulating both TLR9 and TLR6, mediating downstream signaling pathways. This compound induces Th1-type innate and adaptive immune responses, making it a valuable tool for various research applications including COVID-19, breast cancer, and melanoma.
- Induces Th1-type innate and adaptive immune responses
- Activates various immune cells and promotes antigen presentation
- Upregulates the secretion of multiple cytokines
- Enhances cytotoxicity and clears intracellular Salmonella
- Increases radiosensitivity in certain cell lines
- Enhances anti-spike IgG and neutralizing antibody titers
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Cayman Chemical ANTIBODY FRAX597 25mg
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A PAK inhibitor selective for group I PAKs (IC50s = 7.7, 12.8, and 19.3 nM for PAK 1, 2, and 3, respectively) over group II PAKs (IC50 > 10 µM for PAK4 and 50 = 70 nM); reduces proliferation and survival of transformed Schwann cells, ovarian, and pancreatic cells; works synergistically with gemcitabine in pancreatic cancer models in vitro and in vivo
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Cayman Chemical ANTIBODY LuotonIn F 1mg
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A plant alkaloid that demonstrates cytotoxicity against leukemia P-388 cells (IC50 = 2.3 µM) through a mechanism that involves stabilizing the DNA topoisomerase I-DNA complex
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Cayman Chemical Saracatnb 5mg
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A dual inhibitor of c-Src and Abl (IC50 = 2.7 and 30 nM, respectively); less effectively inhibits other kinases; blocks cell motility, migration, adhesion, invasion, proliferation, differentiation, and survival; reduces osteoclast bone resorption
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Cayman Chemical ANTIBODY VU0360223 5mg
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A selective, negative allosteric modulator of the mGlu5 (IC50 = 61 nM; Ki = 477 nM); 10 μM results in a near complete blockade of the glutamate response in cortical astrocytes; 30 mg/kg in mice yields potent inhibition in a marble burying model of anxiety and is efficacious in an operant sensation seeking model of addiction
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Cayman Chemical CP 945 598hydrochlorIde 5mg
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A selective CB1 receptor antagonist (Ki = 0.7 nM); reverses cannabinoid agonist-mediated responses
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![Medchemexpress LLC N-[2-(4-oxo-1-phenyl-1,3,8-triazaspirodec-8-yl)ethyl]-2-naphthalenecarboxamide | 1130067-34-3 | >98.0% | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000231606.png-250.jpg)
Medchemexpress LLC N-[2-(4-oxo-1-phenyl-1,3,8-triazaspirodec-8-yl)ethyl]-2-naphthalenecarboxamide | 1130067-34-3 | >98.0% | 100 MG
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This small-molecule compound (CAS 1130067-34-3) is a potent phospholipase D2 (PLD2) inhibitor used for biochemical and cell-based research. It has reported in vitro IC50 = 140 nM and cellular IC50 = 110 nM, and is supplied at high purity for research applications.
- Potent PLD2 inhibitor with reported IC50 values of 140 nM (in vitro) and 110 nM (cellular).
- High purity (>98.0%).
- Available as solid in multiple pack sizes and as a 10 mM solution in DMSO.
- Suitable for in vitro biochemical assays and cell-based studies of migration and signaling.
- Molecular formula C26H28N4O2; molecular weight 428.5 g/mol.
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Cayman Chemical ANTIBODY CU-CPT9b 1mg
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A TLR8 antagonist; inhibits R-848-induced activation of NF-ĸB in TLR8-overexpressing HEK-Blue cells (IC50 = 0.7 nM)
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BIOGEMS INTERNATIONAL INC NICOTINAMIDE 50MG
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NC1928679 NICOTINAMIDE 50MG
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MEDCHEMEXPRESS LLC RAD51 INHIBITOR B02 5MG
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501871832 RAD51 INHIBITOR B02 5MG
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MEDCHEMEXPRESS LLC SR-18292 5MG
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501871835 SR-18292 5MG
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