Bioactive Small Molecules
Cayman Chemical N-trans-Feruloyltyramine, Purity: ≥98%, CAS: 66648-43-9, 5 mg
A phenolic amide with diverse biological activities; decreases NO production (IC50 = 17.36 µM) and iNOS activity and increases NO scavenging without inducing cytotoxicity in LPS-stimulated BV-2 cells; scavenges DPPH radicals in cell-free assays; inhibits proliferation of HeLa and L929 cells by 72.2 and 22%, respectively, at 30 µg/ml
AdipoGen Glucosylglycerol
Natural chemical product. CAS 22160-26-5. Formula C9H18O8. MW 254.2. Enzymatically processed from natural succrose and glycerine. Glucosylglycerol belongs to the class of compatible solutes osmolytes. It is a non-toxic, non-irritating protective osmolyte responsible for the osmotic adaptation of blue-green algae, rhizobacteria and Pseudomonas and also found in the drought-resistant resurrection plant Myrothamnus flabellifolia. Glucosylglycerol protects its host against osmotic stress, heat, desiccation and UV. Glucosylglycerol is an animal free and protein-free low molecular weight stabilizer which is an excellent cryoprotector for proteins in vitro, especially antibodies. In vitro models and skin models demonstrate strong activity of glucosylglycerol on aged and stressed skin cells with rejuvenating, recovering and radical scavenging properties.
Cayman Chemical TW-37, Purity: ≥98%, CAS: 877877-35-5, 25 mg
An inhibitor of the Bcl-2 family proteins Bcl-2, Mcl-1, and Bcl-xL (Kis = 120, 260, and 1,100 nM, respectively); induces apoptosis, inhibits migration and capillary sprouting in endothelial cells; has apoptotic action against leukemia, lymphoma, and pancreatic cancer cells
Cayman Chemical BI-9627, Purity: ≥95% (mixture of tautomers), CAS: 1204329-34-9, 5 mg
An NHE1 inhibitor (IC50s = 6 and 31 nM in pHi and human platelet swelling assays, respectively); greater than 30-fold selective for NHE1 over NHE2 and is inactive at NHE3 up to 16 μM in a pHi assay; inhibits phenylephrine-induced hypertrophy in neonatal rat cardiomyocytes; increases recovery of left ventricular developed pressure and inhibits increases in LVEDP in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury at 100 nM; attenuates decreases in left ventricular end-systolic pressure and increases in LVEDP in coronary artery-ligated rats at 45 and 150 ppm in the diet
Cayman Chemical NIBR0213, Purity: ≥98%, CAS: 1233332-14-3, 5 mg
A potent and selective S1P1 antagonist (IC50s = 2.5 and 2.0 nM for hS1P1 Ca2+ mobilization and in a GTPγS assay); inactive at S1P2, S1P3, and S1P4 receptors (IC50s = >20, >10, and >10 µM, respectively in a Ca2+ mobilization assay); reduces EAE disease severity in mice up to 26 days; induces pulmonary damage in rats when administered chronically
Medchemexpress LLC Dreadd agonist 21 | 56296-18-5 | 99.5% | 278.35 | C17H18N4 | 5 MG
DREADD agonist 21 is a potent chemogenetic ligand that selectively activates muscarinic DREADDs, exhibiting an EC50 of 1.7 nM at hM3Dq. Supplied as a light yellow solid, it is intended for research use in vitro and in vivo to modulate neuronal activity.
- High potency at hM3Dq with EC50 1.7 nM.
- High chemical purity (≈99.5%).
- Available in small research quantities including 5 MG.
- Stable solid form, light yellow to yellow appearance.
- Recommended storage: powder -20°C for long-term stability.
- Suitable for in vitro and in vivo chemogenetic studies.
Cayman Chemical (±)-3-Carene, Purity: ≥95%, CAS: 13466-78-9, 100 mg
A bicyclic terpene; has been found in Cannabis; decreases phagocytosis by rat alveolar macrophages at 0.5 µM; increases the expression and activity of alkaline phosphatase in mouse osteoblastic MC3T3-E1 subclone 4 cells and induces calcium formation and expression of osteoblast mineralization genes; induces bronchoconstriction in isolated guinea pig lungs when exposed at an air concentration of 3,000 mg/m3
Medchemexpress LLC HY-14188 1g , Amiodarone (hydrochloride) CAS:19774-82-4 Purity:>98%
HY-14188 1g Amiodarone (hydrochloride) CAS: 19774-82-4 Amiodarone hydrochloride, a benzofuran-based Class III antiarrhythmic agent, inhibits WT outwardIhERG tails with an IC50 of ∼45 nM. Amiodarone hydrochloride induces cell proliferation and myofibroblast differentiation via ERK1/2 and p38 MAPK signaling in fibroblasts. Amiodarone hydrochloride can be used in the research of both supraventricular and ventricular arrhythmias. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 2-Pyrrolidinecarboxamide, 1-[(2S)-2-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-3,3-dimethyl-1-oxobutyl]-4-hydroxy-N-[(5S)-6,7,8,9-tetrahydro-2-(4-methyl-5-thiazolyl)-5H-benzocyclohepten-5-yl]-, (2 S,4R)- | 2771069-76-0 | 99.19% | 576.75 | 25 MG
GNE7599 is a high-affinity and orally active von Hippel-Lindau (VHL) ligand with a Kd of 540 pM. It can be linked to a target protein ligand via a linker to form PROTACs.
- High-affinity VHL ligand
- Orally active
- Can be connected to form PROTACs
Medchemexpress LLC HY-14644 50mg , Apilimod CAS:541550-19-0 Purity:>98%
HY-14644 50mg Apilimod CAS: 541550-19-0 Apilimod (STA 5326) is a potent IL-12/IL-23 inhibitor, and strongly inhibits IL-12 with IC50s of 1 nM and 2 nM, in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. Apilimod is a potent and highly selective PIKfyve inhibitor. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CXCL15 Mouse HEK29 50ug
CXCL15 also known as Lungkine or WECHE is a member of the ELR motif-containing CXC chemokines CXCL15 has neutrophil chemotactic activity CXCL15 is high expression in the lungs of mice[1][2] CXCL15 Protein Mouse (HEK293 His) is produced in HEK293 cells with six C-Terminal His-tags It consists of 142 amino acids (Q26-A167)
Medchemexpress LLC HY-139664 5mg , GSK-3685032 CAS:2170137-61-6 Purity:>98%
HY-139664 5mg GSK-3685032 CAS: 2170137-61-6 GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC BMS 299897 | 290315-45-6 | 99.6% | C24H21ClF3NO4S | 1 ML
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
- Sulfonamide γ-secretase inhibitor.
- IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP).
- Reduces levels of Aβ peptides.
- Shows dose- and time-dependent reductions of amyloid β-peptide (Aβ) in brain, cerebrospinal fluid (CSF), and plasma in young transgenic mice.
- Attenuates Aβ25-35-induced Aβ1-42 seeding and toxicity.
- Blocks Aβ25-35-induced deficits in spontaneous alternation or novel object recognition.
Medchemexpress LLC Nifurpirinol | 13411-16-0 | 98.7% | C12H10N2O4 | 10MG
Nifurpirinol is a nitroaromatic compound used as a pro-substrate for bacterial nitroreductase (NTR) in research applications. NTR enzymatic reduction of nifurpirinol produces cytotoxic metabolites that enable selective ablation of NTR-expressing cells in model organisms and cell systems. This reagent is supplied at high purity for analytical and experimental use and is intended for research use only.
- Selective NTR substrate for targeted cell ablation.
- Enables regeneration and disease modeling in vivo.
- Applicable to studies of pancreatic β cell, osteoblast, dopaminergic neuron, and podocyte ablation.
- High purity suitable for analytical and research applications.
- Provided with authoritative chemical identifiers for traceability.
Cayman Chemical CM10, Purity: ≥98%, CAS: 692269-09-3, 5 mg
A pan-ALDH1A inhibitor (IC50s = 1,700, 740, and 640 nM for human ALDH1A1, ALDH1A2, and ALDH1A3, respectively); selective for ALDH1A isoforms over ALDH2, -3A1, -4A1, -5A1, -1B1, and -1L1 at 20 µM; induces necroptosis in ovarian cancer stem cells