Bioactive Small Molecules
Lkt Laboratories Thiolutin, ≥98%, 5MG
Dithiolopyrrolone; RNA polymerase inhibitor. CAS: 87-11-6. Additional sizes available upon request. Ships from Saint Paul, MN.
Medchemexpress LLC Forodesine | 209799-67-7 | 99.1% | 266.25 | 5 MG
Forodesine is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP. It is a potent human lymphocyte proliferation inhibitor and can induce apoptosis in leukemic cells by increasing dGTP levels.
- Highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor.
- Inhibits human, mouse, rat, monkey, and dog PNP.
- Potent human lymphocyte proliferation inhibitor.
- Induces apoptosis in leukemic cells by increasing dGTP levels.
- Excellent oral bioavailability (63%) in mice.
- Elevates dGuo to approximately 5 μM at a single dose of 10 mg/kg in mice.
- Effective in prolonging the life span in the hu-PBL-SCID mouse model.
Cayman Chemical ANTIBODY Sabutoclax 10mg
An internal standard for the quantification of cefprozil by GC- or LC-MS
Medchemexpress LLC Coronastat | 2922281-15-8 | MFCD32757276 | 98.0% | 575.53 g/mol | C22H29F3N3NaO8S | 5 MG
Coronastat is a research-grade small-molecule inhibitor of the SARS-CoV-2 3CL protease intended for in vitro and in vivo pharmacology studies. The compound has molecular weight 575.53 g/mol and CAS 2922281-15-8; manufacturer datasheet provides solubility and storage recommendations for experimental use.
- Potent inhibitor of the SARS-CoV-2 3CL protease.
- High reported purity of 98.0%.
- Soluble in DMSO and water at high in vitro concentrations.
- In vivo formulations achieve ≥ 2.08 mg/mL solubility in recommended vehicles.
- Storage: 4°C sealed; in solvent -80°C (6 months) or -20°C (1 month).
- Supplied in small quantities suitable for assay development and dosing studies.
Medchemexpress LLC MAO-A/5-HT2AR-IN-1 | 2769156-00-3 | C30H28FN3O2 | 5 MG
MAO-A/5-HT2AR-IN-1 is a potent dual inhibitor of MAO-A (IC50: 0.004 μM) and 5-HT2AR (IC50: 0.014 μM), recognized as a potential antidepressant agent. It exhibits significant neurocytoprotective effects in CORT-induced cell depression models and interacts with both targets via hydrogen bonding and π-π stacking. The compound shows low proliferation inhibitory activities against L02, SH-SY5Y, and PC12 cells, indicating a favorable safety profile.
- Improves depression-like behavior in mice.
- Enhances locomotion and depression-like behavior in zebrafish.
- Repairs damage to mouse hippocampal neuronal cells and reduces 5-HT2AR expression.
- Exhibits good clearance rate in rats after intravenous and intragastric administration.
Medchemexpress LLC HY-112301A 5mg Medchemexpress, trans-Pralsetinib CAS:2097132-93-7 Purity:>98%
Medchemexpress, HY-112301A 5mg trans-Pralsetinib CAS:2097132-93-7 trans-Pralsetinib (trans-BLU-667) is a rearranged during transfection (RET) inhibitor extracted from patent US20170121312A1, Compound Example 129. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 2-Naphthalenemethanol | 1592-38-7 | MFCD00004124 | 158.20 | 5 G
2-Naphthalenemethanol is a metabolite of the environmental pollutant 2-methylnaphthalene. It covalently binds to alveolar protein and induces pulmonary toxicity. It appears as a white to off-white solid with the molecular formula C11H10O.
- Metabolite of environmental pollutant 2-methylnaphthalene
- Covalently binds to alveolar protein
- Induces pulmonary toxicity
- White to off-white solid
- Molecular formula: C11H10O
Medchemexpress LLC Irak4-in-14 | 2667681-71-0 | 99.0% | 489.55 g/mol | C25H28FN9O | 5 MG
IRAK4-IN-14 is a small-molecule, selective, orally active inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4) characterized for biochemical potency and in vivo pharmacokinetics. It has been profiled for cellular activity and shows favorable oral exposure in preclinical species.
- Potent IRAK4 inhibition (IC50 0.003 μM).
- Cell pIRAK4 activity (IC50 0.11 μM).
- Selective kinase profile with limited off-target activity reported.
- Oral bioavailability approximately 66% in mouse.
- Molecular formula C25H28FN9O; molecular weight 489.55 g/mol.
- Reported purity 99.01%.
- Available as solid packages (including 5 mg) and as a 10 mM solution in DMSO.
Medchemexpress LLC HY-121513 25mg Medchemexpress, Torcitabine CAS:40093-94-5 Purity:>98%
Medchemexpress, HY-121513 25mg Torcitabine CAS:40093-94-5 Torcitabine (2'-Deoxy-L-cytidine) is an antiviral agent. Torcitabine has the potential for chronic hepatitis B virus infection treatment. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC 2-(4-Fluorophenyl)acetic acid-d2 | 113715-48-3 | 156.15 | 5 MG
2-(4-Fluorophenyl)acetic acid-d2 is the deuterium labeled 2-(4-Fluorophenyl)acetic acid. This compound is intended for research use only and can serve as a tracer or an internal standard for quantitative analysis. Deuterium substitution has the potential to influence the pharmacokinetic and metabolic profiles of drugs.
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Stable heavy isotope for drug development research
Sigma Aldrich Fine Chemicals Biosciences Asenapine maleate >=98% (HPLC) | 85650-56-2 | 10MG
Asenapine maleate >=98% (HPLC) | Purity: >=98% (HPLC) | Mol Wt: 401.84 | 85650-56-2 | 10MG
Selleck Chemical LLC GSK620 S9685-5MG
GSK620 is a pan-BD2 inhibitor which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity developability and in vivo oral pharmacokinetics
Cayman Chemical 1PalmItoyl2Stearoyl3Oleo 5mg
A triacylglycerol; has been detected in RAW 264.7 cells by neutral loss MS; increased serum levels are a potential biomarker for NAFLD
Apexbio Technology LLC CTS-1027 193022-04-7 50mg
CTS-1027 (CAS 193022-04-7) is a selective inhibitor of matrix metalloproteinases (MMPs) demonstrating high potency against MMP-2 and MMP-13 with IC values of 0 4 nM and 0 6 nM respectively MMPs are zinc-dependent endopeptidases involved in degradation of extracellular matrix proteins modulation of membrane receptors the release of apoptotic ligands and inactivation of chemokines and cytokines These enzymes are implicated in numerous cellular processes including proliferation migration differentiation angiogenesis and apoptosis In a murine model of bile duct ligation oral administration of CTS-1027 reduced hepatic injury and fibrosis supporting its use as a tool for investigating MMP function and fibrotic disease mechanisms
Apexbio Technology LLC Meticrane 1084-65-7 10mM (in 1mL DMSO)
Meticrane (CAS 1084-65-7) is a diuretic small molecule that acts on the distal convoluted tubules of the kidney inhibiting the reabsorption of sodium and chloride ions This action promotes increased urinary excretion contributing to the regulation of fluid and electrolyte homeostasis Meticrane is utilized in biomedical research focused on renal function ion transport mechanisms and is relevant for studies investigating the pathophysiology and pharmacology of primary hypertension