Bioactive Small Molecules
Cayman Chemical ANTIBODY WP1130 50mg
Inhibits the deubiquitinase activity of USP9x, USP5, USP14, and UCH37; 5 μM induces the accumulation of protein-ubiquitin conjugates, resulting in the formation of aggresomes and apoptosis in a variety of tumor cells
Medchemexpress LLC HY-138489 10mg , Lats-IN-1 CAS:1424635-83-5 Purity:>98%
HY-138489 10mg Lats-IN-1 CAS: 1424635-83-5 Lats-IN-1 is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. Lats-IN-1 promotes Yap-dependent proliferation in postmitotic mammalian tissues. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical EmedastIn-13C-d3fumarate 5mg
An internal standard for the quantification of emedastine by GC- or LC-MS
Medchemexpress LLC WJ-39 | 3009908-95-3 | >99.6% | 430.32 | 100 MG
WJ-39 is an orally active aldose reductase (AR) inhibitor. It improves tubular damage in diabetic nephropathy rats by activating PINK1/Parkin signaling, promoting mitophagy, and attenuating apoptosis.
- Orally active aldose reductase (AR) inhibitor.
- Ameliorates renal tubular injury in diabetic nephropathy.
- Activates PINK1/Parkin signaling.
- Promotes mitophagy.
- Attenuates apoptosis.
Cayman Chemical ANTIBODY DIFMUP 1mg
A fluorogenic substrate for phosphatases; upon enzymatic cleavage by phosphatases, 6,8-difluoro-7-hydroxy-4-methylcoumarin is released, which has an abs/em maxima of 358/455 nm, respectively, and its fluorescence can be used to quantify phosphatase activity; has been used to detect alkaline phosphatase in isolated rat tibia bone tissue
Selleck Chemical LLC Navitoclax (ABT-263) 5mg 923564-51-6
Navitoclax (ABT-263) is a potent inhibitor of Bcl-xL, Bcl-2 and Bcl-w with Ki of ? 0.5 nM, ?1 nM and ?1 nM in cell-free assays, but binds more weakly to Mcl-1 and A1. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Cayman Chemical PexIdartInIb 10mg
A brain-penetrant inhibitor of CSF1R, as well as c-Kit and FLT3 (IC50s = 20, 10, and 160 nM in vitro, respectively); blocks macrophage recruitment in mammary tumor-bearing mice and blocks glioblastoma invasion in both cell culture and a mouse model of glioblastoma multiforme
Medchemexpress LLC (Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide | 334949-59-6 | 99.9% | 25MG
(Z)-3-(((3-((dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide | 334949-59-6 | 99.9% | 25MG
Medchemexpress LLC AGRP protein, mouse | ≥95.0% | 100 UG
Recombinant mouse agouti-related protein (C-terminal 50 amino acids) expressed in HEK293 as an Fc fusion and supplied as a purified protein fragment for research into melanocortin receptor signaling, appetite regulation, and metabolic studies. The material includes quality controls for endotoxin and has recommended storage and handling to preserve activity.
- 50 amino acid C-terminal fragment suitable for receptor binding studies.
- Expressed in HEK293 cells to support mammalian post-translational modifications.
- Fc fusion tag for improved stability and detection.
- Purity ≥95.0% as determined by reducing SDS-PAGE.
- Endotoxin level <1 EU/μg to minimize assay interference.
- Store at -20°C; after reconstitution stable at 4°C for 1 week or -20°C for longer.
Cayman Chemical RosuvastatIn EP ImpurIty25mg
A potential impurity in commercial preparations of rosuvastatin
Medchemexpress LLC p38 alpha/MAPK14 Antibody (YA696) | 50 UL
p38 alpha/MAPK14 Antibody (YA696) is a mouse-derived, non-conjugated IgG1 monoclonal antibody that targets p38 alpha/MAPK14. This antibody is affinity purified and designed for research use, with applications in Western Blot analysis.
- Host: Mouse
- Clonality: Monoclonal
- Molecular weight: Predicted 41 kDa; observed 41 kDa
- Species reactivity: Human, mouse, rat, monkey
- Immunogen: Synthetic peptide corresponding to human P38 MAPK
- Application: WB (Western Blot) 1:500-1:1000
- Sensitivity: Endogenous
- Purity: Affinity purified
- Conjugation: Non-conjugated
- Isotype: IgG1
- Appearance: Liquid
- Formulation: Supplied in 1*PBS (pH 7.3), 50% glycerol and 0.5% BSA; preservative: 0.02% sodium azide
- Storage conditions: Stored at -20°C for 1 year; avoid repeated freeze/thaw cycles
Selleck Chemical LLC ZT-12-037-01 S8864-5MG
ZT-12-037-01 is a specific and ATP-competitive STK19 inhibitor with IC50s of 23 96 nM and 27 94 nM for STK19 (WT) and STK19 (D89N) respectively It displays extremely high kinase selectivity using KINOMEscan against a panel of 468 diverse kinases using an in vitro ATP-site competition binding assay at 1 M
Cayman Chemical OseltamIvIr AcId 5mg
The active metabolite of the antiviral prodrug oseltamivir; acts as an inhibitor of influenza neuraminidases A and B (IC50 values are 0.1 to 4.9 nM for both enzymes), in this way preventing virus budding and release
Medchemexpress LLC Acetyl CoA Carboxylase 1 (ACC1) Antibody | 266 kDa | 100 UL
Acetyl CoA Carboxylase 1 (ACC1) Antibody (YA646) is a rabbit-derived, non-conjugated IgG monoclonal antibody targeting Acetyl CoA Carboxylase 1 (ACC1). It reacts with human and mouse samples and is suitable for Western Blot (WB) and Immunohistochemistry-Paraffin (IHC-P) applications.
- Supplied in 1*TBS (pH 7.4), 0.05% BSA, and 40% Glycerol
- Concentration of 1 mg/mL
- Preservative: 0.05% Sodium Azide
- Appearance: Liquid
- Shipping: With blue ice
Cayman Chemical BAY 59-3074 10mg
A partial agonist of CB1 and CB2 (Kis = 55.4, 48.3, and 45.5 nM for rat CB1, human CB1, and human CB2, respectively); exhibits anti-hyperalgesic and anti-allodynic properties in rat models of chronic neuropathic and inflammatory pain