Bioactive Small Molecules
Medchemexpress LLC 3-(2-((2-fluorophenyl)amino)oxazol-5-yl)benzoic acid | 2375281-44-8 | 99.8% | C16H11FN2O3 | 10MG
NF-κB activator 2 is a small-molecule research compound that activates the NF-κB signaling pathway. It is provided as a dry powder or as a DMSO solution for biochemical and cell-based studies. Key physicochemical properties include molecular formula C16H11FN2O3, molecular weight 298.27, and high reported purity; follow recommended storage conditions for stability.
Medchemexpress LLC L-beta-Homoalanine hydrochloride | 58610-41-6 | 139.58 | 5 G
L-beta-Homoalanine hydrochloride is an alanine derivative. Amino acids and amino acid derivatives, such as L-beta-Homoalanine hydrochloride, are commercially used as ergogenic supplements. They can influence the secretion of anabolic hormones, supply fuel during exercise, improve mental performance during stress-related tasks, and help prevent exercise-induced muscle damage. These substances are recognized as beneficial ergogenic dietary substances.
- Alanine derivative
- Can be used as an ergogenic supplement
- Influences secretion of anabolic hormones
- Supplies fuel during exercise
- Improves mental performance during stress-related tasks
- Prevents exercise-induced muscle damage
- Recognized as beneficial ergogenic dietary substance
Medchemexpress LLC HYNIC-iPSMA TFA | 2375849-11-7 | 98.1% | 765.69 | 10 MG
HYNIC-iPSMA TFA is a ligand designed for the molecular imaging of tumors. This compound is comprised of two key components: HYNIC (6-hydrazinonicotinamide) and iPSMA (Inhibitor of Prostate-Specific Membrane Antigen). HYNIC serves as a chemical linker, utilized for attaching radioactive isotopes to specific targeted molecules. iPSMA acts as a selective inhibitor, designed to target and inhibit prostate-specific membrane antigen (PSMA).
- Tumor molecular imaging.
- Component-based design.
- Radioactive isotope attachment.
- Prostate-specific membrane antigen inhibition.
- Prostate cancer detection.
- High specificity and sensitivity.
- Radionuclide-drug conjugate synthesis.
Medchemexpress LLC Umbelliferone (7-Hydroxycoumarin) | 93-35-6 | MFCD00006764 | 162.14 | 1 G
Umbelliferone (7-Hydroxycoumarin) is a natural, orally active coumarin family product that functions as a fluorescing compound and can be used as a sunscreen agent. It induces cell cycle arrest, apoptosis, and DNA fragmentation in HepG2 cells. It also exhibits significant anticancer effects, attenuates allergic airway inflammation, displays neuroprotective effects, crosses the blood-brain barrier, and shows anti-inflammatory and antioxidant effects in chronic alcohol-fed rats.
- Induces cell cycle arrest, apoptosis, and DNA fragmentation in HepG2 cells.
- Exhibits significant anticancer effects.
- Attenuates allergic airway inflammation.
- Displays neuroprotective effects and crosses the blood-brain barrier.
- Shows anti-inflammatory and antioxidant properties.
Medchemexpress LLC IDO-2 Human His 500ug
Recombinant human IDO-2 protein with a C-terminal 6xHis tag, expressed in E. coli and supplied as a 0.22 μm-filtered PBS solution. The protein is purified to greater than 95% by reducing SDS-PAGE, provided at approximately 0.707 mg/mL, and is suitable for biochemical assays, antibody development, and structural studies. Store frozen and avoid repeated freeze-thaw cycles.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- C-terminal 6xHis tag for affinity purification and detection.
- Expressed in E. coli for efficient recombinant production.
- Supplied in PBS, pH 7.4, filtered through 0.22 μm.
- Provided at ~0.707 mg/mL concentration; 500 μg format available.
- Store at -80°C for long-term stability; avoid repeated freeze-thaw.
Selleck Chemical LLC BMS-986235 E4628-1G
BMS-986235 (LAR-1219) is a selective orally active and potent agonist of formyl peptide receptor 2 (FPR2) with EC50 values of 0 41 nM and 3 4 nM for hFPR2 and mFPR2 respectively BMS-986235 therapy shows promising improvements in cardiac structure and function in a mouse model of heart failure highlighting its potential for preventing the progression of heart failure
Medchemexpress LLC Alkynyl myristic acid | 82909-47-5 | MFCD18382104 | 95.0% | 224.34 g/mol | C14H24O2 | 5 MG
Alkynyl myristic acid is an alkyl chain-based reagent containing a terminal alkyne functional group, used as a click-chemistry handle and as a hydrophobic linker in chemical biology and PROTAC synthesis. It enables conjugation via copper-catalyzed azide-alkyne cycloaddition (CuAAC) and related chemistries.
- Contains a terminal alkyne for copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Functions as a hydrophobic linker suitable for PROTAC construction.
- Provided at high purity (95.0%) for reliable conjugation.
- Soluble in DMSO for convenient handling during synthesis.
- Available in small research-scale pack sizes for assay development.
Medchemexpress LLC GSK-3β inhibitor 13 | 2227316-74-5 | 99.74% | 414.46 | 5 MG
GSK-3β inhibitor 13 is an orally active and potent GSK-3β inhibitor with blood-brain permeability. It significantly decreases the phosphorylation of tau, which is associated with the formation of neurofibrillary tangles in Alzheimer's disease.
- Orally active and potent GSK-3β inhibitor
- Exhibits blood-brain permeability
- Inhibits GSK-3β with an IC50 of 0.73 nM
- Inhibits GSK-3α with an IC50 of 0.35 nM
- Decreases phosphorylation of tau (IC50=58 nM)
Cayman Chemical ANTIBODY AS1517499 10mg
A STAT6 inhibitor (IC50 = 21 nM in a reporter assay); inhibits IL-4-induced Th2 differentiation of mouse spleen T cells (IC50 = 2.3 nM); inhibits bronchial smooth muscle hyperresponsiveness and IL-13 production in ovalbumin-sensitized mice at 10 mg/kg; inhibits STAT6 phosphorylation and TEC hyperplasia and decreases serum levels of T3 and T4 in a mouse model of Graves’ disease at 10 mg/kg per day; inhibits tumor growth and liver metastasis in a murine orthotopic 4T1 mammary carcinoma model at 20 mg/kg twice weekly
![Medchemexpress LLC N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide | 1174046-72-0 | MFCD18206786 | 99.5% | 468.84 g·mol-1 | C23H15ClF2N4O3 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000244444.png-250.jpg)
Medchemexpress LLC N-[4-(2-amino-3-chloropyridin-4-yl)oxy-3-fluorophenyl]-5-(4-fluorophenyl)-4-oxo-1H-pyridine-3-carboxamide | 1174046-72-0 | MFCD18206786 | 99.5% | 468.84 g·mol-1 | C23H15ClF2N4O3 | 1 ML
BMS-794833 is a small-molecule kinase inhibitor active against VEGFR2 and Met, originally described in patent WO2009094417. It exhibits potent biochemical activity (VEGFR2 IC50 ≈ 15 nM; Met IC50 ≈ 1.7 nM) and is provided for research use in both solution and solid formats. Typical uses include biochemical assays, cell-based kinase studies, and preclinical pharmacology research.
- Potent dual inhibition of VEGFR2 and Met with low-nanomolar IC50s.
- High purity suitable for research applications.
- Available as concentrated solution and solid quantities for flexibility.
- Soluble in common organic solvents such as DMSO; verify before use.
- Applicable to biochemical and cellular kinase assays and preclinical studies.
Cayman Chemical ANTIBODY ATB-343 50mg
A hybrid molecule of an H2S donor and the NSAID indomethacin that does not cause gastric damage or promote leukocyte adherence to vascular endothelium
Cayman Chemical ANTIBODY CefradIn 5g
An orally bioavailable β-lactam cephalosporin antibiotic; active against S. pyogenes, E. coli, K. pneumoniae, and E. cloacae (MICs = 0.04, 9.4, 9.4, and 6.3 μg/ml, respectively); active against clinical isolates of S. aureus (MICs = 0.8-6 μg/ml) and S. pyogenes (MICs = 0.1-0.4 μg/ml), as well as H. influenzae, E. coli, and K. pneumoniae (MICs = 6.2-12.5 μg/ml); increases survival in mouse models of systemic lethal infection by S. pyogenes, E. coli, K. pneumoniae, or E. cloacae (ED50s = 5, 37, 122, and 50 mg/kg, respectively), as well as by penicillin-susceptible or -resistant strains of S. aureus (ED50s = 18 and 91 mg/kg, respectively)
Cayman Chemical ANTIBODY PTIQ 50mg
A neuroprotective compound; inhibits tetrahydro-L-biopterin-induced cytotoxicity and increases in MMP-3 in CATH.a cells (IC50s = 1.8 and 0.06 µM, respectively); inhibits LPS-induced production of MMP-3, TNF-α, and COX-2 in BV-2 microglia (IC50s = 2.4, 6.5, and 9.3 µM, respectively); increases survival of striatal nigral dopaminergic neurons, reduces microglial activation, and alleviates motor deficits in a mouse model of MPTP-induced Parkinson’s disease at 3 and 30 mg/kg
Medchemexpress LLC GNE-0723 | 1883518-31-7 | MFCD30829912 | 99.9% | 467.78 g·mol⁻¹ | C16H8ClF6N5OS | 50 MG
GNE-0723 is a brain-permeable positive allosteric modulator of the N-methyl-D-aspartate receptor (NMDAR) with high potency at GluN2A and characterized pharmacology useful for in-vitro and in-vivo neuroscience research.
- Potent GluN2A activity (EC50 21 nM).
- Lower activity at GluN2C and GluN2D (EC50 7.4 μM and 6.2 μM).
- High purity suitable for biochemical and in vivo assays.
- Solid form, white to yellow, with recommended cold storage for stability.
- Intended for research into NMDAR modulation and neurological disease models.
Medchemexpress LLC HY-111505 5mg Medchemexpress, NAcM-OPT CAS:2089293-61-6 Purity:>98%
Medchemexpress, HY-111505 5mg NAcM-OPT CAS:2089293-61-6 NAcM-OPT is an orally bioavailable cullin neddylation 1 ( DCN1 ) inhibitor, which potently inhibits the DCN1-UBE2M interaction [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.