Bioactive Small Molecules
Cayman Chemical S-JWH 073 N- 3-hydroxyb 5mg
An analytical reference standard categorized as a synthetic cannabinoid metabolite; a metabolite of JWH 073; intended for research and forensic applications
Medchemexpress LLC IL-3 Human His 100ug
Recombinant human interleukin-3 (IL-3) with an N-terminal His tag, expressed in E. coli and supplied lyophilized. This cytokine supports hematopoietic cell proliferation and is intended for activity, binding, and biochemical assays; reported ED50 in TF-1 proliferation assay is 0.05-0.3 ng/mL. Predicted molecular mass is ~16.6 kDa and purity is >95% by reducing SDS-PAGE.
- Supports TF-1 cell proliferation assays with ED50 0.05-0.3 ng/mL.
- His-tag for easy purification and detection.
- High purity (>95%) verified by reducing SDS-PAGE.
- Lyophilized formulation for improved stability and shipping.
- Store at -20°C for long-term stability; aliquot after reconstitution.
- Includes sequence and molecular mass information to aid assay design.
Medchemexpress LLC Animal-Free FGF-21 10ug
Recombinant animal-free human Fibroblast Growth Factor 21 (FGF-21) with a C-terminal His tag, expressed in E. coli and supplied as a lyophilized powder for research use. It supports studies of metabolic regulation, insulin sensitivity, and FGFR/KLB signaling, and is provided in a small vial suitable for biochemical assays and cell-based experiments.
- Animal-free recombinant human protein.
- C-terminal His tag for purification and detection.
- Expressed in E. coli for high-yield production.
- Lyophilized formulation for stability and long-term storage.
- Suitable for biochemical assays and cell-based studies.
- Available in a 10 μg vial for low-volume experiments.
Cayman Chemical 4EpInhydrochLRtetracyclIn 5mg
An inhibitor of MMP-9; a derivative of tetracycline; inhibits MMP-9 activity in a dose-dependent manner in an assay for collagen degradation; completely inhibits neutrophil-derived MMP-9 degradation of denatured collagen at a concentration of 500 μg/ml; lacks antibiotic activity
Medchemexpress LLC ERK5-IN-2 | 1888305-96-1 | 99.0% | 50 MG
ERK5-IN-2 is an orally active, selective ERK5 inhibitor (IC50s of 0.82 μM for ERK5 and 3 μM for ERK5 MEF2D) that does not interact with the BRD4 bromodomain. It has been shown to suppress tumor xenograft growth and bFGF-driven angiogenesis. This compound exhibits favorable pharmacokinetic properties including low intrinsic clearance and high oral bioavailability.
- Selective ERK5 inhibitor with sub-micromolar IC50s
- Does not interact with the BRD4 bromodomain
- Suppresses tumor xenograft growth
- Suppresses basic fibroblast growth factor (bFGF) driven angiogenesis
- Exhibits low intrinsic clearance and high flux
- Demonstrates low efflux ratio in caco-2 cell permeability assays
- Significantly reduces tumor volumes in animal models
- Features an oral bioavailability of 68%
Medchemexpress LLC BMS-214662 (hydrochloride) | 195981-08-9 | 526.073 g/mol | 50 MG
BMS-214662 hydrochloride is an inhibitor of farnesyltransferase. It can effectively block the localization and function of Ras proteins on the cell membrane by inhibiting the prenylation modification of Ras proteins, thereby exerting anti-tumor activity. It can be used in the research of tumor diseases related to Ras.
- Inhibits farnesyltransferase
- Blocks localization and function of Ras proteins
- Exhibits anti-tumor activity
- IC50 value for H-Ras is 1.3 nM
- IC50 value for K-Ras is 8.4 nM
- Suitable for research of tumor diseases related to Ras
AdipoGen DMAPB (1 mg)
Chemical. CAS: 827036-76-0. Formula: C16H25N3O2S. MW: 323.5. Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =114nM). Displays selectivity over other HDACs (IC50=1-8µM). Neuroprotective and anti-neuroinflammatory agent. Reduced neuronal degeneration after traumatic brain injury (TBI). Shown to increase histone H3 acetylation. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
Cayman Chemical 2C-IPhydrochlorIde 5mg
A phenethylamine whose physiological and toxicological properties have not been investigated; intended for research and forensic applications
![Medchemexpress LLC 8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholinyl-4-oxo-chromene-6-carboxamide | 1627494-13-6 | MFCD27987908 | 100.0% | 457.5 g/mol | C24H25F2N3O4 | 50MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000237461.png-250.jpg)
Medchemexpress LLC 8-[(1R)-1-(3,5-difluoroanilino)ethyl]-N,N-dimethyl-2-morpholinyl-4-oxo-chromene-6-carboxamide | 1627494-13-6 | MFCD27987908 | 100.0% | 457.5 g/mol | C24H25F2N3O4 | 50MG
AZD8186 is a selective, small-molecule inhibitor of phosphoinositide 3-kinase beta (PI3Kβ) and delta (PI3Kδ) used as a research compound to probe PI3K signaling pathways in oncology research. It exhibits low-nanomolar potency against PI3Kβ and PI3Kδ, selectivity over other PI3K isoforms, and has been evaluated in preclinical models and early clinical studies.
- Low-nanomolar potency against PI3Kβ and PI3Kδ (IC50 ≈ 4 nM and 12 nM).
- Selectivity over PI3Kα and PI3Kγ to support targeted pathway studies.
- High stated purity suitable for research applications.
- Available in multiple small-scale package sizes for laboratory use.
- Well-characterized chemical identifiers for database cross-referencing.
Cayman Chemical ANTIBODY CPI-637 10mg
An inhibitor of CBP/EP300 bromodomains (IC50s = 30 and 51 nM in a TR-FRET assay); selective for CBP and EP300 over the BET family of bromodomains (IC50s = >10 μM); is active at bromodomain BRD9 (IC50 = 0.73 μM); inhibits CBP (IC50 = 0.3 μM in a BRET assay) and inhibits MYC expression (EC50 = 0.6 μM) in AMO-1 cells
Cayman Chemical ANTIBODY GDC-0980 1mg
A potent inhibitor of class I PI3K isoforms (IC50 values of 5, 27, 7, and 14 nM for PI3Kα, β, δ, and γ, respectively) and mTOR (Ki = 17 nM); induces cell cycle arrest or apoptosis in a range of cancer cell lines; effective in vivo, suppressing the growth of a number of tumor xenografts in mice
Cayman Chemical ANTIBODY Akt-I-1 5mg
An Akt1 inhibitor (IC50 = 4.6 µM); selective for Akt1 over Akt2, Akt3, and SGK (IC50s = >250 µM for all)
Medchemexpress LLC (R)-JNJ-40418677 | 1146594-85-5 | 99.3% | 480.44 g/mol | C26H22F6O2 | 1 ML
(R)-enantiomer of a γ-secretase modulator supplied for laboratory research use. Provided as a solid or as a ready-to-use 10 mM solution in DMSO (1 mL). The high-purity compound is suitable for biochemical and cellular assays studying amyloid-β modulation; not for human or clinical use.
- High purity suitable for research: 99.3%.
- Available as powder and as a 10 mM solution in DMSO (1 mL).
- Molecular formula C26H22F6O2 and molecular weight 480.44 g/mol.
- Stable when stored as powder at -20°C or 4°C; follow recommended solvent storage conditions.
- Intended for in vitro and in vivo research applications requiring stereochemical specificity.
Cayman Chemical ANTIBODY MB-07811 1mg
A liver-targeted prodrug of MB-07344; binds to TRα1 and TRβ1 (Kis = 12.5 and 14.6 µM, respectively); reduces plasma cholesterol levels (ED50 = 0.48 mg/kg) in a cholesterol-fed rat model; reduces hepatic steatosis, as well as plasma levels of cholesterol, in Zucker diabetic fatty rats in a model of NAFLD at 5 mg/kg per day; reverses hepatic steatosis, reducing total hepatic lipids without decreasing body weight, in a mouse model of diet-induced obesity at 10 mg/kg