Bioactive Small Molecules
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Filtered Search Results
Cayman Chemical Lusutrombopag, Purity: ≥98%, CAS: 1110766-97-6, 5 mg
A thrombopoietin receptor agonist; induces proliferation of Ba/F3 cells expressing human MPL (EC50 = 84 nM) but not of those expressing mouse Mpl; increases the number of circulating platelets in a transgenic mouse model expressing human MPL at 0.3-10 mg/kg per day and increases the number of megakaryocytes in the bone marrow at 10 mg/kg per day
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Cayman Chemical Oridonin, Purity: ≥98%, CAS: 28957-04-2, 5 mg
A diterpenoid with diverse biological activities; binds to β-arrestin-1 and -2 (Kds = 362 and 563 nM, respectively); inhibits β-arrestin recruitment and receptor desensitization and internalization of various GPCRs; selective for β-arrestin over Gαs, Gαq, Gα12, and Gi; inhibits Akt1 and Akt2 (IC50s = 8.4 and 8.9 µM, respectively); has anticancer activity in vitro and in a PDX mouse model; inhibits NLRP3 inflammasome assembly and activation; has anti-inflammatory activity in a mouse model of high-fat diet-induced type 2 diabetes
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Cayman Chemical JNJ-55511118, Purity: ≥98%, CAS: 2036081-86-2, 10 mg
A negative modulator of AMPA receptors containing TARP-γ8; inhibits glutamate-induced calcium flux in HEK293F cells co-transfected with TARP-γ8 and either GluA1o, GluA1i, GluA2i, GluA3o, or GluA4o (IC50s = 11.22, 12.3, 7.41, 38.02, and 15.85 nM, respectively); selective for GluA1o receptors containing TARP-γ8 over GluA1o receptors containing TARP-γ2, -γ3, -γ4, or -γ7 (IC50s = >10 μM for all); reduces peak glutamate-induced currents in acutely dissociated murine hippocampal neurons to 60.7% of control cells at 1 μM; reduces fEPSPs in the hippocampal CA1 region from wild-type, but not TARP-γ8 knockout, mice at 1 μM; inhibits corneal kindling-induced seizures in mice (ED50 = 3.7 mg/kg)
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Medchemexpress LLC Z52-L16, 5mg | CAS No. : 3077488-80-0
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Z52-L16 is Drug-Linker Conjugates for ADC, which is composed of a linker and a Ras inhibitor Z52 (HY-178842). Z52-L16 can be used for the research of cancer, such as pancreatic cancer.
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Cayman Chemical SIBA, Purity: ≥98%, CAS: 35899-54-8, 50 mg
A derivative of SAH; reduces viral infectivity in HEp-2 cells infected with HSV-1 at 1 mM; inhibits the RSV-induced oncogenic transformation of primary chicken embryo fibroblasts at 0.5 and 1 mM; decreases the number of metastases in a model of rhabdomyosarcoma in rats fed a low methionine diet at 15 mg/kg three times weekly
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Medchemexpress LLC Sparcl1 protein, mouse (recombinant, HEK293, N-His tag) | >95.0% | 5 UG
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Recombinant mouse SPARCL1 protein (283 amino acids, Y368-F650) produced in HEK293 cells with an N-terminal His tag. Supplied in small quantities for biochemical and cell-based studies; available as lyophilized powder or solution. Purity, storage, and reconstitution guidance provided by the manufacturer.
- Recombinant protein fragment corresponding to amino acids Y368-F650.
- Expressed in HEK293 mammalian cells.
- N-terminal 6xHis tag for purification and detection.
- Available in small premeasured amounts, including 5 μg.
- Purity greater than 95% by reducing SDS-PAGE.
- Apparent molecular weight ~38-48 kDa due to glycosylation.
- Store aliquots at -20 °C to -80 °C and follow reconstitution instructions.
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TARGETMOL CHEMICALS INC MS1943 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MS1943 is a orally bioavailable EZH2 selective degrader(IC50 of 120 nM). purity: 98%
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Medchemexpress LLC Br-PEG3-ethyl acetat 100mg
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Br-PEG3-ethyl acetate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]
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TARGETMOL CHEMICALS INC ERAVACYCLINE DIHYDROCHLO 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Eravacycline dihydrochloride (TP-434-046)is a potent and broad-spectrum antibacterial agent against six E. coli (MICs 0.125-0.25 mg/L). purity: 95%
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Medchemexpress LLC Erso | 2407860-35-7 | 100.0% | C22H13F6NO3 | 10MG
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ErSO is a small-molecule selective anticipatory unfolded protein response (a-UPR) activator that engages estrogen receptor alpha (ERα) to elicit potent and sustained cytotoxic a-UPR signaling in ERα-positive cancer models. It is supplied for research use and characterized by a defined molecular formula and high analytical purity.
- Activates the anticipatory unfolded protein response (a-UPR) via ERα.
- Induces potent and sustained cytotoxic signaling in ERα-positive models.
- Suitable for cancer research applications.
- High analytical purity reported at 99.95%.
- Molecular formula C22H13F6NO3; molecular weight 453.33 g/mol.
- Available in small research pack sizes (for example, 10 mg).
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Cayman Chemical Nefazodone-d6 (hydrochloride), Purity: ≥99% deuterated forms (d1-d6), CAS: 1330236-06-0, 5 mg
An internal standard for the quantification of nefazodone by GC- or LC-MS
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Cayman Chemical Ridaifen-B, Purity: ≥98%, CAS: 886465-70-9, 5 mg
An antagonist of ERα (IC50 = 52.4 nM), an inverse agonist of CB2 (Ki = 43.7 nM), and a derivative of tamoxifen; selective for CB2 over CB1 receptors (Ki = 732 nM); designed to be cytotoxic to cancer cells independent of ER binding; it inhibits growth of ER-positive and ER-negative cells in a panel of 39 cancer cell lines (GI50s = 0.20-2.14 µM); induces apoptosis and autophagy in ER-negative Jurkat cells at 0.4 µM; decreases NO production and protein levels of IL-1α and IL-6 in LPS-stimulated RAW 264.7 cells at 1 µM
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Medchemexpress LLC Izmynd8-34 | 1358901-59-3 | 98.8% | 449.42 | 100 MG
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iZMYND8-34 is a ZMYND8 inhibitor with an IC50 of 0.66 μM. It inhibits the binding of H3K4me1-H3K14ac peptide to the ZMYND8 protein and blocks ZMYND8's histone recognition, also inhibiting neuroendocrine prostate cancer development.
- Binds to recombinant ZMYND8-PBP with a dissociation constant (Kd) of 1.73 μM.
- Significantly inhibits the growth of NE1.3 cells, TKO and ST88 organoids.
- Extended mouse survival and reduced end-stage tumor volume in animal models.
- Shifted tumor histology and eliminated NEPC cell populations.
- Completely prevented metastatic spread to lymph nodes, lungs, and liver.
- Inhibited LTL-331 PDX tumor growth and extended mouse survival in another animal model.
- Reduced the percentage of CHGA+ NEPC cells and decreased Ki67+ proliferating cells.
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Cayman Chemical 4-methyl-N-Propylcathinone (hydrochloride), Purity: ≥98%, CAS: 2802790-62-9, 5 mg
An analytical reference standard categorized as a cathinone; intended for research and forensic applications
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Apexbio Technology LLC DASA-58 1203494-49-8 5mg
DASA-58 (CAS 1203494-49-8) is a selective activator of pyruvate kinase M2 (PKM2) an enzyme involved in the regulation of glycolytic metabolism in cancer cells By promoting PKM2 activity DASA-58 disrupts the interaction between PKM2 and phosphotyrosine-containing proteins that typically suppress PKM2 catalytic function thereby modulating cancer cell metabolism In biochemical assays DASA-58 displays AC90 and AC50 values of 680 nM and 38 nM respectively Cellular studies demonstrate that DASA-58 induces a dose-dependent activation of PKM2 in A549 cell-derived lysates with an EC50 of 19 6 M DASA-58 serves as a valuable tool for probing PKM2-related metabolic pathways and tumorigenesis in cancer research
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