Bioactive Small Molecules
Cayman Chemical SB-4, Purity: ≥98%, CAS: 100874-08-6, 5 mg
An activator of BMP4 signaling; induces BMP4 signaling in a reporter assay using HEK293 cells expressing a recombinant human BMP4 response element (EC50 = 74 nM); increases phosphorylation of SMAD1, -5, and -9 in HEK293 cells at 10 µM; induces Blimp1 and Tfap2c expression in mouse embryonic stem cells
Medchemexpress LLC VP-U-6 | 2361324-80-1 | C24H40N4O9P2 | 100 MG
VP-U-6 is a nucleoside analog that can be used in oligonucleotide synthesis. It is intended for research use only.
- Purity of 95.0%
- Molecular weight of 590.54
- Appears as an oil
- Light yellow to yellow color
- Soluble in DMF (≥ 100 mg/mL) and DMSO (25 mg/mL), insoluble in H2O
- Recommended storage for pure form at -20°C for 3 years, or in solvent at -80°C for 6 months
- Classified as a nucleoside antimetabolite/analog
TARGETMOL CHEMICALS INC SH-4-54 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. SH-4-54 is a most potent small molecule nonphosphorylated STAT3 inhibitor. purity: 99%
Medchemexpress LLC Etelcalcetide hydrochloride | 1334237-71-6 | 99.80% | 1353.33 | 50 MG
Etelcalcetide hydrochloride is a synthetic calcimimetic that acts as an activator of the calcium sensing receptor (CaSR), effective in lowering parathyroid hormone (PTH) concentrations in dialysis patients with secondary hyperparathyroidism.
- Reduces parathyroid hormone (PTH) levels in human parathyroid cells in a dose-dependent manner.
- Significantly reduces plasma PTH concentrations in C57BL7/6J male mice.
- Decreases renal expression of Cyp24a1.
- Promising for research in secondary hyperparathyroidism and chronic kidney disease.
Cayman Chemical trans-β-Ocimene, Purity: ≥90%, CAS: 3779-61-1, 5 mg
A monoterpene; a volatile compound involved in plant-plant signaling and plant defense against pests; emission from L. japonicus plants is induced within 24 hours of spider mite (T. urticae) infestation; conditioning of tomato plants using VOCs from transgenic tobacco plants overexpressing trans-β-ocimene synthase increases production of VOCs, reduces the number of aphids (M. euphorbiae) that settle on the plant and the number of nymphs produced by the aphids that settle, as well as increases the number of landings of the aphid parasitoid A. ervi
Cayman Chemical Kinetensin (human) (trifluoroacetate salt), Purity: ≥95%, 5 mg
A neurotensin ligand; binds to neurotensin receptors in HT-29 cells and mouse brain (Kis = 1,396 and 149.6 nM, respectively) but does not induce the accumulation of intracellular calcium in HT-29 cells (EC50 = >10,000 nM); induces histamine release in isolated rat peritoneal mast cells (EC50 = ~10 µM); induces vascular permeability in rats
Cayman Chemical Carbazomycin B, Purity: ≥95%, CAS: 75139-38-7, 5 mg
A bacterial metabolite with diverse biological activities; active against a panel of seven fungi (MICs = 3.2-200 µg/ml) and a panel of seven bacteria (MICs = 25-50 µg/ml), as well as P. falciparum and C. albicans (IC50s = 2.37 and 19.6 µg/ml, respectively); active against a panel of five plant-pathogenic fungi (MICs = 12.5-200 µg/ml); cytotoxic to MCF-7, KB, NCI H187, and Vero cells (IC50s = 8.4, 8.6, 4.2, and 48.9 µM, respectively); inhibits 5-LO activity in RBL-1 cell extracts (IC50 = 1.5 µM)
Medchemexpress LLC Senktide | 106128-89-6 | 99.9% | 841.97 | 50 MG
Senktide is a potent and selective agonist of the neuromedin K3 (NK3) receptor, with an EC50 ranging from 0.5-3 nM. It also agonizes the NK1 receptor, though less potently (EC50=35 μM). This compound shows promise in research related to neurological diseases.
- Highly potent and selective: demonstrates strong agonistic activity towards the NK3 receptor, with significantly lower potency for the NK1 receptor.
- Neurological research focus: promising for use in the study of neurological diseases.
- Comprehensive data available: detailed information on cellular effects, in vitro, and in vivo studies are provided.
- Multiple package sizes: available in various quantities from 1 mg to 500 mg to suit different research needs.
- High purity: the product boasts a purity of 99.91%.
Selleck Chemical LLC Depatuxizumab mafodotin-1MG
Depatuxizumab Mafodotin (Depatux-M ABT-414) is an antibody-drug conjugate consisting of an EGFR IGg1 monoclonal antibody conjugated to the tubulin inhibitor monomethyl auristatin F via a stable maleimidocaproyl link Depatuxizumab Mafodotin is used in the treatment of recurrent EGFR-amplified Glioblastoma (GBM)
Cayman Chemical Captan, Purity: ≥98%, CAS: 133-06-2, 100 mg
A fungicide; reduces radial growth of and starch depletion by A. fumigatus on the leaf surface of A. tenuis at 50 μg/ml; increases the number of micronuclei and chromosomal aberrations in polychromatic erythrocytes in bone marrow in mice from 50-1,000 mg/kg; induces chromosomal aberrations in spermatocytes and sperm head abnormalities in mice; reduces survival of adult male and female alfalfa leafcutting bees from 150-684 and 24.45-48.9 g/L topically and in diet, respectively
Cayman Chemical L-319, Purity: ≥95%, CAS: 1351586-50-9, 50 mg
An ionizable cationic (pKa = 6.38) and biodegradable lipid derivative of DLin-MC3-DMA; has been used in the formation of LNPs; administration of mouse FVII-targeting siRNA in L-319-containing LNPs reduce serum levels of FVII in mice; LNPs containing L-319 in combination with cKK-E12 and encapsulating VZV mRNA encoding gE increase the lymph node and spleen levels of CD11c+CD80+ and CD11c+CD86+ cells and total serum IgG titers in mice, as well as decrease the number of VZV-induced rashes and the epithelial levels of VZV DNA, in a guinea pig model of VZV-induced shingles
Medchemexpress LLC Mibampator (LY451395) | 375345-95-2 | 99.5% | 438.60 | 100 MG
Mibampator (LY451395) is a potent and highly selective potentiator of the AMPA receptors, intended for research use only. It has shown various cellular effects, including toxicity against Caco-2 cells and inhibition of SARS-CoV-2 induced cytotoxicity. In vivo studies indicated its ability to reverse ethanol-induced deficits in rats. It has also undergone Phase 2 clinical trials for Alzheimer's Disease.
- Potent and highly selective potentiator of AMPA receptors
- Caco-2 CC50 of 8.66 μM and IC50 of 3.28 μM
- HEK293 EC50 of 0.15 μM
- Reverses central effects of acutely intoxicating dose of ethanol in rats
- Clinical trials for Alzheimer's Disease
Medchemexpress LLC Porcn-IN-1 | 2036044-77-4 | 99.6% | 410.44 | 25 MG
Porcn-IN-1 is a potent porcupine inhibitor with an IC50 of 0.5±0.2 nM. It is as potent as the clinical compound LGK974 in a cell-based STF reporter gene assay and potently inhibits the secretion of Wnt3A, confirming it as a porcupine inhibitor. This product is for research use only and not intended for human use.
- Potent porcupine inhibitor
- Exhibits moderate clearance in human and rat liver microsomes
- Shows high clearance in mouse microsomes
- Soluble in DMSO at ≥ 100 mg/mL
Selleck Chemical LLC Panobinostat (LBH589) 200mg 404950-80-7 NVP-LBH589
Panobinostat (LBH589, NVP-LBH589) is a novel broad-spectrum HDAC inhibitor with IC50 of 5 nM in a cell-free assay. Panobinostat (LBH589) induces autophagy and apoptosis. Panobinostat effectively disrupts HIV latency in vivo. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Medchemexpress LLC HY-15437 5mg Medchemexpress, SL327 CAS:305350-87-2 Purity:>98%
Medchemexpress, HY-15437 5mg SL327 CAS:305350-87-2 SL327 inhibits MEK1 and MEK2, with IC50 values of 180 nM and 220 nM, respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.