Bioactive Small Molecules
Cayman Chemical ANTIBODY SNAP 94847 25mg
An antagonist of MCH1 (Ki = 2.2 nM for the recombinant rat receptor); selective for MHC1 over α1A-adrenergic and dopamine D2 receptors (Kis = 180 and 7,400 nM, respectively, for the recombinant human receptors); increases the time mice spend in the light side of the light/dark exploration test at 20 mg/kg; reduces food intake and body weight, as well as plasma levels of glucose, insulin, and triglycerides, in a mouse model of high-fat diet-induced obesity at 5 mg/kg in combination with rimonabant
Medchemexpress LLC N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG
N-Acetyl-L-methionine | 65-82-7 | 99.9% | 191.25 | 5 MG
Medchemexpress LLC 3-isopropylphenyl diphenyl phosphate | 69515-46-4 | MFCD30718732 | 368.36 | C21H21O4P | 25mg
3-Isopropylphenyl diphenyl phosphate is a flame retardant
Apexbio Technology LLC BMS-599626 Hydrochloride 873837-23-1 100mg
BMS-599626 Hydrochloride (CAS 873837-23-1) is a selective small-molecule inhibitor targeting the human epidermal growth factor receptors HER1 (EGFR) and HER2 exhibiting IC50 values of 22 nM and 32 nM respectively By antagonizing these receptor tyrosine kinases BMS-599626 disrupts downstream signaling pathways involved in cellular proliferation and survival In vitro the compound inhibits proliferation of breast tumor cell lines overexpressing HER1 or HER2 but shows limited effects on cells lacking these receptors In vivo oral administration in murine xenograft models suppresses tumor growth in a dose-dependent manner BMS-599626 is valuable for studying HER-mediated oncogenic signaling and targeted therapy development
Cayman Chemical ANTIBODY SB-242235 25mg
A p38α MAPK inhibitor (IC50 = 0.019 µM); selective for p38α MAPK over a panel of 10 kinases, including ERK2, JNK1, EGFR, and C-RAF (IC50s = >10 µM for all); inhibits IL-1α-induced production of NO in bovine articular cartilage explants (IC50 = ~1 µM); inhibits increases in epidermal COX-2 levels and erythema in mice exposed to UVB irradiation at 100 mg/kg; reduces paw edema in a rat model of adjuvant-induced arthritis at 10, 30, and 60 mg/kg
Cayman Chemical ANTIBODY A-771726 25mg
An active metabolite of leflunomide; inhibits DHODH (IC50 = 0.23 µM); inhibits the production of PGE2 in TNF-α- or IL-1α-stimulated isolated human synoviocytes (IC50s = 7 and 3 μM, respectively); inhibits the proliferation of isolated human PBMCs at 25 and 100 µM; delays disease onset and decreases neurological deficits in a rat model of EAE induced by CFA and M. tuberculosis at 3 and 10 mg/kg
Apexbio Technology LLC Choline Fenofibrate 10mg
A3308 is a small molecule designed for biomedical research applications though detailed structural and registry data are currently unavailable Its mechanism of action centers on modulating specific cellular pathways enabling the investigation of signaling events critical to various physiological and pathological processes A3308 s utility is primarily as a research tool to elucidate molecular targets and cellular responses supporting studies in signal transduction pathway characterization and potential therapeutic target identification
TARGETMOL CHEMICALS INC RN-1734 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. RN-1734 is selective TRPV4 channel antagonist(IC50 of 2.3 uM5.9 uM3.2 uM for hTRPV4 mTRPV4 and rTRPV4respectively)purity: 98%
Cayman Chemical GSK2837808A 5mg
A potent inhibitor of LDHA and LDHB (IC50s = 2.6 and 0.43 nM, for human recombinant LDHA and LDHB, respectively); inhibits lactate production in Snu398 hepatocellular carcinoma cells in which LDHB expression is undetectable (EC50 = 400 nM); reduces glucose consumption in Snu398 but not HepG2 cells; 30 cancer cell lines show differential sensitivities to GSK2837808A (EC50s from 400 nM to 30 µM); potency does not correlate with LDHA, LDHB, or total LDH expression levels
TARGETMOL CHEMICALS INC FERULOYLPUTRESCINE 25MG
Also available in 1 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Feruloylputrescine is a natural product. purity: 98%
Cayman Chemical ANTIBODY SIsomIcIn 100mg
A broad-spectrum aminoglycoside antibiotic; active against Gram-positive and Gram-negative bacteria including B. subtilis, S. aureus, E. coli, and P. aeruginosa, among others (MICs = 0.01-0.75 UG/ml); protective against Gram-positive and Gram-negative bacterial infections in mice (PD50s = 0.5-6 mg/kg)
![Medchemexpress LLC 1h-indazole-4-carboxamide, n-[(1,2-dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]- | 1433200-49-7 | 99.9% | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/default.jpg-250.jpg)
Medchemexpress LLC 1h-indazole-4-carboxamide, n-[(1,2-dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]- | 1433200-49-7 | 99.9% | 1 ML
UNC2400 is a close analog of UNC1999, serving as a negative control for cell-based studies with >1,000-fold lower potency than UNC1999. This solid, white to off-white compound has a molecular weight of 597.79 and a chemical formula of C35H47N7O2.
- Used as a negative control for cell-based studies.
- Purity of 99.92%.
- Molecular weight is 597.79.
- Chemical formula is C35H47N7O2.
- Appearance as a white to off-white solid.
- Histone methyltransferase inhibitor.
Cayman Chemical ANTIBODY LY315920 50mg
An inhibitor of hGIIA sPLA2 (IC50 = 9 nM), as well as mouse GIIA (mGIIA), hGIIE, mGIIE, hGX, and mGX PLA2s, but poorly inhibits other PLA2 enzymes; inhibits serum sPLA2 activity in transgenic mice expressing human sPLA2 when given either intravenously or orally
Cayman Chemical Cholyl-putrescIn 5mg
A polyamine bile amidate; has been found in lion and mouse, as well as serval, cheetah, and tiger fecal samples; has been used as a standard for the detection of endogenous bile acid amidates in mammalian intestinal and fecal samples