Bioactive Small Molecules
Cayman Chemical Swerta bmaculta Swertsn 5mg
A flavonoid C-glycoside with diverse biological activities; inhibits SGLT2 in HEK293 at 7.5 UG/ml; is an adenosine A1 receptor antagonist (IC50 = 137 µM); inhibits HBV replication in HepG2 2.2.15 cells at 0.2-5 µM; decreases blood glucose levels in a mouse model of streptozotocin-induced diabetes; prevents scopolamine-induced increases in escape latency in the Morris water maze in mice
Apexbio Technology LLC 5-Aminovaleric acid hydrochloride 660-88-8 25g
5-Aminovaleric acid hydrochloride (CAS 660-88-8) is a five-carbon GABA-related small molecule that acts on GABAergic neurotransmission In vitro studies indicate it inhibits GABA uptake reduces degradation by GABA transaminase and modulates GABAb receptor activity Additionally it has been shown to increase glutamine concentrations potentially compensating for decreased cerebral glutamine levels In animal models of epilepsy administration of 5-aminovaleric acid significantly reduced the severity and frequency of seizures compared to controls This compound is of interest for research into neurological disorders and as a platform chemical for synthesis of polymers and other industrially relevant compounds
Medchemexpress LLC Basimglurant | 802906-73-6 | C18H13ClFN3 | 500 MG
Basimglurant is a selective, orally active, and blood-brain barrier permeable negative allosteric modulator of metabotropic glutamate receptor 5 (mGluR5). It effectively inhibits mGlu5-mediated signaling pathways, regulating dopamine levels in the nucleus accumbens. Basimglurant has shown anxiolytic, antidepressant-like, analgesic, and arousal-promoting effects, and is used in research for depression, fragile X syndrome, and anxiety disorders.
- Potent mGlu5 inhibitor with good oral bioavailability.
- Long half-life, supporting once-daily administration.
- Good brain penetration and high in vivo potency.
- Exhibits antidepressant properties and anxiolytic-like features.
- Undergoing phase II clinical studies for depression and fragile X syndrome.
Medchemexpress LLC HY-N2112 5mg Medchemexpress, Glaucocalyxin A CAS:79498-31-0 Purity:>98%
Medchemexpress, HY-N2112 5mg Glaucocalyxin A CAS:79498-31-0 Glaucocalyxin A, an ent-kauranoid diterpene from Rabdosia japonica var., induces apoptosis in osteosarcoma by inhibiting nuclear translocation of Five-zinc finger Glis 1 (GLI1) via regulating PI3K/Akt signaling pathway. Glaucocalyxin A has antitumor effect. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Cayman Chemical ANTIBODY JSH-23 25mg
An inhibitor of NF-κB, blocking its translocation into the nucleus (IC50 = 7.1 µM); does not affect degradation of IκB; interferes with NF-κB-mediated gene expression and apoptosis in RAW 264.7 cells treated with LPS
Medchemexpress LLC JNJ-26070109 | 844645-08-5 | 99.3% | 547.37 | 10 MG
JNJ-26070109 is a high-affinity, competitive, orally bioactive, and selective cholecystokinin 2 (CCK2) receptor antagonist with good pharmacokinetic properties. It targets CCK2 receptors that regulate gastric acid secretion and growth of the gastrointestinal mucosa, making it a promising tool for gastroesophageal reflux disease research.
- High-affinity, competitive, orally bioactive, and selective.
- Good pharmacokinetic properties.
- Targets CCK2 receptors that regulate gastric acid secretion.
- Supports research into gastroesophageal reflux disease.
Cayman Chemical ANTIBODY Bendazac 1g
An NSAID; prevents denaturation of lens and serum proteins in vitro; prevents cyanate-induced opacification of the eye lens in a rat model of cataract from 10-40 mM
Medchemexpress LLC Benfluorex hydrochloride | 23642-66-2 | 99.85% | 500 MG
Benfluorex hydrochloride (JP-992 hydrochloride) is a hepatic nuclear factor 4 alpha (HNF4α) activator. It is for research use only.
- Consistently activates insulin promoter activity, increasing GFP-positive cells and endogenous insulin mRNA levels.
- Stimulates HNF4α expression and alters HNF4α protease sensitivity.
- Decreases the synthesis of acid-soluble products and ketone bodies from oleate.
- Markedly increases the production of 14CO2 into the citric acid cycle.
- Inhibits gluconeogenesis from lactate/pyruvate in a dose-dependent manner.
TARGETMOL CHEMICALS INC ML240 10MG
Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. ML240 is a selective ATP-competitive p97 inhibitor. purity: 99%
Cayman Chemical ANTIBODY AR231453 5mg
An agonist of GPR119; increases cAMP accumulation in HIT-T15 β cells that endogenously express high levels of GPR119 (EC50 = 4.7 nM); increases insulin release from HIT-T15 cells (EC50 = 3.5 nM); reduces plasma glucose levels in wild-type, KK/Ay, and db/db diabetic mice at 20 mg/kg
Medchemexpress LLC AZD 9272 | 327056-26-8 | 99.9% | 284.22 | 1 MG
AZD 9272 is a selective, orally active, and brain penetrant mGluR5 antagonist. It demonstrates high selectivity over other mGlu receptors and is intended for research use only. This compound causes a concentration-dependent decrease in the intracellular Ca2+ response in mGluR5 expressing cell lines.
- Selective mGluR5 antagonist
- Orally active and brain penetrant
- Shows >3900-fold selectivity over other mGlu receptors
- Causes concentration-dependent decrease in intracellular Ca2+ response
- Completely reverses glutamate-stimulated phosphatidyl inositol hydrolysis
Abcam 4-Thiouridine, RNA synthesis inhibitor, 25MG
MW 260.27 Da, Purity >99%. Ribonucleoside (Uridine ab143255) analog. Antisense agent. RNA synthesis inhibitor. Modifies oligos slated for RNA. Induces p53 and inhibits proliferation. Metabolically labels RNA for stability studies.
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC Glyasperin A | 142474-52-0 | 1 MG
Glyasperin A is a flavonoid compound isolated from the acetone extract of the leaves of Macaranga gigantea.
- Flavonoid compound.
- Isolated from the acetone extract of the leaves of a plant called Macaranga gigantea.
- Intended for research use only.
- Has a molecular weight of 422.47.
- Has a chemical formula of C25H26O6.
- Appears as a light yellow to yellow solid.
- Classified as a flavonoid and flavonol.
- Has a purity of 99.65%.
- Can be stored at 4°C, protected from light.
- In solvent, can be stored at -80°C for 6 months or -20°C for 1 month, protected from light.
Cayman Chemical ANTIBODY RSC-133 10mg
Promotes the reprogramming of human somatic cells to pluripotent stem cells; increases the number of human foreskin fibroblasts that express alkaline phosphatase when used at 10 μM with four standard reprogramming factors; down-regulates inducers of cellular senescence and inhibits Dnmt1 and HDAC1
Cayman Chemical ANTIBODY L-CnalIn 25mg
An aminooxy analog of ornithine that irreversibly inhibits aminotransferases, including ornithine aminotransferase (Ki = 2 µM); cytotoxic to a range of organisms