Bioactive Small Molecules
Apexbio Technology LLC Fluoxetine HCl(Synonyms: Prozac, Sarafem, Fluoxetine Hydrochloride, Lilly 110140, Fluoxeren, Fluctin), 100mg, CAS: 56296-78-7.
Fluoxetine HCl (CAS 56296-78-7) is a selective serotonin reuptake inhibitor (SSRI) that specifically blocks presynaptic serotonin (5-HT) transporters resulting in elevated extracellular serotonin levels It modulates serotonergic signaling through inhibition of serotonin-induced membrane currents in cloned 5HT2C receptors exhibiting an IC50 around 20 M and binds 5HT2C receptors expressed in HeLa cells (Ki approximately 65-97 nM) Fluoxetine treatment has been shown in vivo to stimulate neurogenesis and enhance neuronal maturation and synaptic plasticity within rat hippocampus and prefrontal cortex Widely employed in neuroscience research fluoxetine aids in studies of depression stress resilience and neuro-regulatory mechanisms involving serotonergic signaling
Cayman Chemical ANTIBODY DIl 25mg
A fluorescent neuronal tracer that labels cell bodies, axons, dendrites, and dendritic spines; has been used as an anterograde tracer to study neuronal development in vivo and as a retrograde tracer to label hippocampal neuronal connections in fixed postmortem brain tissue; has been used as a long-term plasma membrane label in live cells; ex/em = 549/565 nm, respectively
Cayman Chemical ANTIBODY NS 11394 5mg
A positive allosteric modulator of the GABAA receptor (Ki = 0.423 nM); selective for GABAA receptors containing α1, α2, α3, or α5 subunits (Kis = 0.41, 0.84, 0.497, and 0.119 nM, respectively) over receptors containing α4 or α6 subunits (Kis = 324 or 1,009 nM, respectively); modulator of GABA receptors containing subunits α3 and α5 with maximal potentiation rates of 52% and 78%, respectively, relative to diazepam; inhibits [3H]flunitrazepam binding to benzodiazepine receptors in mouse and rat forebrain in vivo (EC50s = 0.38 and 1.3 mg/kg, respectively, at 30 minutes and 0.49 and 0.69 mg/kg, respectively, at 120 minutes following oral administration); attenuates spontaneous nociceptive behaviors in a rat model of neuropathic pain when administered at doses of 1-30 mg/kg
Cayman Chemical ANTIBODY AvrIdIn 25mg
A synthetic lipid amine that acts as an adjuvant; subplantar injection of avridine induces paw swelling, tissue destruction, bone and pannus formation, and neutrophil, fibroblast, and osteoclast infiltration in rats; increases the number of CD4+ T and MHC class II+ cells in rat paws at 1.5 mg/animal; has been used to induce experimental rheumatoid arthritis in rats
Abcam Histamine, histamine receptor agonist, 5G
MW 111.1 g/mol. Potent vasodilator. Formed by the decarboxylation of L-histidine. Acts as an agonist for endogenous histamine receptors. Histamine H₁ receptor activation mobilizes Ca²+; H₂ activation stimulates adenylate cyclase activity in neurons. Activates nitric oxide synthase (NOS).
The product is subject to the following: Abcam Restricted Use Statement
Medchemexpress LLC 4-Nitroindole | 4769-97-5 | 96.83% | 162.15 | 10 G
4-Nitroindole is a biochemical reagent applicable as a biological material or organic compound for life science research. It is for research use only and not sold to patients. This product is a controlled substance and may not be available for sale in all territories. It has not been fully validated for medical applications.
- Can be used as a biological material
- Can be used as an organic compound
- Suitable for life science related research
Medchemexpress LLC TD-165 | 2305936-56-3 | >98.1% | 50 MG
TD-165 is a PROTAC-based cereblon (CRBN) degrader comprising a cereblon (CRBN) ligand binding group, a linker, and a von Hippel-Landau (VHL) binding group. This compound is intended for research use only.
- Demonstrates a 50% degradation concentration (DC50) of 20.4 nM.
- Achieves a maximum degradation (Dmax) value of 99.6%.
- Leads to a concentration-dependent decrease in CRBN proteins in HEK293T cells.
Medchemexpress LLC (-)-Fenchone | 7787-20-4 | 1 G
(-)-Fenchone is a chemical compound with the molecular formula C10H16O and a molecular weight of 152.24. It is typically a colorless to light yellow liquid. This product is provided as a standard, with a purity of 98.0% by NMR, and is intended for research use only. It has not been fully validated for medical applications.
- CAS number: 7787-20-4
- Molecular formula: C10H16O
- Molecular weight: 152.24
- Appearance: Colorless to light yellow liquid
- Purity: 98.0% (NMR)
- For research use only
Medchemexpress LLC TGP-377/421 (Targapre-miR-377/421) | 16752-89-9 | 98.2% | 340.38 | 100 MG
TGP-377/421 (Targapre-miR-377/421) is a potent miR-377 and miR-421 inhibitor that binds a functional site in both miRNAs. It is for research use only.
- Potent miR-377 and miR-421 inhibitor
- Binds a functional site in both miRNAs
- Appears as a solid with a light yellow to brown color
- Formula: C20H16N6
TARGETMOL CHEMICALS INC LY450108 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies. purity: 100%
![Medchemexpress LLC Benzoic acid, 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxy- | 1677668-27-7 | 98.0% | 433.84 | 1 ML](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000402029-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzoic acid, 4-[6-(2-chloro-6-cyclopropylbenzoyl)imidazo[1,5-a]pyrimidin-8-yl]-2-hydroxy- | 1677668-27-7 | 98.0% | 433.84 | 1 ML
GNE-6468 is a highly potent and selective RORγ (RORc) inverse agonist with an EC50 value of 13 nM for HEK-293 cells and 30 nM for IL-17 PBMC. It is intended for research use only.
- Highly potent and selective RORγ (RORc) inverse agonist.
- Exhibits anti-inflammatory activity in human PBMC by inhibiting IL-17 production.
- Displays high predicted clearance values in human and rodent hepatocytes.
Medchemexpress LLC Homatropine Bromide | 51-56-9 | 99.9% | 5 G
Homatropine Bromide is an orally active muscarinic acetylcholine receptor antagonist and functions as an anticholinergic agent. This compound is a white to off-white solid with a molecular weight of 356.25 and a chemical formula of C16H22BrNO3. It exhibits affinities for muscarinic receptors in the stomach and atria, and has been shown to block cardiovascular responses to vagal stimulation and acetylcholine in in vivo studies.
- Orally active muscarinic acetylcholine receptor antagonist
- Functions as an anticholinergic agent
- White to off-white solid
- Molecular weight: 356.25
- Chemical formula: C16H22BrNO3
- Soluble in DMSO and H2O at 100 mg/mL
- Solid storage: 4°C, sealed, away from moisture
- In solvent storage: -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC GSK484 hydrochloride | 1652591-81-5 | >98.0% | 510.03 | C27H32ClN5O3 | 1 ML
GSK484 hydrochloride is a selective, reversible inhibitor of protein arginine deiminase 4 (PAD4) used in laboratory research to study PAD4-mediated protein citrullination and neutrophil extracellular trap formation. Supplied as a solid or as a ready-to-use 10 mM solution in DMSO, it is intended for biochemical and cellular assays. For research use only.
- Selective, reversible inhibitor of peptidylarginine deiminase 4 (PAD4).
- Potent biochemical activity with reported IC50 ≈ 50 nM in low-calcium conditions, reduced potency with Ca2+ (~250 nM).
- Available as solid and as a 10 mM solution in DMSO for convenience in assays.
- Molecular formula C27H32ClN5O3 and molecular weight 510.03 g/mol.
- CAS number 1652591-81-5 for unambiguous chemical identification.
- Intended for in vitro research applications; not for human therapeutic use.
Cayman Chemical FerroptosIs InhIbItr D1 5mg
A free radical scavenger and an inhibitor of ferroptosis; scavenges 41.27% of DPPH radicals in a cell-free assay at 0.4 µM; inhibits erastin-induced lipid peroxidation in HT-1080 cells at 0.5 µM and erastin-induced ferroptosis in the same cells (IC50 = 22 nM); reduces infarct volume and improves neurological deficits in a mouse model of transient MCAO-induced ischemic brain injury at 5 mg/kg
Cayman Chemical CItrus maxa peel MernzIn 5mg
A coumarin with diverse biological activities; cytotoxic to NSCLC-N6 and KB cancer cells (IC50s = 14.6 and 12.3 UG/ml, respectively); increases the latency to paw withdrawal in the hot plate test and reduces xylene-induced EAr edema in mice at 10 mg/kg; decreases carrageenan-induced paw edema in rats at 10 mg/kg