Bioactive Small Molecules
Cayman Chemical Thymidine, Purity: ≥98%, CAS: 50-89-5, 5 g
A pyrimidine nucleoside; oral administration in combination with deoxycytidine increases lifespan in a Tk2 H126N knock-in mouse model of TK2 deficiency
Medchemexpress LLC Rotigotine impurity 1 | 244239-68-7 | 233.31 g/mol | 500mg
Rotigotine impurity 1 is an impurity of Rotigotine (HY-75502)
Medchemexpress LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 25 MG
Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP), demonstrating an IC50 of 8 nM in vitro.
- Inhibits microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro.
- Reduces plasma concentrations of low density lipoprotein cholesterol (LDL-C) and triglycerides.
- Indicated for the treatment of Homozygous Familial Hypercholesterolemia (HoFH).
- Metabolized via cytochrome P-450 (CYP) isoenzyme 3A4.
- Bioavailability of 7.1% and a mean half-life of 39.7 hours for the 50-mg capsule.
- Exhibits antiproliferative activity against human HepG2 cells.
- Appears as a solid, white to off-white substance.
Cayman Chemical CID-5721353, Purity: ≥98%, CAS: 301356-95-6, 5 mg
A Bcl-6 inhibitor (Ki = 147 µM); selective for Bcl-6 over Kaiso, HIC1, and PLZF at 50 µM; cytotoxic against SU-DLH-6, SU-DLH-4, Farage, OCI-LY7, OCI-LY1, and OCI-LY10 DLBCL cells (GI50s = 0.024-0.936 mM); increases expression of ATR, TP53, CD69, p21, and CD44 in SU-DLH-6 and SU-DHL-4 cells at 50 µM; reduces tumor growth in OCI-LY7 and SU-DHL-6 mouse xenograft models at 50 mg/kg
Medchemexpress LLC HY-12942 10mg , PF-05175157 CAS:1301214-47-0 Purity:>98%
HY-12942 10mg PF-05175157 CAS: 1301214-47-0 PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC CCR2 antagonist 4 | 226226-39-7 | 100.0% | 439.86 g/mol | C21H21ClF3N3O2 | 1 ML
CCR2 antagonist 4 (Teijin compound 1) is a research-grade small-molecule antagonist of the CC chemokine receptor 2 (CCR2). It selectively inhibits CCR2b (reported IC50 ≈ 180 nM) and potently blocks MCP-1-induced chemotaxis in cellular assays (reported IC50 ≈ 24 nM). The compound is supplied as a solid or as a ready-to-use DMSO stock (10 mM in 1 mL) for in vitro and in vivo studies.
- Potent CCR2b antagonist (IC50 ≈ 180 nM).
- Inhibits MCP-1-induced chemotaxis in cellular assays (IC50 ≈ 24 nM).
- Available as a DMSO stock solution for convenient in vitro dosing.
- Suitable for pharmacology and chemotaxis research applications.
- Molecular formula C21H21ClF3N3O2; molecular weight 439.86 g/mol.
Medchemexpress LLC NSC 107512 | 22242-89-3 | MFCD32671351 | 100.0% | C12H16N6O5 | 10MG
NSC 107512 is a sangivamycin-like small molecule inhibitor of cyclin-dependent kinase 9 (CDK9). It exhibits anti-proliferative activity and induces apoptosis in multiple myeloma models. This compound is supplied for laboratory research use only.
- Potent CDK9 inhibitor with a sangivamycin-like scaffold.
- Demonstrated to inhibit cell growth and induce apoptosis in multiple myeloma models.
- High supplied purity (99.97%).
- Molecular formula C12H16N6O5; molecular weight 324.29 g/mol.
- Available as small-mass solid packs and as DMSO solution formats for convenience.
- Suitable for long-term storage at -20°C (solid) and -80°C (in solvent) to preserve stability.
Medchemexpress LLC Org 48762-0 50mg | 755753-89-0 | 50 MG
Org 48762-0 (UR13870) is a potent, orally active, and selective p38 MAP kinase inhibitor used in research to study inflammatory signaling and cytokine production. It inhibits p38α kinase with low-nanomolar potency in biochemical assays and reduces LPS-induced TNFα release in cellular and animal models.
- Potent p38α/p38β inhibition (EC50 0.1 μM).
- Reduces LPS-induced TNFα release in PBMCs (EC50 0.06 μM).
- Orally bioavailable with demonstrated systemic exposure in mice.
- High reported purity suitable for biochemical and cellular assays.
- Stable as a powder at -20°C for long-term storage.
Medchemexpress LLC (S,S)-Gne 5729 | 2026636-06-4 | MFCD34676612 | 99.7% | 428.20 g/mol | C17H10Cl2F3N5O | 25 MG
(S,S)-Gne 5729 is the (S,S)-enantiomer of the small-molecule compound GNE 5729. Supplied as a solid research chemical, it is intended for biochemical and pharmacological research, stereochemistry-specific studies, analytical characterization, and synthetic chemistry applications.
- High enantiomeric purity suitable for stereospecific assays.
- Verified molecular formula and molecular weight for analytical work.
- Available in small-mass packaging appropriate for discovery-stage research.
- Provided with safety documentation and an SDS for laboratory handling.
Medchemexpress LLC 5-propargylamino-dCTP | 115899-39-3 | MFCD28010326 | 99.5% | C12H19N4O13P3 | 10MG
5-Propargylamino-dCTP is an alkyne-functionalized deoxycytidine triphosphate designed for enzymatic incorporation into DNA and for subsequent covalent labeling via click chemistry. The terminal alkyne enables copper-catalyzed azide-alkyne cycloaddition (CuAAC) for attachment of probes or tags used in detection, sequencing, and imaging workflows.
- Alkyne handle compatible with copper-catalyzed azide-alkyne cycloaddition (CuAAC).
- Designed for enzymatic incorporation into DNA as a dCTP analog.
- Enables post-synthetic conjugation of fluorescent probes or affinity tags.
- High purity for reliable biochemical performance.
- Soluble in water to facilitate aqueous labeling reactions.
- Suitable for nucleic acid labeling, sequence analysis, and probe development.
Medchemexpress LLC JNJ-47965567 | 1428327-31-4 | MFCD00283342 | 99.8% | 488.64 g·mol⁻¹ | C28H32N4O2S | 1 ML
JNJ-47965567 is a centrally permeable, high-affinity, selective antagonist of the P2X7 purinergic receptor supplied as a 10 mM solution in DMSO for research use. It is used to probe P2X7-mediated signaling in vitro and in vivo and has been applied in rodent CNS pharmacology studies.
- High affinity and selectivity for P2X7 receptor.
- Suitable for in vitro and in vivo pharmacology studies.
- Supplied as a ready-to-use 10 mM solution in DMSO (1 mL).
- High chemical purity supports reproducible results.
- Available in multiple solid and solution pack sizes for flexibility.
Selleck Chemical LLC Ilginatinib hydrochloride E4630-25MG
Ilginatinib hydrochloride (NS-018 hydrochloride) is a potent small-molecule inhibitor of JAK2 that is competitive with adenosine triphosphate (ATP) which exhibits 30 50-fold greater selectivity for JAK2 over other Jak-family kinases such as JAK1 JAK3 and TYK2 It inhibits JAK2 JAK1 JAK3 and TYK2 with IC50 of 0 72 nM 33 nM 39 nM and 22 nM respectively It also showed potent inhibition of Src-family kinases SRC and FYN It can be used in research of myeloproliferative neoplasms
TARGETMOL CHEMICALS INC LLY-283 5MG
Also available in 1 mg 10 mg 50 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. LLY-283 is a potent selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor with an IC50 of 22 nM and a Kd of 6 nM for PRMT5MEP50 complex and shows antitumor activity. purity: 98%
Medchemexpress LLC B7-H4 Human Biotin 20ug | 20ug
The B7-H4 protein acts as a negative regulator inhibiting T cell-mediated immune responses including activation proliferation cytokine production and cytotoxicity When expressed on tumor macrophages it cooperates with regulatory T cells to suppress tumor-associated antigen-specific T cell immunity B7-H4 Protein Human (Biotinylated HEK293 His-Avi) is the recombinant human-derived B7-H4 protein expressed by HEK293 with C-Avi C-His labeled tag
Medchemexpress LLC 2-Furancarboxamide, 5-cyano-N-(2,5-di-1-piperidinylphenyl)- | 959626-45-0 | 99.6% | 378.47 | 1 ML
cFMS Receptor Inhibitor IV is a chemical compound with the molecular formula C22H26N4O2 and a molecular weight of 378.47. It appears as a light yellow to yellow solid and has a purity of 99.61%. This inhibitor is consistent with its structure as confirmed by 1H NMR Spectrum and LCMS analysis.
- High purity of 99.61% (LCMS)
- Consistent with structure (1H NMR Spectrum and LCMS)
- Appearance: light yellow to yellow solid
- Storage conditions: 4°C (protect from light); in solvent: -80°C for 6 months, -20°C for 1 month (protect from light)