Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

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6,736 – 6,750 of 60,541 results

6,736

Cayman Chemical Sulthiame, Purity: ≥95%, CAS: 61-56-3, 25 mg

A pan-CA inhibitor (Kis = 6-1,540 nM for CAI, -II, and IV-XIV) and an anticonvulsant; selective for these CAs over CAIII (Ki = 630 µM); inhibits voltage-gated sodium currents in isolated guinea pig hippocampal CA1 neurons at 10 µg/ml; reduces 4-aminopyridine-induced epileptiform activity in guinea pig hippocampal slices at 2.5 mM; induces neuron degeneration in neonatal rats at 100-300 mg/kg, i.p.; decreases forelimb clonus duration in a rat model of partial epilepsy induced by amygdaloid kindling at 25-200 mg/kg

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6,737

TARGETMOL CHEMICALS INC E-6-DEHYDROPARADOL 10MG

Also available in 1 mg 2 mg 5 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. (E)-[6]-Dehydroparadol ((6)-Dehydroparadol) an oxidative metabolite of [6]-Shogaol is a potent Nrf2 activator. purity: 99%

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6,738

Cayman Chemical TGN 020, Purity: ≥98%, CAS: 51987-99-6, 10 mg

An AQP4 inhibitor (IC50 = 3.1 μM in X. laevis oocytes transfected with AQP4); reduces brain edema and cortical infarction size in a mouse model of MCAO-induced transient focal cerebral ischemia at 200 mg/kg; reduces BALF IL-1α, IL-1β, IL-6, TNF-α, IL-23, and IL-17A levels and neutrophil infiltration, as well as increases survival, in a mouse model of LPS-induced acute lung injury at 200 mg/kg every 6 hours

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6,739

Cayman Chemical AB-ICA, Purity: ≥98%, 5 mg

An analytical references standard categorized as a precursor in the synthesis of 5-fluoro ABICA, 4-cyano AB-BUTICA, and AB-FUBICA; intended for research and forensic applications

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6,740

Medchemexpress LLC 5-Bromophthalide | 64169-34-2 | MFCD01797360 | 213.03 | 50 G

5-Bromophthalide is a biochemical reagent used as a biological material or organic compound for life science related research. It is intended for research use only and not for medical applications.

Biochemical reagent for life science research.
Solid appearance, white to light yellow color.
Molecular formula: C8H5BrO2.
Soluble in DMSO (25 mg/mL), requiring sonication.
Powder storage: -20°C for 3 years, 4°C for 2 years.
In solvent storage: -80°C for 6 months, -20°C for 1 month.

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6,741

Cayman Chemical Cevipabulin, Purity: ≥98%, CAS: 849550-05-6, 25 mg

An activator of microtubule polymerization; induces aggregation of isolated bovine brain tubulin; inhibits binding of vinblastine to tubulin in cell-free assays at 100 µM; induces mitotic block in HeLa cells when used at a concentration of 68 nM; cytotoxic to various cancer cell lines (IC50s = 18-40 nM); reduces tumor growth in a LoVo colon adenocarcinoma mouse xenograft model at 20 mg/kg, i.v.

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6,742

Cayman Chemical GW 406381, Purity: ≥98%, 10 mg

A NSAID and COX-2 inhibitor (IC50 = 3 nM); selective for COX-2 over COX-1 (IC50 = >84.2 µM); reverses chronic construction injury-induced decreases in paw withdrawal thresholds in a rat model of neuropathic pain at 5 mg/kg

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6,743

Cayman Chemical Anidulafungin, Purity: ≥95%, CAS: 166663-25-8, 5 mg

A semisynthetic echinocandin antifungal; inhibits 1,3-β-D glucan synthase from several C. albicans clinical isolates (IC50s = 0.89-7.96 ng/ml for the wild-type enzyme); active against C. albicans, C. parapsilosis, C. tropicalis, and C. guiillermondi (MICs = ≤0.03-4 µg/ml) and A. fumigatus (MIC90 = ≤0.03 µg/ml); increases survival and decreases the severity of pulmonary lesions in A. fumigatus-infected neutropenic rabbits at 10 mg/kg

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6,744

Cayman Chemical KYP-2047, Purity: ≥98%, CAS: 796874-99-2, 25 mg

A prolyl endopeptidase inhibitor (Ki = 0.02 nM for the porcine enzyme); inhibits hydrogen peroxide-induced aggregation of α-synuclein in SH-SY5Y cells expressing wild-type, α-synucleinA30P, or α-synucleinA53T in in vitro models of Parkinson’s disease at 1 µM; decreases palmitic acid-induced lipid peroxidation and ROS production in HepG2 cells at 10 µM; decreases ileal and pulmonary edema and pulmonary fibrosis in a mouse model of acute lung injury induced by intestinal ischemia-reperfusion at 2.5 mg/kg; reduces tumor volume and intratumoral levels of Vegf and Cd34 in a U87 glioblastoma mouse xenograft model at 2.5 mg/kg

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6,745

Medchemexpress LLC HY-100490A 5mg Medchemexpress, Rilmenidine (hemifumarate) CAS:207572-68-7 Purity:>98%

Medchemexpress, HY-100490A 5mg Rilmenidine (hemifumarate) CAS:207572-68-7 Rilmenidine hemifumarate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine hemifumarate is an alpha 2-adrenoceptor agonist. Rilmenidine hemifumarate induces autophagy. Rilmenidine hemifumarate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine hemifumarate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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6,746

Cayman Chemical Penetratin (trifluoroacetate salt), Purity: ≥95%, 5 mg

A cell-penetrating peptide; has been used in the surface functionalization of liposomes for drug delivery across the BBB

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6,747

TARGETMOL CHEMICALS INC MSC2530818 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. MSC2530818 is an effective selective and orally available CDK8 inhibitor (IC50 2.6 nM). purity: 99%

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6,748

Medchemexpress LLC Gsk3368715 dihydrochloride | 1628925-77-8 | 100.0% | 25 MG

GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active, reversible, and S-adenosyl-L-methionine (SAM) uncompetitive type I protein arginine methyltransferases (PRMTs) inhibitor. It produces a shift in arginine methylation states, alters exon usage, and exhibits strong anti-cancer activity. This compound shows 50% or more growth inhibition relative to DMSO-treated cells in the majority of 249 cancer cell lines, representing 12 tumor types. In vivo, it significantly affects the growth of BxPC3 xenografts, reducing tumor growth by 78% and 97% in the 150- and 300-mg/kg dose groups, respectively.

Orally active
Reversible inhibitor
SAM uncompetitive type I PRMTs inhibitor
Shifts arginine methylation states
Alters exon usage
Exhibits strong anti-cancer activity
Inhibits growth in various cancer cell lines
Reduces tumor growth in BxPC3 xenografts

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6,749

Medchemexpress LLC Ceperognastat (LY3372689) | 2241514-56-5 | 99.1% | 383.44 g·mol⁻¹ | C16H22FN5O3S | 5 MG

Ceperognastat is a low-dose, orally available, central nervous system-penetrant inhibitor of O-GlcNAcase (OGA) used in research on tauopathies, including Alzheimer's disease. Preclinical and clinical studies report high brain OGA enzyme occupancy and pharmacokinetic properties consistent with oral CNS drugs. Supplied for research use only.

Orally available and central nervous system-penetrant.
Achieves high OGA enzyme occupancy in animal and human brain.
Potent and selective O-GlcNAcase inhibition for tauopathy research.
High purity suitable for laboratory research (≈99.1%).
For research use only; not for human or veterinary use.

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6,750

Apexbio Technology LLC Wnt-C59 1243243-89-1 10mM (in 1mL DMSO)

Wnt-C59 (CAS 1243243-89-1) is a selective inhibitor of the Wnt signaling pathway targeting Porcupine (PORCN) an acyltransferase essential for Wnt protein secretion Exhibiting an IC50 of 74 pM Wnt-C59 blocks cellular secretion of Wnt ligands thus preventing downstream activation of Wnt-dependent transcriptional activity Studies using cell lines such as HT1080 HeLa and cholangiocarcinoma-derived CC-LP-1 SUN-1079 and CC-SW-1 have demonstrated diminished cell viability reduced proliferation and increased apoptosis upon Wnt-C59 treatment In WNT-driven tumor mouse models Wnt-C59 administration significantly inhibits tumor growth highlighting its utility for studying Wnt-mediated cancer pathogenesis and therapeutic intervention strategies

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Bioactive Small Molecules

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Medchemexpress LLC 5-Bromophthalide | 64169-34-2 | MFCD01797360 | 213.03 | 50 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC HY-100490A 5mg Medchemexpress, Rilmenidine (hemifumarate) CAS:207572-68-7 Purity:>98% Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Gsk3368715 dihydrochloride | 1628925-77-8 | 100.0% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ceperognastat (LY3372689) | 2241514-56-5 | 99.1% | 383.44 g·mol⁻¹ | C16H22FN5O3S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 5-Bromophthalide | 64169-34-2 | MFCD01797360 | 213.03 | 50 G

Medchemexpress LLC HY-100490A 5mg Medchemexpress, Rilmenidine (hemifumarate) CAS:207572-68-7 Purity:>98%

Medchemexpress LLC Gsk3368715 dihydrochloride | 1628925-77-8 | 100.0% | 25 MG

Medchemexpress LLC Ceperognastat (LY3372689) | 2241514-56-5 | 99.1% | 383.44 g·mol⁻¹ | C16H22FN5O3S | 5 MG