Bioactive Small Molecules
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Filtered Search Results
Selleck Chemical LLC dBET6 5mg 1950634-92-0
dBET6 is a highly cell-permeable PROTAC degrader of BET bromodomains with an IC50 of 14 nM for BRD4 binding. dBET6 also induces c-MYC downregulation and apoptosis. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Cayman Chemical A8SGLP-1 (trifluoroacetate salt), Purity: ≥98%, CAS: 753024-08-7, 5 mg
A peptide agonist of GLP-1R and a derivative of GLP-1 (7-36) amide; induces cAMP accumulation in RIN T3 cells (EC50 = 15 nM); reduces blood levels of glucose in the OGTT, serum levels of Il-1β, Il-6, and Tnf-α, and fat mass in diabetic db/db mice in lyophilized L. lactis, p.o.
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Medchemexpress LLC Ob-1 | 300803-69-4 | 99.1% | 50MG
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Ob-1 | 300803-69-4 | 99.1% | 50MG
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Selleck Chemical LLC Amsacrine E4925-1G
Amsacrine(m-AMSA acridinyl anisidide) is an inhibitor of topoisomerase II Amsacrine acts as an antineoplastic agent which intercalates into the DNA of tumor cells it is also used in the treatment of acute myelogenous leukemia
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Medchemexpress LLC 1-Ethyl-1H-pyrazole | 2817-71-2 | MFCD03444367 | 50g
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1-Ethyl-1H-pyrazole is a drug impurity
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Selleck Chemical LLC SNX-2112 (PF-04928473) 5mg 908112-43-6
SNX-2112 (PF-04928473) selectively binds to the ATP pocket of HSP90? and HSP90? with Ka of 30 nM and 30 nM, uniformly more potent than 17-AAG. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Selleck Chemical LLC Doxepin E7725-100MG
Doxepin is a potent inhibitor of serotonin reuptake and noradrenaline reuptake with a Ki of 68 nM and 29 5 nM respectively It acts as a receptor antagonist for histamine H1 acetylcholine muscarinic and 1 adrenoceptor with a Ki of 0 24 nM 83 nM and 24 nM respectively and significantly inhibits CYP450
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Cayman Chemical dBET6, Purity: ≥98%, CAS: 1950634-92-0, 10 mg
A PROTAC that drives BRD4 degradation; binds to BRD4 (IC50 = 14 nM) and induces its degradation at 100 nM, leading to a global inhibition of transcription in MOLT-4 cells; reduces leukemic burden in a MOLT-4 T-ALL mouse xenograft model when administered at a dose of 7.5 mg/kg twice per day
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Selleck Chemical LLC Doxorubicin E2516-100MG
Adriamycin (Doxorubicin Hydroxydaunorubicin) a cytotoxic anthracycline antibiotic is an anti-cancer chemotherapy agent inhibits topoisomerase II with an IC50 of 2 67 M thus stopping DNA replication and induces apoptosis also inhibits human DNA topoisomerase I with an IC50 of 0 8 M
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FOCUS BIOMOLECULES Biochemical Reagents, T-10418, G2A agonist, CAS 1608784-68-4, 98% by HPLC/NMR (Conforms)
Biochemical Reagents, T-10418, G2A agonist, CAS 1608784-68-4, 98% by HPLC/NMR (Conforms), T-10418 is a potent (EC50 820 nM) and selective (against 300 non-olfactory GPCRs) agonist of G2 accumulation protein (G2A/ GPR132). At 100 nM, T-10418 resulted in 244% TRPV1 sensitization in mouse sensory neurons. T-10418 is an interesting new chemical tool to study G2A biology.
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Medchemexpress LLC 4-Nh2-Exatecan 5Mg | HY1453975MG
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4-Nh2-Exatecan 5Mg
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Selleck Chemical LLC Derazantinib(ARQ-087) 2mg 1234356-69-4
Derazantinib(ARQ-087) is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with IC50 values of 1.8 nM for FGFR2, and 4.5 nM for FGFR1 and 3, showing lower potency for FGFR4 (IC50=34 nM). It also inhibits RET, DDR2, PDGFR?, VEGFR and KIT. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Cayman Chemical Tegoprazan, Purity: ≥98%, CAS: 942195-55-3, 5 mg
A proton pump inhibitor (IC50 = 0.53 µM in porcine gastric membrane vesicles); inhibits basal gastric acid secretion in pylorus-ligated rats at 10 mg/kg; reduces esophageal mucosal tissue MPO levels in a rat model of reflux esophagitis (ED50 = 5.9 mg/kg); reduces ulcer area in rat models of naproxen-, WIRS-, or ethanol-induced gastric ulcers (ED50s = 0.1, 0.1, and 1.4 mg/kg, respectively)
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Selleck Chemical LLC Thimerosal 25mg 54-64-8 Thiomersalate, Mercurothiolate
Thimerosal (Thiomersalate, Mercurothiolate) is a well-established antiseptic and antifungal agent and usually used as a preservative in vaccines, immunoglobulin preparations, skin test antigens, antivenins, ophthalmic and nasal products, and tattoo inks. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
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Medchemexpress LLC HY-104000 5mg , BAY-320 CAS:1445830-50-1 Purity:>98%
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HY-104000 5mg BAY-320 CAS: 1445830-50-1 BAY-320 is a Bub1 inhibitor, with an IC50 of 680 nM for human Bub1 in the presence of 2 mM ATP. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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