Bioactive Small Molecules
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Filtered Search Results
Apexbio Technology LLC FH1(BRD-K4477) 2719-05-3 10mM (in 1mL DMSO)
FH1 BRD-K4477 is a bioactive small molecule identified for its ability to enhance hepatocyte functionality FH1 BRD-K4477 promotes the expansion and functional maturation of cultured human hepatocytes maintaining liver-specific properties In studies involving induced pluripotent stem cell (iPSC)-derived hepatocytes (iHeps) FH1 BRD-K4477 supplementation increases albumin secretion and elevates the expression of drug-metabolizing enzyme CYP3A4 while reducing alpha-fetoprotein (AFP) secretion Based on these pharmacological properties FH1 BRD-K4477 is a valuable tool for research in liver biology hepatocyte maturation drug metabolism and regenerative medicine applications
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Cayman Chemical GK187, Purity: ≥95%, CAS: 1071001-50-7, 5 mg
A GVIA iPLA2 inhibitor; inhibits GVIA iPLA2 by 99.8% at 0.091 mole fraction; selective for GVIA iPLA2 over GIVA cPLA2 and GV sPLA2 where it shows less than 25% and 32.8% inhibition, respectively
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Medchemexpress LLC HY-14655 500mg , Sulfasalazine CAS:599-79-1 Purity:>98%
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HY-14655 500mg Sulfasalazine CAS: 599-79-1 Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer[4]. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
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Selleck Chemical LLC N-piperidine Ibrutinib HCl E2201-5MG
N-piperidine Ibrutinib hydrochloride a reversible Ibrutinib derivative is a potent BTK inhibitor with IC50s of 51 0 and 30 7 nM for WT BTK and C481S BTK respectively
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Cayman Chemical Diflapolin, Purity: ≥98%, CAS: 724453-98-9, 10 mg
A dual FLAP/sEH inhibitor; inhibits formation of LTB4 and 5-HpETE in isolated human monocytes and neutrophils (IC50s = 30 and 170 nM, respectively); inhibits the epoxide hydrolase activity of sEH (IC50 = 20 nM); selective for FLAP and sEH over 5-LO, LTC4 synthase, mPGES-1, COX-1, or COX-2 in cell-free assays, as well as 12- and 15-LO in neutrophils; reduces production of LTB4 and LTC4 and inhibits leukocyte recruitment in a mouse model of peritonitis at 1, 3, and 10 mg/kg
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Cayman Chemical Echothiophate (iodide), Purity: ≥98%, CAS: 513-10-0, 5 mg
An AChE inhibitor; is more active at ocular acetylcholinesterases than those isolated from rabbit brain, liver, or blood; reduces intraocular pressure and induces miosis in dogs with normotensive eyes and those with inherited glaucoma following topical administration of a 0.125 or 0.25% w/v solution; induces formation of subcapsular cataracts in cynomolgus monkeys
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Medchemexpress LLC BMS-191095 | 166095-21-2 | 98.01% | C22H21ClN4O2 | 50 MG
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BMS-191095 is a selective activator of mitochondrial ATP-sensitive potassium (mitoKATP) channels. It inhibits human platelet aggregation by opening mitochondrial K(ATP) channels and induces mitochondrial depolarization of vascular smooth muscle cells. It has shown to reduce neuronal damage in animal models of cerebral ischemia.
- Induces mitochondrial depolarization of vascular smooth muscle cells.
- Dose-dependently induces vasodilation in endothelium denuded cerebral arteries.
- Increases the frequency of calcium sparks in vascular smooth muscle cells.
- Inhibits human platelet aggregation.
- Reduces neuronal damage in rats with transient focal cerebral ischemia.
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Medchemexpress LLC FGF-18 Rat 100ug
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Recombinant rat FGF-18 is a heparin-binding fibroblast growth factor involved in cartilage growth, maturation, and the development and repair of bone and cartilage tissue. Supplied as a lyophilized fragment corresponding to residues E28-R199 of the rat sequence, it is intended for in vitro receptor-binding studies, cell-based activity assays, and other biochemical applications where defined FGF-18 activity is required.
- High purity (>95%) protein suitable for biochemical and cell-based assays.
- Expressed in Escherichia coli for consistent batch production.
- Lyophilized formulation dialyzed against PBS or 20 mM PB, 150 mM NaCl, pH 7.4.
- Demonstrated bioactivity with ED50 <0.5 μg/mL in 3T3 cell assays.
- Reconstitution guidance recommends a concentration of at least 100 μg/mL to preserve activity.
- Stable when aliquoted and stored at -20°C or -80°C for extended storage.
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Cayman Chemical 1-(4-Bromophenyl)piperazine (hydrochloride), Purity: ≥98%, CAS: 68104-62-1, 5 mg
An analytical reference standard categorized as a piperazine; intended for research and forensic applications
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Medchemexpress LLC Afatinib dimaleate | 850140-73-7 | MFCD25974239 | >98.0% | 718.08 g/mol | C32H33ClFN5O11 | 100 MG
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Afatinib dimaleate is the dimaleate salt form of afatinib, an orally active, irreversible inhibitor of ErbB family tyrosine kinases (EGFR and HER2). It is supplied for research and analytical applications with defined purity and storage recommendations.
- Potent, irreversible inhibitor of EGFR and HER2.
- Provided as the dimaleate salt for improved handling and stability.
- Reported high purity (>98% by HPLC) suitable for research use.
- Molecular weight 718.08 g/mol.
- Recommended storage: sealed and away from moisture; in solvent -80°C (6 months), -20°C (1 month).
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Cayman Chemical α-Propylaminopentiophenone (hydrochloride), Purity: ≥98%, CAS: 18268-15-0, 5 mg
A substituted cathinone that has propyl groups both at the α position of the cathinone structure and at the amine
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Cayman Chemical ANTIBODY BPIPP 10mg
A non-competitive inhibitor of guanylyl and adenylyl cyclases; suppresses STa-, guanylin-, atrial natriuretic peptide-, and C-type natriuretic peptide-induced cGMP accumulation in cells (IC50s = 3.4-11.2 μM); inhibits STa-, forskolin-, cholera toxin-, and isoproterenol-induced chloride efflux in T84 cells; suppresses STa-induced liquid secretion in a rabbit intestinal loop model of toxin-induced secretory diarrhea (10 or 50 μM)
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Cayman Chemical Quassin, Purity: ≥98%, CAS: 76-78-8, 5 mg
A quassinoid with diverse biological activities; active against chloroquine-sensitive and -resistant strains of P. falciparum (IC50 = 0.15 µM for both); has antifeedant and insecticidal activity against the diamondback moth when applied to dietary cabbage leaf discs at 16, 31.9, or 63.7 µg/cm2; increases viability of SH-SY5Y cells in a model of hydrogen peroxide-induced neuronal injury at 25, 50, or 100 µM
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Selleck Chemical LLC BMS-502-E1896-5MG
BMS-502 is a potent dual inhibitor of diacylglycerol kinase (DGK) and with IC50 values of 4 6 nM and 2 1 nM respectively BMS-502 also exhibits an EC50 value of 340 nM in the mouse cytotoxic T cell IFN- assay (mCTC) BMS-502 can be used in tumor immunity-related research
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Medchemexpress LLC MIF protein, human (HEK293, His) | >95.0% | 50UG
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Recombinant human macrophage migration inhibitory factor (MIF) expressed in HEK293 mammalian cells with a C-terminal His tag. Supplied lyophilized from PBS (pH 7.4) with 8% trehalose, the protein is provided at high purity and is suitable for biochemical and cell-based assays. Predicted molecular mass is 13.4 kDa; observed ~25-30 kDa on SDS-PAGE due to glycosylation.
- Expressed in HEK293 mammalian cells with a C-terminal His tag.
- Lyophilized formulation in PBS, pH 7.4, containing 8% trehalose.
- High purity (>95%) as determined by Tris-Bis PAGE.
- Predicted molecular mass 13.4 kDa; apparent ~25-30 kDa on SDS-PAGE (glycosylated).
- Suitable for biochemical and cell-based assays.
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