Bioactive Small Molecules
Selleck Chemical LLC STM2457 S9870-10MM/1ML
STM2457 is a highly potent and selective first-in-class catalytic inhibitor of RNA Methyltransferase METTL3 with an IC50 of 16 9 nM STM2457 is highly specific for METTL3 and showed no inhibition of other RNA methyltransferases
Selleck Chemical LLC FDW028 E4732-25MG
FDW028 is a highly potent and selective inhibitor of FUT8 FDW028 demonstrates strong anti-tumor effects by promoting defucosylation and inducing lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway Additionally FDW028 suppresses the AKT/mTOR signaling pathway FDW028 exhibits potent anti-Metastatic colorectal cancer (mCRC) activities
Medchemexpress LLC Dopamine Receptor D3 Antibody (YA1742) | 50 UL
Dopamine Receptor D3 Antibody (YA1742) is a rabbit-derived and non-conjugated IgG monoclonal antibody targeting Dopamine Receptor D3. It is reactive with human, mouse, and rat species, making it suitable for various research applications, particularly Western Blot (WB). The antibody is supplied as a liquid formulation containing rabbit IgG in 10mM phosphate-buffered saline, pH 7.4, 150mM sodium chloride, 0.05% BSA, 0.02% sodium azide, and 50% glycerol.
- Targets dopamine receptor D3
- Reactive with human, mouse, and rat species
- Non-conjugated IgG monoclonal antibody
- Application in Western blot (WB) with a dilution ratio of 1:500-1:1000
- Predicted and observed band size of 44 kDa
- Stored at -20°C for 1 year
- Avoid repeated freeze/thaw cycles
Medchemexpress LLC Hydroxyethylthio vitamin K3 | 59147-84-1 | 248.30 g/mol | C13H12O3S | 25 MG
Hydroxyethylthio vitamin K3 is a research-grade small molecule reported to inhibit Cdc25 phosphatases and used in cell-cycle and tumor research. It is characterized by molecular formula C13H12O3S and molecular weight 248.30 g/mol, and is supplied in milligram-scale quantities for biochemical and cellular studies.
- Cdc25 phosphatase inhibitor with reported IC50 of 4.56 μM (Cdc25A) and 23.63 μM (Cdc25B).
- Small molecule with formula C13H12O3S and molecular weight 248.30 g/mol.
- Suitable for biochemical and cellular research applications.
- Provided in milligram-scale pack sizes with recommended storage at room temperature or cold solvent conditions.
- Solid appearance; handle according to standard laboratory safety practices.
Medchemexpress LLC Ly2389575 hydrochloride | 885104-09-6 | MFCD28133385 | 99.9% | 438.58 | C15H16BrCl3N4 | 25 MG
LY2389575 hydrochloride is a research-only small molecule that acts as a selective, non-competitive negative allosteric modulator of the metabotropic glutamate receptor 3 (mGlu3). It is used to probe mGlu3 pharmacology and related pathways, including effects on Mrc1 levels and amyloid beta-related toxicity in preclinical studies.
- Selective non-competitive mGlu3 negative allosteric modulator with reported IC50 ≈ 190 nM.
- High reported purity suitable for biochemical and cellular assays.
- Available in small milligram quantities and solution formats for assay flexibility.
- Stable under recommended storage conditions for extended sample retention.
- Useful for studies of receptor modulation, signaling, and amyloid beta interactions.
Cayman Chemical 5-MAPDBhydrochlorIde 5mg
An entactogen belonging to the amphetamine and the phenethylamine classes that is structurally related to the MDA analog, 5-APDB, and MDMA; intended for forensic and research purposes
Cayman Chemical ANTIBODY PImobendn 100mg
An inhibitor of PDE3 (IC50 = 0.32 μM for guinea pig cardiac enzyme); selective for PDE3 over PDE1, PDE2, and PDE4 (IC50s = >30 μM); a calcium sensitizer, decreasing the concentration of calcium required for half-maximal contractile force in isolated, skinned porcine ventricular fibers; increases the force of contraction in electrically-stimulated isolated guinea pig papillary muscles (EC50 = 6 μM); increases survival time in dogs with congestive heart failure due to myxomatous mitral valve disease when administered in combination with angiotensin-converting enzyme inhibitors and furosemide
Medchemexpress LLC 1-Adamantylcarbinyl iodide | 51849-10-6 | 95.0% | 276.16 | 5 MG
1-Adamantylcarbinyl iodide is a drug intermediate used for the synthesis of various active compounds. It is for research use only.
- Drug intermediate
- Solid appearance
- White to off-white color
- Store at 4°C, protected from light
- Store in solvent at -80°C for 6 months or -20°C for 1 month, protected from light
Medchemexpress LLC Benzyl N-[(2S)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxo-6-(propanoylamino)hexan-2-yl]carbam | 787549-26-2 | MFCD08705325 | 99.6% | 493.55 | C27H31N3O6 | 5 MG
MOCPAC is a research-grade small molecule substrate selective for histone deacetylase 1 (HDAC1), intended for use in biochemical and enzymatic assays that require HDAC1-specific activity measurement. The compound is supplied as a solid suitable for formulation and assay preparation.
- HDAC1-specific substrate for biochemical assays.
- Purity 99.6%.
- Molecular weight 493.55.
- Chemical formula C27H31N3O6.
- Appearance white to off-white solid.
- CAS number 787549-26-2.
- Available in small milligram quantities, e.g., 5 MG.
Cayman Chemical URSOCHOLIC ACID 5MG
A bile acid; dietary administration decreases gallbladder cholesterol, phospholipid, and bile acid levels and the occurrence of gallstones in male mice fed a lithogenic diet at 0.25%
Medchemexpress LLC N-[5-[(5-tert-butyl-1,3-oxazol-2-yl)methylsulfanyl]-1,3-thiazol-2-yl]piperidine-4-carboxamide | 345627-80-7 | MFCD09833875 | 99.9% | 380.53 | C17H24N4O2S2 | 25 MG
SNS-032 is a potent, ATP-competitive small-molecule inhibitor of cyclin-dependent kinases CDK9, CDK2, and CDK7. It is used in preclinical research to probe CDK-mediated control of transcription and the cell cycle and displays antitumor activity in experimental models. Reported IC50 values are 4 nM (CDK9), 38 nM (CDK2), and 62 nM (CDK7).
- Potent inhibitor of CDK9, CDK2, and CDK7.
- Low nanomolar potency supports sensitive biochemical assays.
- ATP-competitive mechanism for target-specific profiling.
- Suitable for in vitro and preclinical cellular studies.
- Available as solid and ready-to-use DMSO solution formats.
- High purity for reproducible experimental results.
Medchemexpress LLC HY-119367 5mg Medchemexpress, ODM-203 CAS:1430723-35-5 Purity:>98%
Medchemexpress, HY-119367 5mg ODM-203 CAS:1430723-35-5 ODM-203 is a potent FGFR and VEGFR families inhibitor with IC50s of 11, 16, 6, 35 nM towards recombinant FGFR1, FGFR2, FGFR3 and FGFR4 as well as 26, 9, 5 nM towards VEGFR1, VEGFR2 and VEGFR3, respectively. ODM-203 exhibits strong anti-tumor activity and induces anti-tumor immunity. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Glucosamine (hydrochloride) | 66-84-2 | 215.63 | 25 MG
Glucosamine (hydrochloride) | 66-84-2 | 215.63 | 25 MG
Cayman Chemical DermorphInacetate 5mg
An opioid peptide; binds to μ-opioid receptors (Ki = 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (Ki = 929 nM); inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats at 1.9 µmol/kg; inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons; delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats from 10-120 pmol/animal
Apexbio Technology LLC BMS-794833 1174046-72-0 10mM (in 1mL DMSO)
BMS-794833 (CAS 1174046-72-0) is a small molecule inhibitor that acts as an ATP-competitive dual antagonist of c-Met and VEGFR2 exhibiting IC50 values of 1 7 nM and 15 nM respectively It also inhibits kinases such as Ron Axl and Flt3 with IC50 values below 3 nM BMS-794833 suppresses c-Met-mediated signaling in gastric cancer cell lines (GTL-16) with an IC50 of 39 nM and demonstrates greater than 50% tumor growth inhibition in gastric cancer xenograft models after a minimum of one tumor doubling time without significant toxicity over 14 days In glioblastoma (U87) models 25 mg/kg administration results in complete tumor growth arrest This compound supports research into tyrosine kinase signaling and targeted cancer therapies