Bioactive Small Molecules
Cayman Chemical Bilastine, Purity: ≥98%, CAS: 202189-78-4, 250 mg
A histamine H1 receptor antagonist (IC50 = 180 nM); selective for the histamine H1 receptor in a panel of 30 receptors in vitro at 100 µM; prevents microvascular extravasation (ED50 = 185 µg/kg, i.v.), bronchospasm (ED50 = 4.6 µg/kg, i.v.), and systemic anaphylaxis (ED50 = 0.2 µg/kg, p.o.) induced by subcutaneous histamine in guinea pigs; prevents anaphylaxis induced by subcutaneous administration of ovalbumin or DNP in sensitized rats at 7.6 and 6.0 mg/kg, respectively
Medchemexpress LLC TMX-2039 | 2488892-01-7 | C17H20BrFN6O3S | 50 MG
TMX-2039 is a pan-CDK inhibitor targeting both cell cycle CDKs (CDK1, CDK2, CDK4, CDK5, and CDK6) and transcriptional CDKs (CDK7 and CDK9). It exhibits high potency with low nanomolar IC50 values against several CDKs and can also function as a ligand for target proteins in PROTAC applications.
- Broad-spectrum CDK inhibition: Inhibits multiple cyclin-dependent kinases involved in cell cycle progression and gene transcription.
- High potency: Demonstrates low nanomolar IC50s against several CDKs, particularly CDK2 and CDK5.
- PROTAC ligand: Can be used as a ligand for target proteins in PROTAC (Proteolysis Targeting Chimeras) applications.
- High purity: Reported purity of 99.42%.
- Research use only: Suitable for research applications.
Medchemexpress LLC Dmtr-tna-g(o6-conph2)(n2ac)-amidite | 325683-97-4 | C54H57N8O9P | 1 MG
DMTr-TNA-G(O6-CONPh2)(N2Ac)-amidite is a purine nucleoside analog. These analogs demonstrate broad antitumor activity, specifically targeting indolent lymphoid malignancies. Their mechanisms of action include the inhibition of DNA synthesis and the induction of apoptosis.
- Purine nucleoside analog
- Exhibits broad antitumor activity
- Targets indolent lymphoid malignancies
- Inhibits DNA synthesis
- Induces apoptosis
Active Motif Garcinol
Active Motif's Garcinol is a potent inhibitor of histone acetyltransferases p300 (IC50 = 7 M) and pCAF (IC50 = 5 M). It induces apoptosis in various cell lines and promotes expansion of human hematopoietic stem cells. It is cell permeable.
Cayman Chemical SAR131675, Purity: ≥98%, CAS: 1433953-83-3, 1 mg
An ATP-competitive inhibitor of VEGFR3 (IC50 = 23 nM); selective for VEGFR3 over VEGFR2 and VEGFR1 (IC50s = 230 and >3,000 nM, respectively); inhibits survival of human lymphatic cells cultured with the VEGFR3 ligands VEGF-C and VEGF-D over the non-specific ligand VEGF-A in vitro (IC50s = 14, 17, and 664 nM, respectively); decreases VEGF-C and VEGF-A-induced migration of HMVECs at 100 and 300 nM; reduces tumor size, decreases the number of pancreatic angiogenic islets, and increases survival in the RIP1-Tag2 transgenic mouse model of pancreatic neuroendocrine tumors at 100 mg/kg; decreases tumor size, levels of VEGFR3 in mammary tumor lysates, number of tumor-associated macrophages in mammary tumors, and the number of lung metastases in a 4T1 mouse allograft model at 100 mg/kg
Medchemexpress LLC Cyclo(histidyl-proline) trifluoroacetate | 936749-56-3 | 98.3% | 348.28 | C13H15F3N4O4 | 1 ML
Cyclo(histidyl-proline) trifluoroacetate is the trifluoroacetate salt of the cyclic dipeptide cyclo(His-Pro). It is supplied as a 10 mM solution in DMSO or as solid material and is used in cell-based studies to probe NF-κB signaling, inflammatory responses, and stress-related pathways due to its ability to cross the blood-brain barrier.
- Supplied as a 10 mM solution in DMSO and as solids.
- Molecular formula C13H15F3N4O4 and molecular weight 348.28.
- Reported purity approximately 98.3% (batch-dependent).
- Soluble in DMSO and water for biological assays.
- Inhibits NF-κB nuclear accumulation in cell models.
- Capable of crossing the blood-brain barrier for CNS studies.
Cayman Chemical LOR253, Purity: ≥98%, CAS: 916151-99-0, 5 mg
An activator of KLF4; increases levels of KLF4 and induces apoptosis in HCC1187, HCC38, and MDA-MB-468 cancer cells at 5 and 10 µM; cytotoxic to a panel of 16 AML and lymphoma cell lines (IC50s = 0.057-1.75 µM); induces cell cycle arrest at the G0/G1 phase in MV4-11, KG-1, and EoL-1 cells; accelerates wound healing, as well as increases plasma levels of KLF4 and wound site MDSC accumulation, in an ob/ob mouse model of diabetic wound healing
Apexbio Technology LLC Thalidomide-O-amido-C4-NH2 TFA 1799711-25-3 25mg
Thalidomide-O-amido-C4-NH2 TFA (CAS 1799711-25-3) is a synthetic small molecule composed of a thalidomide-derived cereblon ligand conjugated to a chemical linker This compound selectively binds to cereblon (CRBN) a substrate receptor of the CRL4CRBN E3 ubiquitin ligase complex By facilitating the recruitment of target proteins to the CRBN complex it enables their ubiquitination and subsequent proteasomal degradation Thalidomide-O-amido-C4-NH2 TFA serves as a molecular tool in the development of proteolysis targeting chimeras (PROTACs) and other targeted protein degradation strategies in biomedical research
Medchemexpress LLC Berberine ursodeoxycholate | 1868138-66-2 | 99.3% | 727.93 | 5 MG
Berberine ursodeoxycholate is an orally active and potent hypolipidemic agent. This ionic salt of Berberine and Ursodeoxycholic acid significantly reduces liver fat and exhibits broad metabolic activity. It is used in research for hyperlipidemia, non-alcoholic steatohepatitis (NASH), and diabetes. The compound dissociates in the gastrointestinal tract, allowing differential absorption.
- Orally active and potent hypolipidemic agent
- Reduces liver fat content
- Exhibits broad spectrum of metabolic activity
- Used in research for hyperlipidemia, non-alcoholic steatohepatitis (NASH), and diabetes
- Dissociates in the gastrointestinal tract for differential absorption
- Significantly reduces HbA1c levels
- Stable under recommended storage conditions
Cayman Chemical SB-332235, Purity: ≥95%, CAS: 276702-15-9, 1 mg
A CXCR2 antagonist (IC50 = 9.3 nM); selective for CXCR2 over CXCR1 (IC50 = 9,633 nM); inhibits CXCL1, -5, or -8-induced migration of isolated human peripheral blood monocytes at 10 ng/ml; decreases cigarette smoke-induced increases in BALF neutrophil infiltration at 1 mg/kg; reduces Aβ42-induced increases in neuronal levels of 4-HNE in a rat model of Alzheimer's disease
Medchemexpress LLC Chimmitecan | 100MG
Chimmitecan ((S)-9-Allyl-10-Hydroxycamptothecin) a novel 9-small-alkyl-substituted lipophilic Camptothecin (HY-16560) is a potent inhibitor of topoisomerase I Chimmitecan exhibits anticancer activity[1]
Lkt Laboratories Hydroxyurea, ≥98%, 5GR
Fetal hemoglobin stimulator; ribonucleotide reductase inhibitor. CAS: 127-07-1. Additional sizes available upon request. Ships from Saint Paul, MN.
Medchemexpress LLC FGF basic/bFGF Huma 2ug
FGF-2 is a member of the fibroblast family involved in bone healing cartilage repair bone repair and nerve regeneration FGF-2 is also a mitotic promoter that accelerates cell proliferation FGF-2 regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway For example FGF-2 is involved in the JAK-STAT signaling pathway to regulate cartilage metabolism and also activates ERK signaling to promote cartilage regeneration FGF-2 combined with FGFR1/3 promoted degeneration and repair of articular cartilage respectively[1] FGF-2 is also a known carcinogen in GBM which contributes to glioma growth and vascularization[2] FGF basic/bFGF Protein Human (K128N solution) consists of 155 amino acids produced by E coli with tag free
Medchemexpress LLC HY-W040022 25mg Medchemexpress, Cefcapene pivoxil (hydrochloride hydrate) CAS:147816-24-8 Purity:>98%
Medchemexpress, HY-W040022 25mg Cefcapene pivoxil (hydrochloride hydrate) CAS:147816-24-8 Cefcapene pivoxil hydrochloride hydrate is a prodrug and an orally active 3rd-generation cephalosporin with broad-spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride hydrate is used for the study of palmoplantar pustulosis (PPP) and other infectious diseases. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Selleck Chemical LLC Tisotumab vedotin-D4051-1MG
Tisotumab vedotin (TF-011-MMAE HuMax-TF-ADC) is an antibody-drug conjugate (ADC) composed of a fully human monoclonal antibody to tissue factor III (thromboplastin) also known as CD142 conjugated to Monomethyl Auristatin E (MMAE) via a cleavable maleimidocaproyl-valyl-citrullinylp-aminobenzyloxycarbonyl (mc-val-cit-PABC) type linker Tisotumab vedotin has the potential for use in research of solid tumors mainly in cervical cancer