Bioactive Small Molecules
Bioactive Small Molecules
Tocris Bioscience™ A23187, free acid
CAS: 52665-69-7 Molecular Formula: C29H37N3O6
Cayman Chemical chartreusIs A23187 5mg
Antigen phosphopeptide corresponding to amino acid residues surrounding phospho-Ser31 of rat TH Host rabbit Cross Reactivity ( ) mouse and rat TH Applications WB IF (frozen sections) and IHC (frozen sections)
Cayman Chemical 4-bromo A23187 5mg
The first described limonoid a group of compounds known to impart bitter flavor in citrus fruits reported to demonstrate anti-proliferative and proapoptotic activity on several cancer cell lines as well as pesticidal anti-malarial anti-microbial and anti-HIV activity
Lkt Laboratories 4-bromo-A23187, ≥98%, 1MG
Non-fluorescent halogenated A23187 analog, Ca2+ ionophore. CAS: 76455-48-6. Additional sizes available upon request. Ships from Saint Paul, MN.
Cayman Chemical alcIs4 7 10 13 16Docosape 5mg
An oxidized phospholipid formed in A23187-activated monocytes by direct oxidation of endogenous PE
Cayman Chemical Gap 26trIfluoroacetAT salt 5mg
A natriuretic peptide increases ex vivo A23187-induced vasorelaxation in porcine hearts isolated from a model of acute coronary occlusion at 2 Ug/kg bolus dose followed by 0 01 Ug/kg per minute infusion
Cayman Chemical AlexamorelIntrIfluoroACTAt 5mg
A natriuretic peptide increases ex vivo A23187-induced vasorelaxation in porcine hearts isolated from a model of acute coronary occlusion at 2 Ug/kg bolus dose followed by 0 01 Ug/kg per minute infusion
Cayman Chemical 4-O-MethylhonkIol 5mg
CAY10502 s a potent nhbtor of cPLA2a wth an C50 value of 4 3 nM for the purfed enzyme from human platelets 14126 t nhbts arachdonc acd moblzaton from A23187-stmulated or TPA-stmulated human platelets wth C50 values of 570 and 0 9 nM respectvely 14126
Cayman Chemical 7-epI-10-Deacetyltaxol 5mg
A coumarin with diverse biological activities reduces A23187-induced release of PGE2 and LTC4 in isolated mouse peritoneal macrophages active against S. aureus S. epidermidis B. subtilis S. lutea and V. cholera (MICs 0.5 0.75 0.75 0.75 and 0.5 mg/ml respectively) reduces formalin-induced paw licking and biting responses in mice at 3 and 7.5 mg/kg
Cayman Chemical ANTIBODYS-NIFE 5mg
An inhibitor of IKCa1/KCa3.1 channels (IC50 9.4 nM) inhibits A23187-induced hyperpolarization of human mouse and rat erythrocytes (IC50s 14 15 and 9 nM respectively) selective over Nav and most Kv channels as well as 65 receptors and channels in a panel inhibits T-lymphocyte activation and cytokine release in vitro (IC50 ~50 nM) decreases colon inflammation and improves weight gain in a rat model of DNBS-induced IBD
Cayman Chemical -Talnolol 5mg
A 5-LO inhibitor (IC50 15 nM) selective for 5-LO over 12-LO and 15-LO (IC50s 500 and 300 nM respectively) inhibits A23187-induced 5-LO product formation in isolated human PMNs monocytes and whole blood (IC50s 0.5 0.45 and 1.5 UM respectively) increases survival in a mouse model of PAF-induced lethal shock at 3.5 mg/kg reduces pleural levels of LTB4 in a rat model of carrageenan-induced pleurisy
Cayman Chemical LactosylceramIdebovIn but 5mg
A 5-LO inhibitor (IC50 5 UM for A23187-stimulated 5-LO product synthesis in isolated human granulocytes) inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-b- activin A- BMP- or Wnt-dependent signaling in HEK293T cells (IC50s 9 3 3 2 8 2 9 6 and 3 7 UM respectively in luciferase reporter assays) increases TnnT levels in BMP4- and CHIR99021-stimulated human iPSCs
Cayman Chemical Setpprant 5mg
A potent agonist of GPR35 (EC50 1 61 nM) inhibits histamine release in isolated rat peritoneal mast cells (IC50s 0 1-50 UM) inhibits A23187-induced calcium influx in isolated rat mast cells reduces antigen-induced histamine release from rat conjunctival tissue by 46 in vitro when used at a concentration of 10 Ug/ml dose-dependently reduces the immediate hypersensitivity response in rat conjunctiva in vivo reduces mast cell degranulation in rat conjunctiva
Cayman Chemical Crotonosde 5mg
A potent agonist of GPR35 (EC50 1 61 nM) inhibits histamine release in isolated rat peritoneal mast cells (IC50s 0 1-50 UM) inhibits A23187-induced calcium influx in isolated rat mast cells reduces antigen-induced histamine release from rat conjunctival tissue by 46 in vitro when used at a concentration of 10 Ug/ml dose-dependently reduces the immediate hypersensitivity response in rat conjunctiva in vivo reduces mast cell degranulation in rat conjunctiva
Cayman Chemical Solamargne 5mg
A potent agonist of GPR35 (EC50 1 61 nM) inhibits histamine release in isolated rat peritoneal mast cells (IC50s 0 1-50 UM) inhibits A23187-induced calcium influx in isolated rat mast cells reduces antigen-induced histamine release from rat conjunctival tissue by 46 in vitro when used at a concentration of 10 Ug/ml dose-dependently reduces the immediate hypersensitivity response in rat conjunctiva in vivo reduces mast cell degranulation in rat conjunctiva
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