Protein Modification Reagents
Medchemexpress LLC TCO-PEG-TCO | 97.1% | 25 MG
TCO-PEG-TCO is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, incorporating a TCO group that can engage in an inverse electron demand Diels-Alder reaction (iEDDA) with molecules possessing Tetrazine groups. PROTACs, composed of two distinct ligands connected by a linker, target an E3 ubiquitin ligase and a specific protein, leveraging the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- PEG-based PROTAC linker
- Utilized in PROTAC synthesis
- Functions as a click chemistry reagent
- Incorporates a TCO group
- Engages in inverse electron demand Diels-Alder reaction (iEDDA)
- Leverages the intracellular ubiquitin-proteasome system
- For selective degradation of target proteins
eMolecules 9004-74-4 | m-PEG11-alcohol | Broadpharm | MFCD06201004 | 516.625 | C23H48O12 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 10g | 550803933
m-PEG11-alcohol | Broadpharm | 9004-74-4 | MFCD06201004 | 516.625 | C23H48O12 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO | 10g | 550803933
Medchemexpress LLC DSPE-PEG carboxylic acid (sodium) | 1403744-37-5 | 98.0% | (C2H4O)nC45H86NO12P.Na | 25 MG
DSPE-PEG Carboxylic acid (sodium), MW 2000 is a PEG-lipid that can be used in the preparation of drug delivery nanoparticles. It is capable of extending the blood circulation time and stability of liposomes, while also improving the targeting ability and cellular uptake efficiency of nanoparticles.
- Used in the preparation of drug delivery nanoparticles
- Prolongs the blood circulation time and stability of liposomes
- Enhances the targeting ability of nanoparticles
- Improves cellular uptake efficiency of nanoparticles
Cayman Chemical DSG-PEG 2000 1g
A PEGylated derivative of DSG; LNPs containing DSG-mPEG(2000) and encapsulating an imidazoquinoline TLR7 and TLR8 agonist and a peptide antigen EAch conjugated to PGA increase the activation of dendritic cells, macrophages, and B cells in the draining lymph node and dendritic cells and B cells in the spleen in mice compared to the non-LNP-encapsulated PGA-conjugated TLR7/8 agonist and peptide antigen.
Medchemexpress LLC DNP-PEG4-NHS ester | 858126-78-0 | 96.81% | C21H28N4O12 | 100 MG
DNP-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- For research use only
- Stable for 3 years in pure form at -20°C
- Stable for 6 months in solvent at -80°C
- Stable for 1 month in solvent at -20°C
Medchemexpress LLC Biotin-PEG6-azide | 1085938-09-5 | 99.9% | C24H44N6O8S | 50 MG
Biotin-PEG6-azide is a biotin-labeled, PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules possessing Alkyne groups. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Biotin-labeled, PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains an azide group for copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Engages in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions
Medchemexpress LLC Mal-PEG-mal (MW 2000) | 98.4% | 100 MG
Mal-PEG-mal (MW 2000) is a PEG-based PROTAC linker used in the synthesis of PROTACs. These compounds contain two different ligands connected by a linker; one targets an E3 ubiquitin ligase, and the other targets a specific protein. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- Ligands target E3 ubiquitin ligase and target protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 25 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs comprise two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, facilitating the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Peg-based protac linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC Dbco-peg3-vc-exatecan | 2754384-70-6 | 96.7% | 1331.44 | C71H79FN10O15 | 5 MG
DBCO-PEG3-VC-Exatecan is a research-grade drug-linker conjugate that couples a cleavable DBCO-PEG3-VC linker to the topoisomerase I inhibitor exatecan, supplied as an off-white to light yellow solid for use in antibody-drug conjugate (ADC) research.
- adc drug-linker conjugate for preclinical and conjugation work
- contains exatecan, a DNA topoisomerase I inhibitor
- cleavable DBCO-PEG3-VC linker suitable for bioconjugation
- high reported purity for research applications
- available in small milligram quantities for formulation and testing
BEZWADA BIOMEDICAL LLC PEG Methacrylate, MW 10,000, 5.0 GM
Acrylate/methacrylate end functionalization enables crosslinking. Polymers used in drug delivery and various biomedical applications
Medchemexpress LLC Methyltetrazine-PEG24-NHS ester | 99.3% | C64H111N5O29 | 50 MG
Methyltetrazine-PEG24-NHS ester is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs are compounds that leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC DOTA-PEG5-C6-DBCO | 94.0% | C49H71N7O14 | 50 MG
DOTA-PEG5-C6-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. It functions as a click chemistry reagent containing a DBCO group, enabling strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules that have Azide groups. PROTACs utilize the intracellular ubiquitin-proteome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Functions as a click chemistry reagent
- Contains a DBCO group
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC)
- Degrades target proteins via the ubiquitin-proteasome system
- Off-white to light yellow solid
- Soluble in DMSO and H2O
Medchemexpress LLC Mal-amido-PEG8-TFP ester | 1924596-31-5 | C32H44F4N2O13 | 250 MG
Mal-amido-PEG8-TFP ester is a PEG-based PROTAC linker. It is utilized in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for the selective degradation of target proteins. PROTACs achieve this by containing two different ligands connected by a linker: one ligand binds to an E3 ubiquitin ligase, and the other binds to the target protein.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Exploits the intracellular ubiquitin-proteasome system
- Designed for selective degradation of target proteins