Protein Modification Reagents
Medchemexpress LLC TCO-PEG8-NHS ester | 2353409-95-5 | 95.0% | C32H54N2O14 | 25 MG
TCO-PEG8-NHS ester is a PEG-based PROTAC linker. It can be used in the synthesis of PROTACs, which are compounds containing two different ligands connected by a linker: one for an E3 ubiquitin ligase and the other for a target protein. PROTACs utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Contains two different ligands connected by a linker
- One ligand for an E3 ubiquitin ligase
- Other ligand for a target protein
- Exploits the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Amine-PEG-thiol (MW 2000) | 93.0% | 100 MG
Amine-PEG-thiol (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Molecular weight: 2000 (average)
- Appearance: solid
- Color: white to off-white
- Shipping: room temperature in continental US; may vary elsewhere
- Storage: powder -20°C 3 years; in solvent -80°C 6 months, -20°C 1 month
- Solubility: in DMSO: 50 mg/mL (need ultrasonic; hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
- For research use only
Medchemexpress LLC M-PEG-C1-DSPE sodium (MW 1000) | 1000 | 500 MG
M-PEG-C1-DSPE sodium (MW 1000) is a PEG lipid and a structural analog of m-PEG-DSPE sodium (MW 1000) (HY-W440922). It can improve the delivery efficiency and tissue specificity of poorly soluble drugs.
- Enhances delivery efficiency of poorly soluble drugs.
- Enhances tissue specificity of poorly soluble drugs.
- Suitable for use in drug delivery research.
(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502472885.JPG-250.jpg)
eMolecules DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
DOPE-PEG-Cy5, MW 2,000 | Broadpharm |1295.779 | C76H119N4O11P | 98.000 | CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCCNC(=O)OCCNC(=O)CCCCC[N+]1=C(\C=C\C=C\C=C2\N(C)c3ccccc3C2(C)C)C(C)(C)c2ccccc12)OC(=O)CCCCCCC\C=C/CCCCCCCC | 5mg | 795361851
Medchemexpress LLC N-DBCO-N-bis(PEG2-C2-acid) | 2110449-00-6 | 96.7% | C33H40N2O10 | 25 MG
N-DBCO-N-bis(PEG2-C2-acid) is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. It functions as a click chemistry reagent, containing a DBCO group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules possessing Azide groups. PROTACs comprise two distinct ligands connected by a linker; one ligand targets an E3 ubiquitin ligase, and the other targets a specific protein, facilitating the selective degradation of target proteins through the intracellular ubiquitin-proteasome system.
- Peg-based protac linker
- Click chemistry reagent
- Facilitates strain-promoted alkyne-azide cycloaddition (SPAAC)
- Enables selective degradation of target proteins
Medchemexpress LLC VH032-PEG5-C6-Cl (HaloPROTAC 2) | 1799506-06-1 | 99.9% | 783.41 | 50 MG
VH032-PEG5-C6-Cl, also known as HaloPROTAC 2, is a conjugate of E3 ligase ligands and a 21-atom-length linker. This compound incorporates the VH032 based VHL ligand and a 5-unit PEG linker.
- Conjugate of ligands for E3.
- Features a 21-atom-length linker with a halogen group connector.
- Incorporates a VH032 based VHL ligand.
- Includes a 5-unit PEG linker.
- Capable of inducing degradation of GFP-HaloTag7 in cell-based assays.
Medchemexpress LLC PTDA-PEG4-azide | 2639395-40-5 | 99.3% | 539.54 | C22H33N7O9 | 5 MG
PTDA-PEG4-azide is a PEG4-linked azide reagent used as an ADC linker and for click-chemistry bioconjugation in research applications. The compound is supplied as a white to off-white oil with high purity and is provided in small, research-scale quantities.
- High purity (99.3%).
- Molecular weight 539.54 g/mol.
- Molecular formula C22H33N7O9.
- Soluble in DMSO at 125 mg/mL; ultrasonic assistance recommended; use freshly opened DMSO.
- Storage: pure form -20°C (stable for 3 years); in solvent -80°C (6 months), -20°C (1 month).
- Available in small pack sizes suitable for research use.
![Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000204110.png-250.jpg)
Medchemexpress LLC Propanoic acid, 3-[2-[2-[(4-formylbenzoyl)amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester | 1807521-07-8 | 98.5% | 406.39 g·mol⁻1 | C19H22N2O8 | 100 MG
Ald-Ph-amido-PEG2-C2-NHS ester is a noncleavable two-unit polyethylene glycol (PEG) linker designed for antibody-agent conjugation (ADC) research. It features an NHS-activated ester for amine coupling and an aldehyde-phenyl functional handle for orthogonal conjugation chemistry.
- Provides a noncleavable 2-unit PEG spacer for conjugation
- NHS ester activated for efficient coupling to primary amines
- Aldehyde-phenyl functional group for orthogonal conjugation chemistry
- High purity suitable for research applications
- Available in multiple pack sizes and formats, including 100 MG
Medchemexpress LLC DBCO-PEG5-NHS ester | 2144395-59-3 | MFCD22380747 | 95.0% | 693.74 g/mol | C36H43N3O11 | 5 MG
DBCO-PEG5-NHS ester is a DBCO-functionalized PEG5 N-hydroxysuccinimide (NHS) ester used for copper-free click chemistry and amine-directed coupling in bioconjugation. It combines a strained dibenzocyclooctyne (DBCO) for strain-promoted alkyne-azide cycloaddition (SPAAC) with an NHS ester reactive toward primary amines, making it suitable as an ADC or PROTAC linker and in general lab bioconjugation workflows.
- Contains a DBCO strained alkyne for copper-free click chemistry.
- Contains an NHS ester for efficient coupling to primary amines.
- PEG5 spacer provides hydrophilicity and flexible linkage.
- Suitable for ADC and PROTAC linker construction and general bioconjugation.
- Supplied as a solid with reported purity of approximately 95% and molecular weight ~693.7 g/mol.
Medchemexpress LLC HS-PEG3-CH2CH2NH2 hydrochloride | 2863676-86-0 | 95.0% | 100 MG
HS-PEG3-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs function by leveraging the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- PROTACs utilize two distinct ligands connected by a linker
- Selectively degrades target proteins through the ubiquitin-proteasome system
eMolecules 1334177-86-4 | Mal-amido-PEG8-C2-acid | Medchem Express | MFCD13184956 | 592.639 | C26H44N2O13 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 705859918
Mal-amido-PEG8-C2-acid | Medchem Express | 1334177-86-4 | MFCD13184956 | 592.639 | C26H44N2O13 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CCN1C(=O)C=CC1=O | 500mg | 705859918
Medchemexpress LLC Dota-PEG5-azide | 00-00-0 | 98.0% | C28H52N8O12 | 10MG
DOTA-PEG5-azide is a PEG-based linker that combines a DOTA chelator with an azide functional group for click-chemistry conjugation. Supplied as a white to off-white solid, it is intended for use in PROTAC synthesis, bioconjugation, and radiolabeling workflows where a chelator and a click-reactive handle are required.
- Contains DOTA chelator suitable for metal chelation and radiolabeling.
- Azide functional group enables copper-catalyzed and strain-promoted click reactions.
- PEG5 spacer improves solubility and reduces steric hindrance in conjugates.
- High purity (98.0%) for research-grade synthesis.
- Available in small-scale quantities compatible with iterative synthesis workflows.
Medchemexpress LLC N-(2-(4-(3,5-dioxo-1,2,4-triazolidin-4-yl)-2-methoxyphenoxy)ethyl)-4,7,10,13-tetraoxahexadec-1-5-ynamide | 99.3% | 508.52 g/mol | C23H32N4O9 | 5 MG
PTAD-PEG4-alkyne is a cleavable four-unit polyethylene glycol (PEG) linker bearing an alkyne group for click chemistry and antibody-drug conjugate synthesis. It enables conjugation to azide-functionalized molecules via copper-catalyzed azide-alkyne cycloaddition and provides a hydrophilic, cleavable spacer for payload attachment.
- Contains terminal alkyne for CuAAC (click) conjugation.
- Four-unit PEG spacer provides hydrophilicity and cleavability for ADC applications.
- High purity (99.3%) and molecular weight approximately 508.52 g/mol.
- Available in small research pack sizes, for example 5 mg.
- Storage: powder at -20°C; in solvent: -80°C up to 6 months, -20°C up to 1 month.
Medchemexpress LLC Pomalidomide-PEG2-acetic acid | 2143097-05-4 | 99.4% | 419.39 g·mol⁻1 | C19H21N3O8 | 10 MG
Pomalidomide-PEG2-acetic acid is a pomalidomide-derived cereblon E3 ligase ligand-linker conjugate that incorporates a short PEG2 spacer terminated with an acetic acid (-CH2COOH) functional group for conjugation. It is supplied as a solid building block intended for PROTAC synthesis and related coupling chemistries.
- Used as an E3 ligase ligand-linker building block for PROTAC synthesis.
- PEG2 linker with a terminal acetic acid group for amide or ester coupling.
- High purity (99.43%).
- Molecular formula C19H21N3O8 and molecular weight 419.39 g·mol⁻1.
- CAS number 2143097-05-4.
- Available in mg-scale quantities for synthetic applications.
