Protein Modification Reagents
![eMolecules 1807530-10-4 | AZIDO-PEG3-ALDEHYDE | AstaTech | MFCD28976706 | 231.252 | C9H17N3O4 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCC=O | 0.25g | 570586065](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502480748.JPG-250.jpg)
eMolecules 1807530-10-4 | AZIDO-PEG3-ALDEHYDE | AstaTech | MFCD28976706 | 231.252 | C9H17N3O4 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCC=O | 0.25g | 570586065
AZIDO-PEG3-ALDEHYDE | AstaTech | 1807530-10-4 | MFCD28976706 | 231.252 | C9H17N3O4 | 95.000 | [N-]=[N+]=NCCOCCOCCOCCC=O | 0.25g | 570586065
Cayman Chemical VH 032 LInker 1 25mg
A PROTAC precursor; has been used in the synthesis of PROTACs targeting TEAD in cancer cells
Medchemexpress LLC HY-103599 100mg Medchemexpress, (S,R,S)-AHPC-PEG2-N3 CAS:2010159-45-0 Purity:>98%
Medchemexpress, HY-103599 100mg (S,R,S)-AHPC-PEG2-N3 CAS:2010159-45-0 (S,R,S)-AHPC-PEG2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC based VHL ligand and 2-unit PEG linker used in PROTAC technology. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Methoxy polyethylene glycol succinimidyl carbonate | 1058691-00-1 | MFCD30828680 | 98.0% | 393.39 g/mol | C16H27NO10 | 50 MG
m-PEG5-succinimidyl carbonate is a methoxy-terminated, 5-unit polyethylene glycol succinimidyl carbonate used as a short PEG linker and an NHS carbonate reagent for conjugation to primary amines. It provides a stable, non-cleavable spacer to improve solubility and reduce steric hindrance in bioconjugation workflows such as ADC and PROTAC synthesis.
- Non-cleavable 5-unit methoxy-PEG linker.
- Reactive succinimidyl carbonate for primary amine conjugation.
- Molecular weight 393.39 g/mol.
- Purity 98.0%.
- Appearance: colorless to light yellow liquid.
- Storage: pure form -20°C (stable 3 years); in solvent -80°C (6 months), -20°C (1 month).
Medchemexpress LLC M-PEG15-NHS ester | 98.0% | 875.99 g/mol | C39H73NO20 | 5 MG
m-PEG15-NHS ester is a polyethylene glycol (PEG) linker bearing an N-hydroxysuccinimide (NHS) ester for amine-specific conjugation. It provides a PEG15 spacer to increase solubility and flexibility during bioconjugation and linker assembly, and is supplied with defined purity and molecular weight for research applications.
- Amine-reactive NHS ester for efficient coupling to primary amines.
- PEG15 spacer to enhance solubility and reduce steric hindrance.
- High purity suitable for research-grade bioconjugation.
- Stable when stored sealed at -20°C to preserve activity.
- Designed for linker synthesis and PROTAC construction workflows.
Kyfora Bio DSPE PEG 2000 Amine 10 MG
DSPE-PEG(2000)-amine is DSPE (a phospholipid) functionalized with PEG2000. It can be used in the synthesis of solid lipid and thermosensitive nanoparticles, as well as for encapsulation of hydrophobic drugs. Functionalization with PEG prevents increases bioavailability and prevents opsonization. It has been used for the delivery of anticancer agents as well as other drug cargo. Key application(s): Drug delivery
Medchemexpress LLC En219-alkyne | 99.6% | 488.76 g·mol⁻¹ | C22H19BrClN3O3 | 5 MG
EN219-alkyne is an alkyne-functionalized covalent probe designed to engage RNF114 and enable click-chemistry labeling and activity-based protein profiling. Supplied as a light brown solid with high purity, it provides a reactive alkyne handle for biochemical conjugation and target identification studies.
- High purity of 99.62%.
- Alkyne handle for click-chemistry conjugation.
- Targets RNF114 as a covalent ligand for activity profiling.
- Molecular formula C22H19BrClN3O3 and molecular weight 488.76 g·mol⁻¹.
- Soluble in DMSO at 100 mg/mL; ultrasonic assistance recommended.
- Store sealed at -20°C; in solution store at -80°C for long-term stability.
Medchemexpress LLC MAK683-CH2CH2COOH hydrochloride | 00-00-0 | 99.6% | 484.91 g·mol⁻¹ | C23H22ClFN6O3 | 5 MG
MAK683-CH2CH2COOH hydrochloride is a PROTAC linker supplied as a high-purity solid for research use. It binds to the EED protein and has been used with an E3 ligase ligand to design PROTAC degraders. Handle and store under recommended conditions to preserve stability and activity.
- Binds to EED (embryonic ectoderm development protein).
- High purity: 99.6%.
- Molecular weight: 484.91 g·mol⁻¹.
- Physical form: solid, white to light yellow.
- Storage: keep refrigerated at 4°C and protect from light; store under inert gas for long-term stability.
- Available in small milligram packages for research workflows.
eMolecules 17-(Bromoacetamido-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |873.961 | C40H77BrN2O13 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 490840952
17-(Bromoacetamido-PEG9-ethylcarbamoyl)tridecanoic t-butyl ester | Broadpharm |873.961 | C40H77BrN2O13 | 98.000 | CC(C)(C)OC(=O)CCCCCCCCCCCCC(=O)NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)CBr | 250mg | 490840952
Medchemexpress LLC Biotin-PEG2-alkyne | 2227450-68-0 | MFCD31922733 | 95.6% | 369.48 g/mol | C17H27N3O4S | 100 MG
Biotin-PEG2-alkyne is a short polyethylene glycol (PEG) linker functionalized with a biotin group and a terminal alkyne. It is designed for affinity-based capture and copper(I)-catalyzed azide-alkyne cycloaddition (click chemistry) conjugations in research applications.
- Contains a biotin moiety for affinity capture.
- Includes a terminal alkyne for copper(I)-catalyzed click chemistry.
- Short PEG2 linker improves solubility and reduces steric hindrance.
- Supplied as an off-white to light yellow solid.
- Purity 95.6% by supplier specification.
- Suitable for pull-down assays and biotinylation workflows.
- Store powder at -20°C for long-term stability; 4°C for shorter storage.
eMolecules 2490419-63-9 | m-PEG10-NHS ester | Broadpharm597.655 | C26H47NO14 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 462125600
m-PEG10-NHS ester | Broadpharm | 2490419-63-9597.655 | C26H47NO14 | 98.000 | COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)ON1C(=O)CCC1=O | 500mg | 462125600
Medchemexpress LLC Thiol-PEG5-amine hydrochloride | 1446256-16-1 | MFCD29052169 | 98.0% | 333.87 g/mol | C12H28ClNO5S | 5 MG
HS-PEG5-CH2CH2NH2 hydrochloride is a PEG-based PROTAC linker supplied as the hydrochloride salt. It features a terminal thiol and a terminal primary amine, enabling orthogonal conjugation strategies for assembly of bifunctional molecules and bioconjugates. The reagent is provided in small laboratory quantities for medicinal chemistry and chemical biology research.
- Provides thiol and amine functional groups for bioconjugation.
- PEG5 spacer enhances solubility and flexibility in aqueous and organic media.
- Hydrochloride salt form improves stability and handling.
- Suitable for PROTAC linker synthesis and other bifunctional molecule assembly.
- Manufacturer-stated purity: 98.0%.
- Molecular weight 333.87 g/mol; molecular formula C12H28ClNO5S.
- Soluble in DMSO for use in small-scale reactions.
Medchemexpress LLC Tos-PEG4-t-butyl ester | 217817-01-1 | 50 MG
Tos-PEG4-t-butyl ester is a PROTAC linker with a PEG composition. It is utilized in the synthesis of various PROTACs.
- Molecular weight: 432.53
- Chemical formula: C20H32O8S
- Appearance: Liquid
- Color: Colorless to light yellow
eMolecules Broadpharm | Azido-PEG5-amine | 1g | 311074551 | BP-20590 | 98.000 | 516493-93-9 | MFCD16619318 | 306.363 | C12H26N4O5
Broadpharm | Azido-PEG5-amine | 1g | 311074551 | BP-20590 | 98.000 | 516493-93-9 | MFCD16619318 | 306.363 | C12H26N4O5
Medchemexpress LLC Mal-amido-PEG2-TFP ester | 1431291-44-9 | 98.7% | 250 MG
Mal-amido-PEG2-TFP ester is a PEG-based PROTAC linker designed for use in the synthesis of PROTACs. This product is for research use only.
- PEG-based PROTAC linker
- Can be used in the synthesis of PROTACs
- PROTACs exploit the intracellular ubiquitin-proteasome system
- PROTACs selectively degrade target proteins