Protein Modification Reagents
Medchemexpress LLC Dde Biotin-PEG4-DBCO | 1807512-43-1 | 96.2% | C47H61N5O9S | 25 MG
Dde Biotin-PEG4-DBCO is a PEG-based PROTAC linker used in the synthesis of PROTACs. This click chemistry reagent contains a DBCO group that undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing azide groups.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Click chemistry reagent
- Contains a DBCO group
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC)
- Reacts with azide-containing molecules
Medchemexpress LLC Dbco-nhco-peg4-nh-boc | 1255942-12-1 | 623.74 g·mol⁻1 | C34H45N3O8 | 100 MG
DBCO-NHCO-PEG4-NH-Boc is a DBCO-functionalized PEG4 linker containing a Boc-protected amine used for copper-free click chemistry, PROTAC and ADC linker synthesis, and general bioconjugation.
- Enables strain-promoted alkyne-azide cycloaddition (SPAAC) for copper-free click reactions.
- PEG4 spacer improves solubility and provides flexible linkage.
- Boc-protected amine allows orthogonal deprotection and downstream conjugation.
- Suitable for PROTAC and ADC synthesis and other bioconjugation workflows.
- Refer to the product datasheet for storage, handling, and lot-specific purity information.
Medchemexpress LLC Fluorescein-PEG4-acid | 1807518-76-8 | 96.3% | 654.68 | 250 MG
Fluorescein-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are designed with two ligands, one for an E3 ubiquitin ligase and another for the target protein, to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.
- Functions as a PEG-based PROTAC linker
- Enables synthesis of PROTACs
- Utilizes the ubiquitin-proteasome system to selectively degrade target proteins
Medchemexpress LLC DBCO-PEG6-NHS ester | 95.0% | 737.79 | 50 MG
DBCO-PEG6-NHS ester is a click chemistry PEG reagent containing an NHS ester that reacts specifically with primary amines, such as side chains of lysine residues or aminosilane-coated surfaces, under neutral or slightly alkaline conditions. It reacts efficiently to form covalent bonds. DBCO-PEG6-NHS ester also contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
- Contains an NHS ester that reacts specifically with primary amines.
- Reacts under neutral or slightly alkaline conditions.
- Forms covalent bonds.
- Contains a DBCO group for strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Medchemexpress LLC Azide-peg4-tos | 168640-82-2 | 99.6% | C15H23N3O6S | 100 MG
Azide-PEG4-Tos is a PEG-based PROTAC linker for PROTAC synthesis. It acts as a click chemistry reagent with an Azide group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with Alkyne groups, or strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups. PROTACs use two linked ligands, one targeting an E3 ubiquitin ligase and the other a protein of interest, to selectively degrade proteins via the ubiquitin-proteasome system.
- Peg-based PROTAC linker
- Used in PROTAC synthesis
- Click chemistry reagent with azide group
- Undergoes CuAAc with alkyne groups
- Participates in SPAAC with DBCO or BCN groups
- PROTACs: two linked ligands
- Targets E3 ubiquitin ligase and protein of interest
- Utilizes ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | >=98.0% | 557.55 g/mol | C24H35N3O12 | 1 G
Mal-amido-PEG5-C2-NHS ester is a non-cleavable PEG-based linker containing a maleimide and an N-hydroxysuccinimide (NHS) ester for conjugation to thiol and amine groups in proteins, peptides, and oligonucleotides. It is commonly used in antibody-drug conjugate (ADC) synthesis and other bioconjugation research applications.
- Contains maleimide and NHS ester functional groups
- Non-cleavable PEG-based linker for bioconjugation
- CAS number 1315355-92-0
- Molecular weight 557.55 g/mol
- Formula C24H35N3O12
- Appearance viscous liquid, colorless to light yellow
- Purity >=98.0%
- Storage pure form -20°C; in solvent -80°C (6 months) or -20°C (1 month)
- Available in 1 G package
Medchemexpress LLC 5,8,11-trioxa-2-azatridecanoic acid, 13-hydroxy-, (4E)-4-cycloocten-1-yl ester | 1955497-82-1 | 99.3% | 345.43 g·mol⁻¹ | C17H31NO6
TCO-PEG3-alcohol is a PEG-based PROTAC linker and click-chemistry reagent featuring a trans-cyclooctene (TCO) moiety and a terminal alcohol. It is supplied as a viscous, colorless to light-yellow liquid with high stated purity and recommended cold storage, and is intended for use in bioconjugation, PROTAC assembly, and other chemical biology applications.
- Contains a trans-cyclooctene group for rapid iEDDA click reactions.
- PEG3 spacer provides hydrophilicity and conformational flexibility.
- Terminal alcohol enables additional derivatization and conjugation chemistry.
- High purity suitable for synthetic and bioconjugation workflows.
- Storage recommendations support long-term stability when kept cold.
Medchemexpress LLC Pomalidomide-PEG4-C-COOH | 2097938-44-6 | 99.2% | 507.49 | 5 MG
Pomalidomide-PEG4-C-COOH (Cereblon Ligand -Linker Conjugate 1) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Synthesized E3 ligase ligand-linker conjugate
- Incorporates Pomalidomide based cereblon ligand
- Uses 4-unit PEG linker
- Used in PROTAC technology
Medchemexpress LLC Cholesterol-SA-PEG-azide | 90.0% | 10 MG
Cholesterol-SA-PEG-Azide (MW 2000) is a cholesterol-conjugated polyethylene glycol derivative linked via succinic acid and terminated with an azide. Supplied as a powder with reported purity around 90%, it is used in liposome and nanoparticle formulation and provides a bioorthogonal azide handle for click conjugation.
- Provides cholesterol anchoring for liposomal or nanoparticle membranes.
- Contains a terminal azide for copper-catalyzed azide-alkyne click chemistry.
- Average PEG molecular weight ~2,000 to modulate circulation and steric properties.
- Supplied as a powder; store cold to preserve stability.
- Reported purity ~90%, suitable for formulation and conjugation research.
Medchemexpress LLC Mal-amido-PEG5-C2-NHS ester | 1315355-92-0 | >98.0% | 557.55 g·mol⁻1 | C24H35N3O12 | 250 MG
Mal-amido-PEG5-C2-NHS ester is a non-cleavable antibody-drug conjugate (ADC) linker containing a maleimide group and an N-hydroxysuccinimide (NHS) ester. The NHS ester labels primary amines on proteins and amine-modified oligonucleotides, while the maleimide provides a thiol-reactive handle; the PEG5 spacer improves solubility and spacing for bioconjugation.
- Non-cleavable linker with maleimide and NHS reactive groups.
- PEG5 spacer increases solubility and reduces steric hindrance.
- NHS ester reacts with primary amines for labeling.
- Maleimide enables thiol-selective conjugation.
- High purity suitable for research bioconjugation (≥98.0%).
Medchemexpress LLC CY7-N3 (Sulfo-Cyanine7-N3) | 97.6% | 763.95 | 5 MG
CY7-N3 (Sulfo-Cyanine7-N3) is a water-soluble Near-Infrared (NIR) dye azide designed for Click Chemistry. It possesses an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing molecules. Additionally, it can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
- Water-soluble NIR dye azide
- Contains an azide group for Click Chemistry
- Can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc)
- Can undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC)
eMolecules 1870899-46-9 | DBCO-NHCO-PEG5-acid | Broadpharm | MFCD28334546 | 596.677 | C32H40N2O9 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 500mg | 268505101
DBCO-NHCO-PEG5-acid | Broadpharm | 1870899-46-9 | MFCD28334546 | 596.677 | C32H40N2O9 | 98.000 | OC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCC(=O)N1Cc2ccccc2C#Cc2ccccc12 | 500mg | 268505101
eMolecules Methyltetrazine-PEG23-NH-Boc | Broadpharm |1344.595 | C62H113N5O26 | 0.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)cc1 | 5mg | 411413934
Methyltetrazine-PEG23-NH-Boc | Broadpharm |1344.595 | C62H113N5O26 | 0.000 | Cc1nnc(nn1)-c1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCNC(=O)OC(C)(C)C)cc1 | 5mg | 411413934
Medchemexpress LLC 4,7,10,13-Tetraoxapentadecanoic acid, 15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)- | 518044-41-2 | 99.0% | 25 MG
Mal-PEG4-acid is a PEG-based PROTAC linker used in the synthesis of PROTACs. PROTACs are composed of two distinct ligands joined by a linker, where one ligand targets an E3 ubiquitin ligase and the other targets the desired protein. These compounds utilize the intracellular ubiquitin-proteasome system for the selective degradation of target proteins.
- PEG-based PROTAC linker
- Used in the synthesis of PROTACs
- Composed of two distinct ligands connected by a linker
- One ligand targets an E3 ubiquitin ligase
- Other ligand targets the desired protein
- Utilizes the intracellular ubiquitin-proteasome system
- Selectively degrades target proteins