Substrates
ABclonal Technology c-Abl Rabbit mAb
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes including cell division adhesion differentiation and response to stress The activity of the protein is negatively regulated by its SH3 domain whereby deletion of the region encoding this domain results in an oncogene The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation suggesting a cell cycle function This gene has been found fused to a variety of translocation partner genes in various leukemias most notably the t(9 22) translocation that results in a fusion with the 5 end of the breakpoint cluster region gene (BCR MIM 151410) Alternative splicing of this gene results in two transcript variants which contain alternative first exons that are spliced to the remaining common exons
Sigma Aldrich Fine Chemicals Biosciences N-Succinyl-Gly-Gly-Phe-p-nitroanilide protease substrate | 68982-90-1 | MFCD00038721 | 10MG
N-Succinyl-Gly-Gly-Phe-p-nitroanilide protease substrate | Purity: >=98% (TLC) | Mol Wt: 499.47 | 68982-90-1 | MFCD00038721 | 10MG
Research Products International Corp D-Luciferin Potassium Salt 3 G
RPI offers the highest purity D-Luciferin Potassium Salt for a wide range of bioluminescent applications. Produces bioluminescence when oxidized by firefly luciferase. Allows highly sensitive bioluminescent measurements. Common research uses reporter gene assays, ATP assays, whole animal studies, DNA sequencing and others. Our product is specially purified and tested extensively to ensure the highest signal and reproducibility with low background and sensitivity. Guaranteed purity is determined by both standard HPLC and Chiral HPLC methods. Protect from light and moisture.
ABclonal Technology c-Abl Rabbit mAb
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes including cell division adhesion differentiation and response to stress The activity of the protein is negatively regulated by its SH3 domain whereby deletion of the region encoding this domain results in an oncogene The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation suggesting a cell cycle function This gene has been found fused to a variety of translocation partner genes in various leukemias most notably the t(9 22) translocation that results in a fusion with the 5 end of the breakpoint cluster region gene (BCR MIM 151410) Alternative splicing of this gene results in two transcript variants which contain alternative first exons that are spliced to the remaining common exons
Sigma Aldrich Fine Chemicals Biosciences Azocasein protease substrate | 102110-74-7 | MFCD00130592 | 10g
Azocasein protease substrate | 102110-74-7 | MFCD00130592 | 10g
Apexbio Technology LLC Boc-Lys(Ac)-AMC 233691-67-3 250mg
Boc-Lys Ac -AMC (CAS 233691-67-3) is a fluorescently labeled peptide substrate designed for analyzing enzymatic activity of histone deacetylases (HDACs) It enables monitoring of HDAC-mediated deacetylation reactions Boc-Lys Ac -AMC exerts its biological activity primarily through acting as a fluorogenic substrate for HDACs where deacetylation leads to subsequent fluorescence release following proteolytic cleavage Based on these properties Boc-Lys Ac -AMC holds research potential in biochemical assays and drug screening studies for characterizing HDAC enzyme kinetics and assessing inhibitor potency related to epigenetic modulation
Medchemexpress LLC Boc-LRR-AMC | 5MG
Boc-LRR-AMC (Boc-Leu-Arg-Arg-AMC) is a fluorogenic substrate which can be utilized for detecting the trypsin-like activity of the 26S proteasome or the 20S proteasome core[1]
Medchemexpress LLC Z-Gly-Gly-Arg-AMC | 66216-78-2 | 99.9% | 579.60 | 5 MG
Z-Gly-Gly-Arg-AMC is a thrombin-specific fluorogenic substrate used for testing thrombin generation in PRP (platelet-rich plasma) and PPP (platelet-poor plasma), with excitation/emission wavelengths of 390/480 nm. It is intended for research use only.
- Thrombin-specific fluorogenic substrate
- Used for testing thrombin generation in PRP and PPP
- Excitation/emission wavelengths of 390/480 nm
- Intended for research use only
Cayman Chemical HDAC8 Substrate 1ea
A PARP1 and PARP2 inhibitor (IC50s 50s 1-14.1 nM) inhibits the proliferation of Capan-1 cells (IC50 0.1 nM) as well as talazoparib- or olaparib-resistant Capan-1 cells (IC50s 1.13 and 0.89 nM respectively) inhibits the proliferation of BRCA1 mutant HCC1937 breast cancer cells (IC50 4.54 nM) reduces tumor growth in an olaparib-resistant MDA-MB-436 breast cancer mouse xenograft model at 12.5 and 25 mg/kg
![Alkali Scientific D Luciferin Free Acid [4, 5 Dihydro 2 (6 hydroxy 2 benzothiazoyl) 4 thiazole carboxylic acid], 1 G](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000660397.jpg-250.jpg)
Alkali Scientific D Luciferin Free Acid [4, 5 Dihydro 2 (6 hydroxy 2 benzothiazoyl) 4 thiazole carboxylic acid], 1 G
D-Luciferin Free Acid (1g) is a highly sensitive bioluminescence substrate used for a range of biochemical assays, particularly in high-sensitivity detection systems. The substrate undergoes oxidation by the enzyme luciferase, producing light, which can be measured and quantified. This 1g product is designed for high-throughput applications, offering excellent sensitivity and reliable results in detecting ATP or monitoring various biological activities. It is widely used in molecular biology, environmental monitoring, and pharmacology research for its ability to generate strong luminescent signals in assays involving cellular or enzymatic processes.
Alkali Scientific D Luciferin Sodium Salt [4,5 Dihydro 2 (6 hydroxy 2 benzothiazolyl) 4 thia zolecarboxylic acid, sodium salt], 50 Milligrams
D-Luciferin Sodium Salt (50mg) is a bioluminescence substrate commonly used in high-sensitivity detection assays. When oxidized by luciferase, it generates light, enabling the detection of ATP and the measurement of cellular activity. The sodium salt form of D-Luciferin is favored for applications that require stable light emission, making it essential in biological assays, including ATP monitoring, enzyme activity studies, and cell viability tests. This product is particularly useful in molecular biology, environmental testing, and pharmaceutical research, providing excellent luminescent signals for quantification in high-throughput screening systems.
Enzo Life Sciences OMNICATHEPSIN fluorogenic substrate (10mg). CAS: 65147-22-0
Fluorogenic substrate cleaved by plasma kallikrein and kallikrein 8, but not plasmin; by papain; and by most cathepsins (cathepsins B, C/DPP-I, F, K/O2, L, L2/V, O, S, and X/Z). Ex.: 380 nm, Em.: 460 nm, although the following Ex/Em can also be used: 355,375/440,450. This substrate is useful for inhibitor screening and kinetic analysis. Also available: fluorogenic calibration standard AMC (BML-KI144). Alternative name: Z-FR-AMC, Z-Phe-Arg-AMC. Purity: ≥99%. Long Term Storage: -20°C.
Research Products International Corp X-GAL and IPTG Ready to Use Non-Toxic Solution 10mg/ml, 100 Milligrams
Stable solution of X-GAL and IPTG. Does not contain DMSO or DMF. Solution concentration is 10 mg/ml X-Gal and 8 mg/ml IPTG.
Chromogenic substrate of β-Galactosidase used in combination with IPTG for detection of β-Galactosidase activity in bacterial colonies. X-GAL is cleaved at the B1-4 bond between galactose and the 5-Bromo-4-chloro-3-indolyl portion of X-GAL by β-Galactosidase via hydrolysis. The cleavage of X-GAL results in the production of a water insoluble blue dichloro-dibromo-indigo precipitate. In cloning strategies with vectors such as Lambda-11, M13mp18 and 19, pUC18 and 19, pUR222 the E. coli lacZ gene is transformed to lac+ cells. WARNING! This product can expose you to 1-Methyl-2-Pyrrolidon, a chemical which is known to the State of California to cause developmental harm. For more information go to www.P65Warnings.ca.gov.
Revvity Health Sciences Inc LANCE Ultra IκBα Ulight Peptide Substrate, 5 nmoles
LANCE Ultra IκBα Ulight Peptide Substrate, 5 nmoles