Laboratory Specialty Services
Cambridge Isotope Laboratories Rapid PCB Screening Native PAR Solution 0 5 mL
Rapid PCB Screening Native PAR Solution 0 5 mL
Crescent Chemical Co Inc SERVALYT™ 3-10 ISO-DALT
SERVALYT™ 3-10 Iso-Dalt 40 % (w/v) solution in water Iso-Dalt quality; special 2D grade to be used in 2D electrophoresis. Size - 2ML Storage Conditions - +2 °C TO +8 °C Catalog Number - 42951.04
Apexbio Technology LLC SGI-1027 1020149-73-8 10mg
SGI-1027 (CAS 1020149-73-8) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) exhibiting IC50 values of 12 5 M for DNMT1 8 M for DNMT3A and 7 5 M for DNMT3B It acts by competitively inhibiting the cofactor Ado-Met binding site rather than the DNA substrate site resulting in reduced DNMT activity and subsequent inhibition of DNA methylation SGI-1027 suppresses both mammalian and bacterial DNMTs affecting endogenous and recombinant forms In cancer cell models it induces demethylation of CpG islands in gene promoter regions leading to reactivation of silenced tumor suppressor genes such as P16 and TIMP3 and promotes DNMT1 degradation via the proteasome pathway SGI-1027 is utilized in epigenetics research to study DNA methylation dynamics and gene reactivation
![Medchemexpress LLC Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)- | 1020149-73-8 | 99.8% | 461.52 | 50 MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000366152-logo.png-250.jpg){kind=logo}
Medchemexpress LLC Benzamide, N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)- | 1020149-73-8 | 99.8% | 461.52 | 50 MG
SGI-1027 is a potent DNA methyltransferase (DNMT) inhibitor. It targets DNMT3B, DNMT3A, and DNMT1, exhibiting selective degradation of DNMT1 in various human cancer cell lines. The compound shows minimal cytotoxicity in rat hepatoma cells and does not induce apoptosis in these cells, while demonstrating antiproliferative activity and cytotoxicity against several human cell lines.
- DNA methyltransferase (DNMT) inhibitor
- Targets DNMT3B, DNMT3A, and DNMT1
- Selectively degrades DNMT1 in human cancer cell lines
- Low cytotoxicity in rat hepatoma cells
- Does not induce apoptosis in rat hepatoma cells
- Exhibits antiproliferative activity and cytotoxicity against various human cell lines
Apexbio Technology LLC SGI-1027 1020149-73-8 10mM (in 1mL DMSO)
SGI-1027 (CAS 1020149-73-8) is a small-molecule inhibitor of DNA methyltransferases (DNMTs) exhibiting IC50 values of 12 5 M for DNMT1 8 M for DNMT3A and 7 5 M for DNMT3B It acts by competitively inhibiting the cofactor Ado-Met binding site rather than the DNA substrate site resulting in reduced DNMT activity and subsequent inhibition of DNA methylation SGI-1027 suppresses both mammalian and bacterial DNMTs affecting endogenous and recombinant forms In cancer cell models it induces demethylation of CpG islands in gene promoter regions leading to reactivation of silenced tumor suppressor genes such as P16 and TIMP3 and promotes DNMT1 degradation via the proteasome pathway SGI-1027 is utilized in epigenetics research to study DNA methylation dynamics and gene reactivation
Cambridge Isotope Laboratories RoHS PBDE Calibration Solutions (CS1-CS5) 5 x 0 2 mL
RoHS PBDE Calibration Solutions (CS1-CS5) 5 x 0 2 mL
Cayman Chemical Protectin D1 Specialty Organic
A specialized pro-resolving mediator; increases macrophage phagocytosis of PMNs in vitro and after 24 hours in vivo in mice; decreases PMN infiltration in a zymosan-induced mouse model of inflammation at 300 ng per animal; inhibits increases in neutrophil counts in BALF and lung myeloperoxidase activity in an LPS-induced mouse model of pulmonary injury and inflammation
Cayman Chemical Protectin D1 Specialty Organic
A specialized pro-resolving mediator; increases macrophage phagocytosis of PMNs in vitro and after 24 hours in vivo in mice; decreases PMN infiltration in a zymosan-induced mouse model of inflammation at 300 ng per animal; inhibits increases in neutrophil counts in BALF and lung myeloperoxidase activity in an LPS-induced mouse model of pulmonary injury and inflammation
Cayman Chemical Protectin D1 Specialty Organic
A specialized pro-resolving mediator; increases macrophage phagocytosis of PMNs in vitro and after 24 hours in vivo in mice; decreases PMN infiltration in a zymosan-induced mouse model of inflammation at 300 ng per animal; inhibits increases in neutrophil counts in BALF and lung myeloperoxidase activity in an LPS-induced mouse model of pulmonary injury and inflammation
Cambridge Isotope Laboratories PCB Calibration Solutions (CS1-CS5) 5 x 200 uL
PCB Calibration Solutions (CS1-CS5) 5 x 200 uL
Medchemexpress LLC TAK-285 | 871026-44-7 | C26H25ClF3N5O3 | 25 MG
TAK-285 is a potent, selective, ATP-competitive, and orally active inhibitor of HER2 and EGFR (HER1), with IC50 values of 17 nM and 23 nM, respectively. It demonstrates over 10-fold selectivity for HER1/2 compared to HER4, and is less potent against MEK1/5, c-Met, Aurora B, Lck, and CSK. This compound exhibits effective antitumor activity and can cross the blood-brain barrier (BBB).
- Potent and selective HER2 and EGFR (HER1) inhibitor.
- ATP-competitive.
- Orally active.
- High selectivity for HER1/2 over HER4.
- Effective antitumor activity against HER2-overexpressing human breast cancer cells.
- Capable of crossing the blood-brain barrier (BBB).
Medchemexpress LLC FSL-1 TFA | 99.8% | 1666.16 | 5 MG
FSL-1 TFA is a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist that enhances resistance to experimental HSV-2 infection. It induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells.
- Targets toll-like receptor 2/6.
- Enhances resistance to experimental HSV-2 infection and significantly reduces HSV-2 replication in human vaginal epithelial cells.
- Induces MMP-9 production in monocytic THP-1 cells.
- Activates the MAP kinase/NF-κB signaling pathway.
- Protects against genital HSV-2 challenge in mice.
Hampton Research HR2-928-C6/Grid Screen PEG/LiCl #C6, 185 ml - 0.1 M BICINE pH 9.0, 1.0 M Lithium chloride, 20% w/v Polyethylene glycol 6,000
HR2-928-C6/Grid Screen PEG/LiCl #C6, 185 ml - 0.1 M BICINE pH 9.0, 1.0 M Lithium chloride, 20% w/v Polyethylene glycol 6,000. Please note items from this supplier are non-returnable.