Lipids and Lipid Derivatives
Medchemexpress LLC (S)-N-((3-Methyl-1-(methyl-d3)-1H-pyrazol-4-yl)sulfonyl)-6-(3-(3,3,3-trifluoro-2,2-dimethylpropoxy)-1H-pyrazol-1-yl)-2-(2,2,4-trimethylpyrrolidin-1-yl)nicotinamide | 2216712-66-0 | 99.23% | 600.67 | 500 UG
Elexacaftor-d3 (VX-445-d3) is the deuterium labeled form of Elexacaftor, designed as a tracer and internal standard for quantitative analysis using methods like NMR, GC-MS, or LC-MS. Deuterium substitution can impact the pharmacokinetic and metabolic profiles of drugs. Elexacaftor (VX-445) is a next-generation cystic fibrosis transmembrane conductance regulator (CFTR) corrector, which helps restore Phe508del CFTR protein function and has potential in treating cystic fibrosis. When combined with Tezacaftor and VX-770, it significantly enhances Phe508del CFTR protein processing, trafficking, and chloride transport.
- Tracer and internal standard for quantitative analysis
- Potential to influence pharmacokinetic and metabolic profiles of drugs
- Restores Phe508del CFTR protein function
- Potential to treat cystic fibrosis
- Enhances CFTR protein processing, trafficking, and chloride transport
Medchemexpress LLC Cyclin D2/CCND2 Antibody (YA789) | Predicted band size: 33 kDa; Observed band size: 38 kDa | 100 UL
The Cyclin D2/CCND2 Antibody (YA789) is a Mouse-derived, non-conjugated IgG2b monoclonal antibody designed to target Cyclin D2/CCND2. It is suitable for use in Western Blot (WB) applications.
- Mouse-derived
- Monoclonal antibody
- Reacts with human samples
- Supplied in 1x PBS, 50% glycerol, 0.5% BSA, and 0.02% sodium azide
- Recommended storage at -20°C for up to one year
- Affinity purified
- Non-conjugated
- Isotype IgG2b
Medchemexpress LLC Ibuprofen-d3 | 121662-14-4 | 99.94% | C13H15D3O2 | 50 MG
Ibuprofen-d3 is a deuterium labeled Ibuprofen, acting as a COX-1 and COX-2 inhibitor with IC50s of 13 μM and 370 μM. It incorporates stable heavy isotopes, such as deuterium, into drug molecules as tracers for quantitation during drug development. This process has the potential to affect pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC N-Caproicacid-d3 so 5mg
N-caproicacidsodiumsalt-d3 is the deuterium labeled N-caproicacidsodiumsalt[1]
Medchemexpress LLC Dopamine D2 receptor antagonist-1 | 1055411-77-2 | 99.1% | 1 ML
Dopamine D2 receptor antagonist-1 is a negative allosteric modulator (NAM) of the dopamine D2 receptor (D2R) with sub-mM affinity.
- Acts as a negative allosteric modulator
- Targets the dopamine D2 receptor (D2R)
- Exhibits sub-mM affinity