Lipids and Lipid Derivatives
Medchemexpress LLC Glyceryl triacetate | 102-76-1 | 99.9% | 10 G
Triacetin, also known as Glyceryl triacetate, is an orally active synthetic compound and triester of glycerol and acetic acid. It is notable for its ability to increase acetate bioavailability in glioma cells, leading to growth arrest and apoptosis. This compound can freely cross the blood-brain barrier and plasma membrane, increasing histone acetylation and enhancing the chemotherapeutic efficacy of Temozolomide.
- Increases acetate bioavailability in glioma cells
- Induces glioma cell growth arrest and apoptosis
- Freely crosses blood-brain barrier and plasma membrane
- Increases histone acetylation
- Enhances chemotherapeutic efficacy
- Inhibits HDAC-8 activity
- Activates mTOR complexes downstream genes
- Shows increased tumor suppressor miRs
Medchemexpress LLC MI-538 | 1857417-10-7 | 98.0% | 566.60 | 25 MG
MI-538 is an inhibitor of the interaction between menin and MLL fusion proteins with an IC50 of 21 nM. For research use only. We do not sell to patients.
- Inhibits the proliferation of MLL leukemia cells with a GI50 of 83 nM.
- Shows selectivity toward MLL fusion protein transformed cells, with no effect (up to 6 μM) on control cell lines HL-60 and HM-2 that do not harbor MLL translocations.
- Binds to menin with low nanomolar affinity (Kd=6.5 nM).
- Potent cellular activity due to improved binding affinity to menin and possibly increased cell membrane permeability.
- Results in strong down-regulation of Hoxa9 and Meis1 gene expression.
- In vivo, it causes an approximately 80% reduction in MV4;11 tumor volume without significant toxicity.
- Demonstrates improved exposure (AUC values), Cmax, and lowest clearance in blood plasma.
- Has a half-life of about 1.6 h and high oral bioavailability (~50%).
Medchemexpress LLC Triacetin | 102-76-1 | 99.6% | 1 ML
Triacetin (Glyceryl triacetate) is a synthetic, orally active compound that increases acetate bioavailability in glioma cells. It induces glioma cell growth arrest and apoptosis, freely crossing the blood brain barrier/plasma membrane. This compound also increases histone acetylation and enhances the chemotherapeutic efficacy of Temozolomide. It is intended for research use only.
- Induces growth arrest in various glioma cells
- Inhibits U87MG cell viability
- Induces apoptosis in GBM cancer cells
- Decreases class I and II HDAC mRNA expression
- Inhibits HDAC-8 activity
- Activates mTOR complexes downstream genes
- Increases tumor suppressor miRs
- Enhances chemotherapeutic efficacy with Temozolomide
- Increases survival in animal models with GBM-derived GSCs
Medchemexpress LLC 1,3-glyceryl dilinoleate | 15818-46-9 | MFCD00056310 | ≥95.0% | 616.95 g·mol⁻¹ | C39H68O5 | 25 MG
1,3-Glyceryl dilinoleate is an unsaturated diacylglycerol used as a research reagent in lipid chemistry and biochemical studies. It has chemical formula C39H68O5 and a molecular weight of 616.95 g·mol⁻¹, and is commonly supplied in small-mass packages for laboratory use.
- Used as a reagent in lipid and membrane research.
- Chemical formula C39H68O5 and molecular weight 616.95 g·mol⁻¹.
- CAS number 15818-46-9 for unambiguous identification.
- Commonly supplied in mg-scale quantities for analytical and research use.
- Typically provided at high purity suitable for research applications.
Medchemexpress LLC Trilaurin | 538-24-9 | 99.8% | 1 G
Trilaurin is an anticancer agent capable of inhibiting neoplasms initiated by dimethylbenzanthracene (DMBA) and promoted by croton oil. It functions as an endogenous metabolite.
- Inhibits neoplasm formation
- Functions as an endogenous metabolite
- Molecular weight: 639.00
- Chemical formula: C39H74O6
- Appears as a solid
- Color: White to off-white
- Purity: 99.78%
- Soluble in DMSO and DMF
- Powder storage: -20°C for 3 years, 4°C for 2 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC Tristearin | 555-43-1 | ≥98.0% | 500 MG
Tristearin (Glycerol tristearate) is a triglyceride derived from three units of stearic acid. It is commonly used as a solid-lipid nanoparticle (SLN) component for constructing drug delivery carriers, and has been shown to increase the cellular uptake rate of carried drugs, thereby enhancing drug efficacy.
- Triglyceride derived from stearic acid
- Used as a solid-lipid nanoparticle (SLN) component
- Increases cellular uptake rate of carried drugs
- Enhances drug efficacy
Medchemexpress LLC Triacetin | 102-76-1 | MFCD00008716 | >99.9% | 1 G
Triacetin (Glyceryl triacetate) is a synthetic, orally active compound that acts as a triester of glycerol and acetic acid. It readily crosses the blood-brain barrier and plasma membrane, increasing acetate bioavailability in glioma cells. This leads to glioma cell growth arrest and apoptosis.
- Induces glioma cell growth arrest
- Promotes apoptosis in glioma cells
- Increases histone acetylation
- Enhances chemotherapeutic efficacy of Temozolomide
Medchemexpress LLC Trilaurin | 538-24-9 | >99.7% | 100 MG
Trilaurin is an endogenous metabolite that could inhibit the formation of neoplasms initiated by dimethylbenzanthracene (DMBA) and promoted by croton oil. It appears as a white to off-white solid and is classified as a lipid.
- Endogenous metabolite
- Inhibits neoplasm formation initiated by DMBA
- Inhibits neoplasm formation promoted by croton oil
- Appears as a white to off-white solid
- Molecular weight of 639.00
- Chemical formula is C39H74O6
- Classified as a lipid
Apexbio Technology LLC Triolein 122-32-7 1g
Triolein (CAS 122-32-7) is a neutral triglyceride composed of glycerol esterified with three oleic acid molecules It is utilized in biomedical research for its involvement in lipid metabolism and transport processes Studies have explored Triolein also known as glyceryl trioleate for its potential to modulate very-long-chain fatty acid (VLCFA) metabolism Notably it has been investigated as a dietary intervention in X-linked adrenoleukodystrophy aiming to alter the accumulation of VLCFAs implicated in disease pathology As such Triolein serves as a model compound for understanding lipid-based therapeutic strategies in metabolic and neurodegenerative disorders
Medchemexpress LLC Trielaidin 50mg
TrielaidinIt is an organic compound belonging to the class of triacylglycerols It consists of three molecules of elaidic acid esterified to the glycerin backbone with a mild fatty smell TrieladinIt has a variety of applications in the cosmetic and personal care industries especially as an emollient and conditioning agent in skin and hair care products Additionally it is used as a lubricant and surfactant in industrial settings
Sigma Aldrich Fine Chemicals Biosciences Triacetin 99 fCC fG25KG
Triacetin is a triester of glycerin and acetic acid that occurs naturally in papaya. It is mainly used as a synthetic flavoring agent in ice-creams nonalcoholic beverages and baked goods.
Medchemexpress LLC Sorbitan tristearate | 26658-19-5 | MFCD00151165 | ≥98.0% | 963.54 g/mol | C60H114O8 | 1 KG
Sorbitan tristearate is a non-ionic surfactant used as a pharmaceutical excipient and emulsifier in formulation development. It is commonly used in topical and cosmetic preparations to improve emulsion stability, enhance skin permeability, and support consistent delivery of active ingredients.
- Non-ionic surfactant and emulsifier for oil-in-water and water-in-oil systems.
- Helps improve emulsion stability and product texture.
- Can influence skin permeability and topical delivery.
- High purity suitable for formulation and laboratory use.
- Available in bulk packaging for production-scale applications.
Medchemexpress LLC Bimax2 acetate | 98.7% | 3561.98 (free base) | 10 MG
Bimax2 acetate is a high affinity nuclear localization signal (NLS) peptide. It mimics the activity of the classical nuclear localization signal (cNLS) and competitively binds to importin α, thereby inhibiting the binding of cNLS-cargo proteins to importin α. It can be used to study the role of RBBP4 in regulating nuclear import efficiency and cell senescence.
- High affinity nuclear localization signal (NLS) peptide
- Mimics classical nuclear localization signal (cNLS) activity
- Competitively binds to importin α
- Inhibits binding of cNLS-cargo proteins to importin α
- Useful for studying the role of RBBP4 in regulating nuclear import efficiency and cell senescence
- White to off-white solid
- Soluble in H2O at ≥ 100 mg/mL
- For research use only