Lipids and Lipid Derivatives
TARGETMOL CHEMICALS INC EPITINIB SUCCINATE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer. purity: 99%
TARGETMOL CHEMICALS INC P505-15 ACETATE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage. purity: 99%
Enzo Life Sciences AG-879 (5mg). CAS: 148741-30-4
AG-879, a member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM). AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells. Purity: ≥99% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences AG-879 (25mg). CAS: 148741-30-4
AG-879, a member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM). AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells. Purity: ≥99% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: -20°C.
TARGETMOL CHEMICALS INC VITAMIN K2 25MG
Also available in 5 mg 10 mg 50 mg 100 mg and bulk. Please contact Fisher for quotes. Vitamin K2 (Menatetrenone) is a menaquinone compound and form of vitamin K2 with potential antineoplastic activity. Menatetrenone may act by modulating the signaling of certain tyrosine kinases thereby affecting several transcription factors including c-myc and c-fos. This agent inhibits tumor cell growth by inducing apoptosis and cell cycle arrest. purity: 99%
TARGETMOL CHEMICALS INC Rac-SAR131675 25MG
Also available in 1 mg, 5 mg, 10 mg, 50 mg, 100 mg, 200 mg and bulk. Please contact Fisher for quotes.(Rac)-SAR131675 is an effective and specific VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity (IC50 20 nmol/L) and VEGFR-3 autophosphorylation (IC50 45 nmol/L) in HEK cells, respectively. SAR131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 is a highly specific VEGFR-3-TK inhibitor with significant antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion. Purity 98.34%
Cayman Chemical LIgnocerIc AcId-d3 5mg
A multi-kinase inhibitor inhibits EphB2 EphA3 Kit FMS VEGFR2/KDR FLT1 FGR Src Lyn BMX and Bcr-Abl in tyrosine kinase-transformed Ba/F3 cells (EC50s 50s 51 and 14 nM respectively) inhibits wild-type and mutant RET kinases (IC50s 24 7 94 2 and 15 8 nM for wild-type RETV804L and RETV804M respectively) reduces growth of NCI-H2286 and HCC-366 cancer cells (GI50s 0 51 and 0 65 M respectively) and RAT1 cells transformed by RETC634R or RETM918T (IC50s 44 and 56 nM respectively) inhibits tumor growth in vivo in a mouse PDX model of EphA2-overexpressing TNBC
Cayman Chemical 7-acetyl PaclItaxel 10mg
An inhibitor of native (IC50 0.37 nM) and mutant Bcr-Abl inhibits the tyrosine kinase inhibitor-resistant mutant Bcr-AblT315I (IC50 2 nM) as well as Bcr-AblQ252H Bcr-AblY253F Bcr-AblM351T and Bcr-AblH396P mutants (IC50s 0.44 0.3 0.3 and 0.34 nM respectively) selective for Bcr-Abl and these mutants over the insulin receptor IGF-1R Aurora A kinase and Cdk2/cyclin E but does inhibit c-Src VEGFR2 FGFR1 and PDGFRa (IC50s 5.4 1.5 2.2 and 1.1 nM respectively) inhibits proliferation of Ba/F3 cells expressing native (IC50 0.5 nM) or mutant Bcr-Abl (IC50s 0.5-36 nM) reduces tumor growth in a Ba/F3 Bcr-AblT315I mouse xenograft model at 10-30 mg/kg