Lipids and Lipid Derivatives
Medchemexpress LLC 3-O-methyldopa (3-methoxy-L-tyrosine) | 300-48-1 | MFCD00037205; MFCD07784093 | 99.9% | 211.21 g/mol | C10H13NO4 | 5 MG
3-O-methyldopa (3-methoxy-L-tyrosine) is an analytical standard and a metabolic derivative of L-DOPA used for research and analytical applications. It can cross the blood-brain barrier and is used in studies of neuropharmacology, Parkinson's disease, and related nervous system disorders. Certificates of analysis are available for batch verification.
- Analytical standard suitable for quantitative analysis.
- Metabolite of L-DOPA that crosses the blood-brain barrier.
- Applicable to neuropharmacology and Parkinson's disease research.
- Supplied as solid and ready-to-use solution formats.
- High purity with batch-specific certificate of analysis available.
Medchemexpress LLC L-Glutamic acid, polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt) | 147245-92-9 | 98.0% | 25 MG
L-Glutamic acid, polymer with L-alanine, L-lysine and L-tyrosine, acetate (salt) | 147245-92-9 | 98.0% | 25 MG
Medchemexpress LLC AKN-028 acetate | 98.4% | 362.39 | 50 MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor. It is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response (mean IC50=1 μM). It also induces apoptosis by activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
- Novel tyrosine kinase (TK) inhibitor
- Potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM
- Inhibits FLT3 autophosphorylation
- Induces a dose-dependent cytotoxic response (mean IC50=1 μM)
- Induces apoptosis by activation of caspase 3
- Can be used in research of acute myeloid leukemia (AML)
- Inhibits growth of primary AML and MV4-11 cells in mice
Medchemexpress LLC AKN-028 acetate | 98.38% | 362.39 | 1 ML
AKN-028 acetate is a novel, potent, and orally active tyrosine kinase (TK) inhibitor. It specifically targets FMS-like receptor tyrosine kinase 3 (FLT3) with an IC50 value of 6 nM. This compound inhibits FLT3 autophosphorylation and induces a dose-dependent cytotoxic response. It also induces apoptosis through the activation of caspase 3, making it suitable for research in acute myeloid leukemia (AML).
- Potent and orally active tyrosine kinase inhibitor.
- Targets FLT3 with high specificity (IC50 = 6 nM).
- Induces dose-dependent cytotoxic response.
- Activates caspase 3, leading to apoptosis.
- Useful for acute myeloid leukemia (AML) research.
Medchemexpress LLC N2-(1H-Indol-5-yl)-6-(pyridin-4-yl)pyrazine-2,3-diamine acetate | 98.4% | 362.39 | 25 MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor and a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation, induces a dose-dependent cytotoxic response (mean IC50=1 μM), and induces apoptosis by activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML).
- Potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 of 6 nM.
- Inhibits FLT3 autophosphorylation.
- Induces dose-dependent cytotoxic response (mean IC50=1 μM).
- Induces apoptosis by activation of caspase 3.
- Inhibits growth of primary AML and MV4-11 cells in mice.
- Useful in research of acute myeloid leukemia (AML).
Medchemexpress LLC Epitinib succinate | 2252334-12-4 | 99.0% | 548.59 | 25 MG
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. It can be used for cancer research.
- Selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI)
- Designed for optimal brain penetration
- Can be used for cancer research
- Click chemistry reagent with an alkyne group
- Capable of copper-catalyzed azide-alkyne cycloaddition (CuAAC) with azide groups
Medchemexpress LLC Epitinib succinate | 2252334-12-4 | 99.0% | 548.59 | 1 ML
Epitinib succinate is an orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) designed for optimal brain penetration. It can be used for cancer research. Epitinib succinate is also a click chemistry reagent, containing an alkyne group that can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAC) with molecules containing azide groups.
- Orally active and selective epidermal growth factor receptor tyrosine kinase inhibitor
- Designed for optimal brain penetration
- Used for cancer research
- Click chemistry reagent
- Contains an alkyne group
- Can undergo copper-catalyzed azide-alkyne cycloaddition
TARGETMOL CHEMICALS INC EPITINIB SUCCINATE 5MG
Also available in 1 mg 2 mg 10 mg 25 mg 50 mg 100 mg 500 mg and bulk. Please contact Fisher for quotes. Epitinib succinate (HMPL-813 succinate) is an orally active and brain penetration EGFR tyrosine kinase inhibitor and can be used in studies about cancer. purity: 99%
TARGETMOL CHEMICALS INC P505-15 ACETATE 5MG
Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 500 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. P505-15 Acetate is a selective inhibitor of spleen tyrosine kinase that acts by suppressing leukocyte immune function and inflammation and leading to a reduction in arthritis score and attenuated histological damage. purity: 99%
Medchemexpress LLC Akn-028 (acetate) | 98.38% | 362.39 | 100 MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor. It is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation and induces dose-dependent cytotoxic response (mean IC50=1 μM). AKN-028 acetate induces apoptosis by activation of caspase 3 and can be used in research of acute myeloid leukemia (AML).
- Potent and orally active FLT3 inhibitor with an IC50 of 6 nM.
- Inhibits FLT3 autophosphorylation.
- Induces dose-dependent cytotoxic response with a mean IC50 of 1 μM.
- Induces apoptosis through activation of caspase 3.
- Suitable for research in acute myeloid leukemia (AML).
- Shows cytotoxic activity against AML cell lines.
- Inhibits tumor growth in xenograft models.
Enzo Life Sciences AG-879 (5mg). CAS: 148741-30-4
AG-879, a member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM). AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells. Purity: ≥99% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: -20°C.
Enzo Life Sciences AG-879 (25mg). CAS: 148741-30-4
AG-879, a member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM). AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells. Purity: ≥99% (HPLC). Solubility: Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml). Long Term Storage: -20°C.
Medchemexpress LLC AKN-028 (acetate) | 98.4% | 362.39 | 10 MG
AKN-028 acetate is a novel tyrosine kinase (TK) inhibitor and a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6 nM. It inhibits FLT3 autophosphorylation, induces dose-dependent cytotoxic response (mean IC50=1 μM), and triggers apoptosis by activating caspase 3. This compound is used in research of acute myeloid leukemia (AML).
- Potent, orally active FLT3 inhibitor (IC50 value of 6 nM)
- Inhibits FLT3 and KIT autophosphorylation
- Induces dose-dependent cytotoxic response (mean IC50=1 μM)
- Triggers apoptosis by activating caspase 3
- Effective in research models of acute myeloid leukemia (AML)
- Exhibits cytotoxic activity against AML cell lines
- Targets multiple kinases including CLK1, RPS6KA, VEGFR2, and FGFR2
Medchemexpress LLC Isotanshinone IIA | 20958-15-0 | 5 MG
Isotanshinone IIA is an abietane-type diterpene metabolite that non-competitively inhibits Protein Tyrosine Phosphatase 1B (PTP1B) activity with an IC50 of 11.4 μM. Intended for research use only, this product is an orange to orange-red solid with 98.0% purity. It has a molecular weight of 294.34 and a chemical formula of C19H18O3.
- Non-competitive inhibitor of Protein Tyrosine Phosphatase 1B (PTP1B) activity
- IC50 of 11.4 μM
- 98.0% purity
- Appears as an orange to orange-red solid
- Molecular weight of 294.34
- Chemical formula of C19H18O3
- Classified under Quinones and Naphthalene Quinones
- Powder storage: -20°C for 3 years
- In solvent storage: -80°C for 6 months, -20°C for 1 month
- Soluble in DMSO at 3 mg/mL (10.19 mM)
Medchemexpress LLC 3-O-Methyldopa (Standard) | 300-48-1 | 99.9% | 211.22 | 1 MG
3-O-Methyldopa (Standard) is the analytical standard of 3-O-Methyldopa. This product is intended for research and analytical applications. 3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA, which is formed by catechol-O-methyltransferase (COMT). It competitively inhibits the pharmacodynamics of l-DOPA and dopamine.
- Analytical standard for qualitative, quantitative, and methodological research experiments
- Used in HPLC, GC, and MS
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