Monosaccharides
Medchemexpress LLC K-Ras ligand-Linker Conjugate 6 | 2378261-89-1 | 50 MG
K-Ras ligand-Linker Conjugate 6 incorporates a ligand for K-Ras recruiting moiety and a PROTAC linker. This linker recruits E3 ligases such as VHL, CRBN, MDM2, and IAP, enabling the use of this conjugate in the synthesis of PROTAC K-Ras Degrader-1, a potent degrader exhibiting ≥70% degradation efficacy in SW1573 cells. PROTACs leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins by connecting a ligand for an E3 ubiquitin ligase and another for the target protein.
- Incorporates a ligand for K-Ras recruiting moiety
- Features a PROTAC linker
- Recruits E3 ligases (VHL, CRBN, MDM2, and IAP)
- Used in the synthesis of potent PROTAC K-Ras degraders
- PROTACs utilize the ubiquitin-proteasome system
- Selectively degrades target proteins
Medchemexpress LLC Glucose-6-phosphate 50ug
Recombinant mouse glucose-6-phosphate isomerase (GPI) expressed in Pichia pastoris and purified as a His-tagged protein for research applications. The enzyme catalyzes conversion of glucose-6-phosphate to fructose-6-phosphate and is supplied at >90% purity as determined by reducing SDS-PAGE. Available in small-scale quantities suitable for biochemical assays and method development.
- Recombinant mouse protein expressed in P. pastoris.
- N-terminal 6xHis tag for easy purification and detection.
- Purity greater than 90% by reducing SDS-PAGE.
- Supplied in small-scale sizes suitable for biochemical assays.
- Intended for research use only.
Medchemexpress LLC Baricitinib phosphate | 1187595-84-1 | MFCD25976707 | 100.0% | 469.41 g/mol | C16H20N7O6PS | 10 MG
Baricitinib phosphate is the phosphate salt form of baricitinib, a selective, orally bioavailable inhibitor of JAK1 and JAK2 with low-nanomolar potency. It is supplied as a solid research reagent intended for in vitro and in vivo studies probing JAK-mediated signaling.
- Selective inhibitor of JAK1 and JAK2 (IC50: JAK1 5.9 nM; JAK2 5.7 nM; TYK2 53 nM; JAK3 560 nM).
- Molecular formula C16H20N7O6PS and molecular weight 469.41 g/mol.
- CAS number 1187595-84-1.
- Purity 99.97% as listed by manufacturer.
- High solubility in DMSO (250 mg/mL; 532.58 mM); in vivo formulations show solubility ≥2.08 mg/mL (4.43 mM).
- Appearance white to yellow solid suitable for research use.
- Store sealed at 4°C; in solvent store at -80°C (1 year) or -20°C (6 months).
Medchemexpress LLC Lobenzarit disodium | 64808-48-6 | MFCD00941422 | 99.9% | 335.65 | C14H8ClNNa2O4 | 25 MG
Lobenzarit disodium is the disodium salt form of lobenzarit, supplied as a high-purity solid research reagent (CAS 64808-48-6) described as an anti-arthritic and anti-oxidative agent. It is intended for laboratory research use and is offered in small pack sizes suitable for preclinical and in vitro studies.
- High purity (≈99.9%) suitable for research applications.
- Solid form for easy weighing and handling.
- Supplied as the disodium salt for use in research studies.
- Available in multiple small pack sizes (5-500 mg) for preclinical work.
- Used as an anti-arthritic and anti-oxidative research compound.
Selleck Chemical LLC Clodronate Disodium S4108-50mg
Clodronate Disodium a bisphosphonate is a potent antiosteolytic agent which inhibits bone resorption
Selleck Chemical LLC Disodium Cromoglycate S1911-1g
Disodium Cromoglycate (Gynazole FPL 670 (Cromolyn) Disodium Cromolyn sodium) is an antiallergic drug with IC50 of 39 g/mL
Selleck Chemical LLC D-Glucose 6-phosphate disodium
D-Glucose 6-phosphate disodium salt is the disodium salt form of D-Glucose 6-phosphate a common form of glucose within the cell participating in two major metabolic pathways glycolysis and the pentose phosphate pathway It can be coverted to glycogen or starch for storage
Selleck Chemical LLC Phytic acid dipotassium salt S3326-25mg
Phytic acid dipotassium salt (Phytic acid potassium IP6 (PS)) an endogenous metabolite in rice grain extract and digest inhibits -secretase 1 (BACE1) with IC50 of approximately 0 25 M
Medchemexpress LLC Piperaquine phosphate | 85547-56-4 | 98.6% | 5 MG
Piperaquine phosphate is an antimalarial bisquinoline agent primarily used in antimalarial research. It is often studied in combination with Artemisinin.
- Used in antimalarial research.
- Acts as a bisquinoline antimalarial agent.
- Can be combined with Artemisinin for research purposes.